|What Does PIPs Do ...||Help Document|
PIPs is a database of predicted human protein-protein interactions. The predictions have been made using a naïve Bayesian classifier to calculate a Score of interaction. There are 37606 interactions with a Score ≥1 indicating that the interaction is more likely to occur than not to occur.
The probability of interaction between two proteins is calculated by combining different features including:
|Gene Co-expression||Orthology||Domain Co-occurrence|
|Co-localisation||Post Translational Modification||Network Analysis (Transitive)|
McDowall, MD, Scott, MS and Barton, GJ PIPs: Human protein-protein interactions prediction database Nucleic Acids Research 37:D651-D656 2009, Abstract, doi: 10.1093/nar/gkn870.
Scott, MS and Barton, GJ Probabilistic prediction and ranking of human protein-protein interactions BMC Bioinformatics 2007 8:239-260 Abstract