The Prediction of Protein-Protein Interactions
I have investigated the prediction of human protein-protein interactions by integrating in a Bayesian network numerous features that are indicative of interaction including gene co-epxression, orthology transfer from other organisms, co-localization in the cell, co-occurrence of domains and post-translational modification (PTMs) as well as local network topology.
This is a project that has now been taken over by Mark McDowall in the Barton group.
All the predictions are accessible through the PIPs website.
References
McDowall MD, Scott MS, Barton GJ (2009) PIPs: human protein-protein interaction prediction database, NAR 37:651-6.
Scott MS, Barton GJ (2007) Probabilistic prediction and ranking of human protein-protein interactions. BMC Bioinformatics 8:239.