PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between SNRPG and LSM8

The interaction score between SNRPG and LSM8 is 597.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between SNRPG and LSM8 = 0.84

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

0.027

Orthology

Organism	SNRPG Orthologue		LSM8 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
worm	Q9N4G9	1	Q95XD4	1
fly	Q9VXE0	1	Q9W087	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.23E-3

Domains

Domains present in SNRPG and LSM8:

Domains in SNRPG

Domains in LSM8

IPR001163	Small nuclear ribonucleoprotein (Sm protein)
IPR010920	Small nuclear-like ribonucleoprotein
IPR006649	snRNP domain

IPR001163	Small nuclear ribonucleoprotein (Sm protein)
IPR010920	Small nuclear-like ribonucleoprotein
IPR006649	snRNP domain

The Chi square scores for co-occurrence of domains that are present in SNRPG and LSM8 are listed below.

Domain 1		Domain 2		Chi Square
IPR001163	Small nuclear ribonucleoprotein (Sm protein)	IPR006649	snRNP domain	1325.87
IPR001163	Small nuclear ribonucleoprotein (Sm protein)	IPR001163	Small nuclear ribonucleoprotein (Sm protein)	1297.61
IPR006649	snRNP domain	IPR006649	snRNP domain	1206.57
IPR010920	Small nuclear-like ribonucleoprotein	IPR006649	snRNP domain	1168.89
IPR001163	Small nuclear ribonucleoprotein (Sm protein)	IPR010920	Small nuclear-like ribonucleoprotein	1143.95
IPR010920	Small nuclear-like ribonucleoprotein	IPR010920	Small nuclear-like ribonucleoprotein	355.236

The background colour of the table refers to:

Blue Domain is only present in SNRPG
Yellow Domain is only present in LSM8
Green Domain is present in both SNRPG and LSM8

0.265

Post-translational Modifications

Protein: SNRPG

PTM	Residue	Reference

Protein: LSM8

PTM	Residue	Reference
N-acetylthreonine	1	HPRD

Localisation

Protein: SNRPG

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD

Protein: LSM8

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD

Transitive Score

The common interactors between SNRPG and LSM8 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SNRPG andLSM8. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SNRPG has 256 interactors and LSM8 has 288 interactors of which there are 191 common interactors.

