PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between LIG1 and CDC34

The interaction score between LIG1 and CDC34 is 1.09.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between LIG1 and CDC34 = 0.47

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

4.62E-3

Orthology

Organism	LIG1 Orthologue		CDC34 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
bakers yeast	YDL164C	1	YDR054C	0.719	AffinityCaptureMS Get References From PubMed
worm	Q27474	1	Q95XN7	0.523
fly	Q960P4	1	Q9VUR4	0.397

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.119

Domains

No domains were used in calculating likelihood of interaction

0.014

Post-translational Modifications

Protein: LIG1

PTM	Residue	Reference
Phosphorylation	66	PubMed, HPRD
Phosphorylation	76	PubMed, HPRD
Phosphorylation	141	PubMed, HPRD
Phosphorylation	195	PubMed, HPRD
Phosphorylation	911	PubMed, HPRD
Phosphoserine	66	HPRD
Phosphoserine	76	HPRD
Phosphoserine	141	HPRD
Phosphoserine	911	HPRD
Phosphothreonine	195	HPRD

Protein: CDC34

PTM	Residue	Reference
Phosphorylation	203	PubMed, HPRD
Phosphorylation	222	PubMed, HPRD
Phosphorylation	231	PubMed, HPRD
Phosphorylation	233	PubMed, HPRD
Phosphorylation	236	PubMed, HPRD

Localisation

Protein: LIG1

Localisation	Reference
Nucleus	HPRD
Nucleoplasm	HPRD

Protein: CDC34

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD

Transitive Score

The common interactors between LIG1 and CDC34 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between LIG1 andCDC34. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , LIG1 has 892 interactors and CDC34 has 804 interactors of which there are 444 common interactors.

