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Evidence of Interaction Between SNRPG and POLR2H

The interaction score between SNRPG and POLR2H is 3.36.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between SNRPG and POLR2H = 0.81

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology
OrganismSNRPG OrthologuePOLR2H OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YFL017W-A 1 YOR224C 1
worm Q9N4G9 1 Q19826 1
fly Q9VXE0 1 Q9VNZ3 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains No domains were used in calculating likelihood of interaction 1.48E-3
Post-translational Modifications

Protein: SNRPG

PTMResidueReference

Protein: POLR2H

PTMResidueReference
N-acetylalanine 1 HPRD
Localisation

Protein: SNRPG

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: POLR2H

LocalisationReference
Cytosol HPRD
Nucleus HPRD
Nucleolus HPRD
Nucleoplasm HPRD
Transitive Score

The common interactors between SNRPG and POLR2H that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SNRPG andPOLR2H. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SNRPG has 256 interactors and POLR2H has 295 interactors of which there are 44 common interactors.

Common InteractorName of Common InteractorScore for SNRPG-Interactor (?)Score for POLR2H-Interactor (?)
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 2.07E3 0.276
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 2.07E3 0.276
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 32.60 0.075
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.890 0.032
SNRP70 SNRP70, RNPU1Z, RPU1, U1AP1: U1 small nuclear ribonucleoprotein 70 kDa 0.657 0.037
DDX21 DDX21: Nucleolar RNA helicase 2 0.293 0.084
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.293 0.293
EIF4A1 EIF4A1, DDX2A, EIF4A: Eukaryotic initiation factor 4A-I 0.263 0.038
BAT1 N/A 0.263 0.081
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.263 0.045
GNB2L1 Lung cancer oncogene 7 0.137 0.025
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.137 0.179
DDX50 DDX50: ATP-dependent RNA helicase DDX50 0.137 0.0255
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.137 0.051
ASCC3 ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3 0.123 0.060
DDX47 E4-DBP: DEAD box protein 0.123 0.038
DDX39 DDX39: ATP-dependent RNA helicase DDX39 0.123 0.038
SMARCA4 SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4 0.083 0.084
RECQL RECQL, RECQL1: ATP-dependent DNA helicase Q1 0.074 0.060
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.074 0.027
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.074 0.045
DDX48 EIF4A3, DDX48, KIAA0111: Eukaryotic initiation factor 4A-III 0.074 0.038
DDX41 DDX41, ABS: Probable ATP-dependent RNA helicase DDX41 0.074 0.075
BLM BLM, RECQ2, RECQL3: Bloom syndrome protein 0.074 0.156
WRN WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase 0.074 0.126
DDX27 DDX27, RHLP, HSPC259, PP3241: Probable ATP-dependent RNA helicase DDX27 0.074 0.038
RECQL4 RECQL4, RECQ4: ATP-dependent DNA helicase Q4 0.060 0.036
DHX16 DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN 0.060 0.037
EXOSC8 EXOSC8, OIP2, RRP43: Exosome complex exonuclease RRP43 0.057 0.108
EXOSC7 EXOSC7, KIAA0116, RRP42: Exosome complex exonuclease RRP42 0.051 0.0968
ERCC3 ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit 0.044 0.027
SKIV2L SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti 0.044 0.037
DDX5 DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5 0.044 0.027
SMARCA3 HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor 0.044 0.027
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.044 0.257
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.044 0.048
DDX24 DDX24: ATP-dependent RNA helicase DDX24 0.036 0.027
DDX3Y DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y 0.036 0.027
DDX58 DDX58: Probable ATP-dependent RNA helicase DDX58 0.028 0.028
MRPL22 MRPL22, HSPC158: 39S ribosomal protein L22, mitochondrial precursor 0.027 0.027
HSPC185 CGI-117, HSPC111: UPF0384 protein CGI-117 0.027 0.027
BUB3 N/A 0.027 0.027
KARS KARS, KIAA0070: Lysyl-tRNA synthetase 0.027 0.231
DDX53 DDX53, CAGE: Probable ATP-dependent RNA helicase DDX53 0.027 0.027
0.572
Total Score 3.36