Common Interactor	Name of Common Interactor	Score for SNRPG-Interactor (?)	Score for LSM8-Interactor (?)
SNRPD1	SNRPD1: Small nuclear ribonucleoprotein Sm D1	2.07E3	10.30
SNRPD3	SNRPD3: Small nuclear ribonucleoprotein Sm D3	2.07E3	10.30
SNRPD2	SNRPD2, SNRPD1: Small nuclear ribonucleoprotein Sm D2	691.00	2.60
LSM5	LSM5: U6 snRNA-associated Sm-like protein LSm5	691.00	4.86
LSM4	LSM4: U6 snRNA-associated Sm-like protein LSm4	691.00	1.22
PRPF4	PRPF4, PRP4: U4/U6 small nuclear ribonucleoprotein Prp4	69.60	0.123
KIAA0788	ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase	32.60	0.257
PRP19	PRPF19, NMP200, PRP19, SNEV: Pre-mRNA-processing factor 19	25.60	0.0968
SNRPE	SNRPE: Small nuclear ribonucleoprotein E	8.73	2.91
SNRPB	SNRPB, COD, SNRPB1: Small nuclear ribonucleoprotein-associated proteins B and B'	2.91	2.91
LSM3	LSM3, MDS017: U6 snRNA-associated Sm-like protein LSm3	2.60	10.30
LSM7	LSM7: U6 snRNA-associated Sm-like protein LSm7	2.60	2.60
SNRPF	SNRPF, PBSCF: Small nuclear ribonucleoprotein F	2.60	205.00
LSM2	LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2	1.22	383.00
LSM6	LSM6: U6 snRNA-associated Sm-like protein LSm6	1.22	2.60
LSM1	LSM1, CASM: U6 snRNA-associated Sm-like protein LSm1	1.22	0.739
NUP37	NUP37: Nucleoporin Nup37	0.789	0.123
DDX21	DDX21: Nucleolar RNA helicase 2	0.293	0.613
DHX15	DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase	0.293	0.293
RBBP4	RBBP4, RBAP48: Histone-binding protein RBBP4	0.263	0.257
NUP43	N/A	0.263	0.123
CDC20	CDC20: Cell division cycle protein 20 homolog	0.263	0.156
EIF4A1	EIF4A1, DDX2A, EIF4A: Eukaryotic initiation factor 4A-I	0.263	0.123
BAT1	N/A	0.263	0.263
DDX1	DDX1: ATP-dependent RNA helicase DDX1	0.263	0.074
BOP1	BOP1, KIAA0124: Ribosome biogenesis protein BOP1	0.263	0.074
SMARCA5	SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul	0.263	0.257
LSM10	LSM10: U7 snRNA-associated Sm-like protein LSm10	0.237	0.237
LSM11	LSM11: U7 snRNA-associated Sm-like protein LSm11	0.237	0.237
SNRPN	HCERN3, SNRPN, SMN: Small nuclear ribonucleoprotein-associated protein N	0.158	0.158
SEC13L1	SEC13, D3S1231E, SEC13L1, SEC13R: Protein SEC13 homolog	0.137	0.083
WDR41	N/A	0.137	0.083
GNB2L1	Lung cancer oncogene 7	0.137	0.613
CHD4	CHD4: Chromodomain-helicase-DNA-binding protein 4	0.137	0.287
DDX50	DDX50: ATP-dependent RNA helicase DDX50	0.137	0.137
DDX46	DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46	0.137	0.613
GTF3C2	GTF3C2, KIAA0011: General transcription factor 3C polypeptide 2	0.137	0.137
CGI-48	UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho	0.123	0.257
CDC40	CDC40, EHB3, PRP17, PRPF17: Pre-mRNA-processing factor 17	0.123	0.074
EIF3S2	EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2	0.123	0.257
IEF-SSP-9502	PWP1: Periodic tryptophan protein 1 homolog	0.123	0.257
SND1	SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1	0.123	0.257
ASCC3	ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3	0.123	0.074
POLD1	POLD1, POLD: DNA polymerase delta catalytic subunit	0.123	0.123
TAF5	TAF5, TAF2D: Transcription initiation factor TFIID subunit 5	0.123	0.074
