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Evidence of Interaction Between SNRPG and SNRPE

The interaction score between SNRPG and SNRPE is 1.99E3.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between SNRPG and SNRPE = 0.93

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.082
Orthology N/A N/A
Domains Domains present in SNRPG and SNRPE:
Domains in SNRPGDomains in SNRPE
IPR001163 Small nuclear ribonucleoprotein (Sm protein)
IPR010920 Small nuclear-like ribonucleoprotein
IPR006649 snRNP domain
IPR001163 Small nuclear ribonucleoprotein (Sm protein)
IPR010920 Small nuclear-like ribonucleoprotein
IPR006649 snRNP domain

The Chi square scores for co-occurrence of domains that are present in SNRPG and SNRPE are listed below.

Domain 1Domain 2Chi Square
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR006649 snRNP domain 1325.87
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR001163 Small nuclear ribonucleoprotein (Sm protein) 1297.61
IPR006649 snRNP domain IPR006649 snRNP domain 1206.57
IPR010920 Small nuclear-like ribonucleoprotein IPR006649 snRNP domain 1168.89
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR010920 Small nuclear-like ribonucleoprotein 1143.95
IPR010920 Small nuclear-like ribonucleoprotein IPR010920 Small nuclear-like ribonucleoprotein 355.236

The background colour of the table refers to:

  • Blue Domain is only present in SNRPG
  • Yellow Domain is only present in SNRPE
  • Green Domain is present in both SNRPG and SNRPE

 0.265
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: SNRPG

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: SNRPE

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between SNRPG and SNRPE that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SNRPG andSNRPE. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SNRPG has 256 interactors and SNRPE has 377 interactors of which there are 215 common interactors.

