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The Barton Group

Predicted interactions involving protein EGFR, ERBB1: Epidermal growth factor receptor precursor (IPI00018274) that score above 1.0

Click on the protein name for more information about the protein.

The Score column is the predicted score of interaction between the two proteins

Click on the Evidence link to view a breakdown of the information about the predicted interaction.

Key
Module ScoreDatabases
Where interaction is observed in another database a link is provided:

Protein 1 (?)Protein 2 (?) Name of Protein 2 Module Scores (?) Scores (?) Evidence (?) Database (?)
EGFR ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 9.88E3 Evidence
EGFR SHC3 SHC3, NSHC, SHCC: SHC-transforming protein 3 8.52E3 Evidence
EGFR ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 4.98E3 Evidence
EGFR STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 200.0 Evidence
EGFR FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 200.0 Evidence
EGFR TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 200.0 Evidence
EGFR GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 200.0 Evidence
EGFR NCK2 NCK2: Cytoplasmic protein NCK2 200.0 Evidence
EGFR JAK2 JAK2: Tyrosine-protein kinase JAK2 200.0 Evidence
EGFR KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 125.0 Evidence
EGFR CRKL CRKL: Crk-like protein 121.0 Evidence
EGFR ZAP70 ZAP70: Uncharacterized protein ZAP70 121.0 Evidence
EGFR PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 121.0 Evidence
EGFR NCK1 NCK1, NCK: Cytoplasmic protein NCK1 121.0 Evidence
EGFR SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 117.0 Evidence
EGFR PTK6 PTK6, BRK: Tyrosine-protein kinase 6 117.0 Evidence
EGFR STAT3 117.0 Evidence
EGFR STAT5B STAT5B: Signal transducer and activator of transcription 5B 110.0 Evidence
EGFR STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 110.0 Evidence
EGFR LYN LYN: Tyrosine-protein kinase Lyn 89.20 Evidence
EGFR BMX N/A 89.20 Evidence
EGFR BLNK BLNK, BASH, SLP65: B-cell linker protein 89.20 Evidence
EGFR INSL3 JAK3: Tyrosine-protein kinase JAK3 89.20 Evidence
EGFR ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 89.20 Evidence
EGFR LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 89.20 Evidence
EGFR SYK SYK: Tyrosine-protein kinase SYK 79.90 Evidence
EGFR RASA1 RASA1, RASA: Ras GTPase-activating protein 1 79.90 Evidence
EGFR TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 79.90 Evidence
EGFR HCK N/A 79.90 Evidence
EGFR JAK1 79.90 Evidence
EGFR CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 67.1 Evidence
EGFR LCP2 LCP2: Lymphocyte cytosolic protein 2 64.40 Evidence
EGFR CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 44.00 Evidence
EGFR PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 40.60 Evidence
EGFR INSR INSR: Insulin receptor precursor 33.90 Evidence
EGFR PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 33.90 Evidence
EGFR KIT KIT: Mast/stem cell growth factor receptor precursor 33.90 Evidence
EGFR PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 33.90 Evidence
EGFR GRB7 GRB7: Growth factor receptor-bound protein 7 30.10 Evidence
EGFR GRAP GRAP: GRB2-related adapter protein 23.20 Evidence
EGFR PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 20.50 Evidence
EGFR KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 20.50 Evidence
EGFR CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 20.50 Evidence
EGFR AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 19.70 Evidence
EGFR HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 19.70 Evidence
EGFR IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 19.70 Evidence
EGFR ITGB4 N/A 19.70 Evidence
EGFR EGF EGF: Pro-epidermal growth factor precursor 19.70 Evidence
EGFR ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 19.70 Evidence
EGFR TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 19.70 Evidence
EGFR BTC BTC: Probetacellulin precursor [Contains: Betacellulin 19.70 Evidence
EGFR IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 17.60 Evidence
EGFR ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 17.60 Evidence
EGFR JAG2 JAG2: Jagged-2 precursor 17.60 Evidence
EGFR GHR GHR: Growth hormone receptor precursor 15.00 Evidence
EGFR EPOR EPOR: Erythropoietin receptor precursor 15.00 Evidence
EGFR STAM2 STAM2: Signal transducing adapter molecule 2 13.50 Evidence
EGFR IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 13.50 Evidence
EGFR SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 13.50 Evidence
