Click on the protein name for more information about the protein.
The Score column is the predicted score of interaction between the two proteins
Click on the Evidence link to view a breakdown of the information about the predicted interaction.
Key | |
---|---|
Module Score | Databases |
![]() | Where interaction is observed in another database a link is provided: |
Protein 1 (?) | Protein 2 (?) | Name of Protein 2 | Module Scores (?) | Scores (?) | Evidence (?) | Database (?) | |||
---|---|---|---|---|---|---|---|---|---|
![]() | ![]() | ![]() | ![]() | ||||||
TYK2 | JAK2 | JAK2: Tyrosine-protein kinase JAK2 | 1.38E3 | Evidence | |||||
TYK2 | CSK | CSK: Tyrosine-protein kinase CSK | 1.17E3 | Evidence | |||||
TYK2 | STAT6 | STAT6: Signal transducer and activator of transcription 6 | 1.17E3 | Evidence | |||||
TYK2 | STAT5A | STAT5A, STAT5: Signal transducer and activator of transcription 5A | 835.0 | Evidence | |||||
TYK2 | BTK | BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK | 720.0 | Evidence | |||||
TYK2 | SYK | SYK: Tyrosine-protein kinase SYK | 720.0 | Evidence | |||||
TYK2 | STAT5B | STAT5B: Signal transducer and activator of transcription 5B | 626.0 | Evidence | |||||
TYK2 | FGR | FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR | 613.0 | Evidence | |||||
TYK2 | SH3BP2 | SH3BP2: Uncharacterized protein SH3BP2 | 613.0 | Evidence | |||||
TYK2 | LYN | LYN: Tyrosine-protein kinase Lyn | 613.0 | Evidence |
![]() |
||||
TYK2 | NCK1 | NCK1, NCK: Cytoplasmic protein NCK1 | 506.0 | Evidence | |||||
TYK2 | ZAP70 | ZAP70: Uncharacterized protein ZAP70 | 497.0 | Evidence | |||||
TYK2 | DOCK2 | DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 | 445.0 | Evidence | |||||
TYK2 | CSF1R | CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor | 416.0 | Evidence | |||||
TYK2 | NCK2 | NCK2: Cytoplasmic protein NCK2 | 407.0 | Evidence | |||||
TYK2 | BLNK | BLNK, BASH, SLP65: B-cell linker protein | 392.0 | Evidence | |||||
TYK2 | SLA | SLA, SLAP, SLAP1: SRC-like-adapter | 370.0 | Evidence | |||||
TYK2 | HCK | N/A | 370.0 | Evidence | |||||
TYK2 | LCP2 | LCP2: Lymphocyte cytosolic protein 2 | 364.0 | Evidence | |||||
TYK2 | FYN | FYN: Proto-oncogene tyrosine-protein kinase Fyn | 299.0 | Evidence |
![]() |
||||
TYK2 | CRKL | CRKL: Crk-like protein | 268.0 | Evidence |
![]() |
||||
TYK2 | JAK1 | 268.0 | Evidence |
![]() |
|||||
TYK2 | CBLB | CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B | 263.0 | Evidence | |||||
TYK2 | LCK | LCK: Proto-oncogene tyrosine-protein kinase LCK | 221.0 | Evidence | |||||
TYK2 | KIT | KIT: Mast/stem cell growth factor receptor precursor | 206.0 | Evidence | |||||
TYK2 | WAS | WAS, IMD2: Wiskott-Aldrich syndrome protein | 194.0 | Evidence | |||||
TYK2 | PIK3R2 | PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta | 178.0 | Evidence | |||||
TYK2 | STAT2 | STAT2: Signal transducer and activator of transcription 2 | 165.0 | Evidence |
![]() |
||||
TYK2 | GRB2 | GRB2, ASH: Growth factor receptor-bound protein 2 | 162.0 | Evidence | |||||