Common Interactor	Name of Common Interactor	Score for LIG1-Interactor (?)	Score for CDC34-Interactor (?)
UBE2R2	UBE2R2, CDC34B, UBC3B: Ubiquitin-conjugating enzyme E2 R2	3.39	1.33
ADPRT	PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1	0.704	0.034
ESPL1	N/A	0.307	0.052
TRIM28	TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta	0.307	0.202
DNMT1	DNMT1, AIM, DNMT: DNA	0.307	0.027
TOP2A	TOP2A, TOP2: DNA topoisomerase 2-alpha	0.307	0.027
PRKDC	PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit	0.307	0.032
UBE2G1	UBE2G1, UBE2G: Ubiquitin-conjugating enzyme E2 G1	0.297	0.547
HMGB2	HMGB2, HMG2: High mobility group protein B2	0.276	0.032
MCM2	MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2	0.276	0.032
EIF3S9	EIF3S9: Eukaryotic translation initiation factor 3 subunit 9	0.276	0.032
ANP32B	ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb	0.276	0.040
CBX3	CBX3: Chromobox protein homolog 3	0.276	0.032
ITGB1BP1	ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1	0.251	0.026
E2F1	E2F1, RBBP3: Transcription factor E2F1	0.144	0.027
UBAP2L	UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like	0.144	0.052
KIF22	KIF22, KID, KNSL4: Kinesin-like protein KIF22	0.144	0.036
MKI67	MKI67: Antigen KI-67	0.144	0.091
CHD4	CHD4: Chromodomain-helicase-DNA-binding protein 4	0.144	0.126
UBAP2	N/A	0.144	0.070
RBM14	RBM14, SIP: RNA-binding protein 14	0.144	0.036
FANCA	FANCA, FAA, FACA, FANCH: Fanconi anemia group A protein	0.144	0.0425
CENPA	CENPA: Histone H3-like centromeric protein A	0.144	0.091
HMGN2	HMGN2, HMG17: Non-histone chromosomal protein HMG-17	0.144	0.027
MLH1	MLH1, COCA2: DNA mismatch repair protein Mlh1	0.141	0.046
CAD	CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase	0.141	0.038
ADRBK1	ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1	0.139	0.029
PRKD2	PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2	0.139	0.029
BARD1	BARD1: BRCA1-associated RING domain protein 1	0.129	0.113
BRCA1	BRCA1, RNF53: Breast cancer type 1 susceptibility protein	0.129	0.113
ANAPC5	ANAPC5, APC5: Anaphase-promoting complex subunit 5	0.129	0.038
MYBL2	MYBL2, BMYB: Myb-related protein B	0.129	0.111
CDK4	CDK4: Cell division protein kinase 4	0.129	0.038
KHDRBS1	KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate	0.129	0.038
CDC6	CDC6, CDC18L: Cell division control protein 6 homolog	0.129	1.03
CDK2	CDK2: Cell division protein kinase 2	0.129	0.038
CHEK1	CHEK1, CHK1: Serine/threonine-protein kinase Chk1	0.129	0.029
CGI-48	UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho	0.129	0.038
TCF3	TCF3, E2A, ITF1: Transcription factor E2-alpha	0.129	0.032
VRK1	VRK1: Serine/threonine-protein kinase VRK1	0.129	0.046
WEE1	WEE1: Wee1-like protein kinase	0.129	0.038
CDC7	CDC7, CDC7L1: Cell division cycle 7-related protein kinase	0.129	0.029
H2AFX	H2AFX, H2AX: Histone H2A.x	0.129	0.137
CDC20	CDC20: Cell division cycle protein 20 homolog	0.129	0.032
CCNB1	Cyclin B1	0.129	0.032
TUBB	TUBB, TUBB5, OK/SW-cl.56: Tubulin beta chain	0.129	0.111
POLA2	POLA2: DNA polymerase subunit alpha B	0.129	0.788
HDAC3	HDAC3: Histone deacetylase 3	0.129	0.032
YBX1	YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1	0.129	0.063
ROCK1	ROCK1: Rho-associated protein kinase 1	0.127	0.026
AKT1	AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase	0.114	0.038
SOS1	SOS1: Son of sevenless homolog 1	0.114	0.033
CD2AP	CD2AP: CD2-associated protein	0.112	0.038
BTK	BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK	0.111	0.029
ANKS1A	ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A	0.097	0.035
MPP6	MPP6, VAM1: MAGUK p55 subfamily member 6	0.091	0.026
CSK	CSK: Tyrosine-protein kinase CSK	0.090	0.029
CRKL	CRKL: Crk-like protein	0.090	0.046
NBN	NBN, NBS, NBS1, P95: Nibrin	0.087	0.057
KIF23	N/A	0.087	0.027
ABCF1	N/A	0.087	0.052
XRCC6	XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1	0.087	0.091
UBTF	UBTF, UBF, UBF1: Nucleolar transcription factor 1	0.087	0.027
