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Evidence of Interaction Between SNRPG and PRP19

The interaction score between SNRPG and PRP19 is 22.20.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between SNRPG and PRP19 = 0.78

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.013
Orthology
OrganismSNRPG OrthologuePRP19 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YFL017W-A 1 YLL036C 1
  • Other
  • AffinityCaptureMS

Get References From PubMed
worm Q9N4G9 1 Q10051 1
fly Q9VXE0 1 Q24055 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains Domains present in SNRPG and PRP19:
Domains in SNRPGDomains in PRP19
IPR001163 Small nuclear ribonucleoprotein (Sm protein)
IPR010920 Small nuclear-like ribonucleoprotein
IPR006649 snRNP domain
IPR001680 G-protein beta WD-40 repeat
IPR003613 Zn-finger, modified RING

The Chi square scores for co-occurrence of domains that are present in SNRPG and PRP19 are listed below.

Domain 1Domain 2Chi Square
IPR010920 Small nuclear-like ribonucleoprotein IPR001680 G-protein beta WD-40 repeat 22.3132
IPR006649 snRNP domain IPR001680 G-protein beta WD-40 repeat 19.3621
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR001680 G-protein beta WD-40 repeat 18.7041

The background colour of the table refers to:

  • Blue Domain is only present in SNRPG
  • Yellow Domain is only present in PRP19
  • Green Domain is present in both SNRPG and PRP19

 0.021
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: SNRPG

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: PRP19

LocalisationReference
Nucleus HPRD
Nucleolus HPRD
Nucleoplasm HPRD
Transitive Score

The common interactors between SNRPG and PRP19 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SNRPG andPRP19. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SNRPG has 256 interactors and PRP19 has 216 interactors of which there are 51 common interactors.

Common InteractorName of Common InteractorScore for SNRPG-Interactor (?)Score for PRP19-Interactor (?)
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 2.07E3 25.60
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 2.07E3 25.60
SNRPD2 SNRPD2, SNRPD1: Small nuclear ribonucleoprotein Sm D2 691.00 25.60
LSM5 LSM5: U6 snRNA-associated Sm-like protein LSm5 691.00 0.0968
LSM4 LSM4: U6 snRNA-associated Sm-like protein LSm4 691.00 25.60
PRPF4 PRPF4, PRP4: U4/U6 small nuclear ribonucleoprotein Prp4 69.60 1.82
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 32.60 11.10
SNRPE SNRPE: Small nuclear ribonucleoprotein E 8.73 0.108
PLRG1 PLRG1: Pleiotropic regulator 1 6.33 0.196
SNRPA1 SNRPA1: U2 small nuclear ribonucleoprotein A' 3.89 1.01
SF3B3 N/A 3.89 25.60
SART1 SART1: U4/U6.U5 tri-snRNP-associated protein 1 3.05 3.05
SNRPB SNRPB, COD, SNRPB1: Small nuclear ribonucleoprotein-associated proteins B and B' 2.91 0.108
LSM3 LSM3, MDS017: U6 snRNA-associated Sm-like protein LSm3 2.60 25.60
LSM7 LSM7: U6 snRNA-associated Sm-like protein LSm7 2.60 25.60
LSM8 LSM8: U6 snRNA-associated Sm-like protein LSm8 2.60 0.0968
SNRPF SNRPF, PBSCF: Small nuclear ribonucleoprotein F 2.60 15.50
SF3A2 SF3A2, SAP62: Splicing factor 3A subunit 2 1.84 1.49
SF3A3 SF3A3, SAP61: Splicing factor 3A subunit 3 1.84 1.84
PRPF8 PRPF8, PRPC8: Pre-mRNA-processing-splicing factor 8 1.84 3.05
TXNL4A TXNL4A, DIM1, TXNL4: Thioredoxin-like protein 4A 1.82 1.01
PRPF3 PRPF3, HPRP3, PRP3: U4/U6 small nuclear ribonucleoprotein Prp3 1.49 1.84
LSM2 LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2 1.22 15.50
LSM6 LSM6: U6 snRNA-associated Sm-like protein LSm6 1.22 25.60
LSM1 LSM1, CASM: U6 snRNA-associated Sm-like protein LSm1 1.22 15.50
PRPF31 PRPF31, PRP31: U4/U6 small nuclear ribonucleoprotein Prp31 1.10 1.01
PRPF6 PRPF6, C20orf14: Pre-mRNA-processing factor 6 0.890 10.00
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.890 1.10
SNRP70 SNRP70, RNPU1Z, RPU1, U1AP1: U1 small nuclear ribonucleoprotein 70 kDa 0.657 0.494
SF3B2 SF3B2, SAP145: Splicing factor 3B subunit 2 0.593 0.593
LUC7L N/A 0.593 0.593
PRPF40A PRPF40A, FBP11, HSPC225, FLAF1, FNBP3, HYPA: Pre-mRNA-processing factor 40 homol 0.593 0.593
SF3A1 SF3A1, SAP114: Splicing factor 3 subunit 1 0.412 0.412
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.354 0.196
SNRPEL1 RP11-390F4.1-001: Small nuclear ribonucleoprotein polypeptide E-like protein 1. 0.354 0.196
CROP CROP, CREAP1, O48: Cisplatin resistance-associated overexpressed protein 0.300 0.371
TFIP11 TFIP11, HSPC006: Tuftelin-interacting protein 11 0.249 0.201
CDC40 CDC40, EHB3, PRP17, PRPF17: Pre-mRNA-processing factor 17 0.123 1.82
LOC652595 RP11-395L14.12-001: OTTHUMP00000045488 0.119 0.119
NULL N/A 0.119 0.119
LUC7L2 N/A 0.119 0.119
NULL N/A 0.119 0.119
LOC645472 hCG_23490: Uncharacterized protein ENSP00000329276 0.119 0.119
NULL N/A 0.119 0.119
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.082 0.027
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.074 0.636
LOC119358 similar to small nuclear ribonucleoprotein D2 0.071 0.039
PRPF40B DKFZp434O1520, PRPF40B, hCG_20201: Putative uncharacterized protein DKFZp434O152 0.071 0.039
PLK3 PLK3, CNK, FNK, PRK: Serine/threonine-protein kinase PLK3 0.065 0.0455
DDX3Y DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y 0.036 1.88
HNRPD N/A 0.027 0.027
2.15E-3
Total Score 22.20