TYK2 | APS | SH2B2, APS: SH2B adapter protein 2 | 161.0 | Evidence | |||||
TYK2 | PDGFRA | PDGFRA: Alpha-type platelet-derived growth factor receptor precursor | 149.0 | Evidence | |||||
TYK2 | PDGFRB | PDGFRB: Beta-type platelet-derived growth factor receptor precursor | 149.0 | Evidence |
![]() |
||||
TYK2 | HCLS1 | HCLS1, HS1: Hematopoietic lineage cell-specific protein | 148.0 | Evidence | |||||
TYK2 | PTK2B | PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta | 139.0 | Evidence | |||||
TYK2 | SOCS3 | SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 | 137.0 | Evidence | |||||
TYK2 | ABL1 | ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 | 137.0 | Evidence | |||||
TYK2 | STAT1 | STAT1: Signal transducer and activator of transcription 1-alpha/beta | 135.0 | Evidence |
![]() |
||||
TYK2 | FLT1 | FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor | 134.0 | Evidence | |||||
TYK2 | TEC | TEC, PSCTK4: Tyrosine-protein kinase Tec | 121.0 | Evidence | |||||
TYK2 | PTPN6 | PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 | 119.0 | Evidence |
![]() |
||||
TYK2 | STAT3 | 119.0 | Evidence | ||||||
TYK2 | RASA1 | RASA1, RASA: Ras GTPase-activating protein 1 | 106.0 | Evidence | |||||
TYK2 | WASPIP | N/A | 101.0 | Evidence | |||||
TYK2 | DOK1 | DOK1: Docking protein 1 | 91.10 | Evidence | |||||
TYK2 | CBL | CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL | 90.80 | Evidence |
![]() ![]() |
||||
TYK2 | KHDRBS1 | KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate | 87.80 | Evidence | |||||
TYK2 | INSR | INSR: Insulin receptor precursor | 80.00 | Evidence | |||||
TYK2 | KDR | KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor | 80.00 | Evidence | |||||
TYK2 | EGFR | EGFR, ERBB1: Epidermal growth factor receptor precursor | 79.90 | Evidence | |||||
TYK2 | INSL3 | JAK3: Tyrosine-protein kinase JAK3 | 79.40 | Evidence | |||||
TYK2 | SNX17 | SNX17, KIAA0064: Sorting nexin-17 | 69.40 | Evidence | |||||
TYK2 | RAF1 | RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase | 69.40 | Evidence | |||||
TYK2 | TEK | TEK, TIE2: Angiopoietin-1 receptor precursor | 59.50 | Evidence | |||||
TYK2 | CBLC | CBLC, CBL3, RNF57: Signal transduction protein CBL-C | 58.60 | Evidence | |||||
TYK2 | GRAP | GRAP: GRB2-related adapter protein | 55.80 | Evidence | |||||
TYK2 | EPHB3 | EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor | 53.30 | Evidence | |||||
TYK2 | PSMA5 | PSMA5: Proteasome subunit alpha type-5 | 53.3 | Evidence | |||||
TYK2 | PSMA3 | PSMA3, PSC8: Proteasome subunit alpha type-3 | 53.3 | Evidence | |||||
TYK2 | IGF1R | IGF1R: Insulin-like growth factor 1 receptor precursor | 52.50 | Evidence | |||||
TYK2 | PIK3CG | PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i | 46.90 | Evidence | |||||
TYK2 | MAP4K1 | MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 | 46.90 | Evidence | |||||
TYK2 | PSMA2 | PSMA2, PSC3: Proteasome subunit alpha type-2 | 43.00 | Evidence | |||||
TYK2 | MAPK1 | MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 | 42.00 | Evidence | |||||
