Click on the protein name for more information about the protein.
The Score column is the predicted score of interaction between the two proteins
Click on the Evidence link to view a breakdown of the information about the predicted interaction.
Key | |
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Module Score | Databases |
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Protein 1 (?) | Protein 2 (?) | Name of Protein 2 | Module Scores (?) | Scores (?) | Evidence (?) | Database (?) | |||
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TYK2 | JAK2 | JAK2: Tyrosine-protein kinase JAK2 | 1.38E3 | Evidence | |||||
TYK2 | STAT6 | STAT6: Signal transducer and activator of transcription 6 | 1.17E3 | Evidence | |||||
TYK2 | CSK | CSK: Tyrosine-protein kinase CSK | 1.17E3 | Evidence | |||||
TYK2 | STAT5A | STAT5A, STAT5: Signal transducer and activator of transcription 5A | 835.0 | Evidence | |||||
TYK2 | BTK | BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK | 720.0 | Evidence | |||||
TYK2 | SYK | SYK: Tyrosine-protein kinase SYK | 720.0 | Evidence | |||||
TYK2 | STAT5B | STAT5B: Signal transducer and activator of transcription 5B | 626.0 | Evidence | |||||
TYK2 | FGR | FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR | 613.0 | Evidence | |||||
TYK2 | SH3BP2 | SH3BP2: Uncharacterized protein SH3BP2 | 613.0 | Evidence | |||||
TYK2 | LYN | LYN: Tyrosine-protein kinase Lyn | 613.0 | Evidence |
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TYK2 | NCK1 | NCK1, NCK: Cytoplasmic protein NCK1 | 506.0 | Evidence | |||||
TYK2 | ZAP70 | ZAP70: Uncharacterized protein ZAP70 | 497.0 | Evidence | |||||
TYK2 | DOCK2 | DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 | 445.0 | Evidence | |||||
TYK2 | CSF1R | CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor | 416.0 | Evidence | |||||
TYK2 | NCK2 | NCK2: Cytoplasmic protein NCK2 | 407.0 | Evidence | |||||
TYK2 | BLNK | BLNK, BASH, SLP65: B-cell linker protein | 392.0 | Evidence | |||||
TYK2 | SLA | SLA, SLAP, SLAP1: SRC-like-adapter | 370.0 | Evidence | |||||
TYK2 | HCK | N/A | 370.0 | Evidence | |||||
TYK2 | LCP2 | LCP2: Lymphocyte cytosolic protein 2 | 364.0 | Evidence | |||||
TYK2 | FYN | FYN: Proto-oncogene tyrosine-protein kinase Fyn | 299.0 | Evidence |
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TYK2 | CRKL | CRKL: Crk-like protein | 268.0 | Evidence |
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TYK2 | JAK1 | 268.0 | Evidence |
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TYK2 | CBLB | CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B | 263.0 | Evidence | |||||
TYK2 | LCK | LCK: Proto-oncogene tyrosine-protein kinase LCK | 221.0 | Evidence | |||||
TYK2 | KIT | KIT: Mast/stem cell growth factor receptor precursor | 206.0 | Evidence | |||||
TYK2 | WAS | WAS, IMD2: Wiskott-Aldrich syndrome protein | 194.0 | Evidence | |||||
TYK2 | PIK3R2 | PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta | 178.0 | Evidence | |||||
TYK2 | STAT2 | STAT2: Signal transducer and activator of transcription 2 | 165.0 | Evidence |
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TYK2 | GRB2 | GRB2, ASH: Growth factor receptor-bound protein 2 | 162.0 | Evidence | |||||
TYK2 | APS | SH2B2, APS: SH2B adapter protein 2 | 161.0 | Evidence | |||||