DDX19A	DDX19A, DDX19L: ATP-dependent RNA helicase DDX19A	0.123	0.123
WDR3	WDR3: WD repeat-containing protein 3	0.123	0.123
DDX49	DDX49: Probable ATP-dependent RNA helicase DDX49	0.123	0.074
RBBP7	RBBP7, RBAP46: Histone-binding protein RBBP7	0.123	0.123
WDR77	WDR77, HKMT1069, hCG_39991: Androgen receptor cofactor p44	0.123	0.123
WDR12	WDR12: WD repeat-containing protein 12	0.123	0.074
DDX18	DDX18: ATP-dependent RNA helicase DDX18	0.123	0.123
STRAP	STRAP, MAWD, UNRIP: Serine-threonine kinase receptor-associated protein	0.123	0.074
WDR68	WDR68, HAN11: WD repeat-containing protein 68	0.123	0.074
WDR57	WDR57, PRP8BP, SFP38: WD repeat-containing protein 57	0.123	0.074
DDX23	DDX23: Probable ATP-dependent RNA helicase DDX23	0.123	0.123
CNOT7	CNOT7, CAF1: CCR4-NOT transcription complex subunit 7	0.123	0.263
RNU3IP2	RRP9, RNU3IP2, U355K: U3 small nucleolar RNA-interacting protein 2	0.123	0.074
CHAF1B	CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B	0.123	0.156
RAD54L	RAD54L, RAD54A: DNA repair and recombination protein RAD54-like	0.123	0.074
WDR18	N/A	0.123	0.074
PAK1IP1	PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1	0.123	0.126
DDX47	E4-DBP: DEAD box protein	0.123	0.123
DDX39	DDX39: ATP-dependent RNA helicase DDX39	0.123	0.123
PPP2R2A	PPP2R2A: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alp	0.123	0.123
CSTF1	CSTF1: Cleavage stimulation factor 50 kDa subunit	0.123	0.257
NUTF2	NUTF2, NTF2: Nuclear transport factor 2	0.0968	0.047
SMARCAL1	SMARCAL1, HARP: SWI/SNF-related matrix-associated actin-dependent regulator of c	0.083	0.083
RAD54B	RAD54B: DNA repair and recombination protein RAD54B	0.083	0.050
SMARCA4	SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4	0.083	0.287
DDB2	DDB2: DNA damage-binding protein 2	0.083	0.083
FBXW2	FBXW2, FBW2, FWD2: F-box/WD repeat-containing protein 2	0.083	0.137
CORO1C	CORO1C, CRNN4: Coronin-1C	0.074	0.093
RECQL	RECQL, RECQL1: ATP-dependent DNA helicase Q1	0.074	0.074
FLJ10439	WDR74, NSA1: WD repeat-containing protein 74	0.074	0.074
SEC31L1	N/A	0.074	0.126
DDX3X	DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X	0.074	0.156
LRBA	LRBA, BGL, CDC4L, LBA: Lipopolysaccharide-responsive and beige-like anchor prote	0.074	0.074
DDX54	DDX54: ATP-dependent RNA helicase DDX54	0.074	0.074
IFIH1	IFIH1, MDA5, RH116: Interferon-induced helicase C domain-containing protein 1	0.074	0.074
BTAF1	BTAF1, TAF172: TATA-binding protein-associated factor 172	0.074	0.257
POLE	POLE, POLE1: DNA polymerase epsilon catalytic subunit A	0.074	0.074
HELLS	HELLS, PASG, Nbla10143, SMARCA6: Lymphoid-specific helicase	0.074	0.067
POLA	POLA1, POLA: DNA polymerase alpha catalytic subunit	0.074	0.060
COPB2	COPB2: Coatomer subunit beta'	0.074	0.126
COPA	COPA: Coatomer subunit alpha	0.074	0.126
TSSC1	TSSC1: Protein TSSC1	0.074	0.074
DDX48	EIF4A3, DDX48, KIAA0111: Eukaryotic initiation factor 4A-III	0.074	0.123
DDX41	DDX41, ABS: Probable ATP-dependent RNA helicase DDX41	0.074	0.156
BLM	BLM, RECQ2, RECQL3: Bloom syndrome protein	0.074	0.156
DDX10	DDX10: Probable ATP-dependent RNA helicase DDX10	0.074	0.074
