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Evidence of Interaction Between SNRPG and SNRPB

The interaction score between SNRPG and SNRPB is 2.52.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between SNRPG and SNRPB = 0.86

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology N/A N/A
Domains Domains present in SNRPG and SNRPB:
Domains in SNRPGDomains in SNRPB
IPR001163 Small nuclear ribonucleoprotein (Sm protein)
IPR010920 Small nuclear-like ribonucleoprotein
IPR006649 snRNP domain
IPR001163 Small nuclear ribonucleoprotein (Sm protein)
IPR006649 snRNP domain

The Chi square scores for co-occurrence of domains that are present in SNRPG and SNRPB are listed below.

Domain 1Domain 2Chi Square
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR006649 snRNP domain 1325.87
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR001163 Small nuclear ribonucleoprotein (Sm protein) 1297.61
IPR006649 snRNP domain IPR006649 snRNP domain 1206.57
IPR010920 Small nuclear-like ribonucleoprotein IPR006649 snRNP domain 1168.89
IPR010920 Small nuclear-like ribonucleoprotein IPR001163 Small nuclear ribonucleoprotein (Sm protein) 1143.95

The background colour of the table refers to:

  • Blue Domain is only present in SNRPG
  • Yellow Domain is only present in SNRPB
  • Green Domain is present in both SNRPG and SNRPB

 0.265
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: SNRPG

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: SNRPB

LocalisationReference
Nucleus HPRD
Transitive Score

The common interactors between SNRPG and SNRPB that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SNRPG andSNRPB. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SNRPG has 256 interactors and SNRPB has 268 interactors of which there are 198 common interactors.