TYK2 | PDGFRA | PDGFRA: Alpha-type platelet-derived growth factor receptor precursor | 149.0 | Evidence | |||||
TYK2 | PDGFRB | PDGFRB: Beta-type platelet-derived growth factor receptor precursor | 149.0 | Evidence |
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TYK2 | HCLS1 | HCLS1, HS1: Hematopoietic lineage cell-specific protein | 148.0 | Evidence | |||||
TYK2 | PTK2B | PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta | 139.0 | Evidence | |||||
TYK2 | ABL1 | ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 | 137.0 | Evidence | |||||
TYK2 | SOCS3 | SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 | 137.0 | Evidence | |||||
TYK2 | STAT1 | STAT1: Signal transducer and activator of transcription 1-alpha/beta | 135.0 | Evidence |
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TYK2 | FLT1 | FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor | 134.0 | Evidence | |||||
TYK2 | TEC | TEC, PSCTK4: Tyrosine-protein kinase Tec | 121.0 | Evidence | |||||
TYK2 | STAT3 | 119.0 | Evidence | ||||||
TYK2 | PTPN6 | PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 | 119.0 | Evidence |
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TYK2 | RASA1 | RASA1, RASA: Ras GTPase-activating protein 1 | 106.0 | Evidence | |||||
TYK2 | WASPIP | N/A | 101.0 | Evidence | |||||
TYK2 | DOK1 | DOK1: Docking protein 1 | 91.10 | Evidence | |||||
TYK2 | CBL | CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL | 90.80 | Evidence |
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TYK2 | KHDRBS1 | KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate | 87.80 | Evidence | |||||
TYK2 | KDR | KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor | 80.00 | Evidence | |||||
TYK2 | INSR | INSR: Insulin receptor precursor | 80.00 | Evidence | |||||
TYK2 | EGFR | EGFR, ERBB1: Epidermal growth factor receptor precursor | 79.90 | Evidence | |||||
TYK2 | INSL3 | JAK3: Tyrosine-protein kinase JAK3 | 79.40 | Evidence | |||||
TYK2 | RAF1 | RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase | 69.40 | Evidence | |||||
TYK2 | SNX17 | SNX17, KIAA0064: Sorting nexin-17 | 69.40 | Evidence | |||||
TYK2 | TEK | TEK, TIE2: Angiopoietin-1 receptor precursor | 59.50 | Evidence | |||||
TYK2 | CBLC | CBLC, CBL3, RNF57: Signal transduction protein CBL-C | 58.60 | Evidence | |||||
TYK2 | GRAP | GRAP: GRB2-related adapter protein | 55.80 | Evidence | |||||
TYK2 | EPHB3 | EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor | 53.30 | Evidence | |||||
TYK2 | PSMA5 | PSMA5: Proteasome subunit alpha type-5 | 53.3 | Evidence | |||||
TYK2 | PSMA3 | PSMA3, PSC8: Proteasome subunit alpha type-3 | 53.3 | Evidence | |||||
TYK2 | IGF1R | IGF1R: Insulin-like growth factor 1 receptor precursor | 52.50 | Evidence | |||||
TYK2 | MAP4K1 | MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 | 46.90 | Evidence | |||||
TYK2 | PIK3CG | PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i | 46.90 | Evidence | |||||
TYK2 | PSMA2 | PSMA2, PSC3: Proteasome subunit alpha type-2 | 43.00 | Evidence | |||||
TYK2 | MAPK1 | MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 | 42.00 | Evidence | |||||
TYK2 | HGS | HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate | 36.30 | Evidence | |||||
TYK2 | ACTG1 | ACTB: Actin, cytoplasmic 1 | 35.00 | Evidence | |||||
TYK2 | NMT1 | NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 | 35.00 | Evidence | |||||
