Acknowledgements

The authors thank Dr. David Jones for many insightful discussions, and for making the HELIXFILT program for filtering sequence databases available. We would also thank Prof. Sean Eddy for making the HMMer2 package so widely available and Dr. Steve Searle for aiding the development of the C program Jnet. Finally, we thank all of the authors of the different secondary structure prediction methods that were applied. J.C. is an Oxford Centre for Molecular Sciences/MRC Student.