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Evidence of Interaction Between SNRPG and POLA

The interaction score between SNRPG and POLA is 6.78.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between SNRPG and POLA = 0.63

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 7.78E-3
Orthology
OrganismSNRPG OrthologuePOLA OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YFL017W-A 1 YNL102W 1
worm Q9N4G9 1 Q9NAH1 1
fly Q9VXE0 1 P26019 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains No domains were used in calculating likelihood of interaction 0.027
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: SNRPG

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: POLA

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between SNRPG and POLA that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SNRPG andPOLA. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SNRPG has 256 interactors and POLA has 56 interactors of which there are 25 common interactors.

Common InteractorName of Common InteractorScore for SNRPG-Interactor (?)Score for POLA-Interactor (?)
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 2.07E3 0.074
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 2.07E3 0.060
SNRPD2 SNRPD2, SNRPD1: Small nuclear ribonucleoprotein Sm D2 691.00 0.044
LSM5 LSM5: U6 snRNA-associated Sm-like protein LSm5 691.00 0.060
LSM4 LSM4: U6 snRNA-associated Sm-like protein LSm4 691.00 0.044
SNRPE SNRPE: Small nuclear ribonucleoprotein E 8.73 0.083
SNRPB SNRPB, COD, SNRPB1: Small nuclear ribonucleoprotein-associated proteins B and B' 2.91 0.067
LSM3 LSM3, MDS017: U6 snRNA-associated Sm-like protein LSm3 2.60 0.060
LSM7 LSM7: U6 snRNA-associated Sm-like protein LSm7 2.60 0.060
LSM8 LSM8: U6 snRNA-associated Sm-like protein LSm8 2.60 0.060
SNRPF SNRPF, PBSCF: Small nuclear ribonucleoprotein F 2.60 0.060
LSM2 LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2 1.22 0.044
LSM6 LSM6: U6 snRNA-associated Sm-like protein LSm6 1.22 0.060
LSM1 LSM1, CASM: U6 snRNA-associated Sm-like protein LSm1 1.22 0.028
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.354 1.94
SEC13L1 SEC13, D3S1231E, SEC13L1, SEC13R: Protein SEC13 homolog 0.137 0.0308
CNOT7 CNOT7, CAF1: CCR4-NOT transcription complex subunit 7 0.123 0.132
POLE POLE, POLE1: DNA polymerase epsilon catalytic subunit A 0.074 0.890
PLK3 PLK3, CNK, FNK, PRK: Serine/threonine-protein kinase PLK3 0.065 0.291
WDHD1 WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1 0.060 0.890
CNOT8 CNOT8, CALIF, POP2: CCR4-NOT transcription complex subunit 8 0.060 0.408
EXOSC8 EXOSC8, OIP2, RRP43: Exosome complex exonuclease RRP43 0.057 0.065
PLK2 PLK2, SNK: Serine/threonine-protein kinase PLK2 0.053 0.261
EXOSC7 EXOSC7, KIAA0116, RRP42: Exosome complex exonuclease RRP42 0.051 0.035
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.044 1.82
0.228
Total Score 6.78