EIF5AP1	EIF5A: Eukaryotic translation initiation factor 5A-1	0.087	0.052
AOF2	AOF2, KIAA0601, LSD1: Lysine-specific histone demethylase 1	0.087	0.027
TRRAP	N/A	0.087	0.032
RNPS1	RNPS1, LDC2: RNA-binding protein with serine-rich domain 1	0.087	0.027
FNBP1	N/A	0.087	0.029
CENTB2	CENTB2, KIAA0041: Centaurin-beta 2	0.086	0.043
DOK1	DOK1: Docking protein 1	0.086	0.038
NF2	NF2, SCH: Merlin	0.083	0.028
MTA1	MTA1: Metastasis-associated protein MTA1	0.078	0.0818
STAG2	STAG2, SA2: Cohesin subunit SA-2	0.078	0.046
OXSR1	OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1	0.078	0.046
PIP5K3	PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase	0.078	0.029
SKIIP	SNW1, SKIIP, SKIP: SNW domain-containing protein 1	0.078	0.032
SMARCA3	HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor	0.078	0.148
PBK	PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase	0.078	0.046
PPP1R8	N/A	0.078	0.067
IEF-SSP-9502	PWP1: Periodic tryptophan protein 1 homolog	0.078	0.038
SAFB	SAFB, HAP, HET, SAFB1: Scaffold attachment factor B	0.078	0.067
SMARCA5	SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul	0.078	0.067
HDGF	HDGF, HMG1L2: Hepatoma-derived growth factor	0.078	0.066
TP53	TP53, P53: Cellular tumor antigen p53	0.078	0.041
PKMYT1	PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito	0.078	0.046
YY1	YY1: Transcriptional repressor protein YY1	0.078	0.032
TAF6	TAF6, TAF2E, TAFII70: Transcription initiation factor TFIID subunit 6	0.078	0.067
PRPF4B	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol	0.078	0.029
MDN1	MDN1, KIAA0301: Midasin	0.078	0.054
AURKA	AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6	0.078	0.063
CSNK2A1	CSNK2A1: CSNK2A1 protein	0.078	0.046
ATR	ATR, FRP1: Serine/threonine-protein kinase ATR	0.078	0.029
STK24	STK24, MST3, STK3: Serine/threonine-protein kinase 24	0.078	0.063
SCRIB	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4	0.075	0.0425
PLCG1	PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1	0.075	0.026
PDPK1	PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1	0.075	0.025
ELMO1	N/A	0.075	0.025
AKT3	AKT3: RAC-gamma serine/threonine-protein kinase	0.075	0.025
BIRC5	BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5	0.074	0.070
STOML2	STOML2, SLP2, HSPC108: Stomatin-like protein 2	0.074	0.052
FUBP1	N/A	0.074	0.032
CXorf9	N/A	0.071	0.043
USP24	USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24	0.070	0.0425
RDBP	RDBP, NELFE, RD: Negative elongation factor E	0.070	0.036
PASK	PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase	0.070	0.032
CHUK	N/A	0.070	0.032
IKBKG	IKBKG, FIP3, NEMO: NF-kappa-B essential modulator	0.070	0.027
MAP4K1	MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1	0.070	0.032
ELF1	ELF1: ETS-related transcription factor Elf-1	0.070	0.057
KIAA0528	KIAA0528: Uncharacterized protein KIAA0528	0.070	0.0425
ARFGAP1	N/A	0.070	0.027
API5	N/A	0.070	0.026
BRCA2	BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein	0.070	0.026
IRF3	IRF3: Interferon regulatory factor 3	0.070	0.057
TERF2	TERF2, TRBF2, TRF2: Telomeric repeat-binding factor 2	0.070	0.0453
SH2BP1	CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog	0.070	0.032
MYB	MYB: Myb proto-oncogene protein	0.070	0.037
ELMO2	ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2	0.069	0.029
OSBP	OSBP, OSBP1: Oxysterol-binding protein 1	0.067	0.029
XPO1	XPO1, CRM1: Exportin-1	0.066	0.038
ATAD2	ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2	0.066	0.046
RAN	RAN, ARA24, OK/SW-cl.81: GTP-binding nuclear protein Ran	0.066	0.038
EIF2S3	EIF2S3, EIF2G: Eukaryotic translation initiation factor 2 subunit 3	0.066	0.029
RACGAP1	RACGAP1, KIAA1478, MGCRACGAP: Rac GTPase-activating protein 1	0.066	0.063
COPS3	COPS3, CSN3: COP9 signalosome complex subunit 3	0.066	0.078
LAMR1	RPSA, LAMBR, LAMR1: 40S ribosomal protein SA	0.066	0.029
CCT8	CCT8: Uncharacterized protein CCT8	0.066	0.038
HSPD1		0.066	0.029
CCT4	CCT4, CCTD, SRB: T-complex protein 1 subunit delta	0.066	0.038
