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Evidence of Interaction Between SNRPG and TAF5

The interaction score between SNRPG and TAF5 is 28.2.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between SNRPG and TAF5 = 0.71

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.013
Orthology
OrganismSNRPG OrthologueTAF5 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YFL017W-A 1 YBR198C 1
worm Q9N4G9 1 O01985 1
fly Q9VXE0 1 P49846 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in SNRPG and TAF5:
Domains in SNRPGDomains in TAF5
IPR001163 Small nuclear ribonucleoprotein (Sm protein)
IPR010920 Small nuclear-like ribonucleoprotein
IPR006649 snRNP domain
IPR001680 G-protein beta WD-40 repeat
IPR006594 Lissencephaly type-1-like homology motif
IPR007582 WD40 associated region in TFIID subunit

The Chi square scores for co-occurrence of domains that are present in SNRPG and TAF5 are listed below.

Domain 1Domain 2Chi Square
IPR010920 Small nuclear-like ribonucleoprotein IPR001680 G-protein beta WD-40 repeat 22.3132
IPR006649 snRNP domain IPR001680 G-protein beta WD-40 repeat 19.3621
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR001680 G-protein beta WD-40 repeat 18.7041

The background colour of the table refers to:

  • Blue Domain is only present in SNRPG
  • Yellow Domain is only present in TAF5
  • Green Domain is present in both SNRPG and TAF5

 0.027
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: SNRPG

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: TAF5

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD
Transitive Score

The common interactors between SNRPG and TAF5 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SNRPG andTAF5. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SNRPG has 256 interactors and TAF5 has 131 interactors of which there are 20 common interactors.

Common InteractorName of Common InteractorScore for SNRPG-Interactor (?)Score for TAF5-Interactor (?)
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 2.07E3 0.123
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 2.07E3 0.123
SNRPD2 SNRPD2, SNRPD1: Small nuclear ribonucleoprotein Sm D2 691.00 0.074
LSM5 LSM5: U6 snRNA-associated Sm-like protein LSm5 691.00 0.123
LSM4 LSM4: U6 snRNA-associated Sm-like protein LSm4 691.00 0.060
SNRPE SNRPE: Small nuclear ribonucleoprotein E 8.73 0.137
SF3B3 N/A 3.89 0.123
SART1 SART1: U4/U6.U5 tri-snRNP-associated protein 1 3.05 1.84
SNRPB SNRPB, COD, SNRPB1: Small nuclear ribonucleoprotein-associated proteins B and B' 2.91 0.083
LSM3 LSM3, MDS017: U6 snRNA-associated Sm-like protein LSm3 2.60 0.123
LSM7 LSM7: U6 snRNA-associated Sm-like protein LSm7 2.60 0.074
LSM8 LSM8: U6 snRNA-associated Sm-like protein LSm8 2.60 0.074
SNRPF SNRPF, PBSCF: Small nuclear ribonucleoprotein F 2.60 0.074
LSM2 LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2 1.22 0.060
LSM6 LSM6: U6 snRNA-associated Sm-like protein LSm6 1.22 0.074
LSM1 LSM1, CASM: U6 snRNA-associated Sm-like protein LSm1 1.22 0.060
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.293 0.0278
DDX50 DDX50: ATP-dependent RNA helicase DDX50 0.137 0.0278
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.137 0.0278
CEP57 CEP57, KIAA0092, TSP57: Centrosomal protein of 57 kDa 0.027 0.027
0.572
Total Score 28.2