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Evidence of Interaction Between FIGF and FLT1

The interaction score between FIGF and FLT1 is 1.77E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between FIGF and FLT1 = 0.07

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.85E-3
Orthology
OrganismFIGF OrthologueFLT1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00028076 0.22 IPI00021396 1
  • Other
  • Immunoprecipitation
  • InVivo

Get References From PubMed
human IPI00028076 0.22 IPI00293565 0.322
  • Immunoprecipitation
  • InVitroBinding
  • Other
  • InVivo

Get References From PubMed
human IPI00028076 0.22 IPI00005722 0.081
fly Q9BLX1 0.22 Q7KTI7 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.58
Domains Domains present in FIGF and FLT1:
Domains in FIGFDomains in FLT1
IPR000072 Platelet-derived growth factor (PDGF)
IPR004153 CXCXC repeat
IPR000719 Protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR007110 Immunoglobulin-like
IPR001824 Receptor tyrosine kinase, class III
IPR009134 Vascular endothelial growth factor receptor, VEGFR
IPR009135 Vascular endothelial growth factor receptor 1, VEGFR1

The Chi square scores for co-occurrence of domains that are present in FIGF and FLT1 are listed below.

Domain 1Domain 2Chi Square
IPR000072 Platelet-derived growth factor (PDGF) IPR009134 Vascular endothelial growth factor receptor, VEGFR 75.9139
IPR000072 Platelet-derived growth factor (PDGF) IPR001824 Receptor tyrosine kinase, class III 63.1082
IPR000072 Platelet-derived growth factor (PDGF) IPR007110 Immunoglobulin-like 20.1534
IPR000072 Platelet-derived growth factor (PDGF) IPR008266 Tyrosine protein kinase, active site 2.08627
IPR000072 Platelet-derived growth factor (PDGF) IPR000719 Protein kinase 0.0118644

The background colour of the table refers to:

  • Blue Domain is only present in FIGF
  • Yellow Domain is only present in FLT1
  • Green Domain is present in both FIGF and FLT1

 0.165
Post-translational Modifications

Protein: FIGF

PTMResidueReference
Proteolytic Cleavage 88 PubMed, HPRD
Proteolytic Cleavage 99 PubMed, HPRD

Protein: FLT1

PTMResidueReference
Dephosphorylation 1213 PubMed, HPRD
Phosphorylation 794 PubMed, HPRD
Phosphorylation 1169 PubMed, HPRD
Phosphorylation 1213 PubMed, HPRD
Phosphorylation 1242 PubMed, HPRD
Phosphorylation 1327 PubMed, HPRD
Phosphorylation 1333 PubMed, HPRD
Phosphotyrosine 1213 PubMed, HPRD
Phosphotyrosine 1242 PubMed, HPRD
Phosphotyrosine 1327 PubMed, HPRD
Phosphotyrosine 1333 PubMed, HPRD
Localisation

Protein: FIGF

LocalisationReference
Secreted HPRD

Protein: FLT1

LocalisationReference
Plasma membrane HPRD
Secreted HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between FIGF and FLT1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between FIGF andFLT1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , FIGF has 498 interactors and FLT1 has 1443 interactors of which there are 434 common interactors.