TK1	TK1: Thymidine kinase, cytosolic	0.066	0.046
RRM2	RRM2, RR2: Ribonucleoside-diphosphate reductase subunit M2	0.066	0.046
CTPS	CTPS: CTP synthase 1	0.066	0.038
PSMA5	PSMA5: Proteasome subunit alpha type-5	0.066	0.038
CCT2	CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta	0.066	0.046
CDC23	CDC23: Cell division cycle protein 23 homolog	0.066	0.038
CCT6A	CCT6A, CCT6, CCTZ: T-complex protein 1 subunit zeta	0.066	0.038
CUL5	CUL5, VACM1: Cullin-5	0.063	0.113
EXOSC2	EXOSC2, RRP4: Exosome complex exonuclease RRP4	0.063	0.029
ACIN1	ACIN1, ACINUS, KIAA0670: Apoptotic chromatin condensation inducer in the nucleus	0.063	0.0818
SEC24C	SEC24C, KIAA0079: Protein transport protein Sec24C	0.063	0.038
K-ALPHA-1	TUBA1B: Tubulin alpha-1B chain	0.063	0.0818
PSMD1	PSMD1: 26S proteasome non-ATPase regulatory subunit 1	0.063	0.046
ATF1	ATF1: Cyclic AMP-dependent transcription factor ATF-1	0.063	0.032
TAF10	TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10	0.063	0.032
REXO2	REXO2, SFN, CGI-114, SMFN: Oligoribonuclease, mitochondrial precursor	0.063	0.032
SNF1LK2	SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2	0.063	0.188
HIRA	HIRA, DGCR1, HIR, TUPLE1: Protein HIRA	0.063	0.078
TOPORS	TOPORS, LUN, TP53BPL: E3 ubiquitin-protein ligase Topors	0.063	0.032
KIAA0683	DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized	0.063	0.029
NOC2L	NOC2L: Nucleolar complex protein 2 homolog	0.063	0.046
NCOR1	NCOR1, KIAA1047: Nuclear receptor corepressor 1	0.063	0.041
AKAP8L	AKAP8L, NAKAP95, HRIHFB2018: A-kinase anchor protein 8-like	0.063	0.066
GTF2B	GTF2B, TF2B, TFIIB: Transcription initiation factor IIB	0.063	0.032
SF3B4	SF3B4, SAP49: Splicing factor 3B subunit 4	0.063	0.032
PSMD4	PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4	0.063	0.090
NACA	NACA, HSD48: Nascent polypeptide-associated complex subunit alpha	0.063	0.051
SAPS3	N/A	0.063	0.029
SF3B1	SF3B1, SAP155: Splicing factor 3B subunit 1	0.063	0.029
OSBPL11	OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11	0.062	0.026
GAB1	GAB1: GRB2-associated-binding protein 1	0.062	0.026
SPTA1	SPTA1, SPTA: Spectrin alpha chain, erythrocyte	0.061	0.144
SNAPC4	SNAPC4, SNAP190: snRNA-activating protein complex subunit 4	0.052	0.057
EIF4G1	EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1	0.052	0.036
MAPK6	MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6	0.052	0.032
DRIM	UTP20, DRIM: Small subunit processome component 20 homolog	0.052	0.026
TLK1	TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1	0.052	0.026
XRCC1	XRCC1: DNA-repair protein XRCC1	0.052	0.075
EMD	EMD, EDMD, STA: Emerin	0.052	0.027
WAS	WAS, IMD2: Wiskott-Aldrich syndrome protein	0.051	0.029
MSN	MSN: Moesin	0.051	0.029
ITSN1	ITSN1, ITSN, SH3D1A: Intersectin-1	0.049	0.028
DNM3	DNM3: Uncharacterized protein DNM3	0.049	0.028
LNK	SH2B3, LNK: SH2B adapter protein 3	0.049	0.028
PSCD1	PSCD1, D17S811E: Cytohesin-1	0.049	0.028
PDZD2	CDNA FLJ46853 fis, clone UTERU3009775, moderately similar to Rattus norvegicus P	0.049	0.028
PSCD2	N/A	0.049	0.028
EZH2	EZH2: Enhancer of zeste homolog 2	0.0479	0.036
KIAA1804	MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase	0.047	0.025
IRAK1	IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1	0.046	0.114
PTEN	PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du	0.046	0.038
SYMPK	SYMPK, SPK: Symplekin	0.046	0.063
HSF2	HSF2, HSTF2: Heat shock factor protein 2	0.046	0.041
STK25	STK25, SOK1, YSK1: Serine/threonine-protein kinase 25	0.046	0.046
TUBA1	TUBA4A, TUBA1: Tubulin alpha-4A chain	0.046	0.067
H3F3A	H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3	0.046	0.0818
CSDA	CSDA, DBPA: DNA-binding protein A	0.046	0.078
KLF1	KLF1, EKLF: Krueppel-like factor 1	0.046	0.040
AIP	AIP, XAP2: AH receptor-interacting protein	0.046	0.029
ETV6	ETV6, TEL, TEL1: Transcription factor ETV6	0.046	0.051
CDK7	CDK7, MO15: Cell division protein kinase 7	0.046	0.038
HIST1H3A	HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD,	0.046	0.041