Common InteractorName of Common InteractorScore for SNRPG-Interactor (?)Score for SNRPE-Interactor (?)
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 2.07E3 8.73
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 2.07E3 8.73
SNRPD2 SNRPD2, SNRPD1: Small nuclear ribonucleoprotein Sm D2 691.00 8.73
LSM5 LSM5: U6 snRNA-associated Sm-like protein LSm5 691.00 8.73
LSM4 LSM4: U6 snRNA-associated Sm-like protein LSm4 691.00 2.91
PRPF4 PRPF4, PRP4: U4/U6 small nuclear ribonucleoprotein Prp4 69.60 0.293
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 32.60 0.137
PRP19 PRPF19, NMP200, PRP19, SNEV: Pre-mRNA-processing factor 19 25.60 0.108
PLRG1 PLRG1: Pleiotropic regulator 1 6.33 0.027
SNRPB SNRPB, COD, SNRPB1: Small nuclear ribonucleoprotein-associated proteins B and B' 2.91 2.91
LSM3 LSM3, MDS017: U6 snRNA-associated Sm-like protein LSm3 2.60 2.91
LSM7 LSM7: U6 snRNA-associated Sm-like protein LSm7 2.60 8.73
LSM8 LSM8: U6 snRNA-associated Sm-like protein LSm8 2.60 2.91
SNRPF SNRPF, PBSCF: Small nuclear ribonucleoprotein F 2.60 8.73
LSM2 LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2 1.22 1.36
LSM6 LSM6: U6 snRNA-associated Sm-like protein LSm6 1.22 2.91
LSM1 LSM1, CASM: U6 snRNA-associated Sm-like protein LSm1 1.22 0.824
NUP37 NUP37: Nucleoporin Nup37 0.789 0.293
DDX21 DDX21: Nucleolar RNA helicase 2 0.293 0.293
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.293 0.881
RBBP4 RBBP4, RBAP48: Histone-binding protein RBBP4 0.263 0.293
NUP43 N/A 0.263 0.293
CDC20 CDC20: Cell division cycle protein 20 homolog 0.263 0.137
EIF4A1 EIF4A1, DDX2A, EIF4A: Eukaryotic initiation factor 4A-I 0.263 0.293
BAT1 N/A 0.263 0.293
DDX1 DDX1: ATP-dependent RNA helicase DDX1 0.263 0.293
BOP1 BOP1, KIAA0124: Ribosome biogenesis protein BOP1 0.263 0.293
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.263 0.137
LSM10 LSM10: U7 snRNA-associated Sm-like protein LSm10 0.237 0.265
LSM11 LSM11: U7 snRNA-associated Sm-like protein LSm11 0.237 0.265
SNRPN HCERN3, SNRPN, SMN: Small nuclear ribonucleoprotein-associated protein N 0.158 0.176
SEC13L1 SEC13, D3S1231E, SEC13L1, SEC13R: Protein SEC13 homolog 0.137 0.137
WDR41 N/A 0.137 0.293
GNB2L1 Lung cancer oncogene 7 0.137 0.137
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.137 0.293
DDX50 DDX50: ATP-dependent RNA helicase DDX50 0.137 0.293
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.137 0.137
GTF3C2 GTF3C2, KIAA0011: General transcription factor 3C polypeptide 2 0.137 0.137
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.123 0.293
CDC40 CDC40, EHB3, PRP17, PRPF17: Pre-mRNA-processing factor 17 0.123 0.137
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 0.123 0.293
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.123 0.293
SND1 SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1 0.123 0.137
ASCC3 ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3 0.123 0.137
POLD1 POLD1, POLD: DNA polymerase delta catalytic subunit 0.123 0.137
TAF5 TAF5, TAF2D: Transcription initiation factor TFIID subunit 5 0.123 0.137
DDX19A DDX19A, DDX19L: ATP-dependent RNA helicase DDX19A 0.123 0.137
WDR3 WDR3: WD repeat-containing protein 3 0.123 0.137
DDX49 DDX49: Probable ATP-dependent RNA helicase DDX49 0.123 0.137
RBBP7 RBBP7, RBAP46: Histone-binding protein RBBP7 0.123 0.137
WDR77 WDR77, HKMT1069, hCG_39991: Androgen receptor cofactor p44 0.123 0.137
