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The Barton Group

Predicted interactions involving protein TYK2: Non-receptor tyrosine-protein kinase TYK2 (IPI00022353) that score above 25.0

Click on the protein name for more information about the protein.

The Score column is the predicted score of interaction between the two proteins

Click on the Evidence link to view a breakdown of the information about the predicted interaction.

Key
Module ScoreDatabases
Where interaction is observed in another database a link is provided:

Protein 1 (?)Protein 2 (?) Name of Protein 2 Module Scores (?) Scores (?) Evidence (?) Database (?)
TYK2 JAK2 JAK2: Tyrosine-protein kinase JAK2 1.38E3 Evidence
TYK2 STAT6 STAT6: Signal transducer and activator of transcription 6 1.17E3 Evidence
TYK2 CSK CSK: Tyrosine-protein kinase CSK 1.17E3 Evidence
TYK2 STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 835.0 Evidence
TYK2 SYK SYK: Tyrosine-protein kinase SYK 720.0 Evidence
TYK2 BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 720.0 Evidence
TYK2 STAT5B STAT5B: Signal transducer and activator of transcription 5B 626.0 Evidence
TYK2 SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 613.0 Evidence
TYK2 LYN LYN: Tyrosine-protein kinase Lyn 613.0 Evidence
TYK2 FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 613.0 Evidence
TYK2 NCK1 NCK1, NCK: Cytoplasmic protein NCK1 506.0 Evidence
TYK2 ZAP70 ZAP70: Uncharacterized protein ZAP70 497.0 Evidence
TYK2 DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 445.0 Evidence
TYK2 CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 416.0 Evidence
TYK2 NCK2 NCK2: Cytoplasmic protein NCK2 407.0 Evidence
TYK2 BLNK BLNK, BASH, SLP65: B-cell linker protein 392.0 Evidence
TYK2 HCK N/A 370.0 Evidence
TYK2 SLA SLA, SLAP, SLAP1: SRC-like-adapter 370.0 Evidence
TYK2 LCP2 LCP2: Lymphocyte cytosolic protein 2 364.0 Evidence
TYK2 FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 299.0 Evidence
TYK2 JAK1 268.0 Evidence
TYK2 CRKL CRKL: Crk-like protein 268.0 Evidence
TYK2 CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 263.0 Evidence
TYK2 LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 221.0 Evidence
TYK2 KIT KIT: Mast/stem cell growth factor receptor precursor 206.0 Evidence
TYK2 WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 194.0 Evidence
TYK2 PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 178.0 Evidence
TYK2 STAT2 STAT2: Signal transducer and activator of transcription 2 165.0 Evidence
TYK2 GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 162.0 Evidence
TYK2 APS SH2B2, APS: SH2B adapter protein 2 161.0 Evidence
TYK2 PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 149.0 Evidence
TYK2 PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 149.0 Evidence
TYK2 HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 148.0 Evidence
TYK2 PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 139.0 Evidence
TYK2 ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 137.0 Evidence
TYK2 SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 137.0 Evidence
TYK2 STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 135.0 Evidence
TYK2 FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 134.0 Evidence
TYK2 TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 121.0 Evidence
TYK2 STAT3 119.0 Evidence
TYK2 PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 119.0 Evidence
TYK2 RASA1 RASA1, RASA: Ras GTPase-activating protein 1 106.0 Evidence
TYK2 WASPIP N/A 101.0 Evidence
TYK2 DOK1 DOK1: Docking protein 1 91.10 Evidence
TYK2 CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 90.80 Evidence
TYK2 KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 87.80 Evidence
TYK2 KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 80.00 Evidence
TYK2 INSR INSR: Insulin receptor precursor 80.00 Evidence
TYK2 EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 79.90 Evidence
TYK2 INSL3 JAK3: Tyrosine-protein kinase JAK3 79.40 Evidence
TYK2 SNX17 SNX17, KIAA0064: Sorting nexin-17 69.40 Evidence
TYK2 RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 69.40 Evidence
TYK2 TEK TEK, TIE2: Angiopoietin-1 receptor precursor 59.50 Evidence
TYK2 CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 58.60 Evidence
TYK2 GRAP GRAP: GRB2-related adapter protein 55.80 Evidence
TYK2 EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 53.30 Evidence
TYK2 PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 53.3 Evidence
TYK2 PSMA5 PSMA5: Proteasome subunit alpha type-5 53.3 Evidence
TYK2 IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 52.50 Evidence
TYK2 MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 46.90 Evidence
TYK2 PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 46.90 Evidence
TYK2 PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 43.00 Evidence
TYK2 MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 42.00 Evidence
TYK2 HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 36.30 Evidence
TYK2 NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 35.00 Evidence
TYK2 ACTG1 ACTB: Actin, cytoplasmic 1 35.00 Evidence
TYK2 NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 33.90 Evidence
TYK2 HNRPK N/A 32.90 Evidence
TYK2 CXCR4 CXCR4: C-X-C chemokine receptor type 4 32.70 Evidence
TYK2 TGFB1 TGFB1, TGFB: Transforming growth factor beta-1 precursor 28.90 Evidence
TYK2 MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 27.90 Evidence
TYK2 SCAP2 SKAP2, PRAP, RA70, SAPS, SCAP2, SKAP55R: Src kinase-associated phosphoprotein 2 26.70 Evidence
TYK2 ARHGDIB ARHGDIB, GDIA2, GDID4, RAP1GN1: Rho GDP-dissociation inhibitor 2 25.00 Evidence
TYK2 QARS QARS: Glutaminyl-tRNA synthetase 25.00 Evidence