PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between SNRPG and SF3A1

The interaction score between SNRPG and SF3A1 is 0.357.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between SNRPG and SF3A1 = 0.70

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

0.013

Orthology

Organism	SNRPG Orthologue		SF3A1 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
bakers yeast	YFL017W-A	1	YJL203W	1	Other AffinityCaptureMS Get References From PubMed
worm	Q9N4G9	1	Q10577	1
fly	Q9VXE0	1	Q9VEP9	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.593

Domains

No domains were used in calculating likelihood of interaction

3.25E-4

Post-translational Modifications

Protein: SNRPG

PTM	Residue	Reference

Protein: SF3A1

PTM	Residue	Reference
Phosphorylation	359	PubMed, HPRD
Phosphoserine	359	HPRD
Phosphotyrosine	456	HPRD
Phosphotyrosine	759	HPRD

Localisation

Protein: SNRPG

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD

Protein: SF3A1

Localisation	Reference
Nucleus	HPRD

Transitive Score

The common interactors between SNRPG and SF3A1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SNRPG andSF3A1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SNRPG has 256 interactors and SF3A1 has 451 interactors of which there are 22 common interactors.

Common Interactor	Name of Common Interactor	Score for SNRPG-Interactor (?)	Score for SF3A1-Interactor (?)
SNRPD1	SNRPD1: Small nuclear ribonucleoprotein Sm D1	2.07E3	2.82
LSM4	LSM4: U6 snRNA-associated Sm-like protein LSm4	691.00	0.249
PRPF4	PRPF4, PRP4: U4/U6 small nuclear ribonucleoprotein Prp4	69.60	0.412
KIAA0788	ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase	32.60	9.98
PRP19	PRPF19, NMP200, PRP19, SNEV: Pre-mRNA-processing factor 19	25.60	0.412
SNRPA1	SNRPA1: U2 small nuclear ribonucleoprotein A'	3.89	2.79
SF3B3	N/A	3.89	0.249
SF3A3	SF3A3, SAP61: Splicing factor 3A subunit 3	1.84	193.00
PRPF8	PRPF8, PRPC8: Pre-mRNA-processing-splicing factor 8	1.84	1.84
SF3A2	SF3A2, SAP62: Splicing factor 3A subunit 2	1.84	18.70
SF3B1	SF3B1, SAP155: Splicing factor 3B subunit 1	0.890	4.67
SF3B2	SF3B2, SAP145: Splicing factor 3B subunit 2	0.593	5.20
PLK1	PLK1, PLK: Serine/threonine-protein kinase PLK1	0.354	0.908
TFIP11	TFIP11, HSPC006: Tuftelin-interacting protein 11	0.249	0.129
SND1	SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1	0.123	0.076
LOC652595	RP11-395L14.12-001: OTTHUMP00000045488	0.119	0.119
NULL	N/A	0.119	3.01
PTGES3	PTGES3, P23, TEBP: Prostaglandin E synthase 3	0.082	0.025
SSRP1	SSRP1, FACT80: FACT complex subunit SSRP1	0.044	0.072
PHF20	PHF20, C20orf104, GLEA2, HCA58, NZF, TZP: PHD finger protein 20	0.039	0.061
HNRPD	N/A	0.027	0.027
C11orf58	SMAP, C11orf58: Small acidic protein	0.027	0.053

2.15E-3

Total Score

0.357