Common InteractorName of Common InteractorScore for FIGF-Interactor (?)Score for FLT1-Interactor (?)
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 283.00 183.00
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 71.40 112.00
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 35.00 82.20
KIT KIT: Mast/stem cell growth factor receptor precursor 30.80 127.00
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 27.80 112.00
C1S C1S: Complement C1s subcomponent precursor 0.307 0.055
THBD THBD, THRM: Thrombomodulin precursor 0.307 0.191
LAMA2 LAMA2: Uncharacterized protein LAMA2 0.275 0.097
NOTCH3 NOTCH3: Neurogenic locus notch homolog protein 3 precursor 0.251 0.086
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.251 0.152
C1R C1R: Complement C1r subcomponent precursor 0.251 0.062
CEACAM6 CEACAM6, NCA: Carcinoembryonic antigen-related cell adhesion molecule 6 precurso 0.251 0.123
SLIT2 SLIT2, SLIL3: Slit homolog 2 protein precursor 0.225 0.069
TNC TNC, HXB: Tenascin precursor 0.225 0.111
PROS1 PROS1, PROS: Vitamin K-dependent protein S precursor 0.201 0.077
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.191 0.191
NOTCH4 N/A 0.191 0.086
IGFBP5 IGFBP5, IBP5: Insulin-like growth factor-binding protein 5 precursor 0.191 0.048
SHBG SHBG: Sex hormone-binding globulin precursor 0.191 0.077
IGFBP4 IGFBP4, IBP4: Insulin-like growth factor-binding protein 4 precursor 0.191 0.039
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.166 0.251
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.165 0.165
AZGP1 AZGP1, tcag7.638: Alpha-2-glycoprotein 1, zinc-binding 0.165 0.165
NULL A1BG: Alpha-1B-glycoprotein precursor 0.165 0.165
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.165 0.165
COL5A1 N/A 0.161 0.062
F7 F7: Coagulation factor VII precursor 0.156 0.075
BGLAP BGLAP: Osteocalcin precursor 0.152 0.028
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.152 0.152
LGALS3 LGALS3, MAC2: Galectin-3 0.152 0.049
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.152 0.109
IGFBP6 IGFBP6, IBP6: Insulin-like growth factor-binding protein 6 precursor 0.152 0.048
CFI CFI, IF: Complement factor I precursor 0.152 0.096
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.152 0.191
LRP1 LRP1, A2MR, APR: Prolow-density lipoprotein receptor-related protein 1 precursor 0.148 0.049
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.148 0.136
CNTN4 CNTN4: Contactin-4 precursor 0.148 0.148
CNTN1 CNTN1: Contactin-1 precursor 0.148 0.148
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.148 0.148
PLAT PLAT: Tissue-type plasminogen activator precursor 0.148 0.075
BMP1 N/A 0.148 0.075
SPOCK1 SPOCK1, SPOCK, TIC1, TICN1: Testican-1 precursor 0.148 0.148
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.137 0.056
FCN3 FCN3, FCNH, HAKA1: Ficolin-3 precursor 0.137 0.148
C7 C7: Complement component C7 precursor 0.136 0.056
C6 C6: Complement component C6 precursor 0.136 0.069
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.136 0.056
C9 C9: Complement component C9 precursor [Contains: Complement component C9a; Compl 0.136 0.086
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.136 0.097
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.136 0.111
PROZ PROZ: Vitamin K-dependent protein Z precursor 0.130 0.096
MFAP4 MFAP4: Microfibril-associated glycoprotein 4 precursor 0.129 0.111
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.126 0.191
C8A C8A: Complement component C8 alpha chain precursor 0.123 0.077
APCS APCS, PTX2: Serum amyloid P-component precursor 0.123 0.152
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.123 0.123
COL15A1 COL15A1: Collagen alpha-1(XV) chain precursor [Contains: Endostatin 0.123 0.062
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.123 0.109
F9 F9: Coagulation factor IX precursor 0.117 0.086
F10 F10: Coagulation factor X precursor 0.117 0.069
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.113 0.136
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.113 0.136
NEO1 NEO1, NGN: Neogenin precursor 0.113 0.136
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.113 0.171
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.111 0.111
C8B C8B: Complement component C8 beta chain precursor 0.111 0.086
