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The Barton Group

Predicted interactions involving protein BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK (IPI00029132) that score above 1.0

Click on the protein name for more information about the protein.

The Score column is the predicted score of interaction between the two proteins

Click on the Evidence link to view a breakdown of the information about the predicted interaction.

Key
Module ScoreDatabases
Where interaction is observed in another database a link is provided:

Protein 1 (?)Protein 2 (?) Name of Protein 2 Module Scores (?) Scores (?) Evidence (?) Database (?)
BTK JAK2 JAK2: Tyrosine-protein kinase JAK2 835.0 Evidence
BTK TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 720.0 Evidence
BTK SYK SYK: Tyrosine-protein kinase SYK 720.0 Evidence
BTK CRKL CRKL: Crk-like protein 674.0 Evidence
BTK LYN LYN: Tyrosine-protein kinase Lyn 613.0 Evidence
BTK FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 565.0 Evidence
BTK CSK CSK: Tyrosine-protein kinase CSK 549.0 Evidence
BTK STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 497.0 Evidence
BTK HCK N/A 392.0 Evidence O
BTK BLNK BLNK, BASH, SLP65: B-cell linker protein 370.0 Evidence
BTK VAV1 VAV1, VAV: Proto-oncogene vav 332.0 Evidence O
BTK STAT5B STAT5B: Signal transducer and activator of transcription 5B 305.0 Evidence
BTK SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 299.0 Evidence
BTK FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 299.0 Evidence
BTK NCK1 NCK1, NCK: Cytoplasmic protein NCK1 259.0 Evidence
BTK KIT KIT: Mast/stem cell growth factor receptor precursor 206.0 Evidence
BTK APS SH2B2, APS: SH2B adapter protein 2 198.0 Evidence
BTK SLA SLA, SLAP, SLAP1: SRC-like-adapter 181.0 Evidence
BTK SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 181.0 Evidence
BTK LCP2 LCP2: Lymphocyte cytosolic protein 2 177.0 Evidence
BTK JAK1 162.0 Evidence O
BTK STAT3 156.0 Evidence
BTK PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 149.0 Evidence
BTK GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 139.0 Evidence O
BTK STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 135.0 Evidence
BTK CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 135.0 Evidence
BTK ZAP70 ZAP70: Uncharacterized protein ZAP70 121.0 Evidence
BTK PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 119.0 Evidence
BTK ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 119.0 Evidence
BTK ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 109.0 Evidence
BTK PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 106.0 Evidence
BTK ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 106.0 Evidence
BTK RASA1 RASA1, RASA: Ras GTPase-activating protein 1 106.0 Evidence
BTK TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 98.20 Evidence
BTK WASPIP N/A 95.20 Evidence
BTK CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 92.20 Evidence
BTK PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 90.70 Evidence
BTK LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 88.80 Evidence
BTK KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 87.80 Evidence
BTK INSR INSR: Insulin receptor precursor 80.00 Evidence
BTK KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 80.00 Evidence
BTK INSL3 JAK3: Tyrosine-protein kinase JAK3 78.20 Evidence
BTK PTK6 PTK6, BRK: Tyrosine-protein kinase 6 78.20 Evidence
BTK BMX N/A 78.20 Evidence
BTK CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 78.20 Evidence O
BTK MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 77.50 Evidence
BTK PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 70.10 Evidence
BTK HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 69.40 Evidence
BTK TEK TEK, TIE2: Angiopoietin-1 receptor precursor 59.50 Evidence
BTK WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 55.10 Evidence O
BTK CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 52.80 Evidence
BTK EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 47.30 Evidence
BTK CDK7 CDK7, MO15: Cell division protein kinase 7 38.10 Evidence
BTK PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 37.80 Evidence
BTK GRAP GRAP: GRB2-related adapter protein 36.40 Evidence
BTK NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 35.00 Evidence
