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The Barton Group

Predicted interactions involving protein MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 (IPI00003479) that score above 1.0

Click on the protein name for more information about the protein.

The Score column is the predicted score of interaction between the two proteins

Click on the Evidence link to view a breakdown of the information about the predicted interaction.

Key
Module ScoreDatabases
Where interaction is observed in another database a link is provided:

Protein 1 (?)Protein 2 (?) Name of Protein 2 Module Scores (?) Scores (?) Evidence (?) Database (?)
MAPK1 MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 3.50E4 Evidence
MAPK1 PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 496.0 Evidence
MAPK1 DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 100.0 Evidence O
MAPK1 JAK2 JAK2: Tyrosine-protein kinase JAK2 85.20 Evidence
MAPK1 SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 82.00 Evidence
MAPK1 DUSP21 DUSP21, LMWDSP21: Dual specificity protein phosphatase 21 72.50 Evidence
MAPK1 CRKL CRKL: Crk-like protein 64.00 Evidence
MAPK1 JUNB JUNB: Transcription factor jun-B 62.90 Evidence
MAPK1 JAK1 55.10 Evidence
MAPK1 SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 53.90 Evidence
MAPK1 DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 53.90 Evidence O
MAPK1 DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 53.90 Evidence
MAPK1 RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 51.60 Evidence
MAPK1 JUN JUN: Transcription factor AP-1 51.50 Evidence O
MAPK1 DUSP14 DUSP14, MKP6: Dual specificity protein phosphatase 14 46.80 Evidence
MAPK1 ZAP70 ZAP70: Uncharacterized protein ZAP70 44.40 Evidence
MAPK1 TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 42.00 Evidence
MAPK1 STAT5B STAT5B: Signal transducer and activator of transcription 5B 38.10 Evidence O
MAPK1 BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 38.10 Evidence
MAPK1 FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 33.90 Evidence
MAPK1 CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 33.90 Evidence
MAPK1 AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 32.80 Evidence
MAPK1 MAFG MAFG: Transcription factor MafG 32.80 Evidence
MAPK1 MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 31.70 Evidence O
MAPK1 STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 31.20 Evidence O
MAPK1 MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 27.80 Evidence O
MAPK1 SMAD2 SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2 27.80 Evidence
MAPK1 DUSP2 DUSP2, PAC1: Dual specificity protein phosphatase 2 27.40 Evidence
MAPK1 SYK SYK: Tyrosine-protein kinase SYK 25.00 Evidence
MAPK1 PRKCI PRKCI, DXS1179E: Protein kinase C iota type 23.70 Evidence
MAPK1 STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 20.50 Evidence
MAPK1 SOS1 SOS1: Son of sevenless homolog 1 20.50 Evidence
MAPK1 LNK SH2B3, LNK: SH2B adapter protein 3 19.70 Evidence
MAPK1 DIAPH1 Diaphanous 1 17.80 Evidence
MAPK1 FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 17.60 Evidence
MAPK1 PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 17.60 Evidence
MAPK1 STAT2 STAT2: Signal transducer and activator of transcription 2 17.30 Evidence
MAPK1 ATR ATR, FRP1: Serine/threonine-protein kinase ATR 16.50 Evidence
