Home
Advanced Search
Help
Update History
Statistics
Downloads
The Barton Group
<<< Back to LSM6

Evidence of Interaction Between LSM6 and SNRPD2

The interaction score between LSM6 and SNRPD2 is 7.41E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between LSM6 and SNRPD2 = 0.77

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.013
Orthology
OrganismLSM6 OrthologueSNRPD2 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YDR378C 1 YLR275W 1
  • Y2H
  • Other
  • AffinityCaptureMS

Get References From PubMed
worm Q95XN6 1 Q18786 1
fly Q9W2P5 1 Q9VI10 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains Domains present in LSM6 and SNRPD2:
Domains in LSM6Domains in SNRPD2
IPR001163 Small nuclear ribonucleoprotein (Sm protein)
IPR010920 Small nuclear-like ribonucleoprotein
IPR006649 snRNP domain
IPR001163 Small nuclear ribonucleoprotein (Sm protein)
IPR010920 Small nuclear-like ribonucleoprotein
IPR006649 snRNP domain

The Chi square scores for co-occurrence of domains that are present in LSM6 and SNRPD2 are listed below.

Domain 1Domain 2Chi Square
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR006649 snRNP domain 1325.87
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR001163 Small nuclear ribonucleoprotein (Sm protein) 1297.61
IPR006649 snRNP domain IPR006649 snRNP domain 1206.57
IPR010920 Small nuclear-like ribonucleoprotein IPR006649 snRNP domain 1168.89
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR010920 Small nuclear-like ribonucleoprotein 1143.95
IPR010920 Small nuclear-like ribonucleoprotein IPR010920 Small nuclear-like ribonucleoprotein 355.236

The background colour of the table refers to:

  • Blue Domain is only present in LSM6
  • Yellow Domain is only present in SNRPD2
  • Green Domain is present in both LSM6 and SNRPD2

 0.265
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: LSM6

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: SNRPD2

LocalisationReference
Nucleus HPRD
Transitive Score

The common interactors between LSM6 and SNRPD2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between LSM6 andSNRPD2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , LSM6 has 213 interactors and SNRPD2 has 248 interactors of which there are 191 common interactors.