ALK ALK: ALK tyrosine kinase receptor precursor 0.111 0.136
THBS1 THBS1, TSP, TSP1: Thrombospondin-1 precursor 0.111 0.056
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.109 0.165
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.109 0.165
KIR3DL1 N/A 0.109 0.165
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.109 0.165
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.109 0.165
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.109 0.165
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.109 0.165
EMR2 EMR2: EGF-like module-containing mucin-like hormone receptor-like 2 precursor 0.109 0.083
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.109 0.165
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.109 0.165
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.109 0.165
TMPRSS9 N/A 0.109 0.025
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.109 0.165
DLK1 DLK1, DLK: Delta-like protein precursor 0.109 0.083
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.109 0.088
F12 F12: Coagulation factor XII precursor 0.109 0.077
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.109 0.048
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.109 0.048
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.109 0.110
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.109 0.109
MUC2 MUC2, SMUC: Mucin-2 precursor 0.109 0.096
UMOD UMOD: Uromodulin precursor 0.109 0.062
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.109 0.088
HGFAC HGFAC: Hepatocyte growth factor activator precursor 0.109 0.077
PROC PROC: Vitamin K-dependent protein C precursor 0.103 0.069
MBL2 MBL2, MBL: Mannose-binding protein C precursor 0.102 0.171
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.100 0.191
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.100 0.191
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.100 0.191
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.100 0.251
PVR PVR, PVS: Poliovirus receptor precursor 0.100 0.251
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.100 0.152
GPA33 GPA33: Cell surface A33 antigen precursor 0.100 0.123
SELE SELE, ELAM1: E-selectin precursor 0.100 0.152
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.100 0.123
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.100 0.031
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.098 0.088
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.098 0.088
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.098 0.110
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.098 0.110
CSPG2 N/A 0.098 0.098
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.098 0.075
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.098 0.148
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.098 0.148
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.148
JAG2 JAG2: Jagged-2 precursor 0.098 0.075
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.098 0.148
BSG N/A 0.098 0.148
ATRN N/A 0.098 0.148
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.097 0.111
FAT2 FAT2, CDHF8, KIAA0811, MEGF1: Protocadherin Fat 2 precursor 0.097 0.069
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.097 0.136
TMPRSS2 TMPRSS2, PRSS10: Transmembrane protease, serine 2 precursor 0.090 0.056
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.090 0.136
SFTPA2 SFTPA2, PSAP, SFTP1, SFTPA: Pulmonary surfactant-associated protein A2 precursor 0.087 0.109
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.081 0.109
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.081 0.123
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.081 0.152
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.081 0.191
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.081 0.109
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.081 0.109
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.081 0.096
EGF EGF: Pro-epidermal growth factor precursor 0.081 0.152
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.081 0.110
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.081 0.109
GPR116 GPR116, KIAA0758: Probable G-protein coupled receptor 116 precursor 0.0782 0.059
SFTPD SFTPD, PSPD, SFTP4: Pulmonary surfactant-associated protein D precursor 0.078 0.097