TYK2 | NRBP1 | NRBP1, BCON3, NRBP: Nuclear receptor-binding protein | 33.90 | Evidence | |||||
TYK2 | HNRPK | N/A | 32.90 | Evidence | |||||
TYK2 | CXCR4 | CXCR4: C-X-C chemokine receptor type 4 | 32.70 | Evidence | |||||
TYK2 | TGFB1 | TGFB1, TGFB: Transforming growth factor beta-1 precursor | 28.90 | Evidence | |||||
TYK2 | MAP3K8 | MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 | 27.90 | Evidence | |||||
TYK2 | SCAP2 | SKAP2, PRAP, RA70, SAPS, SCAP2, SKAP55R: Src kinase-associated phosphoprotein 2 | 26.70 | Evidence | |||||
TYK2 | ARHGDIB | ARHGDIB, GDIA2, GDID4, RAP1GN1: Rho GDP-dissociation inhibitor 2 | 25.00 | Evidence | |||||
TYK2 | QARS | QARS: Glutaminyl-tRNA synthetase | 25.00 | Evidence | |||||
TYK2 | TUBA1 | TUBA4A, TUBA1: Tubulin alpha-4A chain | 24.90 | Evidence | |||||
TYK2 | CSF2RB | CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor | 24.90 | Evidence | |||||
TYK2 | SOCS1 | SOCS1, SSI1, TIP3: Suppressor of cytokine signaling 1 | 24.90 | Evidence | |||||
TYK2 | GAK | GAK: Cyclin G-associated kinase | 24.60 | Evidence | |||||
TYK2 | ITGAE | ITGAE: Integrin alpha-E precursor | 23.00 | Evidence | |||||
TYK2 | PASK | PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase | 22.80 | Evidence | |||||
TYK2 | HLA-F | HLA-F, HLA-5.4, HLAF: HLA class I histocompatibility antigen, alpha chain F prec | 21.00 | Evidence | |||||
TYK2 | CDK2 | CDK2: Cell division protein kinase 2 | 20.50 | Evidence | |||||
TYK2 | PRKDC | PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit | 19.10 | Evidence | |||||
TYK2 | PRKCQ | PRKCQ, PRKCT: Protein kinase C theta type | 16.20 | Evidence | |||||
TYK2 | CD22 | CD22, SIGLEC2: B-cell receptor CD22 precursor | 15.00 | Evidence | |||||
TYK2 | SNCA | SNCA, NACP, PARK1: Alpha-synuclein | 15.00 | Evidence | |||||
TYK2 | DNM3 | DNM3: Uncharacterized protein DNM3 | 15.00 | Evidence | |||||
TYK2 | CDC2 | CDC2: Cell division control protein 2 homolog | 15.00 | Evidence | |||||
TYK2 | PECAM1 | PECAM1: Platelet endothelial cell adhesion molecule precursor | 14.50 | Evidence | |||||
TYK2 | GRB7 | GRB7: Growth factor receptor-bound protein 7 | 14.20 | Evidence | |||||
TYK2 | PRKAA1 | N/A | 13.80 | Evidence | |||||
TYK2 | GAB1 | GAB1: GRB2-associated-binding protein 1 | 13.80 | Evidence | |||||
TYK2 | NEK3 | NEK3: Serine/threonine-protein kinase Nek3 | 13.80 | Evidence | |||||
TYK2 | LATS1 | LATS1, WARTS: Serine/threonine-protein kinase LATS1 | 13.40 | Evidence | |||||
TYK2 | AKT3 | AKT3: RAC-gamma serine/threonine-protein kinase | 13.40 | Evidence | |||||
TYK2 | NEDD9 | NEDD9, CASL: Enhancer of filamentation 1 | 13.40 | Evidence | |||||
TYK2 | RHOA | RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor | 13.10 | Evidence | |||||
TYK2 | MAPK3 | MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 | 12.40 | Evidence | |||||
TYK2 | EPOR | EPOR: Erythropoietin receptor precursor | 11.90 | Evidence | |||||
TYK2 | STAG2 | STAG2, SA2: Cohesin subunit SA-2 | 11.70 | Evidence | |||||
TYK2 | PPP1R12A | PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A | 11.70 | Evidence | |||||
TYK2 | RPS3 | RPS3, OK/SW-cl.26: 40S ribosomal protein S3 | 11.70 | Evidence | |||||
TYK2 | PTPN2 | PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 | 11.60 | Evidence | |||||
TYK2 | IL2RB | IL2RB: Interleukin-2 receptor subunit beta precursor | 11.40 | Evidence | |||||