WDR12 WDR12: WD repeat-containing protein 12 0.123 0.293
DDX18 DDX18: ATP-dependent RNA helicase DDX18 0.123 0.293
STRAP STRAP, MAWD, UNRIP: Serine-threonine kinase receptor-associated protein 0.123 0.137
WDR68 WDR68, HAN11: WD repeat-containing protein 68 0.123 0.137
WDR57 WDR57, PRP8BP, SFP38: WD repeat-containing protein 57 0.123 0.137
DDX23 DDX23: Probable ATP-dependent RNA helicase DDX23 0.123 0.137
CNOT7 CNOT7, CAF1: CCR4-NOT transcription complex subunit 7 0.123 0.293
RNU3IP2 RRP9, RNU3IP2, U355K: U3 small nucleolar RNA-interacting protein 2 0.123 0.137
CHAF1B CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B 0.123 0.137
RAD54L RAD54L, RAD54A: DNA repair and recombination protein RAD54-like 0.123 0.137
WDR18 N/A 0.123 0.137
PAK1IP1 PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1 0.123 0.137
DDX47 E4-DBP: DEAD box protein 0.123 0.137
DDX39 DDX39: ATP-dependent RNA helicase DDX39 0.123 0.137
PPP2R2A PPP2R2A: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alp 0.123 0.137
CSTF1 CSTF1: Cleavage stimulation factor 50 kDa subunit 0.123 0.137
NUTF2 NUTF2, NTF2: Nuclear transport factor 2 0.0968 0.065
SMARCAL1 SMARCAL1, HARP: SWI/SNF-related matrix-associated actin-dependent regulator of c 0.083 0.083
RAD54B RAD54B: DNA repair and recombination protein RAD54B 0.083 0.067
SMARCA4 SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4 0.083 0.137
DDB2 DDB2: DNA damage-binding protein 2 0.083 0.083
FBXW2 FBXW2, FBW2, FWD2: F-box/WD repeat-containing protein 2 0.083 0.083
SERBP1 N/A 0.082 0.027
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.082 0.082
CORO1C CORO1C, CRNN4: Coronin-1C 0.074 0.067
RECQL RECQL, RECQL1: ATP-dependent DNA helicase Q1 0.074 0.083
FLJ10439 WDR74, NSA1: WD repeat-containing protein 74 0.074 0.137
SEC31L1 N/A 0.074 0.083
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.074 0.083
LRBA LRBA, BGL, CDC4L, LBA: Lipopolysaccharide-responsive and beige-like anchor prote 0.074 0.083
DDX54 DDX54: ATP-dependent RNA helicase DDX54 0.074 0.083
IFIH1 IFIH1, MDA5, RH116: Interferon-induced helicase C domain-containing protein 1 0.074 0.083
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.074 0.137
POLE POLE, POLE1: DNA polymerase epsilon catalytic subunit A 0.074 0.137
HELLS HELLS, PASG, Nbla10143, SMARCA6: Lymphoid-specific helicase 0.074 0.137
POLA POLA1, POLA: DNA polymerase alpha catalytic subunit 0.074 0.083
COPB2 COPB2: Coatomer subunit beta' 0.074 0.083
COPA COPA: Coatomer subunit alpha 0.074 0.067
TSSC1 TSSC1: Protein TSSC1 0.074 0.137
DDX48 EIF4A3, DDX48, KIAA0111: Eukaryotic initiation factor 4A-III 0.074 0.137
DDX41 DDX41, ABS: Probable ATP-dependent RNA helicase DDX41 0.074 0.137
BLM BLM, RECQ2, RECQL3: Bloom syndrome protein 0.074 0.137
DDX10 DDX10: Probable ATP-dependent RNA helicase DDX10 0.074 0.137
WRN WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase 0.074 0.083
PWP2H PWP2, PWP2H: Periodic tryptophan protein 2 homolog 0.074 0.083
KIAA0052 SKIV2L2, KIAA0052: Superkiller viralicidic activity 2-like 2 0.074 0.083
DDX27 DDX27, RHLP, HSPC259, PP3241: Probable ATP-dependent RNA helicase DDX27 0.074 0.137
CGI-55 SERBP1, PAIRBP1, CGI-55: Plasminogen activator inhibitor 1 RNA-binding protein 0.0739 0.082
PA2G4 PA2G4, EBP1: Proliferation-associated protein 2G4 0.0739 0.082
WDR8 WDR8: WD repeat-containing protein 8 0.067 0.067
WDR1 N/A 0.067 0.067
PIK3R4 PIK3R4: Phosphoinositide 3-kinase regulatory subunit 4 0.060 0.067