WRN	WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase	0.074	0.126
PWP2H	PWP2, PWP2H: Periodic tryptophan protein 2 homolog	0.074	0.074
KIAA0052	SKIV2L2, KIAA0052: Superkiller viralicidic activity 2-like 2	0.074	0.074
DDX27	DDX27, RHLP, HSPC259, PP3241: Probable ATP-dependent RNA helicase DDX27	0.074	0.123
WDR8	WDR8: WD repeat-containing protein 8	0.067	0.083
WDR1	N/A	0.067	0.140
PIK3R4	PIK3R4: Phosphoinositide 3-kinase regulatory subunit 4	0.060	0.044
JMJD2C	JMJD2C, GASC1, JHDM3C, KIAA0780: JmjC domain-containing histone demethylation pr	0.060	0.060
WDHD1	WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1	0.060	0.093
CORO7	CORO7: Coronin-7	0.060	0.074
DDX28	DDX28, MDDX28: Probable ATP-dependent RNA helicase DDX28	0.060	0.060
REXO2	REXO2, SFN, CGI-114, SMFN: Oligoribonuclease, mitochondrial precursor	0.060	0.093
WDR39	CIAO1, WDR39: Protein CIAO1	0.060	0.074
AAMP	AAMP: Angio-associated migratory cell protein	0.060	0.060
GRWD1	GRWD1, GRWD, WDR28: Glutamate-rich WD repeat-containing protein 1	0.060	0.060
DHX35	C20orf15, DHX35, DDX35: Probable ATP-dependent RNA helicase DHX35	0.060	0.060
RECQL4	RECQL4, RECQ4: ATP-dependent DNA helicase Q4	0.060	0.036
WDR26	WDR26, CDW2, PRO0852, MIP2: WD repeat-containing protein 26	0.060	0.060
AAAS	AAAS, ADRACALA, GL003: Aladin	0.060	0.044
CNOT8	CNOT8, CALIF, POP2: CCR4-NOT transcription complex subunit 8	0.060	0.074
TTF2	TTF2: Transcription termination factor 2	0.060	0.060
DHX38	DHX38, DDX38, KIAA0224, PRP16: Pre-mRNA-splicing factor ATP-dependent RNA helica	0.060	0.074
XPMC2H	REXO4, PMC2, XPMC2H: RNA exonuclease 4	0.060	0.074
Nle	NLE1, HUSSY-07: Notchless protein homolog 1	0.060	0.126
WIPI2	WIPI2, CGI-50: WD repeat domain phosphoinositide-interacting protein 2	0.060	0.060
DHX16	DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN	0.060	0.156
DDX17	DDX17: Probable ATP-dependent RNA helicase DDX17	0.060	0.074
EXOSC8	EXOSC8, OIP2, RRP43: Exosome complex exonuclease RRP43	0.057	0.027
ISG20	ISG20, HEM45: Interferon-stimulated gene 20 kDa protein	0.050	0.083
GNB1L	GNB1L, GY2, FKSG1, KIAA1645, WDR14: Guanine nucleotide-binding protein subunit b	0.050	0.041
THRAP5	MED16, DRIP92, THRAP5: Mediator of RNA polymerase II transcription subunit 16	0.044	0.044
DICER1	DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer	0.044	0.093
ERCC3	ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit	0.044	0.093
NBEAL2	N/A	0.044	0.044
SKIV2L	SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti	0.044	0.126
RAE1	RAE1, MRNP41: mRNA export factor	0.044	0.060
CORO1A	CORO1A, CORO1: Coronin-1A	0.044	0.074
LGP2	DHX58, D11LGP2E, LGP2: Probable ATP-dependent RNA helicase DHX58	0.044	0.050
ARPC1B	ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B	0.044	0.126
PARN	PARN, DAN: Poly(A)-specific ribonuclease PARN	0.044	0.044
GNB1	GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.044	0.093
WDR67	WDR67: WD repeat-containing protein 67	0.044	0.044
EML3	EML3: Echinoderm microtubule-associated protein-like 3	0.044	0.074
GNB2	GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.044	0.093
ARPC1A	ARPC1A, SOP2L: Actin-related protein 2/3 complex subunit 1A	0.044	0.036