TYK2 | CD79A | CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain | 11.40 | Evidence | |||||
TYK2 | IRS4 | IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 | 11.20 | Evidence | |||||
TYK2 | VAV1 | VAV1, VAV: Proto-oncogene vav | 11.10 | Evidence |
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TYK2 | TYRO3 | TYRO3, BYK, DTK, RSE, SKY: Tyrosine-protein kinase receptor TYRO3 precursor | 10.40 | Evidence | |||||
TYK2 | LAT | LAT: Linker for activation of T-cells family member 1 | 9.92 | Evidence | |||||
TYK2 | IL6ST | IL6ST: Interleukin-6 receptor subunit beta precursor | 9.92 | Evidence |
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TYK2 | FCGR2B | FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor | 9.92 | Evidence | |||||
TYK2 | CD79B | CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p | 9.92 | Evidence | |||||
TYK2 | TRPV4 | TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb | 9.92 | Evidence | |||||
TYK2 | PTPRC | PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ | 9.92 | Evidence |
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TYK2 | IL4R | IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor | 9.92 | Evidence | |||||
TYK2 | IRS1 | IRS1: Insulin receptor substrate 1 | 9.89 | Evidence |
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TYK2 | IL10RB | IL10RB, CRFB4, D21S58, D21S66: Interleukin-10 receptor beta chain precursor | 9.84 | Evidence | |||||
TYK2 | PRKCE | PRKCE, PKCE: Protein kinase C epsilon type | 9.37 | Evidence | |||||
TYK2 | IFNAR1 | IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor | 9.14 | Evidence |
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TYK2 | GHR | GHR: Growth hormone receptor precursor | 9.14 | Evidence |
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TYK2 | PARD6A | PARD6A, PAR6A: Partitioning defective 6 homolog alpha | 8.92 | Evidence | |||||
TYK2 | RANGAP1 | RANGAP1, SD: Ran GTPase-activating protein 1 | 8.84 | Evidence | |||||
TYK2 | TNKS2 | TNKS2, PARP5B, TANK2, TNKL: Tankyrase-2 | 8.81 | Evidence | |||||
TYK2 | PSMA6 | PSMA6, PROS27: Proteasome subunit alpha type-6 | 8.65 | Evidence | |||||
TYK2 | CD36 | CD36, GP3B, GP4: Platelet glycoprotein 4 | 8.31 | Evidence | |||||
TYK2 | UBAP2L | UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like | 7.93 | Evidence | |||||
TYK2 | DNM2 | N/A | 7.93 | Evidence | |||||
TYK2 | DAPP1 | N/A | 7.93 | Evidence | |||||
TYK2 | HNRPK | HNRPK, HNRNPK: Heterogeneous nuclear ribonucleoprotein K | 7.59 | Evidence | |||||
TYK2 | MTMR6 | MTMR6: Myotubularin-related protein 6 | 7.18 | Evidence | |||||
TYK2 | ACTB | ACTG1, ACTB, ACTG: Actin, cytoplasmic 2 | 6.83 | Evidence | |||||
TYK2 | MRCL3 | MRLC2, MLCB, RLC: Myosin regulatory light chain 2, nonsarcomeric | 6.78 | Evidence | |||||
TYK2 | MTMR1 | MTMR1: Myotubularin-related protein 1 | 6.78 | Evidence | |||||
TYK2 | PRKX | PRKX, PKX1: Serine/threonine-protein kinase PRKX | 6.78 | Evidence | |||||
TYK2 | XRCC6 | XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1 | 6.71 | Evidence | |||||
TYK2 | PRLR | PRLR: Prolactin receptor precursor | 6.62 | Evidence | |||||
TYK2 | ITGB4 | N/A | 6.52 | Evidence | |||||
TYK2 | CDC42EP1 | CDC42EP1, BORG5, CEP1, MSE55: Cdc42 effector protein 1 | 6.14 | Evidence | |||||
TYK2 | PPP1R8 | N/A | 6.01 | Evidence | |||||