Common InteractorName of Common InteractorScore for SNRPG-Interactor (?)Score for SNRPB-Interactor (?)
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 2.07E3 2.91
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 2.07E3 2.91
LSM5 LSM5: U6 snRNA-associated Sm-like protein LSm5 691.00 2.91
LSM4 LSM4: U6 snRNA-associated Sm-like protein LSm4 691.00 2.91
SNRPD2 SNRPD2, SNRPD1: Small nuclear ribonucleoprotein Sm D2 691.00 2.91
PRPF4 PRPF4, PRP4: U4/U6 small nuclear ribonucleoprotein Prp4 69.60 0.293
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 32.60 0.137
PRP19 PRPF19, NMP200, PRP19, SNEV: Pre-mRNA-processing factor 19 25.60 0.108
SNRPE SNRPE: Small nuclear ribonucleoprotein E 8.73 2.91
PLRG1 PLRG1: Pleiotropic regulator 1 6.33 0.027
LSM7 LSM7: U6 snRNA-associated Sm-like protein LSm7 2.60 2.91
LSM8 LSM8: U6 snRNA-associated Sm-like protein LSm8 2.60 2.91
SNRPF SNRPF, PBSCF: Small nuclear ribonucleoprotein F 2.60 2.91
LSM3 LSM3, MDS017: U6 snRNA-associated Sm-like protein LSm3 2.60 1.36
LSM2 LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2 1.22 2.91
LSM6 LSM6: U6 snRNA-associated Sm-like protein LSm6 1.22 2.91
LSM1 LSM1, CASM: U6 snRNA-associated Sm-like protein LSm1 1.22 0.824
NUP37 NUP37: Nucleoporin Nup37 0.789 0.293
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.293 0.293
DDX21 DDX21: Nucleolar RNA helicase 2 0.293 0.137
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.263 0.137
RBBP4 RBBP4, RBAP48: Histone-binding protein RBBP4 0.263 0.293
NUP43 N/A 0.263 0.137
CDC20 CDC20: Cell division cycle protein 20 homolog 0.263 0.137
EIF4A1 EIF4A1, DDX2A, EIF4A: Eukaryotic initiation factor 4A-I 0.263 0.293
DDX1 DDX1: ATP-dependent RNA helicase DDX1 0.263 0.083
BAT1 N/A 0.263 0.293
BOP1 BOP1, KIAA0124: Ribosome biogenesis protein BOP1 0.263 0.137
LSM10 LSM10: U7 snRNA-associated Sm-like protein LSm10 0.237 0.265
LSM11 LSM11: U7 snRNA-associated Sm-like protein LSm11 0.237 0.265
SNRPN HCERN3, SNRPN, SMN: Small nuclear ribonucleoprotein-associated protein N 0.158 0.157
GTF3C2 GTF3C2, KIAA0011: General transcription factor 3C polypeptide 2 0.137 0.293
WDR41 N/A 0.137 0.137
SEC13L1 SEC13, D3S1231E, SEC13L1, SEC13R: Protein SEC13 homolog 0.137 0.137
DDX50 DDX50: ATP-dependent RNA helicase DDX50 0.137 0.137
GNB2L1 Lung cancer oncogene 7 0.137 0.137
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.137 0.293
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.137 0.293
DDX47 E4-DBP: DEAD box protein 0.123 0.137
DDX39 DDX39: ATP-dependent RNA helicase DDX39 0.123 0.137
PPP2R2A PPP2R2A: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alp 0.123 0.137
CSTF1 CSTF1: Cleavage stimulation factor 50 kDa subunit 0.123 0.137
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.123 0.137
CDC40 CDC40, EHB3, PRP17, PRPF17: Pre-mRNA-processing factor 17 0.123 0.083
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 0.123 0.137
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.123 0.137
SND1 SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1 0.123 0.137
ASCC3 ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3 0.123 0.083
DDX19A DDX19A, DDX19L: ATP-dependent RNA helicase DDX19A 0.123 0.137
POLD1 POLD1, POLD: DNA polymerase delta catalytic subunit 0.123 0.293
TAF5 TAF5, TAF2D: Transcription initiation factor TFIID subunit 5 0.123 0.083
WDR77 WDR77, HKMT1069, hCG_39991: Androgen receptor cofactor p44 0.123 0.137
WDR12 WDR12: WD repeat-containing protein 12 0.123 0.083
DDX18 DDX18: ATP-dependent RNA helicase DDX18 0.123 0.137
WDR3 WDR3: WD repeat-containing protein 3 0.123 0.083
DDX49 DDX49: Probable ATP-dependent RNA helicase DDX49 0.123 0.137
RBBP7 RBBP7, RBAP46: Histone-binding protein RBBP7 0.123 0.137
WDR57 WDR57, PRP8BP, SFP38: WD repeat-containing protein 57 0.123 0.083
DDX23 DDX23: Probable ATP-dependent RNA helicase DDX23 0.123 0.137
CNOT7 CNOT7, CAF1: CCR4-NOT transcription complex subunit 7 0.123 0.137
STRAP STRAP, MAWD, UNRIP: Serine-threonine kinase receptor-associated protein 0.123 0.137
WDR68 WDR68, HAN11: WD repeat-containing protein 68 0.123 0.293
RAD54L RAD54L, RAD54A: DNA repair and recombination protein RAD54-like 0.123 0.137
WDR18 N/A 0.123 0.083
PAK1IP1 PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1 0.123 0.083
