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Evidence of Interaction Between MAPK1 and IL6ST

The interaction score between MAPK1 and IL6ST is 5.87.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology N/A N/A
Domains Domains present in MAPK1 and IL6ST:
Domains in MAPK1Domains in IL6ST
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008349 ERK1/2 MAP kinase
IPR003961 Fibronectin, type III
IPR003529 Long hematopoietin receptor, gp130 family 2
IPR010457 Ig-like C2-type
IPR002996 Cytkn_recept_B/G.

The Chi square scores for co-occurrence of domains that are present in MAPK1 and IL6ST are listed below.

Domain 1Domain 2Chi Square
IPR008271 Serine/threonine protein kinase, active site IPR003961 Fibronectin, type III 30.5883
IPR002290 Serine/threonine protein kinase IPR003961 Fibronectin, type III 13.198
IPR002290 Serine/threonine protein kinase IPR002996 Cytkn_recept_B/G. 2.93674
IPR011009 Protein kinase-like IPR010457 Ig-like C2-type 2.02998
IPR011009 Protein kinase-like IPR002996 Cytkn_recept_B/G. 1.93327
IPR008349 ERK1/2 MAP kinase IPR003961 Fibronectin, type III 1.72177
IPR000719 Protein kinase IPR002996 Cytkn_recept_B/G. 1.43014
IPR000719 Protein kinase IPR003961 Fibronectin, type III 0.712801
IPR011009 Protein kinase-like IPR003961 Fibronectin, type III 0.616354
IPR011009 Protein kinase-like IPR003529 Long hematopoietin receptor, gp130 family 2 0.338037
IPR003527 MAP kinase IPR003961 Fibronectin, type III 0.246402
IPR000719 Protein kinase IPR010457 Ig-like C2-type 0.176496
IPR000719 Protein kinase IPR003529 Long hematopoietin receptor, gp130 family 2 0.00128107

The background colour of the table refers to:

  • Blue Domain is only present in MAPK1
  • Yellow Domain is only present in IL6ST
  • Green Domain is present in both MAPK1 and IL6ST

 0.049
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: IL6ST

PTMResidueReference
Dephosphorylation 759 PubMed, HPRD
Disulfide Bridge 54 PubMed, HPRD
Disulfide Bridge 103 PubMed, HPRD
Disulfide Bridge 144 PubMed, HPRD
Disulfide Bridge 182 PubMed, HPRD
Disulfide Bridge 466 PubMed, HPRD
Glycosylation 43 PubMed, HPRD
Glycosylation 83 PubMed, HPRD
Glycosylation 131 PubMed, HPRD
Glycosylation 157 PubMed, HPRD
Glycosylation 227 PubMed, HPRD
Glycosylation 379 PubMed, HPRD
Glycosylation 383 PubMed, HPRD
Glycosylation 553 PubMed, HPRD
Glycosylation 564 PubMed, HPRD
N-linked 43 PubMed, HPRD
N-linked 83 PubMed, HPRD
N-linked 131 PubMed, HPRD
N-linked 157 PubMed, HPRD
N-linked 227 PubMed, HPRD
N-linked 379 PubMed, HPRD
N-linked 383 PubMed, HPRD
N-linked 553 PubMed, HPRD
N-linked 564 PubMed, HPRD
Phosphorylation 782 PubMed, HPRD
Phosphorylation 890 PubMed, HPRD
Phosphorylation 909 PubMed, HPRD
Phosphoserine 782 HPRD
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: IL6ST

LocalisationReference
Plasma membrane HPRD
Secreted HPRD
Transitive Score

The common interactors between MAPK1 and IL6ST that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andIL6ST. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and IL6ST has 1168 interactors of which there are 572 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for IL6ST-Interactor (?)