EGFR MT2A MT2A, CES1, MT2: Metallothionein-2 13.00 Evidence
EGFR NF2 NF2, SCH: Merlin 13.00 Evidence
EGFR IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 13.00 Evidence
EGFR VASP VASP: Vasodilator-stimulated phosphoprotein 13.00 Evidence
EGFR HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 11.60 Evidence
EGFR DOK1 DOK1: Docking protein 1 11.60 Evidence
EGFR CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 11.60 Evidence
EGFR WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 11.60 Evidence
EGFR PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 11.60 Evidence
EGFR BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 11.60 Evidence
EGFR COL5A1 N/A 11.40 Evidence
EGFR SHC2 N/A 10.70 Evidence
EGFR RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 10.30 Evidence
EGFR ATP2A3 ATP2A3: Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 9.96 Evidence
EGFR EFNA1 EFNA1, EPLG1, LERK1, TNFAIP4: Ephrin-A1 precursor 9.06 Evidence
EGFR CD82 CD82, KAI1, SAR2, ST6, TSPAN27: CD82 antigen 8.92 Evidence
EGFR PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 8.92 Evidence
EGFR GNAT1 GNAT1, GNATR: Guanine nucleotide-binding protein G(t), alpha-1 subunit 8.92 Evidence
EGFR WASL WASL: Neural Wiskott-Aldrich syndrome protein 8.89 Evidence
EGFR STAM STAM, STAM1: Signal transducing adapter molecule 1 8.89 Evidence
EGFR SOS1 SOS1: Son of sevenless homolog 1 8.55 Evidence
EGFR MET MET: Hepatocyte growth factor receptor precursor 7.59 Evidence
EGFR ANXA2 ANXA2, ANX2, ANX2L4, CAL1H, LPC2D: Annexin A2 6.24 Evidence
EGFR YLPM1 N/A 6.14 Evidence
EGFR TESK1 TESK1: Dual specificity testis-specific protein kinase 1 5.87 Evidence
EGFR CSH2 GH1: Somatotropin precursor 5.87 Evidence
EGFR GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 5.59 Evidence
EGFR GRIN1 GRIN1, NMDAR1: Glutamate [NMDA] receptor subunit zeta-1 precursor 5.59 Evidence
EGFR CAV1 CAV1, CAV: Caveolin-1 5.50 Evidence
EGFR THOP1 THOP1: Thimet oligopeptidase 5.26 Evidence
EGFR HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 5.26 Evidence
EGFR HSP90AA1 Hsp89-alpha-delta-N 5.26 Evidence
EGFR KLK6 KLK6, PRSS18, PRSS9: Kallikrein-6 precursor 5.26 Evidence
EGFR JUP JUP, CTNNG, DP3: Junction plakoglobin 5.26 Evidence
EGFR WASPIP N/A 5.26 Evidence
EGFR ALK ALK: ALK tyrosine kinase receptor precursor 5.26 Evidence
EGFR DPP8 DPP8, DPRP1, MSTP097, MSTP135, MSTP141: Dipeptidyl peptidase 8 5.26 Evidence
EGFR IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 4.78 Evidence
EGFR SERPINA6 SERPINA6, CBG: Corticosteroid-binding globulin precursor 4.78 Evidence
EGFR SERPINA3 N/A 4.78 Evidence
EGFR ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 4.28 Evidence
EGFR ESR1 ESR1, ESR, NR3A1: Estrogen receptor 4.03 Evidence
EGFR PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 4.01 Evidence
EGFR PRKCI PRKCI, DXS1179E: Protein kinase C iota type 4.01 Evidence
EGFR PRKCG PRKCG, PKCG: Protein kinase C gamma type 4.01 Evidence
EGFR HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 3.61 Evidence
EGFR ASGR2 ASGR2: Asialoglycoprotein receptor 2 3.34 Evidence
EGFR TRPV2 TRPV2: Uncharacterized protein TRPV2 3.18 Evidence
EGFR SIGLEC6 N/A 3.18 Evidence
EGFR IL31RA IL31RA, CRL3, UNQ6368/PRO21073/PRO21384, GPL: Interleukin-31 receptor A precurso 3.18 Evidence
EGFR TSPAN9 TSPAN9, NET5: Tetraspanin-9 3.05 Evidence
EGFR CD37 CD37, TSPAN26: Leukocyte antigen CD37 3.05 Evidence
EGFR STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 2.99 Evidence
EGFR DLG1 N/A 2.99 Evidence
EGFR CELSR1 CELSR1, CDHF9, FMI2: Cadherin EGF LAG seven-pass G-type receptor 1 precursor 2.85 Evidence
EGFR EFNA2 EFNA2, EPLG6, LERK6: Ephrin-A2 precursor 2.60 Evidence
EGFR GNA12 GNA12: Guanine nucleotide-binding protein alpha-12 subunit 2.28 Evidence
EGFR RAB40B RAB40B, SEC4L: Ras-related protein Rab-40B 2.24 Evidence
EGFR HYAL2 HYAL2, LUCA2: Hyaluronidase-2 precursor 2.24 Evidence
EGFR EFNA3 EFNA3, EFL2, EPLG3, LERK3: Ephrin-A3 precursor 1.91 Evidence
EGFR EFNA5 EFNA5, EPLG7, LERK7: Ephrin-A5 precursor 1.91 Evidence
EGFR ITPKA ITPKA: Inositol-trisphosphate 3-kinase A 1.79 Evidence
EGFR ACTG1 ACTB: Actin, cytoplasmic 1 1.78 Evidence
EGFR GRIN2A GRIN2A, NMDAR2A: Glutamate [NMDA] receptor subunit epsilon-1 precursor 1.67 Evidence
EGFR YWHAB YWHAB: 14-3-3 protein beta/alpha 1.53 Evidence
EGFR MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 1.53 Evidence
EGFR CAMKK1 N/A 1.53 Evidence
EGFR SERPINF2 SERPINF2, AAP, PLI: Alpha-2-antiplasmin precursor 1.32 Evidence
EGFR GSK3A GSK3A: Glycogen synthase kinase-3 alpha 1.16 Evidence