AACon is a set of tools implementing 17 different conservation scores reviewed by Valdar as well as the more complex SMERFS algorithm for predicting protein functional sites. AACon has been written with efficiency in mind and takes less than a second to calculate conservation by all 18 methods for an alignment of 500 sequences 350 residues long on a single CPU. AACon exploits parallelism for the more demanding methods and to allow multiple methods to run simultaneously. The parallel code gives close to linear speedup with the number of processors, thus making it suitable for server applications or other demanding environments.
AACon is available as a SOAP web service, a stand alone Java executable and a Java library with concise API for accessing all the conservation methods programmatically. The executable runs on all platforms that support Java version 5 and above (Windows, Unix/Linux, Mac).
If you have any issues, questions or suggestions feel free to contact us on firstname.lastname@example.org
Peter Troshin, Agnieszka Golicz, David Martin and Geoff Barton are the authors of the AACon Web Services.