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 153.00 0.049
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 115.00 0.0688
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 94.70 0.0688
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 62.30 0.109
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 62.30 0.109
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 62.30 0.0688
GNAI3 GNAI3: Guanine nucleotide-binding protein G(k) subunit alpha 10.50 0.028
CDK2 CDK2: Cell division protein kinase 2 6.80 0.049
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 4.15 0.04
HSP90AA1 Hsp89-alpha-delta-N 3.95 0.109
GNAI1 GNAI1: Guanine nucleotide-binding protein G(i), alpha-1 subunit 2.53 0.028
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 2.17 0.109
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 2.02 0.049
GNAI2 Galphai2 protein 1.71 0.028
MYL9 MYL9, MLC2, MRLC1, MYRL2: Myosin regulatory light chain 2, smooth muscle isoform 1.42 0.049
GNAQ GNAQ, GAQ: Guanine nucleotide-binding protein G(q) subunit alpha 1.03 0.028
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.975 0.0688
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 1 0.683 0.028
PLEK PLEK, P47: Pleckstrin 0.515 0.0688
GNAZ GNAZ: Guanine nucleotide-binding protein G(z) subunit alpha 0.509 0.028
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.461 0.049
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.461 0.109
CRKL CRKL: Crk-like protein 0.461 0.109
JAK1 0.461 0.109
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.461 0.109
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.461 0.109
VAV1 VAV1, VAV: Proto-oncogene vav 0.461 0.109
MSN MSN: Moesin 0.461 0.109
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.461 0.109
GNA11 GNA11, GA11: Guanine nucleotide-binding protein subunit alpha-11 0.456 0.028
GNAT1 GNAT1, GNATR: Guanine nucleotide-binding protein G(t), alpha-1 subunit 0.449 0.028
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.416 0.109
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.416 0.0688
GNAT2 GNAT2, GNATC: Guanine nucleotide-binding protein G(t), alpha-2 subunit 0.405 0.028
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.385 0.049
STK10 STK10: Uncharacterized protein STK10 0.385 0.049
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.385 0.049
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.372 0.109
STAT6 STAT6: Signal transducer and activator of transcription 6 0.372 0.109
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.372 0.0688
PSCD4 PSCD4, CYT4: Cytohesin-4 0.372 0.109
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.372 0.109
LYN LYN: Tyrosine-protein kinase Lyn 0.372 0.109
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.372 0.109
CSK CSK: Tyrosine-protein kinase CSK 0.372 0.109
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.372 0.109
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.372 0.109
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.372 0.049
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.372 0.109
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.372 0.109
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.344 0.0333
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.307 0.109
ROCK1 ROCK1: Rho-associated protein kinase 1 0.307 0.109
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.307 0.109
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.307 0.109
VASP VASP: Vasodilator-stimulated phosphoprotein 0.307 0.049
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.275 0.109
DOK1 DOK1: Docking protein 1 0.275 0.109
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.275 0.109
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.275 0.0688
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.275 0.109
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.275 0.109
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.275 0.109
HCK N/A 0.275 0.109
SYK SYK: Tyrosine-protein kinase SYK 0.275 0.109
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.260 0.109
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.260 0.109
GAB2 N/A 0.251 0.109
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.251 0.109
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.251 0.109
IRS2 IRS2: Insulin receptor substrate 2 0.251 0.109
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.233 0.034
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.233 0.109
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.233 0.049
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.233 0.049
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.233 0.049
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.233 0.049
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.233 0.109
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.233 0.109
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.225 0.109
STAT4 STAT4: Signal transducer and activator of transcription 4 0.225 0.0688
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.225 0.109
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.225 0.109
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.225 0.109
RASA3 RASA3: Ras GTPase-activating protein 3 0.225 0.109
SOS1 SOS1: Son of sevenless homolog 1 0.225 0.0688
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.225 0.034
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.210 0.049
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.210 0.049
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.210 0.109
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.191 0.109
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.191 0.109