BTK DOK1 DOK1: Docking protein 1 33.90 Evidence
BTK SOCS1 SOCS1, SSI1, TIP3: Suppressor of cytokine signaling 1 32.80 Evidence
BTK CDK2 CDK2: Cell division protein kinase 2 25.00 Evidence
BTK CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 24.90 Evidence
BTK TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 24.90 Evidence
BTK CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 24.90 Evidence
BTK BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 24.10 Evidence
BTK ACTG1 ACTB: Actin, cytoplasmic 1 21.20 Evidence
BTK NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 20.50 Evidence
BTK PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 19.10 Evidence
BTK IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 18.40 Evidence
BTK CXCR4 CXCR4: C-X-C chemokine receptor type 4 18.40 Evidence
BTK CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 18.40 Evidence
BTK SOCS5 SOCS5, CIS6, CISH5, CISH6, KIAA0671: Suppressor of cytokine signaling 5 15.80 Evidence
BTK SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 15.00 Evidence
BTK CDC2 CDC2: Cell division control protein 2 homolog 15.00 Evidence
BTK DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 15.00 Evidence
BTK SNCA SNCA, NACP, PARK1: Alpha-synuclein 15.00 Evidence
BTK PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 13.80 Evidence
BTK PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 13.50 Evidence
BTK SOS1 SOS1: Son of sevenless homolog 1 13.50 Evidence
BTK NEDD9 NEDD9, CASL: Enhancer of filamentation 1 13.40 Evidence
BTK MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 13.2 Evidence
BTK AMHR2 AMHR2, AMHR: Anti-Muellerian hormone type-2 receptor precursor 13.00 Evidence
BTK SCAP2 SKAP2, PRAP, RA70, SAPS, SCAP2, SKAP55R: Src kinase-associated phosphoprotein 2 12.50 Evidence
BTK EPOR EPOR: Erythropoietin receptor precursor 11.90 Evidence
BTK PECAM1 PECAM1: Platelet endothelial cell adhesion molecule precursor 11.70 Evidence
BTK QARS QARS: Glutaminyl-tRNA synthetase 11.70 Evidence
BTK HNRPK N/A 11.70 Evidence
BTK ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 11.40 Evidence
BTK PRKAA1 N/A 11.20 Evidence
BTK IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 9.92 Evidence
BTK TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 9.92 Evidence
BTK CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 9.92 Evidence
BTK ADAM15 ADAM15, MDC15: ADAM 15 precursor 9.92 Evidence
BTK PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 9.92 Evidence
BTK FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 9.92 Evidence
BTK LAT LAT: Linker for activation of T-cells family member 1 9.92 Evidence
BTK MYL9 MYL9, MLC2, MRLC1, MYRL2: Myosin regulatory light chain 2, smooth muscle isoform 9.0 Evidence
BTK PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 9.0 Evidence
BTK PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 9.0 Evidence O
BTK TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 8.89 Evidence
BTK PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 8.86 Evidence
BTK CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 8.86 Evidence
BTK ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 8.84 Evidence
BTK GNA15 GNA15, GNA16: Guanine nucleotide-binding protein alpha-15 subunit 8.31 Evidence
BTK PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 7.99 Evidence
BTK CTTN CTTN, EMS1: Src substrate cortactin 7.97 Evidence
BTK VAV2 VAV2, RP11-153P4.1-003: Vav 2 oncogene 7.93 Evidence
BTK UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 7.93 Evidence
BTK DAPP1 N/A 7.93 Evidence
BTK EIF4EBP1 EIF4EBP1: Eukaryotic translation initiation factor 4E-binding protein 1 7.79 Evidence
BTK HNRPK HNRPK, HNRNPK: Heterogeneous nuclear ribonucleoprotein K 7.59 Evidence
BTK CASP9 CASP9, MCH6: Caspase-9 precursor 7.59 Evidence
BTK IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 7.40 Evidence
BTK STAG2 STAG2, SA2: Cohesin subunit SA-2 7.10 Evidence
BTK CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 6.81 Evidence
BTK GIT2 N/A 6.80 Evidence
BTK IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 6.52 Evidence
BTK CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 6.52 Evidence
BTK GNA12 GNA12: Guanine nucleotide-binding protein alpha-12 subunit 6.1 Evidence
BTK ARPC1B ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B 6.01 Evidence