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.073 0.171
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.073 0.136
MEP1B MEP1B: Meprin A subunit beta precursor 0.073 0.069
DCC DCC: Netrin receptor DCC precursor 0.073 0.136
ITGB3 ITGB3, GP3A: Integrin beta-3 precursor 0.073 0.171
LDLR LDLR: Low-density lipoprotein receptor precursor 0.073 0.049
ST14 ST14, PRSS14, SNC19, TADG15: Suppressor of tumorigenicity protein 14 0.073 0.056
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.073 0.171
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.0727 0.088
SORL1 SORL1: Sortilin-related receptor precursor 0.0727 0.110
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.0727 0.110
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.072 0.109
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.072 0.098
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.072 0.109
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.072 0.097
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.072 0.098
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.072 0.110
ITGB4 N/A 0.072 0.123
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.072 0.098
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.072 0.048
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.072 0.098
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.072 0.123
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.072 0.109
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.072 0.123
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.072 0.123
AREG AREG, SDGF: Amphiregulin precursor 0.072 0.055
CD7 CD7: T-cell antigen CD7 precursor 0.072 0.110
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.072 0.098
CLEC3B CLEC3B, TNA: Tetranectin precursor 0.070 0.123
A2M A2M, FWP007: Alpha-2-macroglobulin precursor 0.070 0.096
RPS6KA6 RPS6KA6, RSK4: Ribosomal protein S6 kinase alpha-6 0.069 0.054
PTGS1 PTGS1, COX1: Prostaglandin G/H synthase 1 precursor 0.0688 0.034
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.065 0.049
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.065 0.110
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.065 0.062
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.065 0.110
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.065 0.098
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.065 0.088
MEP1A MEP1A: Meprin A subunit alpha precursor 0.064 0.049
NOTCH2 NOTCH2: Neurogenic locus notch homolog protein 2 precursor 0.064 0.044
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.064 0.111
VWF VWF, F8VWF: von Willebrand factor precursor 0.063 0.136
ITGB7 ITGB7: Integrin beta-7 precursor 0.058 0.099
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.058 0.099
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.058 0.056
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.058 0.044
TTN N/A 0.057 0.113
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.056 0.165
EDN1 EDN1: Endothelin-1 precursor 0.052 0.026
C1QA C1QA: Complement C1q subcomponent subunit A precursor 0.052 0.026
IGHG3 N/A 0.051 0.051
NULL Ig kappa chain V region EV15 precursor 0.051 0.051
IGHM N/A 0.051 0.051
IGHD N/A 0.051 0.051
IGHA1 N/A 0.051 0.051
NULL Ig kappa chain V-I region CAR 0.051 0.051
NRCAM NRCAM, KIAA0343: Neuronal cell adhesion molecule precursor 0.051 0.051
FCGR2A FCGR2A, CD32, FCG2, FCGR2A1, IGFR2: Low affinity immunoglobulin gamma Fc region 0.051 0.051
HLA-A N/A 0.051 0.051
NULL Ig lambda chain V-II region NEI 0.051 0.051
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-68 alpha chain precursor 0.051 0.051
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.051 0.051
ITGB1 ITGB1, FNRB, MDF2, MSK12: Integrin beta-1 precursor 0.051 0.051
NULL Ig lambda chain V-I region EPS 0.051 0.051
LOC649805 Ig heavy chain V-II region COR 0.051 0.051
HLA-DRA HLA-DRA, HLA-DRA1: HLA class II histocompatibility antigen, DR alpha chain precu 0.051 0.051
C6orf25 G6B, C6orf25: Protein G6b precursor 0.051 0.051
NULL Ig heavy chain V-III region WEA 0.051 0.051
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-27 alpha chain precursor 0.051 0.051
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.051 0.051