STAT2 STAT2: Signal transducer and activator of transcription 2 0.191 0.0688
GMIP GMIP: GEM-interacting protein 0.188 0.049
CXorf9 N/A 0.188 0.109
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.188 0.109
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.188 0.049
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.188 0.109
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.188 0.049
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.188 0.109
RPS6KB1 N/A 0.188 0.109
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.188 0.109
FNBP1 N/A 0.188 0.109
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.171 0.034
RIN1 RIN1: Ras and Rab interactor 1 0.171 0.109
NCK2 NCK2: Cytoplasmic protein NCK2 0.171 0.109
PSD TYL: TYL protein 0.171 0.109
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.171 0.109
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.171 0.049
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.171 0.049
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.171 0.049
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 0.109
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.165 0.109
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.109
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.109
PSCD2 N/A 0.165 0.109
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.165 0.109
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.165 0.109
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.165 0.109
NF2 NF2, SCH: Merlin 0.165 0.109
MAP2K5 N/A 0.165 0.049
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.109
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.155 0.049
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.155 0.109
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.155 0.109
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.153 0.165
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.152 0.109
GAB1 GAB1: GRB2-associated-binding protein 1 0.152 0.109
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.152 0.109
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.152 0.109
ETS2 ETS2: Protein C-ets-2 0.152 0.034
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.148 0.0688
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.148 0.109
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.109
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.148 0.109
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.049
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.148 0.109
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.148 0.109
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.148 0.109
STAT3 0.148 0.109
ELMO1 N/A 0.148 0.109
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.109
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.109
ARHGEF7 N/A 0.148 0.109
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.148 0.109
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.148 0.109
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.139 0.049
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.139 0.034
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.139 0.109
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.139 0.049
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.139 0.109
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.139 0.049
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.139 0.049
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.139 0.049
ATM ATM: Serine-protein kinase ATM 0.139 0.049
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.139 0.049
CD2AP CD2AP: CD2-associated protein 0.139 0.109
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.139 0.083
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.139 0.049
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.136 0.0688
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.136 0.109
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.136 0.049
RDX RDX: Radixin 0.136 0.109
VIL2 N/A 0.136 0.109
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.136 0.109
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.136 0.109
CENTA1 CENTA1: Centaurin-alpha 1 0.128 0.0688
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.127 0.049
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.127 0.109
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.127 0.049
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.127 0.049
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.127 0.049
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.127 0.109
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.124 0.165
TNFRSF1B TNFRSF1B, TNFBR, TNFR2: Tumor necrosis factor receptor superfamily member 1B pre 0.124 0.028
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.123 0.109
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.123 0.109
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.114 0.109
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.114 0.049
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.114 0.109
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.114 0.049
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.114 0.049
CDK5 CDK5: Cell division protein kinase 5 0.114 0.049
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.114 0.049
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.114 0.049
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.114 0.049
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.114 0.049
EDD1 EDD1, EDD, HYD, KIAA0896: E3 ubiquitin-protein ligase EDD1 0.113 0.034
PLD2 PLD2: Phospholipase D2 0.111 0.109
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.111 0.049
