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Evidence of Interaction Between SNRPG and BOP1

The interaction score between SNRPG and BOP1 is 60.20.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between SNRPG and BOP1 = 0.82

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology
OrganismSNRPG OrthologueBOP1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YFL017W-A 1 YMR049C 1
worm Q9N4G9 1 Q9U2A9 1
fly Q9VXE0 1 O96841 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in SNRPG and BOP1:
Domains in SNRPGDomains in BOP1
IPR001163 Small nuclear ribonucleoprotein (Sm protein)
IPR010920 Small nuclear-like ribonucleoprotein
IPR006649 snRNP domain
IPR001680 G-protein beta WD-40 repeat
IPR011046 WD40-like
IPR012953 BOP1NT.

The Chi square scores for co-occurrence of domains that are present in SNRPG and BOP1 are listed below.

Domain 1Domain 2Chi Square
IPR010920 Small nuclear-like ribonucleoprotein IPR001680 G-protein beta WD-40 repeat 22.3132
IPR006649 snRNP domain IPR001680 G-protein beta WD-40 repeat 19.3621
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR001680 G-protein beta WD-40 repeat 18.7041
IPR010920 Small nuclear-like ribonucleoprotein IPR011046 WD40-like 13.0624
IPR006649 snRNP domain IPR011046 WD40-like 11.3909
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR011046 WD40-like 11.0178

The background colour of the table refers to:

  • Blue Domain is only present in SNRPG
  • Yellow Domain is only present in BOP1
  • Green Domain is present in both SNRPG and BOP1

 0.027
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: SNRPG

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: BOP1

LocalisationReference
Nucleus HPRD
Nucleolus HPRD
Nucleoplasm HPRD
Transitive Score

The common interactors between SNRPG and BOP1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SNRPG andBOP1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SNRPG has 256 interactors and BOP1 has 200 interactors of which there are 31 common interactors.

Common InteractorName of Common InteractorScore for SNRPG-Interactor (?)Score for BOP1-Interactor (?)
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 2.07E3 0.263
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 2.07E3 0.123
SNRPD2 SNRPD2, SNRPD1: Small nuclear ribonucleoprotein Sm D2 691.00 0.123
LSM5 LSM5: U6 snRNA-associated Sm-like protein LSm5 691.00 0.123
LSM4 LSM4: U6 snRNA-associated Sm-like protein LSm4 691.00 0.263
SNRPE SNRPE: Small nuclear ribonucleoprotein E 8.73 0.293
SF3B3 N/A 3.89 0.123
SNRPB SNRPB, COD, SNRPB1: Small nuclear ribonucleoprotein-associated proteins B and B' 2.91 0.137
LSM3 LSM3, MDS017: U6 snRNA-associated Sm-like protein LSm3 2.60 0.074
LSM7 LSM7: U6 snRNA-associated Sm-like protein LSm7 2.60 0.123
LSM8 LSM8: U6 snRNA-associated Sm-like protein LSm8 2.60 0.074
SNRPF SNRPF, PBSCF: Small nuclear ribonucleoprotein F 2.60 0.074
TXNL4A TXNL4A, DIM1, TXNL4: Thioredoxin-like protein 4A 1.82 0.038
LSM2 LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2 1.22 0.263
LSM6 LSM6: U6 snRNA-associated Sm-like protein LSm6 1.22 0.123
LSM1 LSM1, CASM: U6 snRNA-associated Sm-like protein LSm1 1.22 0.044
DDX21 DDX21: Nucleolar RNA helicase 2 0.293 0.0278
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.293 0.0278
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.137 0.0278
WDR12 WDR12: WD repeat-containing protein 12 0.123 1.10
DDX18 DDX18: ATP-dependent RNA helicase DDX18 0.123 6.60
PAK1IP1 PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1 0.123 1.10
NUTF2 NUTF2, NTF2: Nuclear transport factor 2 0.0968 0.059
SERBP1 N/A 0.082 0.027
FLJ10439 WDR74, NSA1: WD repeat-containing protein 74 0.074 1.82
DDX27 DDX27, RHLP, HSPC259, PP3241: Probable ATP-dependent RNA helicase DDX27 0.074 3.22
JMJD2C JMJD2C, GASC1, JHDM3C, KIAA0780: JmjC domain-containing histone demethylation pr 0.060 0.060
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.044 0.081
DDX24 DDX24: ATP-dependent RNA helicase DDX24 0.036 1.94
BUB3 N/A 0.027 0.027
C22orf18 N/A 0.027 0.027
0.572
Total Score 60.20