TYK2 | SFRS2 | SFRS2: Splicing factor, arginine/serine-rich 2 | 6.01 | Evidence | |||||
TYK2 | PABPN1 | PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2 | 6.01 | Evidence | |||||
TYK2 | DHX16 | DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN | 6.01 | Evidence | |||||
TYK2 | FCER1G | FCER1G: High affinity immunoglobulin epsilon receptor subunit gamma precursor | 5.95 | Evidence | |||||
TYK2 | ASB8 | ASB8, PP14212: Ankyrin repeat and SOCS box protein 8 | 5.92 | Evidence | |||||
TYK2 | AGTR1 | AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor | 5.88 | Evidence | |||||
TYK2 | YWHAZ | YWHAZ: 14-3-3 protein zeta/delta | 5.74 | Evidence | |||||
TYK2 | RPA2 | RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit | 5.74 | Evidence | |||||
TYK2 | PTPN11 | N/A | 5.74 | Evidence | |||||
TYK2 | CASP3 | CASP3, CPP32: Caspase-3 precursor | 5.55 | Evidence | |||||
TYK2 | BCAR1 | BCAR1, CAS, CRKAS: Breast cancer anti-estrogen resistance protein 1 | 5.50 | Evidence | |||||
TYK2 | TUBB2A | TUBB2A, TUBB2: Tubulin beta-2A chain | 5.27 | Evidence | |||||
TYK2 | PSMA4 | PSMA4, PSC9: Proteasome subunit alpha type-4 | 5.23 | Evidence | |||||
TYK2 | ZYX | ZYX: Zyxin | 5.08 | Evidence | |||||
TYK2 | PTPN7 | PTPN7: Tyrosine-protein phosphatase non-receptor type 7 | 4.84 | Evidence | |||||
TYK2 | BFAR | BFAR, BAR, RNF47: Bifunctional apoptosis regulator | 4.80 | Evidence | |||||
TYK2 | IGHE | IGHE: Ig epsilon chain C region | 4.68 | Evidence | |||||
TYK2 | PLAUR | PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor | 4.48 | Evidence |
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TYK2 | GRIA3 | GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor | 4.01 | Evidence | |||||
TYK2 | CREBBP | CREBBP, CBP: CREB-binding protein | 3.85 | Evidence | |||||
TYK2 | RANBP1 | RANBP1: Ran-specific GTPase-activating protein | 3.69 | Evidence | |||||
TYK2 | NFATC3 | NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3 | 3.64 | Evidence | |||||
TYK2 | GTF2B | GTF2B, TF2B, TFIIB: Transcription initiation factor IIB | 3.64 | Evidence | |||||
TYK2 | EVL | N/A | 3.47 | Evidence | |||||
TYK2 | TTN | TTN: Uncharacterized protein TTN (Fragment) | 3.44 | Evidence | |||||
TYK2 | SREBF2 | N/A | 3.28 | Evidence | |||||
TYK2 | ZNF217 | ZNF217, ZABC1: Zinc finger protein 217 | 3.28 | Evidence | |||||
TYK2 | STOM | STOM, BND7, EPB72: Erythrocyte band 7 integral membrane protein | 3.26 | Evidence | |||||
TYK2 | GUCA1C | GUCA1C, GCAP3: Guanylyl cyclase-activating protein 3 | 3.18 | Evidence | |||||
TYK2 | AQP2 | AQP2: Aquaporin-2 | 3.18 | Evidence | |||||
TYK2 | SHC2 | N/A | 3.08 | Evidence | |||||
TYK2 | RPS6KA6 | RPS6KA6, RSK4: Ribosomal protein S6 kinase alpha-6 | 2.97 | Evidence | |||||
TYK2 | IREB2 | IREB2: Iron-responsive element-binding protein 2 | 2.94 | Evidence | |||||
TYK2 | CTLA4 | CTLA4, CD152: Cytotoxic T-lymphocyte protein 4 precursor | 2.77 | Evidence | |||||
TYK2 | STUB1 | STUB1, CHIP, PP1131: STIP1 homology and U box-containing protein 1 | 2.63 | Evidence | |||||
TYK2 | TXN | TXN, TRDX, TRX, TRX1: Thioredoxin | 2.63 | Evidence | |||||
TYK2 | NPR3 | N/A | 2.62 | Evidence | |||||
TYK2 | NASP | NASP: Nuclear autoantigenic sperm protein | 2.54 | Evidence | |||||
TYK2 | MATK | 2.54 | Evidence | ||||||
TYK2 | CDC42 | N/A | 2.54 | Evidence | |||||
TYK2 | CASP9 | CASP9, MCH6: Caspase-9 precursor | 2.54 | Evidence |