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.111 0.109
APS SH2B2, APS: SH2B adapter protein 2 0.111 0.109
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.111 0.049
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.111 0.109
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.111 0.109
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.110 0.109
BMX N/A 0.110 0.109
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.109 0.165
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.109 0.165
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.109 0.109
MCF2 MCF2, DBL: Proto-oncogene DBL 0.109 0.109
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.109 0.0688
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.109 0.0688
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.099 0.109
IRS1 IRS1: Insulin receptor substrate 1 0.098 0.109
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.098 0.109
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.098 0.165
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.098 0.165
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.098 0.165
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.098 0.028
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.165
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.097 0.109
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.097 0.109
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.097 0.109
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.097 0.0688
PLD1 PLD1: Phospholipase D1 0.097 0.109
DAB1 DAB1: Disabled homolog 1 0.097 0.049
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.097 0.109
DAB2 DAB2, DOC2: Disabled homolog 2 0.097 0.049
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.096 0.109
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.096 0.049
CIITA CIITA, MHC2TA: MHC class II transactivator 0.096 0.04
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.096 0.049
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.096 0.034
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.096 0.049
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.096 0.049
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.091 0.165
CD44 N/A 0.091 0.083
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.090 0.028
PTPRZ1 N/A 0.090 0.165
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.088 0.109
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.088 0.109
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.086 0.049
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.086 0.109
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.086 0.049
CDK7 CDK7, MO15: Cell division protein kinase 7 0.086 0.049
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.086 0.083
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.086 0.049
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.086 0.049
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.086 0.109
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.086 0.049
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.086 0.049
TP53 TP53, P53: Cellular tumor antigen p53 0.086 0.034
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.083 0.049
MAPKAPK5 N/A 0.083 0.049
AMPH AMPH, AMPH1: Amphiphysin 0.083 0.109
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.083 0.049
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.083 0.049
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.083 0.109
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.083 0.049
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.083 0.049
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.083 0.049
MAPK15 N/A 0.083 0.109
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.083 0.049
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.083 0.049
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.049
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.0818 0.083
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.078 0.165
LCP1 LCP1, PLS2: Plastin-2 0.078 0.049
GNB1 GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0.078 0.034
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.077 0.049
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.077 0.049
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.077 0.109
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.077 0.109
PRKAA1 N/A 0.077 0.049
LIMK2 LIMK2: LIM domain kinase 2 0.077 0.049
STK16 N/A 0.077 0.109
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.077 0.165
TNFSF12 TNFSF12, APO3L, UNQ181/PRO207, DR3LG: Tumor necrosis factor ligand superfamily m 0.075 0.028
ATP2B1 N/A 0.075 0.028
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.075 0.165
FADD FADD, MORT1: Protein FADD 0.075 0.028
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.075 0.109
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.075 0.049
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.075 0.049
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.075 0.049
CDC2 CDC2: Cell division control protein 2 homolog 0.075 0.049
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.075 0.049
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.075 0.109
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.075 0.049
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.075 0.049
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.075 0.049
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.075 0.109
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.075 0.034
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.075 0.0688
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.075 0.109