DDX5	DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5	0.044	0.156
HIRA	HIRA, DGCR1, HIR, TUPLE1: Protein HIRA	0.044	0.093
SMARCA3	HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor	0.044	0.103
SSRP1	SSRP1, FACT80: FACT complex subunit SSRP1	0.044	0.048
REV3L	REV3L, POLZ, REV3: DNA polymerase zeta catalytic subunit	0.041	0.041
WDR13	WDR13: WD repeat-containing protein 13	0.041	0.041
PHF20	PHF20, C20orf104, GLEA2, HCA58, NZF, TZP: PHD finger protein 20	0.039	0.053
WDR48	WDR48, KIAA1449: WD repeat-containing protein 48	0.036	0.036
WDR45L	N/A	0.036	0.036
WDR42A	N/A	0.036	0.044
SETDB1	SETDB1, KIAA0067: Histone-lysine N-methyltransferase SETDB1	0.036	0.036
BCDO2	PTS: 6-pyruvoyl tetrahydrobiopterin synthase	0.036	0.046
DDX24	DDX24: ATP-dependent RNA helicase DDX24	0.036	0.076
DDX3Y	DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y	0.036	0.093
WIPI1	WIPI1, WIPI49: WD repeat domain phosphoinositide-interacting protein 1	0.036	0.028
DDX56	DDX56, DDX21, NOH61: Probable ATP-dependent RNA helicase DDX56	0.036	0.044
DDX52	DDX52, ROK1, HUSSY-19: Probable ATP-dependent RNA helicase DDX52	0.036	0.044
LBR	LBR: Lamin-B receptor	0.0331	0.0331
RNASEH1	RNASEH1, RNH1: Ribonuclease H1	0.0331	0.055
POLG	POLG, MDP1, POLG1, POLGA: DNA polymerase subunit gamma-1	0.0331	0.055
NUP214	N/A	0.0308	0.085
BRIP1	BRIP1, BACH1, FANCJ: Fanconi anemia group J protein	0.028	0.076
WDR37	N/A	0.028	0.036
DYNC1I2	N/A	0.028	0.037
DDX58	DDX58: Probable ATP-dependent RNA helicase DDX58	0.028	0.044
NOL7	NOL7, C6orf90, NOP27: Nucleolar protein 7	0.027	0.027
HNRPD	N/A	0.027	0.027
BUB3	N/A	0.027	0.027
XTP3TPA	XTP3TPA, CDA03: XTP3-transactivated gene A protein	0.027	0.027
DKFZP586L0724	NOL11, L14: Nucleolar protein 11	0.027	0.027
CEP57	CEP57, KIAA0092, TSP57: Centrosomal protein of 57 kDa	0.027	0.027
TPRKB	TPRKB, CGI-121, My019: TP53RK-binding protein	0.027	0.027
WDR17	N/A	0.027	0.027
PHF1	N/A	0.027	0.027
WSB1	WSB1, SWIP1: WD repeat and SOCS box-containing protein 1	0.027	0.027
TDRD4	TDRD4: Tudor domain-containing protein 4	0.027	0.027
FBXW8	FBXW8, FBW6, FBW8, FBX29, FBXO29, FBXW6: F-box/WD repeat-containing protein 8	0.027	0.027
KIF21A	N/A	0.027	0.027
SMARCAD1	SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator	0.027	0.056
WDR53	N/A	0.027	0.027
TLE6	TLE6: Transducin-like enhancer protein 6	0.027	0.027
BRWD1	N/A	0.027	0.027
TAF5L	TAF5L, PAF65B: TAF5-like RNA polymerase II p300/CBP-associated factor-associated	0.027	0.027
DDX53	DDX53, CAGE: Probable ATP-dependent RNA helicase DDX53	0.027	0.027
TLE3	TLE3, KIAA1547: Transducin-like enhancer protein 3	0.027	0.056
NEDD1	N/A	0.027	0.027
WDR34	N/A	0.027	0.027
WDR54	N/A	0.027	0.056
TREX1	TREX1: Three prime repair exonuclease 1	0.027	0.027
WDR72	N/A	0.027	0.027
ERCC8	ERCC8, CKN1, CSA: DNA excision repair protein ERCC-8	0.027	0.027
REXO1L1	REXO1L1, GOR: Exonuclease GOR	0.027	0.027
RFWD2	RFWD2, COP1, RNF200: E3 ubiquitin-protein ligase RFWD2	0.027	0.027
FLJ12671	ISG20L2, HSD38, HSD-38: Interferon-stimulated 20 kDa exonuclease-like 2	0.027	0.027
SNRPB	N/A	0.0258	0.0258

0.572

Total Score

597.00