Common InteractorName of Common InteractorScore for LSM6-Interactor (?)Score for SNRPD2-Interactor (?)
LSM5 LSM5: U6 snRNA-associated Sm-like protein LSm5 1.64E3 3.51E3
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 691.00 2.07E3
LSM2 LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2 323.00 1.64E3
LSM4 LSM4: U6 snRNA-associated Sm-like protein LSm4 323.00 323.00
LSM3 LSM3, MDS017: U6 snRNA-associated Sm-like protein LSm3 323.00 2.60
LSM7 LSM7: U6 snRNA-associated Sm-like protein LSm7 323.00 691.00
LSM1 LSM1, CASM: U6 snRNA-associated Sm-like protein LSm1 158.00 0.739
PRPF4 PRPF4, PRP4: U4/U6 small nuclear ribonucleoprotein Prp4 32.60 69.60
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 32.60 32.60
PRP19 PRPF19, NMP200, PRP19, SNEV: Pre-mRNA-processing factor 19 25.60 25.60
SNRPE SNRPE: Small nuclear ribonucleoprotein E 2.91 8.73
SNRPB SNRPB, COD, SNRPB1: Small nuclear ribonucleoprotein-associated proteins B and B' 2.91 2.91
LSM8 LSM8: U6 snRNA-associated Sm-like protein LSm8 2.60 2.60
PRPF3 PRPF3, HPRP3, PRP3: U4/U6 small nuclear ribonucleoprotein Prp3 1.84 1.84
PRPF8 PRPF8, PRPC8: Pre-mRNA-processing-splicing factor 8 1.84 3.05
PRPF31 PRPF31, PRP31: U4/U6 small nuclear ribonucleoprotein Prp31 1.82 1.10
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 1.22 691.00
SNRPF SNRPF, PBSCF: Small nuclear ribonucleoprotein F 1.22 1.05E4
SNRPG SNRPG, PBSCG: Small nuclear ribonucleoprotein G 1.22 691.00
GTF3C2 GTF3C2, KIAA0011: General transcription factor 3C polypeptide 2 0.293 0.137
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.293 0.293
BAT1 N/A 0.263 0.263
LSM11 LSM11: U7 snRNA-associated Sm-like protein LSm11 0.237 0.237
LSM10 LSM10: U7 snRNA-associated Sm-like protein LSm10 0.237 0.237
SNRPN HCERN3, SNRPN, SMN: Small nuclear ribonucleoprotein-associated protein N 0.141 0.141
DDX21 DDX21: Nucleolar RNA helicase 2 0.137 0.137
FBXW2 FBXW2, FBW2, FWD2: F-box/WD repeat-containing protein 2 0.137 0.083
GNB2L1 Lung cancer oncogene 7 0.137 0.293
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.137 0.137
DDX50 DDX50: ATP-dependent RNA helicase DDX50 0.137 0.293
WDR41 N/A 0.137 0.137
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.137 0.293
NUP43 N/A 0.123 0.123
DDX39 DDX39: ATP-dependent RNA helicase DDX39 0.123 0.123
WDR68 WDR68, HAN11: WD repeat-containing protein 68 0.123 0.074
DDX49 DDX49: Probable ATP-dependent RNA helicase DDX49 0.123 0.123
BOP1 BOP1, KIAA0124: Ribosome biogenesis protein BOP1 0.123 0.123
DDX23 DDX23: Probable ATP-dependent RNA helicase DDX23 0.123 0.123
CORO1A CORO1A, CORO1: Coronin-1A 0.123 0.060
WDR3 WDR3: WD repeat-containing protein 3 0.123 0.123
DDX27 DDX27, RHLP, HSPC259, PP3241: Probable ATP-dependent RNA helicase DDX27 0.123 0.123
TSSC1 TSSC1: Protein TSSC1 0.123 0.123
DDX47 E4-DBP: DEAD box protein 0.123 0.123
DDX19A DDX19A, DDX19L: ATP-dependent RNA helicase DDX19A 0.123 0.123
CNOT7 CNOT7, CAF1: CCR4-NOT transcription complex subunit 7 0.123 0.263
DHX16 DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN 0.123 0.074
CSTF1 CSTF1: Cleavage stimulation factor 50 kDa subunit 0.123 0.123
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.123 0.263
DDX18 DDX18: ATP-dependent RNA helicase DDX18 0.123 0.123
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.123 0.123
WDR39 CIAO1, WDR39: Protein CIAO1 0.123 0.074
PPP2R2A PPP2R2A: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alp 0.123 0.263
CDC40 CDC40, EHB3, PRP17, PRPF17: Pre-mRNA-processing factor 17 0.123 0.074
EIF4A1 EIF4A1, DDX2A, EIF4A: Eukaryotic initiation factor 4A-I 0.123 0.123
RBBP4 RBBP4, RBAP48: Histone-binding protein RBBP4 0.123 0.123
NULL N/A 0.119 0.119
DDB2 DDB2: DNA damage-binding protein 2 0.083 0.083
SMARCA4 SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4 0.083 0.137
SMARCAL1 SMARCAL1, HARP: SWI/SNF-related matrix-associated actin-dependent regulator of c 0.083 0.083
WDR8 WDR8: WD repeat-containing protein 8 0.083 0.067
SEC13L1 SEC13, D3S1231E, SEC13L1, SEC13R: Protein SEC13 homolog 0.083 0.137
SND1 SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1 0.074 0.123