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.075 0.109
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.075 0.049
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.075 0.109
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.075 0.049
SNX3 N/A 0.075 0.109
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.075 0.049
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.075 0.04
CNN2 CNN2: Calponin-2 0.075 0.049
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.075 0.049
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.075 0.034
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.075 0.109
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.075 0.083
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.075 0.109
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.075 0.049
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.075 0.049
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.075 0.109
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.075 0.049
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.049
GABRB1 GABRB1: Gamma-aminobutyric acid receptor subunit beta-1 precursor 0.073 0.028
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.073 0.165
GABRR1 N/A 0.0727 0.028
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.072 0.165
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.071 0.049
CAPNS1 CAPNS1, CAPN4, CAPNS: Calpain small subunit 1 0.070 0.049
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.069 0.083
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.069 0.109
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.069 0.049
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.069 0.049
CDK6 CDK6: Cell division protein kinase 6 0.069 0.049
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.069 0.049
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.069 0.049
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.069 0.109
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.069 0.049
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.069 0.109
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.069 0.049
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.069 0.049
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.069 0.109
CDK4 CDK4: Cell division protein kinase 4 0.069 0.049
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.067 0.165
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.064 0.165
ARPC1B ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B 0.063 0.034
COPA COPA: Coatomer subunit alpha 0.063 0.04
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.063 0.049
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.063 0.049
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.063 0.049
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.063 0.083
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.063 0.049
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.063 0.049
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.063 0.049
GRLF1 N/A 0.062 0.049
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.062 0.049
SPTAN1 N/A 0.062 0.109
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.062 0.165
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.058 0.165
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.058 0.165
GLRA1 N/A 0.058 0.028
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.057 0.083
TNF TNF, TNFA, TNFSF2: Tumor necrosis factor precursor 0.057 0.028
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.057 0.052
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.057 0.165
HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 0.056 0.109
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.056 0.109
WEE1 WEE1: Wee1-like protein kinase 0.056 0.049
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.056 0.049
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.056 0.049
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.056 0.109
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.056 0.049
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.056 0.049
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.056 0.049
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.056 0.049
STAM2 STAM2: Signal transducing adapter molecule 2 0.056 0.109
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.055 0.049
TP73 TP73, P73: Tumor protein p73 0.055 0.0688
SUPT5H SUPT5H, SPT5, SPT5H: Transcription elongation factor SPT5 0.054 0.029
TBC1D2 TBC1D2, PARIS1: TBC1 domain family member 2 0.053 0.051
FUBP1 N/A 0.052 0.049
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.052 0.04
DNM2 DNM2, DYN2: Dynamin-2 0.051 0.051
C9orf88 N/A 0.051 0.051
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.051
CRK CRK: Proto-oncogene C-crk 0.051 0.051
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
GRB10 N/A 0.051 0.051
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
PTPRA N/A 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.051
RAPH1 N/A 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.051 0.083
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.051 0.028
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.050 0.044
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.050 0.049
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.050 0.049
CDKL5 N/A 0.049 0.049
DAPK2 DAPK2: Death-associated protein kinase 2 0.049 0.049
TNFSF12 TNFSF13, APRIL, UNQ383/PRO715, TALL2, ZTNF2: Tumor necrosis factor ligand superf 0.049 0.028
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.049 0.165
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.049 0.083
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.049 0.028