MAPK1 FYN N/A 16.40 Evidence
MAPK1 EWSR1 EWSR1, EWS: RNA-binding protein EWS 16.30 Evidence
MAPK1 EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 16.20 Evidence
MAPK1 NRAS NRAS, HRAS1: GTPase NRas precursor 14.00 Evidence
MAPK1 SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 13.50 Evidence
MAPK1 STAT3 13.40 Evidence
MAPK1 GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 13.40 Evidence
MAPK1 PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 13.40 Evidence
MAPK1 STMN2 STMN2, SCG10, SCGN10: Stathmin-2 13.2 Evidence
MAPK1 PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 11.60 Evidence
MAPK1 MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 11.60 Evidence
MAPK1 DAB1 DAB1: Disabled homolog 1 11.60 Evidence
MAPK1 MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 11.50 Evidence
MAPK1 DUSP10 DUSP10, MKP5: Dual specificity protein phosphatase 10 10.90 Evidence
MAPK1 DUSP18 DUSP18, LMWDSP20: Dual specificity protein phosphatase 18 10.90 Evidence
MAPK1 DUSP19 DUSP19, DUSP17, SKRP1: Dual specificity protein phosphatase 19 10.90 Evidence
MAPK1 YWHAB YWHAB: 14-3-3 protein beta/alpha 10.80 Evidence
MAPK1 SH2BP1 CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog 10.40 Evidence
MAPK1 SMAD3 SMAD3, MADH3: Mothers against decapentaplegic homolog 3 10.30 Evidence
MAPK1 TP53 TP53, P53: Cellular tumor antigen p53 10.30 Evidence
MAPK1 SKIIP SNW1, SKIIP, SKIP: SNW domain-containing protein 1 10.10 Evidence
MAPK1 DUSP8 DUSP8, VH5: Dual specificity protein phosphatase 8 10.00 Evidence
MAPK1 MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 9.96 Evidence
MAPK1 MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 9.96 Evidence
MAPK1 UBE4A N/A 9.32 Evidence
MAPK1 UBE2E3 UBE2E3, UBCE4, UBCH9: Ubiquitin-conjugating enzyme E2 E3 9.32 Evidence
MAPK1 KIT KIT: Mast/stem cell growth factor receptor precursor 9.29 Evidence
MAPK1 NEK3 NEK3: Serine/threonine-protein kinase Nek3 9.17 Evidence
MAPK1 GNAI3 GNAI3: Guanine nucleotide-binding protein G(k) subunit alpha 9.16 Evidence
MAPK1 MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 8.92 Evidence
MAPK1 SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 8.92 Evidence
MAPK1 CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 8.86 Evidence
MAPK1 CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 8.74 Evidence
MAPK1 EEF1B2 EEF1B2, EEF1B, EF1B: Elongation factor 1-beta 8.72 Evidence
MAPK1 HDAC1 HDAC1, RPD3L1: Histone deacetylase 1 7.52 Evidence
MAPK1 BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 7.52 Evidence
MAPK1 MDM4 MDM4, MDMX: Mdm4 protein 7.43 Evidence
MAPK1 DUSP4 DUSP4, MKP2, VH2: Dual specificity protein phosphatase 4 7.18 Evidence O
MAPK1 PPID PPID, CYP40, CYPD: 40 kDa peptidyl-prolyl cis-trans isomerase 7.10 Evidence
MAPK1 SMAD1 SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1 6.80 Evidence
MAPK1 NAP1L1 NAP1L1, NRP: Nucleosome assembly protein 1-like 1 6.39 Evidence O
MAPK1 TERF2IP TERF2IP, RAP1, PP8000: Telomeric repeat-binding factor 2-interacting protein 1 6.20 Evidence
MAPK1 RNPS1 RNPS1, LDC2: RNA-binding protein with serine-rich domain 1 6.20 Evidence
MAPK1 CDK2 CDK2: Cell division protein kinase 2 5.89 Evidence
MAPK1 IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 5.87 Evidence
MAPK1 HIST1H1B HIST1H1B, H1F5: Histone H1.5 5.86 Evidence
MAPK1 MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 5.86 Evidence
