PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between SNRPG and DDX20

The interaction score between SNRPG and DDX20 is 5.47.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

N/A

Orthology

Organism	SNRPG Orthologue		DDX20 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
fly	Q9VXE0	1	Q9V3C4	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.23E-3

Domains

Domains present in SNRPG and DDX20:

Domains in SNRPG

Domains in DDX20

IPR001163	Small nuclear ribonucleoprotein (Sm protein)
IPR010920	Small nuclear-like ribonucleoprotein
IPR006649	snRNP domain

IPR000629	ATP-dependent helicase, DEAD-box
IPR001410	DEAD/DEAH box helicase
IPR001650	Helicase, C-terminal
IPR011545	DEAD/DEAH_N.

The Chi square scores for co-occurrence of domains that are present in SNRPG and DDX20 are listed below.

Domain 1		Domain 2		Chi Square
IPR010920	Small nuclear-like ribonucleoprotein	IPR000629	ATP-dependent helicase, DEAD-box	129.429
IPR006649	snRNP domain	IPR000629	ATP-dependent helicase, DEAD-box	117.853
IPR001163	Small nuclear ribonucleoprotein (Sm protein)	IPR000629	ATP-dependent helicase, DEAD-box	115.254
IPR010920	Small nuclear-like ribonucleoprotein	IPR001410	DEAD/DEAH box helicase	54.2779
IPR006649	snRNP domain	IPR001410	DEAD/DEAH box helicase	48.949
IPR001163	Small nuclear ribonucleoprotein (Sm protein)	IPR001410	DEAD/DEAH box helicase	47.7536
IPR010920	Small nuclear-like ribonucleoprotein	IPR011545	DEAD/DEAH_N.	32.4775
IPR006649	snRNP domain	IPR011545	DEAD/DEAH_N.	28.8609
IPR001163	Small nuclear ribonucleoprotein (Sm protein)	IPR011545	DEAD/DEAH_N.	28.0511
IPR010920	Small nuclear-like ribonucleoprotein	IPR001650	Helicase, C-terminal	22.3985
IPR006649	snRNP domain	IPR001650	Helicase, C-terminal	19.7813
IPR001163	Small nuclear ribonucleoprotein (Sm protein)	IPR001650	Helicase, C-terminal	19.1958

The background colour of the table refers to:

Blue Domain is only present in SNRPG
Yellow Domain is only present in DDX20
Green Domain is present in both SNRPG and DDX20

0.027

Post-translational Modifications

Protein: SNRPG

PTM	Residue	Reference

Protein: DDX20

PTM	Residue	Reference
Phosphorylation	705	PubMed, HPRD
Phosphorylation	714	PubMed, HPRD
Phosphoserine	714	HPRD
Phosphothreonine	705	HPRD

Localisation

Protein: SNRPG

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD

Protein: DDX20

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD

Transitive Score

The common interactors between SNRPG and DDX20 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SNRPG andDDX20. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SNRPG has 256 interactors and DDX20 has 989 interactors of which there are 61 common interactors.

Common Interactor	Name of Common Interactor	Score for SNRPG-Interactor (?)	Score for DDX20-Interactor (?)
SNRPD1	SNRPD1: Small nuclear ribonucleoprotein Sm D1	2.07E3	0.148
SNRPD3	SNRPD3: Small nuclear ribonucleoprotein Sm D3	2.07E3	0.148
LSM5	LSM5: U6 snRNA-associated Sm-like protein LSm5	691.00	0.050
LSM4	LSM4: U6 snRNA-associated Sm-like protein LSm4	691.00	0.027
KIAA0788	ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase	32.60	0.075
SNRPE	SNRPE: Small nuclear ribonucleoprotein E	8.73	0.027
SNRPB	SNRPB, COD, SNRPB1: Small nuclear ribonucleoprotein-associated proteins B and B'	2.91	0.027
LSM3	LSM3, MDS017: U6 snRNA-associated Sm-like protein LSm3	2.60	0.050
LSM8	LSM8: U6 snRNA-associated Sm-like protein LSm8	2.60	0.050
LSM2	LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2	1.22	0.148
SF3B1	SF3B1, SAP155: Splicing factor 3B subunit 1	0.890	0.047
SNRP70	SNRP70, RNPU1Z, RPU1, U1AP1: U1 small nuclear ribonucleoprotein 70 kDa	0.657	0.075
SF3B2	SF3B2, SAP145: Splicing factor 3B subunit 2	0.593	0.046
PLK1	PLK1, PLK: Serine/threonine-protein kinase PLK1	0.354	0.025
DDX21	DDX21: Nucleolar RNA helicase 2	0.293	0.083
CDC20	CDC20: Cell division cycle protein 20 homolog	0.263	0.047
SMARCA5	SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul	0.263	0.075
GNB2L1	Lung cancer oncogene 7	0.137	0.052
CHD4	CHD4: Chromodomain-helicase-DNA-binding protein 4	0.137	0.083
DDX46	DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46	0.137	0.083
CGI-48	UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho	0.123	0.047
EIF3S2	EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2	0.123	0.047
IEF-SSP-9502	PWP1: Periodic tryptophan protein 1 homolog	0.123	0.047
SND1	SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1	0.123	0.025
CHAF1B	CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B	0.123	0.047
PAK1IP1	PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1	0.123	0.047
CSTF1	CSTF1: Cleavage stimulation factor 50 kDa subunit	0.123	0.047
SMARCA4	SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4	0.083	0.083
CORO1C	CORO1C, CRNN4: Coronin-1C	0.074	0.047
SEC31L1	N/A	0.074	0.047
DDX3X	DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X	0.074	0.075
BTAF1	BTAF1, TAF172: TATA-binding protein-associated factor 172	0.074	0.075
COPB2	COPB2: Coatomer subunit beta'	0.074	0.047
COPA	COPA: Coatomer subunit alpha	0.074	0.047
DDX41	DDX41, ABS: Probable ATP-dependent RNA helicase DDX41	0.074	0.148
BLM	BLM, RECQ2, RECQL3: Bloom syndrome protein	0.074	0.075
WRN	WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase	0.074	0.075
WDR1	N/A	0.067	0.052
WDHD1	WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1	0.060	0.047
REXO2	REXO2, SFN, CGI-114, SMFN: Oligoribonuclease, mitochondrial precursor	0.060	0.025
DHX16	DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN	0.060	0.075
DICER1	DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer	0.044	0.075
ERCC3	ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit	0.044	0.075
SKIV2L	SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti	0.044	0.075
ARPC1B	ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B	0.044	0.047
GNB1	GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.044	0.047
GNB2	GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.044	0.047
DDX5	DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5	0.044	0.075
HIRA	HIRA, DGCR1, HIR, TUPLE1: Protein HIRA	0.044	0.047
SMARCA3	HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor	0.044	0.083
EIF2S1	EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1	0.044	0.075
SSRP1	SSRP1, FACT80: FACT complex subunit SSRP1	0.044	0.025
BCDO2	PTS: 6-pyruvoyl tetrahydrobiopterin synthase	0.036	0.047
DDX24	DDX24: ATP-dependent RNA helicase DDX24	0.036	0.075
DDX3Y	DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y	0.036	0.075
NUP214	N/A	0.0308	0.052
BRIP1	BRIP1, BACH1, FANCJ: Fanconi anemia group J protein	0.028	0.083
DYNC1I2	N/A	0.028	0.047
SMARCAD1	SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator	0.027	0.083
TLE3	TLE3, KIAA1547: Transducin-like enhancer protein 3	0.027	0.052
WDR54	N/A	0.027	0.052

0.572

Total Score

5.47