WDR77 WDR77, HKMT1069, hCG_39991: Androgen receptor cofactor p44 0.074 0.263
IFIH1 IFIH1, MDA5, RH116: Interferon-induced helicase C domain-containing protein 1 0.074 0.060
WDR57 WDR57, PRP8BP, SFP38: WD repeat-containing protein 57 0.074 0.123
DDX54 DDX54: ATP-dependent RNA helicase DDX54 0.074 0.074
HELLS HELLS, PASG, Nbla10143, SMARCA6: Lymphoid-specific helicase 0.074 0.060
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.074 0.060
POLD1 POLD1, POLD: DNA polymerase delta catalytic subunit 0.074 0.074
DHX38 DHX38, DDX38, KIAA0224, PRP16: Pre-mRNA-splicing factor ATP-dependent RNA helica 0.074 0.060
STRAP STRAP, MAWD, UNRIP: Serine-threonine kinase receptor-associated protein 0.074 0.123
EML3 EML3: Echinoderm microtubule-associated protein-like 3 0.074 0.060
DDX10 DDX10: Probable ATP-dependent RNA helicase DDX10 0.074 0.123
TAF5 TAF5, TAF2D: Transcription initiation factor TFIID subunit 5 0.074 0.074
NUP37 NUP37: Nucleoporin Nup37 0.074 0.123
XPMC2H REXO4, PMC2, XPMC2H: RNA exonuclease 4 0.074 0.074
POLE POLE, POLE1: DNA polymerase epsilon catalytic subunit A 0.074 0.074
DICER1 DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer 0.074 0.036
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.074 0.074
BLM BLM, RECQ2, RECQL3: Bloom syndrome protein 0.074 0.074
RBBP7 RBBP7, RBAP46: Histone-binding protein RBBP7 0.074 0.123
DDX28 DDX28, MDDX28: Probable ATP-dependent RNA helicase DDX28 0.074 0.060
CNOT8 CNOT8, CALIF, POP2: CCR4-NOT transcription complex subunit 8 0.074 0.060
DDX48 EIF4A3, DDX48, KIAA0111: Eukaryotic initiation factor 4A-III 0.074 0.123
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 0.074 0.263
DDX17 DDX17: Probable ATP-dependent RNA helicase DDX17 0.074 0.060
ARPC1B ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B 0.074 0.044
DDX41 DDX41, ABS: Probable ATP-dependent RNA helicase DDX41 0.074 0.123
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.074 0.123
RECQL RECQL, RECQL1: ATP-dependent DNA helicase Q1 0.074 0.074
CORO7 CORO7: Coronin-7 0.074 0.060
FLJ10439 WDR74, NSA1: WD repeat-containing protein 74 0.074 0.123
DDX5 DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5 0.074 0.060
LRBA LRBA, BGL, CDC4L, LBA: Lipopolysaccharide-responsive and beige-like anchor prote 0.074 0.074
WDR1 N/A 0.067 0.083
PHF20 PHF20, C20orf104, GLEA2, HCA58, NZF, TZP: PHD finger protein 20 0.065 0.053
LGP2 DHX58, D11LGP2E, LGP2: Probable ATP-dependent RNA helicase DHX58 0.060 0.044
JMJD2C JMJD2C, GASC1, JHDM3C, KIAA0780: JmjC domain-containing histone demethylation pr 0.060 0.060
PAK1IP1 PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1 0.060 0.074
CDC20 CDC20: Cell division cycle protein 20 homolog 0.060 0.074
PWP2H PWP2, PWP2H: Periodic tryptophan protein 2 homolog 0.060 0.074
ASCC3 ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3 0.060 0.074
DDX1 DDX1: ATP-dependent RNA helicase DDX1 0.060 0.123
DHX35 C20orf15, DHX35, DDX35: Probable ATP-dependent RNA helicase DHX35 0.060 0.060
COPA COPA: Coatomer subunit alpha 0.060 0.060
RAE1 RAE1, MRNP41: mRNA export factor 0.060 0.060
CHAF1B CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B 0.060 0.074
WDR67 WDR67: WD repeat-containing protein 67 0.060 0.044
WDR12 WDR12: WD repeat-containing protein 12 0.060 0.123
RAD54L RAD54L, RAD54A: DNA repair and recombination protein RAD54-like 0.060 0.074
WDR18 N/A 0.060 0.123
WIPI2 WIPI2, CGI-50: WD repeat domain phosphoinositide-interacting protein 2 0.060 0.044
COPB2 COPB2: Coatomer subunit beta' 0.060 0.060
SKIV2L SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti 0.060 0.060
RNU3IP2 RRP9, RNU3IP2, U355K: U3 small nucleolar RNA-interacting protein 2 0.060 0.074
POLA POLA1, POLA: DNA polymerase alpha catalytic subunit 0.060 0.044
GNB1 GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0.060 0.060
PIK3R4 PIK3R4: Phosphoinositide 3-kinase regulatory subunit 4 0.060 0.060
KIAA0052 SKIV2L2, KIAA0052: Superkiller viralicidic activity 2-like 2 0.060 0.074
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.060 0.044
SEC31L1 N/A 0.060 0.074
DDX3Y DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y 0.060 0.044
