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Evidence of Interaction Between SNRPG and WDR45L

The interaction score between SNRPG and WDR45L is 8.32.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between SNRPG and WDR45L = 0.31

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 3.80E-3
Orthology
OrganismSNRPG OrthologueWDR45L OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YFL017W-A 1 YFR021W 0.197
worm Q9N4G9 1 Q86MP3 0.194
fly Q9VXE0 1 Q9VHJ2 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in SNRPG and WDR45L:
Domains in SNRPGDomains in WDR45L
IPR001163 Small nuclear ribonucleoprotein (Sm protein)
IPR010920 Small nuclear-like ribonucleoprotein
IPR006649 snRNP domain
IPR001680 G-protein beta WD-40 repeat

The Chi square scores for co-occurrence of domains that are present in SNRPG and WDR45L are listed below.

Domain 1Domain 2Chi Square
IPR010920 Small nuclear-like ribonucleoprotein IPR001680 G-protein beta WD-40 repeat 22.3132
IPR006649 snRNP domain IPR001680 G-protein beta WD-40 repeat 19.3621
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR001680 G-protein beta WD-40 repeat 18.7041

The background colour of the table refers to:

  • Blue Domain is only present in SNRPG
  • Yellow Domain is only present in WDR45L
  • Green Domain is present in both SNRPG and WDR45L

 0.027
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: SNRPG

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: WDR45L

No localisation data was used in calculating likelihood of interaction
Transitive Score

The common interactors between SNRPG and WDR45L that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SNRPG andWDR45L. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SNRPG has 256 interactors and WDR45L has 55 interactors of which there are 16 common interactors.

Common InteractorName of Common InteractorScore for SNRPG-Interactor (?)Score for WDR45L-Interactor (?)
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 2.07E3 0.028
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 2.07E3 0.036
LSM5 LSM5: U6 snRNA-associated Sm-like protein LSm5 691.00 0.036
LSM4 LSM4: U6 snRNA-associated Sm-like protein LSm4 691.00 0.044
SNRPD2 SNRPD2, SNRPD1: Small nuclear ribonucleoprotein Sm D2 691.00 0.036
SNRPE SNRPE: Small nuclear ribonucleoprotein E 8.73 0.041
SF3B3 N/A 3.89 0.028
SNRPB SNRPB, COD, SNRPB1: Small nuclear ribonucleoprotein-associated proteins B and B' 2.91 0.041
LSM7 LSM7: U6 snRNA-associated Sm-like protein LSm7 2.60 0.044
LSM8 LSM8: U6 snRNA-associated Sm-like protein LSm8 2.60 0.036
SNRPF SNRPF, PBSCF: Small nuclear ribonucleoprotein F 2.60 0.028
LSM3 LSM3, MDS017: U6 snRNA-associated Sm-like protein LSm3 2.60 0.036
LSM2 LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2 1.22 0.036
LSM6 LSM6: U6 snRNA-associated Sm-like protein LSm6 1.22 0.044
LSM1 LSM1, CASM: U6 snRNA-associated Sm-like protein LSm1 1.22 0.044
PPP2R2A PPP2R2A: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alp 0.123 0.058
0.572
Total Score 8.32