BTK ITGB4 N/A 5.88 Evidence
BTK DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 5.88 Evidence
BTK MIP MIP, AQP0: Lens fiber major intrinsic protein 5.84 Evidence
BTK PPP1R12A PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A 5.74 Evidence
BTK HSPD1 5.74 Evidence
BTK STAT6 STAT6: Signal transducer and activator of transcription 6 5.22 Evidence
BTK FCER1G FCER1G: High affinity immunoglobulin epsilon receptor subunit gamma precursor 4.80 Evidence
BTK IFNAR2 N/A 4.80 Evidence
BTK HLA-F HLA-F, HLA-5.4, HLAF: HLA class I histocompatibility antigen, alpha chain F prec 4.80 Evidence
BTK DNM2 N/A 4.73 Evidence
BTK IGHE IGHE: Ig epsilon chain C region 4.68 Evidence
BTK CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 4.68 Evidence
BTK PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 4.48 Evidence
BTK TNKS2 TNKS2, PARP5B, TANK2, TNKL: Tankyrase-2 4.30 Evidence
BTK BCAR1 BCAR1, CAS, CRKAS: Breast cancer anti-estrogen resistance protein 1 4.19 Evidence
BTK CD19 N/A 4.06 Evidence
BTK MTMR1 MTMR1: Myotubularin-related protein 1 4.04 Evidence
BTK PRKX PRKX, PKX1: Serine/threonine-protein kinase PRKX 4.04 Evidence
BTK GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 4.01 Evidence
BTK STOM STOM, BND7, EPB72: Erythrocyte band 7 integral membrane protein 4.01 Evidence
BTK PPP1R8 N/A 3.64 Evidence
BTK GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 3.64 Evidence
BTK FCGR1A FCGR1A, FCG1, FCGR1, IGFR1: High affinity immunoglobulin gamma Fc receptor I pre 3.54 Evidence
BTK CASP3 CASP3, CPP32: Caspase-3 precursor 3.47 Evidence
BTK LYPD3 LYPD3, C4.4A, UNQ491/PRO1007: Ly6/PLAUR domain-containing protein 3 precursor 2.94 Evidence
BTK SLC9A3R1 SLC9A3R1, NHERF: Ezrin-radixin-moesin-binding phosphoprotein 50 2.94 Evidence
BTK ZYX ZYX: Zyxin 2.94 Evidence
BTK DHX16 DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN 2.93 Evidence
BTK BFAR BFAR, BAR, RNF47: Bifunctional apoptosis regulator 2.90 Evidence
BTK AQP2 AQP2: Aquaporin-2 2.80 Evidence
BTK CTLA4 CTLA4, CD152: Cytotoxic T-lymphocyte protein 4 precursor 2.77 Evidence
BTK AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 2.65 Evidence
BTK KCNJ12 KCNJ12, IRK2, KCNJN1: ATP-sensitive inward rectifier potassium channel 12 2.63 Evidence
BTK TSHR N/A 2.63 Evidence
BTK TXN TXN, TRDX, TRX, TRX1: Thioredoxin 2.63 Evidence
BTK MATK 2.54 Evidence
BTK NASP NASP: Nuclear autoantigenic sperm protein 2.54 Evidence
BTK FIGF FIGF, VEGFD: Vascular endothelial growth factor D precursor 2.48 Evidence
BTK SLC4A1 SLC4A1, AE1, DI, EPB3: Band 3 anion transport protein 2.43 Evidence
BTK ASB6 ASB6: Ankyrin repeat and SOCS box protein 6 2.43 Evidence
BTK DOK6 DOK6: Uncharacterized protein DOK6 2.43 Evidence
BTK CAPN12 CAPN12: Calpain-12 2.43 Evidence
BTK FCGR2A FCGR2A: Fc of IgG, low affinity IIa, receptor 2.42 Evidence
BTK HES1 HES1, HL, HRY: Transcription factor HES-1 2.37 Evidence
BTK SHC2 N/A 2.35 Evidence
BTK IREB2 IREB2: Iron-responsive element-binding protein 2 2.34 Evidence
BTK DBNL N/A 2.28 Evidence
BTK PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 2.28 Evidence
BTK MYO18A 2.28 Evidence
BTK BCR N/A 2.28 Evidence
BTK CASP7 N/A 2.28 Evidence
BTK DOK3 N/A 2.17 Evidence
BTK URP2 URP2, KIND3, MIG2B: Unc-112-related protein 2 2.17 Evidence
BTK ZNF217 ZNF217, ZABC1: Zinc finger protein 217 1.98 Evidence
BTK NOS2A NOS2A, NOS2: Nitric oxide synthase, inducible 1.87 Evidence
BTK EVL N/A 1.70 Evidence
BTK STAT2 STAT2: Signal transducer and activator of transcription 2 1.57 Evidence
BTK CD48 CD48, BCM1, BLAST1: CD48 antigen precursor 1.41 Evidence
BTK DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 1.41 Evidence
BTK C1QBP C1QBP, GC1QBP, HABP1, SF2P32: Complement component 1 Q subcomponent-binding prot 1.36 Evidence
BTK SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 1.30 Evidence
BTK FLT3 FLT3, STK1: FL cytokine receptor precursor 1.29 Evidence
BTK NCK2 NCK2: Cytoplasmic protein NCK2 1.17 Evidence
BTK RNF20 1.16 Evidence
BTK LNK SH2B3, LNK: SH2B adapter protein 3 1.13 Evidence
BTK SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 1.13 Evidence
BTK MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 1.13 Evidence
BTK TESK1 TESK1: Dual specificity testis-specific protein kinase 1 1.04 Evidence
BTK RIN1 RIN1: Ras and Rab interactor 1 1.04 Evidence