TUBA6	TUBA1C, TUBA6: Tubulin alpha-1C chain	0.046	0.0818
RPS6KB1	N/A	0.046	0.029
STK11	STK11, LKB1, PJS: Serine/threonine-protein kinase 11	0.046	0.276
KIAA1012	KIAA1012: Protein TRS85 homolog	0.046	0.029
DIAPH1	Diaphanous 1	0.046	0.038
RPA2	RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit	0.046	0.038
PIK4CB	PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic,	0.046	0.046
FHOD1	FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1	0.046	0.038
HGS	HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate	0.046	0.181
UTX	UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein	0.046	0.029
PKN2	PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2	0.046	0.038
FKBP4	FKBP4: FK506-binding protein 4	0.046	0.038
KLHDC4	N/A	0.046	0.046
TAL1	TAL1, SCL, TCL5: T-cell acute lymphocytic leukemia protein 1	0.046	0.066
ABL1	ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1	0.046	0.026
NCF4	NCF4, SH3PXD4: Neutrophil cytosol factor 4	0.046	0.026
SLC9A3R1	SLC9A3R1, NHERF: Ezrin-radixin-moesin-binding phosphoprotein 50	0.0453	0.026
VASP	VASP: Vasodilator-stimulated phosphoprotein	0.0453	0.026
LIMK2	LIMK2: LIM domain kinase 2	0.0453	0.026
NME1	NME1, NDPKA, NM23: Nucleoside diphosphate kinase A	0.0446	0.026
RANGAP1	RANGAP1, SD: Ran GTPase-activating protein 1	0.0446	0.087
PHB2	PHB2, BAP, REA: Prohibitin-2	0.0446	0.0425
HSP90AB1	HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta	0.0446	0.026
EPB41L1	EPB41L1, KIAA0338: Band 4.1-like protein 1	0.044	0.025
GOPC	GOPC, CAL, FIG: Golgi-associated PDZ and coiled-coil motif-containing protein	0.044	0.025
PARD6A	PARD6A, PAR6A: Partitioning defective 6 homolog alpha	0.044	0.025
MYO18A		0.044	0.025
RASA1	RASA1, RASA: Ras GTPase-activating protein 1	0.044	0.025
LRRC7	LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7	0.044	0.025
DGKD	DGKD, KIAA0145: Diacylglycerol kinase delta	0.044	0.047
ITSN2	ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2	0.044	0.025
SPTBN1	SPTBN1, SPTB2: Spectrin beta chain, brain 1	0.044	0.025
ITK	ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK	0.044	0.025
DEF6	DEF6, IBP: Differentially expressed in FDCP 6	0.0425	0.026
TERF2IP	TERF2IP, RAP1, PP8000: Telomeric repeat-binding factor 2-interacting protein 1	0.0425	0.124
PIK3CD	PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i	0.0425	0.032
TERF1	TERF1, PIN2, TRBF1, TRF, TRF1: Telomeric repeat-binding factor 1	0.0425	0.0453
ERG	ERG: Transcriptional regulator ERG	0.0425	0.032
STK16	N/A	0.0425	0.032
MAP2K3	MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki	0.0425	0.144
STAM	STAM, STAM1: Signal transducing adapter molecule 1	0.041	0.225
PLCB3	PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3	0.041	0.029
IQSEC1	IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein	0.041	0.029
RDX	RDX: Radixin	0.041	0.029
MATK	MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase	0.04	0.028
ABI1	ABI1, SSH3BP1: Abl interactor 1	0.04	0.028
SLA2	SLA2, C20orf156, SLAP2: Src-like-adapter 2	0.04	0.028
ABL2	ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2	0.04	0.028
AMPH	AMPH, AMPH1: Amphiphysin	0.04	0.028
PSMB7	PSMB7: Proteasome subunit beta type-7 precursor	0.040	0.046
FRG1	FRG1: Protein FRG1	0.040	0.038
EEF1G	EEF1G, EF1G, PRO1608: Elongation factor 1-gamma	0.040	0.029
CASP3	CASP3, CPP32: Caspase-3 precursor	0.040	0.029
TRIP13	TRIP13: Thyroid receptor-interacting protein 13	0.040	0.038
PSMD11	PSMD11: 26S proteasome non-ATPase regulatory subunit 11	0.040	0.046
RPL8	RPL8: 60S ribosomal protein L8	0.040	0.038
ME2	ME2: NAD-dependent malic enzyme, mitochondrial precursor	0.040	0.029
QARS	QARS: Glutaminyl-tRNA synthetase	0.040	0.038
HNRPK	N/A	0.040	0.046
PPIA	PPIA, CYPA: Peptidyl-prolyl cis-trans isomerase A	0.040	0.029
RPS3	RPS3, OK/SW-cl.26: 40S ribosomal protein S3	0.040	0.038
EPRS	EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes:	0.040	0.038
ACP1	ACP1: Low molecular weight phosphotyrosine protein phosphatase	0.040	0.129
