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Evidence of Interaction Between SNRPG and RECQL4

The interaction score between SNRPG and RECQL4 is 13.70.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between SNRPG and RECQL4 = 0.58

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 6.27E-3
Orthology
OrganismSNRPG OrthologueRECQL4 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
fly Q9VXE0 1 Q9VSE6 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in SNRPG and RECQL4:
Domains in SNRPGDomains in RECQL4
IPR001163 Small nuclear ribonucleoprotein (Sm protein)
IPR010920 Small nuclear-like ribonucleoprotein
IPR006649 snRNP domain
IPR001410 DEAD/DEAH box helicase
IPR001650 Helicase, C-terminal
IPR002464 ATP-dependent helicase, DEAH-box
IPR004589 ATP-dependent DNA helicase RecQ
IPR011545 DEAD/DEAH_N.

The Chi square scores for co-occurrence of domains that are present in SNRPG and RECQL4 are listed below.

Domain 1Domain 2Chi Square
IPR010920 Small nuclear-like ribonucleoprotein IPR001410 DEAD/DEAH box helicase 54.2779
IPR006649 snRNP domain IPR001410 DEAD/DEAH box helicase 48.949
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR001410 DEAD/DEAH box helicase 47.7536
IPR010920 Small nuclear-like ribonucleoprotein IPR011545 DEAD/DEAH_N. 32.4775
IPR006649 snRNP domain IPR011545 DEAD/DEAH_N. 28.8609
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR011545 DEAD/DEAH_N. 28.0511
IPR010920 Small nuclear-like ribonucleoprotein IPR001650 Helicase, C-terminal 22.3985
IPR006649 snRNP domain IPR001650 Helicase, C-terminal 19.7813
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR001650 Helicase, C-terminal 19.1958

The background colour of the table refers to:

  • Blue Domain is only present in SNRPG
  • Yellow Domain is only present in RECQL4
  • Green Domain is present in both SNRPG and RECQL4

 0.027
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: SNRPG

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: RECQL4

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between SNRPG and RECQL4 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SNRPG andRECQL4. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SNRPG has 256 interactors and RECQL4 has 98 interactors of which there are 22 common interactors.

Common InteractorName of Common InteractorScore for SNRPG-Interactor (?)Score for RECQL4-Interactor (?)
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 2.07E3 0.074
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 2.07E3 0.060
SNRPD2 SNRPD2, SNRPD1: Small nuclear ribonucleoprotein Sm D2 691.00 0.036
LSM5 LSM5: U6 snRNA-associated Sm-like protein LSm5 691.00 0.060
LSM4 LSM4: U6 snRNA-associated Sm-like protein LSm4 691.00 0.041
SNRPE SNRPE: Small nuclear ribonucleoprotein E 8.73 0.067
SNRPB SNRPB, COD, SNRPB1: Small nuclear ribonucleoprotein-associated proteins B and B' 2.91 0.050
LSM3 LSM3, MDS017: U6 snRNA-associated Sm-like protein LSm3 2.60 0.060
LSM7 LSM7: U6 snRNA-associated Sm-like protein LSm7 2.60 0.044
LSM8 LSM8: U6 snRNA-associated Sm-like protein LSm8 2.60 0.036
SNRPF SNRPF, PBSCF: Small nuclear ribonucleoprotein F 2.60 0.044
LSM2 LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2 1.22 0.036
LSM6 LSM6: U6 snRNA-associated Sm-like protein LSm6 1.22 0.036
LSM1 LSM1, CASM: U6 snRNA-associated Sm-like protein LSm1 1.22 0.036
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.263 0.044
DDX41 DDX41, ABS: Probable ATP-dependent RNA helicase DDX41 0.074 0.028
WRN WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase 0.074 0.038
EXOSC8 EXOSC8, OIP2, RRP43: Exosome complex exonuclease RRP43 0.057 0.065
EXOSC7 EXOSC7, KIAA0116, RRP42: Exosome complex exonuclease RRP42 0.051 0.029
SMARCA3 HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor 0.044 0.0255
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.044 0.074
KARS KARS, KIAA0070: Lysyl-tRNA synthetase 0.027 0.039
0.572
Total Score 13.70