TYK2 | HGS | HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate | 36.30 | Evidence | |||||
TYK2 | NMT1 | NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 | 35.00 | Evidence | |||||
TYK2 | ACTG1 | ACTB: Actin, cytoplasmic 1 | 35.00 | Evidence | |||||
TYK2 | NRBP1 | NRBP1, BCON3, NRBP: Nuclear receptor-binding protein | 33.90 | Evidence | |||||
TYK2 | HNRPK | N/A | 32.90 | Evidence | |||||
TYK2 | CXCR4 | CXCR4: C-X-C chemokine receptor type 4 | 32.70 | Evidence | |||||
TYK2 | TGFB1 | TGFB1, TGFB: Transforming growth factor beta-1 precursor | 28.90 | Evidence | |||||
TYK2 | MAP3K8 | MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 | 27.90 | Evidence | |||||
TYK2 | SCAP2 | SKAP2, PRAP, RA70, SAPS, SCAP2, SKAP55R: Src kinase-associated phosphoprotein 2 | 26.70 | Evidence | |||||
TYK2 | ARHGDIB | ARHGDIB, GDIA2, GDID4, RAP1GN1: Rho GDP-dissociation inhibitor 2 | 25.00 | Evidence | |||||
TYK2 | QARS | QARS: Glutaminyl-tRNA synthetase | 25.00 | Evidence | |||||
TYK2 | CSF2RB | CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor | 24.90 | Evidence | |||||
TYK2 | TUBA1 | TUBA4A, TUBA1: Tubulin alpha-4A chain | 24.90 | Evidence | |||||
TYK2 | SOCS1 | SOCS1, SSI1, TIP3: Suppressor of cytokine signaling 1 | 24.90 | Evidence | |||||
TYK2 | GAK | GAK: Cyclin G-associated kinase | 24.60 | Evidence | |||||
TYK2 | ITGAE | ITGAE: Integrin alpha-E precursor | 23.00 | Evidence | |||||
TYK2 | PASK | PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase | 22.80 | Evidence | |||||
TYK2 | HLA-F | HLA-F, HLA-5.4, HLAF: HLA class I histocompatibility antigen, alpha chain F prec | 21.00 | Evidence | |||||
TYK2 | CDK2 | CDK2: Cell division protein kinase 2 | 20.50 | Evidence | |||||
TYK2 | PRKDC | PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit | 19.10 | Evidence | |||||
TYK2 | PRKCQ | PRKCQ, PRKCT: Protein kinase C theta type | 16.20 | Evidence | |||||
TYK2 | CD22 | CD22, SIGLEC2: B-cell receptor CD22 precursor | 15.00 | Evidence | |||||
TYK2 | CDC2 | CDC2: Cell division control protein 2 homolog | 15.00 | Evidence | |||||
TYK2 | DNM3 | DNM3: Uncharacterized protein DNM3 | 15.00 | Evidence | |||||
TYK2 | SNCA | SNCA, NACP, PARK1: Alpha-synuclein | 15.00 | Evidence | |||||
TYK2 | PECAM1 | PECAM1: Platelet endothelial cell adhesion molecule precursor | 14.50 | Evidence | |||||
TYK2 | GRB7 | GRB7: Growth factor receptor-bound protein 7 | 14.20 | Evidence | |||||
TYK2 | GAB1 | GAB1: GRB2-associated-binding protein 1 | 13.80 | Evidence | |||||
TYK2 | NEK3 | NEK3: Serine/threonine-protein kinase Nek3 | 13.80 | Evidence | |||||
TYK2 | PRKAA1 | N/A | 13.80 | Evidence | |||||
TYK2 | NEDD9 | NEDD9, CASL: Enhancer of filamentation 1 | 13.40 | Evidence | |||||
TYK2 | LATS1 | LATS1, WARTS: Serine/threonine-protein kinase LATS1 | 13.40 | Evidence | |||||
TYK2 | AKT3 | AKT3: RAC-gamma serine/threonine-protein kinase | 13.40 | Evidence | |||||
TYK2 | RHOA | RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor | 13.10 | Evidence |