NCAM1 N/A 0.051 0.051
IGHA2 IGHA2: Ig alpha-2 chain C region 0.051 0.051
PTPNS1 SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP: Tyrosine-protein phosphatase non-rec 0.051 0.051
NULL Ig heavy chain V-III region BUR 0.051 0.051
HLA-DRB2 HLA class II histocompatibility antigen, DW2.2/DR2.2 beta chain (Fragment) 0.051 0.051
HLA-DQB1 HLA-DQB1: HLA class II histocompatibility antigen, DQB1*0602 beta chain precurso 0.051 0.051
TRB@ TCRB: T-cell receptor beta chain V region CTL-L17 precursor 0.051 0.051
IGHG1 N/A 0.051 0.051
C6orf21 LY6G6F, C6orf21, G6F, LY6G6D, NG32: Lymphocyte antigen 6 complex locus protein G 0.051 0.051
FN1 FN1, FN: Fibronectin precursor 0.051 0.051
PAPPA PAPPA: Pappalysin-1 precursor 0.051 0.051
NULL TCRA: T-cell receptor alpha chain V region CTL-L17 precursor 0.051 0.051
IGHE IGHE: Ig epsilon chain C region 0.051 0.051
CEACAM5 CEACAM5, CEA: Carcinoembryonic antigen-related cell adhesion molecule 5 precurso 0.051 0.0416
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.051 0.043
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.051 0.171
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.050 0.148
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.049 0.044
CTLA4 CTLA4, CD152: Cytotoxic T-lymphocyte protein 4 precursor 0.047 0.047
FLT4 VEGFR3 long form 0.046 0.046
AGC1 AGC1, CSPG1, MSK16: Aggrecan core protein precursor 0.046 0.046
CNTN3 CNTN3, KIAA1496, PANG: Contactin-3 precursor 0.046 0.046
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.046 0.026
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.0453 0.171
MET MET: Hepatocyte growth factor receptor precursor 0.0453 0.191
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.044 0.083
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.044 0.148
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.044 0.047
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.044 0.075
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.044 0.148
LGALS3BP LGALS3BP, M2BP: Galectin-3-binding protein precursor 0.0425 0.152
LUM LUM, LDC: Lumican precursor 0.0425 0.077
CCL14 CCL14, NCC2, SCYA14: Small-inducible cytokine A14 precursor 0.0425 0.077
COL16A1 COL16A1: Collagen alpha-1(XVI) chain precursor 0.0416 0.062
LGALS1 LGALS1: Galectin-1 0.0416 0.049
ISLR ISLR, UNQ189: ISLR precursor 0.041 0.0308
DAPK2 DAPK2: Death-associated protein kinase 2 0.039 0.037
MMP2 MMP2, CLG4A: 72 kDa type IV collagenase precursor 0.038 0.097
SPON1 SPON1, KIAA0762, VSGP: Spondin-1 precursor 0.038 0.054
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.036 0.171
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.036 0.097
LAMB2 LAMB2, LAMS: Laminin subunit beta-2 precursor 0.036 0.028
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.035 0.067
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.035 0.041
TNN TNN: Tenascin-N precursor 0.034 0.042
PECAM1 PECAM1: Platelet endothelial cell adhesion molecule precursor 0.0338 0.030
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.034 0.04
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.034 0.049
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.034 0.044
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.034 0.049
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.034 0.04
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.034 0.036
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.034 0.04
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.034 0.04
MAPKAPK5 N/A 0.034 0.04
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.034 0.04
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.034 0.04
MAPK15 N/A 0.034 0.049
CDC2 CDC2: Cell division control protein 2 homolog 0.034 0.044
B2M B2M, CDABP0092, HDCMA22P: Beta-2-microglobulin precursor [Contains: Beta-2-micro 0.033 0.030
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.033 0.191
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.033 0.049
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.033 0.136
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.033 0.054
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.033 0.056
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.033 0.097
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.032 0.031