MAPRE1	MAPRE1: Microtubule-associated protein RP/EB family member 1	0.040	0.038
PSMA3	PSMA3, PSC8: Proteasome subunit alpha type-3	0.040	0.029
G3BP	G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1	0.040	0.029
RPL3	RPL3, OK/SW-cl.32: 60S ribosomal protein L3	0.040	0.029
FXR1	FXR1: Fragile X mental retardation syndrome-related protein 1	0.040	0.038
MAP2K2	MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki	0.040	0.063
EIF5B	EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B	0.040	0.038
THOC1	THOC1, HPR1: THO complex subunit 1	0.040	0.114
EEF1B2	EEF1B2, EEF1B, EF1B: Elongation factor 1-beta	0.040	0.029
PSMA2	PSMA2, PSC3: Proteasome subunit alpha type-2	0.040	0.038
HSP90AA1	Hsp89-alpha-delta-N	0.040	0.038
MTHFD1	MTHFD1, MTHFC, MTHFD: C-1-tetrahydrofolate synthase, cytoplasmic	0.040	0.038
USP7	USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7	0.040	0.129
NME2	NME2, NM23B: Nucleoside diphosphate kinase B	0.040	0.029
TXNL1	TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1	0.040	0.188
GSR	GSR, GLUR, GRD1: Glutathione reductase, mitochondrial precursor	0.040	0.038
EIF3S6	EIF3S6, INT6: Eukaryotic translation initiation factor 3 subunit 6	0.040	0.029
SCYL3	SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin	0.038	0.029
SGTA	SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A	0.038	0.029
BRPF1	BRPF1, BR140: Peregrin	0.038	0.038
PCAF	PCAF: Histone acetyltransferase PCAF	0.038	0.040
RANBP9	RANBP9, RANBPM: Ran-binding protein 9	0.038	0.067
GGCX	GGCX, GC: Vitamin K-dependent gamma-carboxylase	0.038	0.051
MAFG	MAFG: Transcription factor MafG	0.038	0.032
RPS6KA1	RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1	0.038	0.038
TMEM1	TMEM1, EHOC1: Transmembrane protein 1	0.038	0.029
COPA	COPA: Coatomer subunit alpha	0.038	0.038
RPS6KB2	RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2	0.038	0.046
COPE	COPE: Coatomer subunit epsilon	0.038	0.063
KLF13	KLF13, BTEB3, NSLP1: Krueppel-like factor 13	0.038	0.032
CDK6	CDK6: Cell division protein kinase 6	0.038	0.029
SATB1	SATB1: DNA-binding protein SATB1	0.038	0.027
CBLB	CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B	0.038	0.090
FZR1	N/A	0.038	0.032
C20orf4	C20orf4, CGI-23, PRO0225: Uncharacterized protein C20orf4	0.038	0.038
HSF1	HSF1, HSTF1: Heat shock factor protein 1	0.038	0.137
PPP1R12A	PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A	0.038	0.054
NCF1	Neutrophil cytosolic factor 1 variant (Fragment)	0.037	0.032
PSTPIP1	PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1	0.037	0.026
SLA	SLA, SLAP, SLAP1: SRC-like-adapter	0.037	0.026
SRC	SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src	0.037	0.026
PDLIM1	PDLIM1, CLIM1, CLP36: PDZ and LIM domain protein 1	0.037	0.026
SH3BP2	SH3BP2: Uncharacterized protein SH3BP2	0.037	0.026
TRAF2	TRAF2, TRAP3: TNF receptor-associated factor 2	0.036	0.251
YWHAQ	YWHAQ: 14-3-3 protein theta	0.036	0.0425
STIP1	STIP1: Stress-induced-phosphoprotein 1	0.036	0.052
MNAR	PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1	0.036	0.0425
IPO7	IPO7: Uncharacterized protein IPO7	0.036	0.026
BIN1	BIN1, AMPHL: Myc box-dependent-interacting protein 1	0.036	0.025
BAIAP2	BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2	0.036	0.025
FYN	FYN: Proto-oncogene tyrosine-protein kinase Fyn	0.036	0.025
NEDD9	NEDD9, CASL: Enhancer of filamentation 1	0.036	0.025
GRB2	GRB2, ASH: Growth factor receptor-bound protein 2	0.036	0.025
SH3KBP1	SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1	0.036	0.025
STAM2	STAM2: Signal transducing adapter molecule 2	0.033	0.171
LCP2	LCP2: Lymphocyte cytosolic protein 2	0.032	0.037
RIPK1	RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1	0.032	0.077
FRAP1	FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein	0.032	0.032
VCPIP1	VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135	0.032	0.032
PRKAA1	N/A	0.032	0.032
IKBKB	IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta	0.032	0.152