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.049 0.083
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.049 0.165
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.049 0.028
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.049 0.028
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.049 0.028
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.049 0.165
EDA N/A 0.049 0.083
TNFSF13B TNFSF13B, BAFF, UNQ401/PRO738, BLYS, TALL1, TNFSF20, ZTNF4: Tumor necrosis facto 0.049 0.028
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.049 0.028
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.049 0.028
LAT LAT: Linker for activation of T-cells family member 1 0.049 0.028
ATP2A3 ATP2A3: Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 0.049 0.028
LSP1 LSP1, WP34: Lymphocyte-specific protein 1 0.049 0.028
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.049 0.083
SORBS3 SORBS3, SCAM1: Vinexin 0.049 0.109
DYRK3 N/A 0.049 0.049
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.049 0.049
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.046 0.04
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.046 0.034
TBCE TBCE: Tubulin-specific chaperone E 0.046 0.04
DLG1 N/A 0.046 0.028
FLII FLII, FLIL: Protein flightless-1 homolog 0.046 0.049
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.046 0.049
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.046 0.04
CCR5 CCR5: CCR5 receptor (Fragment) 0.046 0.028
PHLDB2 PHLDB2, LL5B: Pleckstrin homology-like domain family B member 2 0.046 0.051
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.046 0.051
VAV2 VAV2: Uncharacterized protein VAV2 0.046 0.051
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.046 0.051
KIF1B KIF1B, KIAA0591, KIAA1448: Kinesin-like protein KIF1B 0.046 0.051
EPB41 EPB41, E41P: Protein 4.1 0.046 0.051
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.046 0.044
EFNB1 EFNB1, EFL-3, EPLG2, LERK2: Ephrin-B1 precursor 0.046 0.109
CD40LG CD40LG, CD40L, TNFSF5, TRAP: CD40 ligand 0.0453 0.028
LTA LTA, TNFB, TNFSF1: Lymphotoxin-alpha precursor 0.0453 0.028
EPOR EPOR: Erythropoietin receptor precursor 0.0453 0.165
FASLG FASLG, APT1LG1, FASL, TNFSF6: Tumor necrosis factor ligand superfamily member 6 0.0453 0.028
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.0453 0.165
TNFRSF10C TNFRSF10C, DCR1, UNQ321/PRO366, LIT, TRAILR3, TRID: Tumor necrosis factor recept 0.0453 0.028
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.0446 0.083
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.044 0.049
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.044 0.049
MYO3A MYO3A: Myosin IIIA 0.044 0.049
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.044 0.109
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.044 0.049
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.044 0.049
CTTN CTTN, EMS1: Src substrate cortactin 0.044 0.109
CNN3 CNN3: Calponin-3 0.044 0.049
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.044 0.109
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.044 0.109
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.044 0.109
ABCC1 ABCC1, MRP, MRP1: Multidrug resistance-associated protein 1 0.044 0.028
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.044 0.083
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.044 0.028
AQP4 AQP4: Aquaporin-4 0.044 0.028
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.044 0.028
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.044 0.028
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.044 0.083
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.044 0.028
NUP214 N/A 0.0425 0.034
GNB2L1 Lung cancer oncogene 7 0.0425 0.034
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.0425 0.049
XRCC1 XRCC1: DNA-repair protein XRCC1 0.0425 0.034
SLC4A7 SLC4A7: Uncharacterized protein SLC4A7 0.041 0.028
EFNB2 EFNB2, EPLG5, HTKL, LERK5: Ephrin-B2 precursor 0.041 0.109
VWF VWF, F8VWF: von Willebrand factor precursor 0.041 0.049
NDP NDP: Norrin precursor 0.041 0.049
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.041 0.165
GRM3 GRM3, GPRC1C, MGLUR3: Metabotropic glutamate receptor 3 precursor 0.041 0.028
KIT KIT: Mast/stem cell growth factor receptor precursor 0.041 0.165
GLRB GLRB: Glycine receptor subunit beta precursor 0.041 0.028
TBXA2R TBXA2R: Thromboxane A2 receptor 0.04 0.028
SLC4A3 SLC4A3, AE3: Anion exchange protein 3 0.04 0.028
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.040 0.083
UNC84B UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2: Sad1/unc-84-like protein 2 0.040 0.083
ITGB7 ITGB7: Integrin beta-7 precursor 0.040 0.083
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.040 0.049
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.040 0.049
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 0.038 0.034
TLN1 TLN1: Uncharacterized protein TLN1 0.038 0.109
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.038 0.04
DYNC1I2 N/A 0.038 0.04
CHP CHP: Calcium-binding protein p22 0.038 0.049
MDN1 MDN1, KIAA0301: Midasin 0.038 0.04
CSTF1 CSTF1: Cleavage stimulation factor 50 kDa subunit 0.038 0.034
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.037 0.165
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.037 0.165
MS4A1 MS4A1, CD20: B-lymphocyte antigen CD20 0.037 0.028
CD3D CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor 0.037 0.028
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.037 0.083
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.037 0.083
GHR GHR: Growth hormone receptor precursor 0.037 0.165
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.037 0.165
CD5 CD5, LEU1: T-cell surface glycoprotein CD5 precursor 0.037 0.028