JMJD2C JMJD2C, GASC1, JHDM3C, KIAA0780: JmjC domain-containing histone demethylation pr 0.060 0.067
WDHD1 WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1 0.060 0.067
CORO7 CORO7: Coronin-7 0.060 0.067
DDX28 DDX28, MDDX28: Probable ATP-dependent RNA helicase DDX28 0.060 0.067
REXO2 REXO2, SFN, CGI-114, SMFN: Oligoribonuclease, mitochondrial precursor 0.060 0.067
WDR39 CIAO1, WDR39: Protein CIAO1 0.060 0.083
AAMP AAMP: Angio-associated migratory cell protein 0.060 0.067
GRWD1 GRWD1, GRWD, WDR28: Glutamate-rich WD repeat-containing protein 1 0.060 0.083
DHX35 C20orf15, DHX35, DDX35: Probable ATP-dependent RNA helicase DHX35 0.060 0.067
RECQL4 RECQL4, RECQ4: ATP-dependent DNA helicase Q4 0.060 0.067
WDR26 WDR26, CDW2, PRO0852, MIP2: WD repeat-containing protein 26 0.060 0.050
AAAS AAAS, ADRACALA, GL003: Aladin 0.060 0.050
CNOT8 CNOT8, CALIF, POP2: CCR4-NOT transcription complex subunit 8 0.060 0.067
TTF2 TTF2: Transcription termination factor 2 0.060 0.067
DHX38 DHX38, DDX38, KIAA0224, PRP16: Pre-mRNA-splicing factor ATP-dependent RNA helica 0.060 0.067
XPMC2H REXO4, PMC2, XPMC2H: RNA exonuclease 4 0.060 0.083
Nle NLE1, HUSSY-07: Notchless protein homolog 1 0.060 0.083
WIPI2 WIPI2, CGI-50: WD repeat domain phosphoinositide-interacting protein 2 0.060 0.067
DHX16 DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN 0.060 0.067
DDX17 DDX17: Probable ATP-dependent RNA helicase DDX17 0.060 0.067
EXOSC8 EXOSC8, OIP2, RRP43: Exosome complex exonuclease RRP43 0.057 0.057
EXOSC7 EXOSC7, KIAA0116, RRP42: Exosome complex exonuclease RRP42 0.051 0.057
ISG20 ISG20, HEM45: Interferon-stimulated gene 20 kDa protein 0.050 0.050
GNB1L GNB1L, GY2, FKSG1, KIAA1645, WDR14: Guanine nucleotide-binding protein subunit b 0.050 0.050
HNRPC N/A 0.049 0.049
THRAP5 MED16, DRIP92, THRAP5: Mediator of RNA polymerase II transcription subunit 16 0.044 0.050
DICER1 DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer 0.044 0.067
ERCC3 ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit 0.044 0.050
NBEAL2 N/A 0.044 0.050
SKIV2L SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti 0.044 0.067
RAE1 RAE1, MRNP41: mRNA export factor 0.044 0.050
CORO1A CORO1A, CORO1: Coronin-1A 0.044 0.050
LGP2 DHX58, D11LGP2E, LGP2: Probable ATP-dependent RNA helicase DHX58 0.044 0.050
ARPC1B ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B 0.044 0.050
PARN PARN, DAN: Poly(A)-specific ribonuclease PARN 0.044 0.050
GNB1 GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0.044 0.067
WDR67 WDR67: WD repeat-containing protein 67 0.044 0.050
EML3 EML3: Echinoderm microtubule-associated protein-like 3 0.044 0.067
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.044 0.050
ARPC1A ARPC1A, SOP2L: Actin-related protein 2/3 complex subunit 1A 0.044 0.050
DDX5 DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5 0.044 0.067
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.044 0.050
SMARCA3 HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor 0.044 0.067
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.044 0.049
REV3L REV3L, POLZ, REV3: DNA polymerase zeta catalytic subunit 0.041 0.050
WDR13 WDR13: WD repeat-containing protein 13 0.041 0.0308
PHF20 PHF20, C20orf104, GLEA2, HCA58, NZF, TZP: PHD finger protein 20 0.039 0.053
WDR48 WDR48, KIAA1449: WD repeat-containing protein 48 0.036 0.041
WDR45L N/A 0.036 0.041
WDR42A N/A 0.036 0.041