RNU3IP2 RRP9, RNU3IP2, U355K: U3 small nucleolar RNA-interacting protein 2 0.123 0.083
CHAF1B CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B 0.123 0.083
NUTF2 NUTF2, NTF2: Nuclear transport factor 2 0.0968 0.108
FBXW2 FBXW2, FBW2, FWD2: F-box/WD repeat-containing protein 2 0.083 0.137
SMARCAL1 SMARCAL1, HARP: SWI/SNF-related matrix-associated actin-dependent regulator of c 0.083 0.083
RAD54B RAD54B: DNA repair and recombination protein RAD54B 0.083 0.067
DDB2 DDB2: DNA damage-binding protein 2 0.083 0.083
SMARCA4 SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4 0.083 0.137
SERBP1 N/A 0.082 0.027
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.082 0.027
BLM BLM, RECQ2, RECQL3: Bloom syndrome protein 0.074 0.083
DDX10 DDX10: Probable ATP-dependent RNA helicase DDX10 0.074 0.083
WRN WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase 0.074 0.067
PWP2H PWP2, PWP2H: Periodic tryptophan protein 2 homolog 0.074 0.083
DDX27 DDX27, RHLP, HSPC259, PP3241: Probable ATP-dependent RNA helicase DDX27 0.074 0.137
KIAA0052 SKIV2L2, KIAA0052: Superkiller viralicidic activity 2-like 2 0.074 0.067
CORO1C CORO1C, CRNN4: Coronin-1C 0.074 0.067
RECQL RECQL, RECQL1: ATP-dependent DNA helicase Q1 0.074 0.083
FLJ10439 WDR74, NSA1: WD repeat-containing protein 74 0.074 0.137
SEC31L1 N/A 0.074 0.067
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.074 0.083
LRBA LRBA, BGL, CDC4L, LBA: Lipopolysaccharide-responsive and beige-like anchor prote 0.074 0.083
IFIH1 IFIH1, MDA5, RH116: Interferon-induced helicase C domain-containing protein 1 0.074 0.067
DDX54 DDX54: ATP-dependent RNA helicase DDX54 0.074 0.083
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.074 0.083
POLE POLE, POLE1: DNA polymerase epsilon catalytic subunit A 0.074 0.137
HELLS HELLS, PASG, Nbla10143, SMARCA6: Lymphoid-specific helicase 0.074 0.137
POLA POLA1, POLA: DNA polymerase alpha catalytic subunit 0.074 0.067
COPB2 COPB2: Coatomer subunit beta' 0.074 0.067
COPA COPA: Coatomer subunit alpha 0.074 0.067
TSSC1 TSSC1: Protein TSSC1 0.074 0.137
DDX41 DDX41, ABS: Probable ATP-dependent RNA helicase DDX41 0.074 0.137
DDX48 EIF4A3, DDX48, KIAA0111: Eukaryotic initiation factor 4A-III 0.074 0.137
CGI-55 SERBP1, PAIRBP1, CGI-55: Plasminogen activator inhibitor 1 RNA-binding protein 0.0739 0.027
PA2G4 PA2G4, EBP1: Proliferation-associated protein 2G4 0.0739 0.027
WDR1 N/A 0.067 0.083
WDR8 WDR8: WD repeat-containing protein 8 0.067 0.083
DHX16 DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN 0.060 0.083
DDX17 DDX17: Probable ATP-dependent RNA helicase DDX17 0.060 0.067
PIK3R4 PIK3R4: Phosphoinositide 3-kinase regulatory subunit 4 0.060 0.067
JMJD2C JMJD2C, GASC1, JHDM3C, KIAA0780: JmjC domain-containing histone demethylation pr 0.060 0.050
DDX28 DDX28, MDDX28: Probable ATP-dependent RNA helicase DDX28 0.060 0.083
WDHD1 WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1 0.060 0.050
CORO7 CORO7: Coronin-7 0.060 0.067
GRWD1 GRWD1, GRWD, WDR28: Glutamate-rich WD repeat-containing protein 1 0.060 0.067
DHX35 C20orf15, DHX35, DDX35: Probable ATP-dependent RNA helicase DHX35 0.060 0.067
REXO2 REXO2, SFN, CGI-114, SMFN: Oligoribonuclease, mitochondrial precursor 0.060 0.050
WDR39 CIAO1, WDR39: Protein CIAO1 0.060 0.083
AAMP AAMP: Angio-associated migratory cell protein 0.060 0.083
WDR26 WDR26, CDW2, PRO0852, MIP2: WD repeat-containing protein 26 0.060 0.050
AAAS AAAS, ADRACALA, GL003: Aladin 0.060 0.067
CNOT8 CNOT8, CALIF, POP2: CCR4-NOT transcription complex subunit 8 0.060 0.083
RECQL4 RECQL4, RECQ4: ATP-dependent DNA helicase Q4 0.060 0.050
DHX38 DHX38, DDX38, KIAA0224, PRP16: Pre-mRNA-splicing factor ATP-dependent RNA helica 0.060 0.083
XPMC2H REXO4, PMC2, XPMC2H: RNA exonuclease 4 0.060 0.083
Nle NLE1, HUSSY-07: Notchless protein homolog 1 0.060 0.067
TTF2 TTF2: Transcription termination factor 2 0.060 0.067
WIPI2 WIPI2, CGI-50: WD repeat domain phosphoinositide-interacting protein 2 0.060 0.050
EXOSC8 EXOSC8, OIP2, RRP43: Exosome complex exonuclease RRP43 0.057 0.027
EXOSC7 EXOSC7, KIAA0116, RRP42: Exosome complex exonuclease RRP42 0.051 0.027
ISG20 ISG20, HEM45: Interferon-stimulated gene 20 kDa protein 0.050 0.050