PRKD3 PRKD3, EPK2, PRKCN: Serine/threonine-protein kinase D3 0.036 0.027
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.036 0.083
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.036 0.083
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.036 0.083
CRLF3 N/A 0.036 0.165
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.036 0.083
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.036 0.083
CD7 CD7: T-cell antigen CD7 precursor 0.036 0.083
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.036 0.083
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.036 0.083
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.036 0.083
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.036 0.083
TRAF1 TRAF1, EBI6: TNF receptor-associated factor 1 0.035 0.04
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.034 0.051
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.034 0.980
SLC4A1 SLC4A1, AE1, DI, EPB3: Band 3 anion transport protein 0.033 0.028
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.033 0.083
GRIA1 GRIA1, GLUH1, GLUR1: Glutamate receptor 1 precursor 0.033 0.028
SCARB2 SCARB2, CD36L2, LIMPII: Lysosome membrane protein 2 0.033 0.028
GRIN1 GRIN1, NMDAR1: Glutamate [NMDA] receptor subunit zeta-1 precursor 0.033 0.028
GRM1 GRM1, GPRC1A, MGLUR1: Metabotropic glutamate receptor 1 precursor 0.033 0.028
GRIK2 GRIK2, GLUR6: Glutamate receptor, ionotropic kainate 2 precursor 0.033 0.028
PRLR PRLR: Prolactin receptor precursor 0.033 0.165
RHO RHO, OPN2: Rhodopsin 0.033 0.028
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.033 0.028
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.033 0.165
ITGB4 N/A 0.032 0.165
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.032 0.083
F3 F3: Tissue factor precursor 0.032 0.165
TNFSF15 TNFSF15, RP11-428F18.1-001, hCG_27396: TNF superfamily ligand TL1A 0.032 0.028
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.032 0.083
IL9R IL9R: Interleukin-9 receptor precursor 0.032 0.165
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.032 0.083
CASR CASR, GPRC2A, PCAR1: Extracellular calcium-sensing receptor precursor 0.032 0.028
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.032 0.049
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.049
PLSCR1 PLSCR1: Phospholipid scramblase 1 0.032 0.028
NCSTN NCSTN, KIAA0253, UNQ1874/PRO4317: Nicastrin precursor 0.032 0.028
SORL1 SORL1: Sortilin-related receptor precursor 0.032 0.165
RYR2 RYR2: Ryanodine receptor 2 0.031 0.034
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.029 0.165
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.029 0.165
NEO1 NEO1, NGN: Neogenin precursor 0.029 0.165
ATP4A ATP4A: Potassium-transporting ATPase alpha chain 1 0.029 0.028
EGF EGF: Pro-epidermal growth factor precursor 0.029 0.083
ADAMDEC1 ADAMDEC1: ADAM DEC1 precursor 0.029 0.028
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.029 0.052
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.029 0.028
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.029 0.083
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.029 0.165
BCDO2 PTS: 6-pyruvoyl tetrahydrobiopterin synthase 0.029 0.04
CHAF1B CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B 0.029 0.034
EML4 EML4, C2orf2, EMAPL4: Echinoderm microtubule-associated protein-like 4 0.029 0.04
HPCAL1 HPCAL1, BDR1: Hippocalcin-like protein 1 0.029 0.049
WWOX WWOX, FOR, WOX1: WW domain-containing oxidoreductase 0.029 0.04
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
S100A16 S100A16, AAG13: Protein S100-A16 0.028 0.049
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.028 0.049
PPEF1 N/A 0.028 0.049
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.028 0.049
PTGIR PTGIR, PRIPR: Prostacyclin receptor 0.027 0.028
SLC2A1 SLC2A1, GLUT1: Solute carrier family 2, facilitated glucose transporter member 1 0.027 0.028
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.027
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
ITGAE ITGAE: Integrin alpha-E precursor 0.027 0.083
LILRB1 N/A 0.027 0.083
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.027 0.083
LTB4R LTB4R, BLT, BLT1, BLTR, CMKRL1, GPR16, P2RY7: Leukotriene B4 receptor 1 0.027 0.028
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.027 0.083
CD69 CD69: Early activation antigen CD69 0.027 0.083
CD59 CD59, MIC11, MIN1, MIN2, MIN3, MSK21: CD59 glycoprotein precursor 0.0263 0.028
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.026 0.083
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.026 0.165
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.026 0.165
GRIA4 GRIA4, GLUR4: Glutamate receptor 4 precursor 0.026 0.028
MT3 MT3: Metallothionein-3 0.026 0.028
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.026 0.028
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.026 0.109
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.026 0.049
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.026 0.049
F5 F5: Coagulation factor V precursor 0.025 0.109
SMU1 SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog 0.025 0.034
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.025 0.049
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.025 0.049
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.025 0.049
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.04
CETN1 CETN1, CEN1, CETN: Centrin-1 0.025 0.034
ACTN4 ACTN4: Alpha-actinin-4 0.025 0.049
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.025 0.049
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.025 0.034
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.025 0.049
0.299
Total Score 5.87