MAPK1 SEC31L1 N/A 5.55 Evidence
MAPK1 EPOR EPOR: Erythropoietin receptor precursor 5.41 Evidence
MAPK1 PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 5.34 Evidence
MAPK1 HSPD1 5.29 Evidence
MAPK1 LIMK1 LIMK1, LIMK: LIM domain kinase 1 5.29 Evidence
MAPK1 ZNF267 ZNF267: Zinc finger protein 267 5.08 Evidence
MAPK1 NUP214 N/A 5.08 Evidence
MAPK1 ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 4.77 Evidence
MAPK1 SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 4.55 Evidence
MAPK1 CREBBP CREBBP, CBP: CREB-binding protein 4.55 Evidence
MAPK1 SND1 SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1 4.55 Evidence
MAPK1 MRE11A MRE11A, HNGS1, MRE11: Double-strand break repair protein MRE11A 4.55 Evidence
MAPK1 EEF1G EEF1G, EF1G, PRO1608: Elongation factor 1-gamma 4.55 Evidence
MAPK1 PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 4.08 Evidence
MAPK1 ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 4.01 Evidence
MAPK1 TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 3.92 Evidence
MAPK1 CASR CASR, GPRC2A, PCAR1: Extracellular calcium-sensing receptor precursor 3.86 Evidence
MAPK1 RBM6 RBM6, DEF3: RNA-binding protein 6 3.85 Evidence
MAPK1 SYMPK SYMPK, SPK: Symplekin 3.45 Evidence
MAPK1 RREB1 RREB1, FINB: RAS-responsive element-binding protein 1 3.45 Evidence
MAPK1 FXR2 FXR2, FMR1L2: Fragile X mental retardation syndrome-related protein 2 3.45 Evidence
MAPK1 EHBP1 EHBP1, KIAA0903, NACSIN: EH domain-binding protein 1 3.45 Evidence
MAPK1 HSP90AA1 Hsp89-alpha-delta-N 3.42 Evidence O
MAPK1 ZFP91 ZFP91, FKSG11: Zinc finger protein 91 homolog 3.34 Evidence
MAPK1 LOC642558 FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1 3.34 Evidence
MAPK1 HNRPK HNRPK, HNRNPK: Heterogeneous nuclear ribonucleoprotein K 3.34 Evidence
MAPK1 GRIA4 GRIA4, GLUR4: Glutamate receptor 4 precursor 3.12 Evidence
MAPK1 EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 3.12 Evidence
MAPK1 ZFPM1 ZFPM1, FOG1: Zinc finger protein ZFPM1 2.99 Evidence
MAPK1 SVIL SVIL: Supervillin 2.99 Evidence
MAPK1 CAMK2A N/A 2.99 Evidence
MAPK1 RBM10 RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10 2.99 Evidence
MAPK1 PSMD11 PSMD11: 26S proteasome non-ATPase regulatory subunit 11 2.90 Evidence O
MAPK1 DNM1 N/A 2.75 Evidence
MAPK1 MEF2C MEF2C: Myocyte-specific enhancer factor 2C 2.75 Evidence
MAPK1 SNRK SNRK, KIAA0096, SNFRK: SNF-related serine/threonine-protein kinase 2.75 Evidence
MAPK1 PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 2.62 Evidence
MAPK1 GNAI1 GNAI1: Guanine nucleotide-binding protein G(i), alpha-1 subunit 2.19 Evidence
MAPK1 PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 1.88 Evidence
MAPK1 IKBKE IKBKE, IKKE, IKKI, KIAA0151: Inhibitor of nuclear factor kappa-B kinase subunit 1.79 Evidence
MAPK1 CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 1.75 Evidence O
MAPK1 MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 1.71 Evidence
MAPK1 SHC3 SHC3, NSHC, SHCC: SHC-transforming protein 3 1.62 Evidence
MAPK1 GNAI2 Galphai2 protein 1.48 Evidence
MAPK1 MYL9 MYL9, MLC2, MRLC1, MYRL2: Myosin regulatory light chain 2, smooth muscle isoform 1.23 Evidence
MAPK1 ASGR2 ASGR2: Asialoglycoprotein receptor 2 1.12 Evidence
MAPK1 INSR INSR: Insulin receptor precursor 1.05 Evidence
MAPK1 DCC DCC: Netrin receptor DCC precursor 1.00 Evidence