GNB1L GNB1L, GY2, FKSG1, KIAA1645, WDR14: Guanine nucleotide-binding protein subunit b 0.050 0.050
ARPC1A ARPC1A, SOP2L: Actin-related protein 2/3 complex subunit 1A 0.044 0.050
EML3 EML3: Echinoderm microtubule-associated protein-like 3 0.044 0.067
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.044 0.067
DDX5 DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5 0.044 0.067
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.044 0.050
SMARCA3 HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor 0.044 0.050
THRAP5 MED16, DRIP92, THRAP5: Mediator of RNA polymerase II transcription subunit 16 0.044 0.050
DICER1 DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer 0.044 0.050
ERCC3 ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit 0.044 0.050
NBEAL2 N/A 0.044 0.067
SKIV2L SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti 0.044 0.083
RAE1 RAE1, MRNP41: mRNA export factor 0.044 0.067
LGP2 DHX58, D11LGP2E, LGP2: Probable ATP-dependent RNA helicase DHX58 0.044 0.067
CORO1A CORO1A, CORO1: Coronin-1A 0.044 0.067
WDR67 WDR67: WD repeat-containing protein 67 0.044 0.050
ARPC1B ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B 0.044 0.067
PARN PARN, DAN: Poly(A)-specific ribonuclease PARN 0.044 0.050
GNB1 GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0.044 0.067
WDR13 WDR13: WD repeat-containing protein 13 0.041 0.041
REV3L REV3L, POLZ, REV3: DNA polymerase zeta catalytic subunit 0.041 0.041
PHF20 PHF20, C20orf104, GLEA2, HCA58, NZF, TZP: PHD finger protein 20 0.039 0.053
DDX56 DDX56, DDX21, NOH61: Probable ATP-dependent RNA helicase DDX56 0.036 0.050
DDX3Y DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y 0.036 0.050
WIPI1 WIPI1, WIPI49: WD repeat domain phosphoinositide-interacting protein 1 0.036 0.0308
DDX52 DDX52, ROK1, HUSSY-19: Probable ATP-dependent RNA helicase DDX52 0.036 0.041
WDR48 WDR48, KIAA1449: WD repeat-containing protein 48 0.036 0.041
WDR45L N/A 0.036 0.041
WDR42A N/A 0.036 0.041
SETDB1 SETDB1, KIAA0067: Histone-lysine N-methyltransferase SETDB1 0.036 0.050
DDX24 DDX24: ATP-dependent RNA helicase DDX24 0.036 0.041
BCDO2 PTS: 6-pyruvoyl tetrahydrobiopterin synthase 0.036 0.0308
LBR LBR: Lamin-B receptor 0.0331 0.037
RNASEH1 RNASEH1, RNH1: Ribonuclease H1 0.0331 0.061
POLG POLG, MDP1, POLG1, POLGA: DNA polymerase subunit gamma-1 0.0331 0.061
NUP214 N/A 0.0308 0.0308
KATNB1 KATNB1: Katanin p80 WD40-containing subunit B1 0.028 0.0308
WDR37 N/A 0.028 0.041
DDX58 DDX58: Probable ATP-dependent RNA helicase DDX58 0.028 0.0308
BRIP1 BRIP1, BACH1, FANCJ: Fanconi anemia group J protein 0.028 0.0308
PEX7 PEX7, PTS2R: Peroxisomal targeting signal 2 receptor 0.028 0.0308
TPRKB TPRKB, CGI-121, My019: TP53RK-binding protein 0.027 0.027
PSME3 PSME3: Proteasome activator complex subunit 3 0.027 0.027
ILF2 ILF2, NF45, PRO3063: Interleukin enhancer-binding factor 2 0.027 0.027
HNRPD N/A 0.027 0.027
C22orf18 N/A 0.027 0.027
NOLC1 NOLC1, KIAA0035: Nucleolar phosphoprotein p130 0.027 0.027
BUB3 N/A 0.027 0.027
XTP3TPA XTP3TPA, CDA03: XTP3-transactivated gene A protein 0.027 0.027
NEDD1 N/A 0.027 0.027
WDR34 N/A 0.027 0.027
WDR54 N/A 0.027 0.027
TREX1 TREX1: Three prime repair exonuclease 1 0.027 0.027
TLE3 TLE3, KIAA1547: Transducin-like enhancer protein 3 0.027 0.027
RFWD2 RFWD2, COP1, RNF200: E3 ubiquitin-protein ligase RFWD2 0.027 0.027
FLJ12671 ISG20L2, HSD38, HSD-38: Interferon-stimulated 20 kDa exonuclease-like 2 0.027 0.027
WDR72 N/A 0.027 0.027
ERCC8 ERCC8, CKN1, CSA: DNA excision repair protein ERCC-8 0.027 0.027
REXO1L1 REXO1L1, GOR: Exonuclease GOR 0.027 0.027
WDR17 N/A 0.027 0.027
PHF1 N/A 0.027 0.027
WSB1 WSB1, SWIP1: WD repeat and SOCS box-containing protein 1 0.027 0.027
TDRD4 TDRD4: Tudor domain-containing protein 4 0.027 0.027
FBXW8 FBXW8, FBW6, FBW8, FBX29, FBXO29, FBXW6: F-box/WD repeat-containing protein 8 0.027 0.027
KIF21A N/A 0.027 0.027
TLE6 TLE6: Transducin-like enhancer protein 6 0.027 0.027
BRWD1 N/A 0.027 0.027
SMARCAD1 SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator 0.027 0.027
WDR53 N/A 0.027 0.027
TAF5L TAF5L, PAF65B: TAF5-like RNA polymerase II p300/CBP-associated factor-associated 0.027 0.027
DDX53 DDX53, CAGE: Probable ATP-dependent RNA helicase DDX53 0.027 0.027
SNRPB N/A 0.0258 0.0288
2.15E-3
Total Score 2.52