AAMP AAMP: Angio-associated migratory cell protein 0.060 0.060
GRWD1 GRWD1, GRWD, WDR28: Glutamate-rich WD repeat-containing protein 1 0.060 0.060
Nle NLE1, HUSSY-07: Notchless protein homolog 1 0.060 0.060
NBEAL2 N/A 0.060 0.036
RNASEH1 RNASEH1, RNH1: Ribonuclease H1 0.055 0.055
ISG20 ISG20, HEM45: Interferon-stimulated gene 20 kDa protein 0.050 0.067
GNB1L GNB1L, GY2, FKSG1, KIAA1645, WDR14: Guanine nucleotide-binding protein subunit b 0.050 0.050
RAD54B RAD54B: DNA repair and recombination protein RAD54B 0.050 0.050
NUTF2 NUTF2, NTF2: Nuclear transport factor 2 0.047 0.059
ERCC3 ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit 0.044 0.044
AAAS AAAS, ADRACALA, GL003: Aladin 0.044 0.044
DDX56 DDX56, DDX21, NOH61: Probable ATP-dependent RNA helicase DDX56 0.044 0.060
CORO1C CORO1C, CRNN4: Coronin-1C 0.044 0.044
PARN PARN, DAN: Poly(A)-specific ribonuclease PARN 0.044 0.060
WDR26 WDR26, CDW2, PRO0852, MIP2: WD repeat-containing protein 26 0.044 0.044
WRN WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase 0.044 0.060
DDX58 DDX58: Probable ATP-dependent RNA helicase DDX58 0.044 0.044
DDX24 DDX24: ATP-dependent RNA helicase DDX24 0.044 0.044
TTF2 TTF2: Transcription termination factor 2 0.044 0.044
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.044 0.044
WDR37 N/A 0.044 0.044
WDR42A N/A 0.044 0.036
WDR48 WDR48, KIAA1449: WD repeat-containing protein 48 0.044 0.036
THRAP5 MED16, DRIP92, THRAP5: Mediator of RNA polymerase II transcription subunit 16 0.044 0.044
WDR45L N/A 0.044 0.036
SETDB1 SETDB1, KIAA0067: Histone-lysine N-methyltransferase SETDB1 0.044 0.036
REV3L REV3L, POLZ, REV3: DNA polymerase zeta catalytic subunit 0.041 0.041
WDR13 WDR13: WD repeat-containing protein 13 0.041 0.0308
CORO1B CORO1B: Coronin-1B 0.036 0.028
REXO2 REXO2, SFN, CGI-114, SMFN: Oligoribonuclease, mitochondrial precursor 0.036 0.044
PEX7 PEX7, PTS2R: Peroxisomal targeting signal 2 receptor 0.036 0.028
EIF4A2 EIF4A2, DDX2B, EIF4F: Eukaryotic initiation factor 4A-II 0.036 0.036
SMARCA3 HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor 0.036 0.044
WDHD1 WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1 0.036 0.044
BRIP1 BRIP1, BACH1, FANCJ: Fanconi anemia group J protein 0.036 0.028
DDX52 DDX52, ROK1, HUSSY-19: Probable ATP-dependent RNA helicase DDX52 0.036 0.044
EML4 EML4, C2orf2, EMAPL4: Echinoderm microtubule-associated protein-like 4 0.036 0.036
RECQL4 RECQL4, RECQ4: ATP-dependent DNA helicase Q4 0.036 0.036
BRWD2 BRWD2, WDR11, WDR15: Bromodomain and WD repeat-containing protein 2 0.0331 0.027
POLG POLG, MDP1, POLG1, POLGA: DNA polymerase subunit gamma-1 0.0331 0.055
LBR LBR: Lamin-B receptor 0.0331 0.027
ARPC1A ARPC1A, SOP2L: Actin-related protein 2/3 complex subunit 1A 0.028 0.044
KATNB1 KATNB1: Katanin p80 WD40-containing subunit B1 0.028 0.028
HNRPD N/A 0.027 0.027
DGUOK N/A 0.027 0.027
WDR17 N/A 0.027 0.027
WSB1 WSB1, SWIP1: WD repeat and SOCS box-containing protein 1 0.027 0.027
PHF1 N/A 0.027 0.027
KIF21A N/A 0.027 0.027
FBXW8 FBXW8, FBW6, FBW8, FBX29, FBXO29, FBXW6: F-box/WD repeat-containing protein 8 0.027 0.027
BRWD1 N/A 0.027 0.027
WDR53 N/A 0.027 0.027
WDR34 N/A 0.027 0.027
TLE6 TLE6: Transducin-like enhancer protein 6 0.027 0.027
TREX1 TREX1: Three prime repair exonuclease 1 0.027 0.027
WDR72 N/A 0.027 0.027
SMARCAD1 SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator 0.027 0.027
TAF5L TAF5L, PAF65B: TAF5-like RNA polymerase II p300/CBP-associated factor-associated 0.027 0.027
ERCC8 ERCC8, CKN1, CSA: DNA excision repair protein ERCC-8 0.027 0.027
DDX53 DDX53, CAGE: Probable ATP-dependent RNA helicase DDX53 0.027 0.027
NEDD1 N/A 0.027 0.027
WDR54 N/A 0.027 0.027
TLE3 TLE3, KIAA1547: Transducin-like enhancer protein 3 0.027 0.027
REXO1L1 REXO1L1, GOR: Exonuclease GOR 0.027 0.027
RFWD2 RFWD2, COP1, RNF200: E3 ubiquitin-protein ligase RFWD2 0.027 0.027
FLJ12671 ISG20L2, HSD38, HSD-38: Interferon-stimulated 20 kDa exonuclease-like 2 0.027 0.027
TDRD4 TDRD4: Tudor domain-containing protein 4 0.027 0.027
EXOSC8 EXOSC8, OIP2, RRP43: Exosome complex exonuclease RRP43 0.027 0.027
SNRPB N/A 0.0258 0.0258
0.572
Total Score 7.41E4