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Evidence of Interaction Between SNRPG and WDR54

The interaction score between SNRPG and WDR54 is 3.18.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology N/A N/A
Domains Domains present in SNRPG and WDR54:
Domains in SNRPGDomains in WDR54
IPR001163 Small nuclear ribonucleoprotein (Sm protein)
IPR010920 Small nuclear-like ribonucleoprotein
IPR006649 snRNP domain
IPR001680 G-protein beta WD-40 repeat

The Chi square scores for co-occurrence of domains that are present in SNRPG and WDR54 are listed below.

Domain 1Domain 2Chi Square
IPR010920 Small nuclear-like ribonucleoprotein IPR001680 G-protein beta WD-40 repeat 22.3132
IPR006649 snRNP domain IPR001680 G-protein beta WD-40 repeat 19.3621
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR001680 G-protein beta WD-40 repeat 18.7041

The background colour of the table refers to:

  • Blue Domain is only present in SNRPG
  • Yellow Domain is only present in WDR54
  • Green Domain is present in both SNRPG and WDR54

 0.027
Post-translational Modifications

Protein: SNRPG

PTMResidueReference

Protein: WDR54

PTMResidueReference
Phosphotyrosine 33 HPRD
Localisation

Protein: SNRPG

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: WDR54

No localisation data was used in calculating likelihood of interaction
Transitive Score

The common interactors between SNRPG and WDR54 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SNRPG andWDR54. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SNRPG has 256 interactors and WDR54 has 863 interactors of which there are 61 common interactors.

Common InteractorName of Common InteractorScore for SNRPG-Interactor (?)Score for WDR54-Interactor (?)
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 2.07E3 0.165
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 2.07E3 0.165
LSM5 LSM5: U6 snRNA-associated Sm-like protein LSm5 691.00 0.056
LSM4 LSM4: U6 snRNA-associated Sm-like protein LSm4 691.00 0.027
SNRPD2 SNRPD2, SNRPD1: Small nuclear ribonucleoprotein Sm D2 691.00 0.027
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 32.60 0.052
SNRPE SNRPE: Small nuclear ribonucleoprotein E 8.73 0.027
SF3B3 N/A 3.89 0.027
SNRPB SNRPB, COD, SNRPB1: Small nuclear ribonucleoprotein-associated proteins B and B' 2.91 0.027
LSM7 LSM7: U6 snRNA-associated Sm-like protein LSm7 2.60 0.027
LSM8 LSM8: U6 snRNA-associated Sm-like protein LSm8 2.60 0.056
SNRPF SNRPF, PBSCF: Small nuclear ribonucleoprotein F 2.60 0.027
LSM3 LSM3, MDS017: U6 snRNA-associated Sm-like protein LSm3 2.60 0.056
LSM2 LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2 1.22 0.165
LSM6 LSM6: U6 snRNA-associated Sm-like protein LSm6 1.22 0.027
LSM1 LSM1, CASM: U6 snRNA-associated Sm-like protein LSm1 1.22 0.027
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.890 0.028
SNRP70 SNRP70, RNPU1Z, RPU1, U1AP1: U1 small nuclear ribonucleoprotein 70 kDa 0.657 0.028
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.354 0.028
DDX21 DDX21: Nucleolar RNA helicase 2 0.293 0.052
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.263 0.052
CDC20 CDC20: Cell division cycle protein 20 homolog 0.263 0.028
LSM10 LSM10: U7 snRNA-associated Sm-like protein LSm10 0.237 0.027
LSM11 LSM11: U7 snRNA-associated Sm-like protein LSm11 0.237 0.027
SNRPN HCERN3, SNRPN, SMN: Small nuclear ribonucleoprotein-associated protein N 0.158 0.027
GNB2L1 Lung cancer oncogene 7 0.137 0.028
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.137 0.052
CSTF1 CSTF1: Cleavage stimulation factor 50 kDa subunit 0.123 0.028
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 0.123 0.028
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.123 0.028
SND1 SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1 0.123 0.028
PAK1IP1 PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1 0.123 0.028
CHAF1B CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B 0.123 0.028
SMARCA4 SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4 0.083 0.052
BLM BLM, RECQ2, RECQL3: Bloom syndrome protein 0.074 0.052
WRN WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase 0.074 0.052
CORO1C CORO1C, CRNN4: Coronin-1C 0.074 0.028
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.074 0.052
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.074 0.052
COPA COPA: Coatomer subunit alpha 0.074 0.028
DDX41 DDX41, ABS: Probable ATP-dependent RNA helicase DDX41 0.074 0.052
WDR1 N/A 0.067 0.028
DHX16 DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN 0.060 0.052
WDHD1 WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1 0.060 0.028
REXO2 REXO2, SFN, CGI-114, SMFN: Oligoribonuclease, mitochondrial precursor 0.060 0.028
DDX5 DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5 0.044 0.052
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.044 0.028
SMARCA3 HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor 0.044 0.052
DICER1 DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer 0.044 0.052
ERCC3 ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit 0.044 0.052
SKIV2L SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti 0.044 0.052
ARPC1B ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B 0.044 0.028
GNB1 GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0.044 0.028
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.044 0.028
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.044 0.028
DDX3Y DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y 0.036 0.052
DDX24 DDX24: ATP-dependent RNA helicase DDX24 0.036 0.052
BCDO2 PTS: 6-pyruvoyl tetrahydrobiopterin synthase 0.036 0.028
NUP214 N/A 0.0308 0.028
BRIP1 BRIP1, BACH1, FANCJ: Fanconi anemia group J protein 0.028 0.052
TLE3 TLE3, KIAA1547: Transducin-like enhancer protein 3 0.027 0.028
0.299
Total Score 3.18