CDKN2D	CDKN2D: Cyclin-dependent kinase 4 inhibitor D	0.032	0.0971
ZAK	MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT	0.032	0.046
TRAFD1	TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1	0.032	0.032
HUWE1	HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1	0.032	0.307
MAP3K5	MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5	0.032	0.026
TRAP1	TRAP1, HSP75: Heat shock protein 75 kDa, mitochondrial precursor	0.032	0.029
CARS	CARS: Cysteinyl-tRNA synthetase, cytoplasmic	0.032	0.038
HSPH1	HSPH1, HSP105, HSP110, KIAA0201: Heat shock protein 105 kDa	0.032	0.029
USP10	USP10, KIAA0190: Ubiquitin carboxyl-terminal hydrolase 10	0.032	0.038
PCBP1	PCBP1: Poly(rC)-binding protein 1	0.032	0.063
RPS10	RPS10: 40S ribosomal protein S10	0.032	0.086
THOP1	THOP1: Thimet oligopeptidase	0.032	0.038
PCBP2	PCBP2: Poly(rC)-binding protein 2	0.032	0.046
PPARBP	N/A	0.032	0.029
TBCE	TBCE: Tubulin-specific chaperone E	0.032	0.038
RARS	RARS: Arginyl-tRNA synthetase, cytoplasmic	0.032	0.029
EEF1A1	EEF1A1: Elongation factor 1-alpha	0.032	0.029
EIF3S8	EIF3S8: Eukaryotic translation initiation factor 3 subunit 8	0.032	0.046
PSMC1	PSMC1: 26S protease regulatory subunit 4	0.032	0.046
PSMC2	PSMC2, MSS1: 26S protease regulatory subunit 7	0.032	0.046
NMT1	NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1	0.032	0.046
PPID	PPID, CYP40, CYPD: 40 kDa peptidyl-prolyl cis-trans isomerase	0.032	0.029
KPNA2	KPNA2, RCH1, SRP1: Importin subunit alpha-2	0.032	0.046
DPF2	DPF2, REQ, UBID4: Zinc finger protein ubi-d4	0.032	0.225
EEF2	EEF2, EF2: Elongation factor 2	0.032	0.038
VCP	VCP: Transitional endoplasmic reticulum ATPase	0.032	0.046
DYNC1LI1	DYNC1LI1, DNCLI1: Cytoplasmic dynein 1 light intermediate chain 1	0.029	0.029
NRBP1	NRBP1, BCON3, NRBP: Nuclear receptor-binding protein	0.029	0.038
STK10	STK10: Uncharacterized protein STK10	0.029	0.029
FOXO3A	FOXO3A, FKHRL1: Forkhead box protein O3A	0.029	0.066
CLASP1	CLASP1, KIAA0622, MAST1: CLIP-associating protein 1	0.029	0.029
MAP2K1	MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1	0.029	0.029
GIT1	GIT1: ARF GTPase-activating protein GIT1	0.029	0.054
GSK3B	N/A	0.029	0.029
ETS1	ETS1, EWSR2: Protein C-ets-1	0.029	0.051
STK38	STK38, NDR1: Serine/threonine-protein kinase 38	0.029	0.029
MAPK1	MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1	0.029	0.038
PSKH1	PSKH1: Serine/threonine-protein kinase H1	0.029	0.029
C20orf18	N/A	0.028	0.109
UHRF1		0.028	0.109
SF1	SF1, ZFM1, ZNF162: Splicing factor 1	0.028	0.028
MAPK9	MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9	0.028	0.028
C14orf151	C14orf151: Uncharacterized protein C14orf151 (Fragment)	0.028	0.028
BMP2K	BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase	0.028	0.028
PPEF1	N/A	0.028	0.028
MAPKAPK5	N/A	0.028	0.028
MINK1	MAP4K6, MINK1, MINK: Misshapen-like kinase 1	0.028	0.028
ZNF687	ZNF687, KIAA1441: Zinc finger protein 687	0.028	0.028
GPRASP2	GPRASP2: G-protein coupled receptor-associated sorting protein 2	0.028	0.028
PKN1	PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1	0.028	0.028
PPP1R12C	PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C	0.028	0.028
CDC2L1	CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1	0.028	0.028
DYRK1A	DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin	0.028	0.028
MAPK15	N/A	0.028	0.028
MLL2	MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2	0.028	0.109
ELF2	ELF2, NERF: ETS-related transcription factor Elf-2	0.028	0.049
PHLDB2	N/A	0.028	0.028
CCAR1	CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1	0.028	0.083
FBXO4	FBXO4, FBX4: F-box only protein 4	0.028	0.083
CDC2L2	CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2	0.028	0.028
CASKIN2	CASKIN2, KIAA1139: Caskin-2	0.028	0.0308
FGR	FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR	0.027	0.029
USP21	USP21, USP23: Ubiquitin carboxyl-terminal hydrolase 21	0.027	0.0425
HD	HD, IT15: Huntingtin	0.027	0.0425
