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Evidence of Interaction Between SNRPG and PRPF4

The interaction score between SNRPG and PRPF4 is 60.3.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between SNRPG and PRPF4 = 0.85

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology
OrganismSNRPG OrthologuePRPF4 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YFL017W-A 1 YPR178W 1
  • Other
  • AffinityCaptureMS

Get References From PubMed
worm Q9N4G9 1 Q93339 1
fly Q9VXE0 1 Q9VVI0 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains Domains present in SNRPG and PRPF4:
Domains in SNRPGDomains in PRPF4
IPR001163 Small nuclear ribonucleoprotein (Sm protein)
IPR010920 Small nuclear-like ribonucleoprotein
IPR006649 snRNP domain
IPR001680 G-protein beta WD-40 repeat
IPR003648 Splicing factor motif

The Chi square scores for co-occurrence of domains that are present in SNRPG and PRPF4 are listed below.

Domain 1Domain 2Chi Square
IPR010920 Small nuclear-like ribonucleoprotein IPR001680 G-protein beta WD-40 repeat 22.3132
IPR006649 snRNP domain IPR001680 G-protein beta WD-40 repeat 19.3621
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR001680 G-protein beta WD-40 repeat 18.7041

The background colour of the table refers to:

  • Blue Domain is only present in SNRPG
  • Yellow Domain is only present in PRPF4
  • Green Domain is present in both SNRPG and PRPF4

 0.027
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: SNRPG

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: PRPF4

LocalisationReference
Nucleus HPRD
Nucleolus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between SNRPG and PRPF4 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SNRPG andPRPF4. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SNRPG has 256 interactors and PRPF4 has 134 interactors of which there are 43 common interactors.

Common InteractorName of Common InteractorScore for SNRPG-Interactor (?)Score for PRPF4-Interactor (?)
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 2.07E3 0.123
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 2.07E3 69.60
SNRPD2 SNRPD2, SNRPD1: Small nuclear ribonucleoprotein Sm D2 691.00 69.60
LSM5 LSM5: U6 snRNA-associated Sm-like protein LSm5 691.00 32.60
LSM4 LSM4: U6 snRNA-associated Sm-like protein LSm4 691.00 69.60
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 32.60 14.00
PRP19 PRPF19, NMP200, PRP19, SNEV: Pre-mRNA-processing factor 19 25.60 1.82
SNRPE SNRPE: Small nuclear ribonucleoprotein E 8.73 0.293
SF3B3 N/A 3.89 0.123
SART1 SART1: U4/U6.U5 tri-snRNP-associated protein 1 3.05 3.05
SNRPB SNRPB, COD, SNRPB1: Small nuclear ribonucleoprotein-associated proteins B and B' 2.91 0.293
LSM3 LSM3, MDS017: U6 snRNA-associated Sm-like protein LSm3 2.60 32.60
LSM7 LSM7: U6 snRNA-associated Sm-like protein LSm7 2.60 69.60
LSM8 LSM8: U6 snRNA-associated Sm-like protein LSm8 2.60 0.123
SNRPF SNRPF, PBSCF: Small nuclear ribonucleoprotein F 2.60 32.60
PRPF8 PRPF8, PRPC8: Pre-mRNA-processing-splicing factor 8 1.84 3.05
PRPF3 PRPF3, HPRP3, PRP3: U4/U6 small nuclear ribonucleoprotein Prp3 1.49 1.49
LSM2 LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2 1.22 32.60
LSM6 LSM6: U6 snRNA-associated Sm-like protein LSm6 1.22 32.60
LSM1 LSM1, CASM: U6 snRNA-associated Sm-like protein LSm1 1.22 0.074
PRPF31 PRPF31, PRP31: U4/U6 small nuclear ribonucleoprotein Prp31 1.10 1.82
PRPF6 PRPF6, C20orf14: Pre-mRNA-processing factor 6 0.890 6.05
SF3A1 SF3A1, SAP114: Splicing factor 3 subunit 1 0.412 0.412
SNRPEL1 RP11-390F4.1-001: Small nuclear ribonucleoprotein polypeptide E-like protein 1. 0.354 0.354
DDX21 DDX21: Nucleolar RNA helicase 2 0.293 0.059
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.293 0.059
EIF4A1 EIF4A1, DDX2A, EIF4A: Eukaryotic initiation factor 4A-I 0.263 0.053
BAT1 N/A 0.263 0.053
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.137 0.059
DDX50 DDX50: ATP-dependent RNA helicase DDX50 0.137 0.0278
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.137 0.0278
DDX19A DDX19A, DDX19L: ATP-dependent RNA helicase DDX19A 0.123 0.053
DDX18 DDX18: ATP-dependent RNA helicase DDX18 0.123 0.053
RNU3IP2 RRP9, RNU3IP2, U355K: U3 small nucleolar RNA-interacting protein 2 0.123 1.82
NULL N/A 0.119 0.119
LOC645472 hCG_23490: Uncharacterized protein ENSP00000329276 0.119 0.119
SERBP1 N/A 0.082 0.027
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.082 0.027
LOC119358 similar to small nuclear ribonucleoprotein D2 0.071 0.071
RTCD1 RTCD1, RPC, RPC1, RTC1: RNA 3'-terminal phosphate cyclase 0.027 0.027
C11orf58 SMAP, C11orf58: Small acidic protein 0.027 0.027
HNRPD N/A 0.027 0.027
BUB3 N/A 0.027 0.027
2.15E-3
Total Score 60.3