F8 F8, F8C: Coagulation factor VIII precursor 0.032 0.251
CXCL10 CXCL10, INP10, SCYB10: Small-inducible cytokine B10 precursor 0.032 0.077
RLN2 RLN2: Prorelaxin H2 precursor [Contains: Relaxin B chain; Relaxin A chain] 0.032 0.096
BGN BGN: Biglycan precursor 0.032 0.096
PZP PZP: Pregnancy zone protein precursor 0.032 0.127
CCL13 CCL13, MCP4, NCC1, SCYA13: Small-inducible cytokine A13 precursor 0.032 0.062
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.032 0.062
CCL1 CCL1, SCYA1: Small-inducible cytokine A1 precursor 0.032 0.096
PCOLCE PCOLCE, PCPE1: Procollagen C-endopeptidase enhancer 1 precursor 0.032 0.123
SERPING1 SERPING1, C1IN, C1NH: Plasma protease C1 inhibitor precursor 0.032 0.026
C4BPA C4BPA, C4BP: C4b-binding protein alpha chain precursor 0.032 0.077
CFH CFH, HF, HF1, HF2: Complement factor H precursor 0.032 0.077
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.031 1.13
SEMA7A SEMA7A, CD108, SEMAL: Semaphorin-7A precursor 0.0308 0.0308
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.030 0.098
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.030 0.098
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.030 0.098
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.030 0.030
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.030 0.036
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.030 0.030
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.030 0.036
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.030 0.044
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.030 0.036
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.030 0.036
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.030 0.044
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.030 0.098
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.030 0.098
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.030 0.036
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.030 0.036
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.030 0.878
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.030 1.01E3
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.030 0.036
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.030 0.171
INSR INSR: Insulin receptor precursor 0.029 0.111
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.029 0.111
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.029 0.136
PRG4 PRG4, MSF, SZP: Proteoglycan-4 precursor 0.029 0.069
SPARC SPARC, ON: SPARC precursor 0.029 0.111
EFNB2 EFNB2, EPLG5, HTKL, LERK5: Ephrin-B2 precursor 0.029 0.136
IFNG IFNG: Interferon gamma precursor 0.028 0.165
FN1 N/A 0.028 0.165
NOG NOG: Noggin precursor 0.028 0.028
CCL15 CCL15, MIP5, NCC3, SCYA15: Small-inducible cytokine A15 precursor 0.028 0.083
C1QTNF4 C1QTNF4, CTRP4: Complement C1q tumor necrosis factor-related protein 4 precursor 0.028 0.028
MMRN2 MMRN2, EMILIN3: Multimerin-2 precursor 0.028 0.028
DSP DSP: Desmoplakin 0.028 0.028
ZP3 ZP3, ZP3A, ZP3B, ZPC: Zona pellucida sperm-binding protein 3 precursor 0.028 0.028
GUCA2A GUCA2A, GUCA2: Guanylin precursor 0.028 0.028
TFPI TFPI, LACI, TFPI1: Tissue factor pathway inhibitor precursor 0.028 0.028
PTHLH N/A 0.028 0.028
PCGF6 N/A 0.028 0.028
RAD18 RAD18, RNF73: E3 ubiquitin-protein ligase RAD18 0.028 0.028
CCL26 CCL26, SCYA26, UNQ216/PRO242: Small-inducible cytokine A26 precursor 0.028 0.083
PLTP PLTP: Phospholipid transfer protein precursor 0.028 0.025
IRF2BP2 IRF2BP2, RP4-781K5.1-002: Interferon regulatory factor 2-binding protein 2. 0.028 0.028
DCN DCN: Decorin precursor 0.028 0.083
ACCN3 ACCN3, ASIC3, SLNAC1, TNAC1: Amiloride-sensitive cation channel 3 0.028 0.028
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.028 0.165
F11 F11: Coagulation factor XI precursor 0.028 0.028
CSF3 CSF3, GCSF: Granulocyte colony-stimulating factor precursor 0.028 0.165
RTN4R RTN4R, NOGOR, UNQ330/PRO526: Reticulon-4 receptor precursor 0.028 0.083
GRN GRN: Granulins precursor 0.028 0.025
PLAU Plasminogen activator, urokinase 0.028 0.028
GRP Gastrin-releasing peptide 0.028 0.028
C1QC C1QC, C1QG: Complement C1q subcomponent subunit C precursor 0.028 0.028
ECM1 ECM1: Extracellular matrix protein 1 precursor 0.028 0.083
CST4 CST4: Cystatin-S precursor 0.028 0.028