SETDB1 SETDB1, KIAA0067: Histone-lysine N-methyltransferase SETDB1 0.036 0.041
BCDO2 PTS: 6-pyruvoyl tetrahydrobiopterin synthase 0.036 0.0308
DDX24 DDX24: ATP-dependent RNA helicase DDX24 0.036 0.041
DDX3Y DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y 0.036 0.050
WIPI1 WIPI1, WIPI49: WD repeat domain phosphoinositide-interacting protein 1 0.036 0.0308
DDX56 DDX56, DDX21, NOH61: Probable ATP-dependent RNA helicase DDX56 0.036 0.050
DDX52 DDX52, ROK1, HUSSY-19: Probable ATP-dependent RNA helicase DDX52 0.036 0.050
LBR LBR: Lamin-B receptor 0.0331 0.037
RNASEH1 RNASEH1, RNH1: Ribonuclease H1 0.0331 0.061
POLG POLG, MDP1, POLG1, POLGA: DNA polymerase subunit gamma-1 0.0331 0.037
NUP214 N/A 0.0308 0.0308
BRIP1 BRIP1, BACH1, FANCJ: Fanconi anemia group J protein 0.028 0.041
PEX7 PEX7, PTS2R: Peroxisomal targeting signal 2 receptor 0.028 0.0308
WDR37 N/A 0.028 0.041
DYNC1I2 N/A 0.028 0.0308
CETN2 CETN2, CALT, CEN2: Centrin-2 0.028 0.0308
KATNB1 KATNB1: Katanin p80 WD40-containing subunit B1 0.028 0.0308
DDX58 DDX58: Probable ATP-dependent RNA helicase DDX58 0.028 0.041
RTCD1 RTCD1, RPC, RPC1, RTC1: RNA 3'-terminal phosphate cyclase 0.027 0.027
PTD004 N/A 0.027 0.027
NOL7 NOL7, C6orf90, NOP27: Nucleolar protein 7 0.027 0.027
MRPL22 MRPL22, HSPC158: 39S ribosomal protein L22, mitochondrial precursor 0.027 0.027
RAD51AP1 N/A 0.027 0.027
HSPC185 CGI-117, HSPC111: UPF0384 protein CGI-117 0.027 0.027
PSME3 PSME3: Proteasome activator complex subunit 3 0.027 0.027
C11orf58 SMAP, C11orf58: Small acidic protein 0.027 0.027
GMNN GMNN: Geminin 0.027 0.027
ILF2 ILF2, NF45, PRO3063: Interleukin enhancer-binding factor 2 0.027 0.082
HNRPD N/A 0.027 0.027
NOLC1 NOLC1, KIAA0035: Nucleolar phosphoprotein p130 0.027 0.082
BUB3 N/A 0.027 0.027
XTP3TPA XTP3TPA, CDA03: XTP3-transactivated gene A protein 0.027 0.027
DKFZP586L0724 NOL11, L14: Nucleolar protein 11 0.027 0.082
C22orf18 N/A 0.027 0.027
CEP57 CEP57, KIAA0092, TSP57: Centrosomal protein of 57 kDa 0.027 0.027
TPRKB TPRKB, CGI-121, My019: TP53RK-binding protein 0.027 0.027
SMC4L1 N/A 0.027 0.027
PSMA1 PSMA1, PROS30, PSC2: Proteasome subunit alpha type-1 0.027 0.027
KARS KARS, KIAA0070: Lysyl-tRNA synthetase 0.027 0.027
WDR17 N/A 0.027 0.027
PHF1 N/A 0.027 0.027
WSB1 WSB1, SWIP1: WD repeat and SOCS box-containing protein 1 0.027 0.027
TDRD4 TDRD4: Tudor domain-containing protein 4 0.027 0.027
FBXW8 FBXW8, FBW6, FBW8, FBX29, FBXO29, FBXW6: F-box/WD repeat-containing protein 8 0.027 0.027
KIF21A N/A 0.027 0.027
SMARCAD1 SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator 0.027 0.027
WDR53 N/A 0.027 0.027
TLE6 TLE6: Transducin-like enhancer protein 6 0.027 0.027
BRWD1 N/A 0.027 0.027
TAF5L TAF5L, PAF65B: TAF5-like RNA polymerase II p300/CBP-associated factor-associated 0.027 0.027
DDX53 DDX53, CAGE: Probable ATP-dependent RNA helicase DDX53 0.027 0.027
TLE3 TLE3, KIAA1547: Transducin-like enhancer protein 3 0.027 0.027
NEDD1 N/A 0.027 0.027
WDR34 N/A 0.027 0.027
WDR54 N/A 0.027 0.027
TREX1 TREX1: Three prime repair exonuclease 1 0.027 0.027
WDR72 N/A 0.027 0.027
ERCC8 ERCC8, CKN1, CSA: DNA excision repair protein ERCC-8 0.027 0.027
REXO1L1 REXO1L1, GOR: Exonuclease GOR 0.027 0.027
RFWD2 RFWD2, COP1, RNF200: E3 ubiquitin-protein ligase RFWD2 0.027 0.027
FLJ12671 ISG20L2, HSD38, HSD-38: Interferon-stimulated 20 kDa exonuclease-like 2 0.027 0.027
SNRPB N/A 0.0258 0.0288
0.572
Total Score 1.99E3