CNKSR2	CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2	0.026	0.0308
MAPK7	mitogen-activated protein kinase 7 isoform 1	0.026	0.0425
GRLF1	N/A	0.026	0.0425
ERF	ERF: ETS domain-containing transcription factor ERF	0.026	0.0453
FAM65A	FAM65A, KIAA1930: Protein FAM65A	0.026	0.0425
AANAT	AANAT, SNAT: Serotonin N-acetyltransferase	0.026	0.0425
MAP3K14	MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14	0.026	0.032
MAP3K8	MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8	0.026	0.026
MDM4	MDM4, MDMX: Mdm4 protein	0.026	0.072
MAPKAPK2	MAPKAPK2: MAP kinase-activated protein kinase 2	0.026	0.032
MAPK4	MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4	0.026	0.026
MARK2	N/A	0.026	0.026
WNK4	WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4	0.025	0.025
RPS6KA2	RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2	0.025	0.025
SMAD1	SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1	0.025	0.044
MAP2K3	N/A	0.025	0.025
BCOR	N/A	0.025	0.025
CAMK1D	CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D	0.025	0.025
CDC2L5	CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5	0.025	0.025
LATS1	LATS1, WARTS: Serine/threonine-protein kinase LATS1	0.025	0.075
ADK	ADK: Adenosine kinase	0.025	0.025
RFFL	RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin	0.025	0.098
DUSP6	DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6	0.025	0.025
PPP1R9B	PPP1R9B, PPP1R6: Neurabin-2	0.025	0.025
DUSP16	DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16	0.025	0.025
SMC4L1	SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4	0.025	0.025
RPS6KA4	RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4	0.025	0.025
PHKG1	PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo	0.025	0.025
CAMKK1	N/A	0.025	0.025
FBXL10	FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio	0.025	0.075
CDC25C	CDC25C: M-phase inducer phosphatase 3	0.025	0.025
CDC25A	CDC25A: M-phase inducer phosphatase 1	0.025	0.025
ARID1A	ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A	0.025	0.025
RNF113A	RNF113A, RNF113, ZNF183: RING finger protein 113A	0.025	0.098
CAMK2A	N/A	0.025	0.025
CARHSP1	CARHSP1: Calcium-regulated heat stable protein 1	0.025	0.025
NIPBL	N/A	0.025	0.025
CDC2	CDC2: Cell division control protein 2 homolog	0.025	0.025
PDE8B	PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies	0.025	0.025
GRK6	N/A	0.025	0.025
NEK6	NEK6: Serine/threonine-protein kinase Nek6	0.025	0.025
MKNK1	MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1	0.025	0.025
MKNK2	MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2	0.025	0.025
CPNE1	RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12	0.025	0.025
GIT2	N/A	0.025	0.047
DYRK1B	DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0.025	0.025
ARL5A	ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A	0.025	0.025
PHC2	PHC2, EDR2, PH2: Polyhomeotic-like protein 2	0.025	0.036
CHEK2	CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2	0.025	0.044
C14orf4	C14orf4, KIAA1865, My039: RING finger protein C14orf4	0.025	0.098
SGK2	SGK2: Serine/threonine-protein kinase Sgk2	0.025	0.025
PRKACA	PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit	0.025	0.025
H2-ALPHA	TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain	0.025	0.044
EEF2K	EEF2K: Elongation factor 2 kinase	0.025	0.025
EXO1	EXO1, EXOI, HEX1: Exonuclease 1	0.025	0.047
MAP3K7	MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7	0.025	0.025
HIST2H2AC	HIST2H2AC, H2AFQ: Histone H2A type 2-C	0.025	0.044
PKN3	PKN3, PKNBETA: Serine/threonine-protein kinase N3	0.025	0.025
TRERF1	TRERF1, BCAR2, RAPA, TREP132: Transcriptional-regulating factor 1	0.025	0.044
RAD51	RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1	0.025	0.025
RNF20		0.025	0.098
LATS2	LATS2, KPM: Serine/threonine-protein kinase LATS2	0.025	0.075
PRKCB1	N/A	0.025	0.025
DLX3	DLX3: Homeobox protein DLX-3	0.025	0.036
MIER1	MIER1, KIAA1610: Mesoderm induction early response protein 1	0.025	0.044

2.15E-3

Total Score

1.09