CFHR1 CFHR1, CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, HFL1, HFL2: Complement factor H-relate 0.028 0.083
IL4 IL4: Interleukin-4 precursor 0.028 0.165
C4A C4A: Complement C4-A precursor 0.028 0.165
PCSK6 N/A 0.028 0.028
CGN N/A 0.028 0.083
LRG1 LRG1, LRG: Leucine-rich alpha-2-glycoprotein precursor 0.028 0.083
LNX1 N/A 0.028 0.028
CD46 N/A 0.028 0.083
OPTC OPTC, OPT: Opticin precursor 0.028 0.083
KITLG KITLG, MGF, SCF: Kit ligand precursor 0.028 0.165
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.028 0.083
LECT1 LECT1, CHMI: Chondromodulin-1 precursor 0.028 0.028
CCL14 N/A 0.028 0.028
CSF1 CSF1: Macrophage colony-stimulating factor 1 precursor 0.028 0.028
TUBGCP6 TUBGCP6, GCP6, KIAA1669: Gamma-tubulin complex component 6 0.028 0.028
LOC643930 CCL3L1, D17S1718, G0S19-2, SCYA3L1: Small-inducible cytokine A3-like 1 precursor 0.028 0.083
GHRL GHRL, MTLRP, UNQ524/PRO1066: Appetite-regulating hormone precursor 0.028 0.028
THPO THPO, MGDF: Thrombopoietin precursor 0.028 0.165
MYO3A MYO3A: Myosin IIIA 0.028 0.041
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.028 0.113
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.028 0.067
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.028 0.033
ROBO1 N/A 0.027 0.027
SIGLEC6 N/A 0.027 0.027
PSG6 PSG5: Pregnancy-specific beta-1-glycoprotein 5 precursor 0.027 0.027
NTN4 NTN4: Netrin-4 precursor 0.027 0.027
FCAR FCAR, CD89: Immunoglobulin alpha Fc receptor precursor 0.027 0.027
LILRB3 LILRB3, ILT5, LIR3: Leukocyte immunoglobulin-like receptor subfamily B member 3 0.027 0.027
CEACAM7 CEACAM7, CGM2: Carcinoembryonic antigen-related cell adhesion molecule 7 precurs 0.027 0.027
CLEC14A CLEC14A, C14orf27, UNQ236/PRO269, EGFR5: C-type lectin domain family 14 member A 0.027 0.027
FSTL5 FSTL5, KIAA1263: Follistatin-related protein 5 precursor 0.027 0.027
CRLF1 CRLF1, ZCYTOR5, UNQ288/PRO327: Cytokine receptor-like factor 1 precursor 0.027 0.027
PSG4 PSG4, CGM4, PSG9: Pregnancy-specific beta-1-glycoprotein 4 precursor 0.027 0.027
HLA-DRB5 N/A 0.027 0.027
CSPG3 CSPG3, NCAN, NEUR: Neurocan core protein precursor 0.027 0.027
PSG6 PSG6, CGM3, PSGGB: Pregnancy-specific beta-1-glycoprotein 6 precursor 0.027 0.027
HFE HFE, HLAH: Hereditary hemochromatosis protein precursor 0.027 0.027
CILP2 CILP2: Cartilage intermediate layer protein 2 precursor 0.027 0.027
C20orf102 N/A 0.027 0.027
HLA-DRB5 N/A 0.027 0.027
MGC33530 N/A 0.027 0.027
HLA-DQA1 HLA-DQA2, HLA-DXA: HLA class II histocompatibility antigen, DQ(6) alpha chain pr 0.027 0.027
PSG7 PSG7: Pregnancy-specific beta-1-glycoprotein 7 precursor 0.027 0.027
PTPRT PTPRT, KIAA0283: Receptor-type tyrosine-protein phosphatase T precursor 0.027 0.027
MADCAM1 MADCAM1: Mucosal addressin cell adhesion molecule 1 precursor 0.027 0.027
NEGR1 NEGR1, UNQ2433/PRO4993: Neuronal growth regulator 1 precursor 0.027 0.027
NTNG2 N/A 0.027 0.027
SIRPD N/A 0.027 0.027
PSG11 PSG11, PSG13, PSG14: Pregnancy-specific beta-1-glycoprotein 11 precursor 0.027 0.027
IGLL1 IGLL1, IGL1: Immunoglobulin lambda-like polypeptide 1 precursor 0.027 0.027
SIGLEC11 N/A 0.027 0.027
CDH5 CDH5: Cadherin-5 precursor 0.027 0.048
LILRB1 N/A 0.026 0.098
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.026 0.0308
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.026 0.044
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.026 0.028
APOE APOE: Apolipoprotein E precursor 0.026 0.026
FSTL1 FSTL1, FRP: Follistatin-related protein 1 precursor 0.026 0.109
IL3 IL3: Interleukin-3 precursor 0.026 0.152
EPO EPO: Erythropoietin precursor 0.026 0.152
CXCL9 CXCL9, CMK, MIG, SCYB9: Small-inducible cytokine B9 precursor 0.026 0.077
IL15RA IL15RA: Interleukin-15 receptor alpha chain precursor 0.026 0.049
C2 C2: Complement C2 precursor 0.026 0.096
SEPP1 SEPP1, SELP: Selenoprotein P precursor 0.026 0.032
NDP NDP: Norrin precursor 0.026 0.191
C3 0.026 0.123
SLC14A2 SLC14A2, HUT2, UT2: Urea transporter, kidney 0.026 0.026
TFF2 TFF2, SML1: Trefoil factor 2 precursor 0.026 0.032
DSPG3 EPYC, DSPG3, PGLB: Epiphycan precursor 0.026 0.096
ASPN ASPN: ASPN protein 0.026 0.077
IL18 IL18, IGIF, IL1F4: Interleukin-18 precursor 0.026 0.098
CXCL11 CXCL11, ITAC, SCYB11, SCYB9B: Small-inducible cytokine B11 precursor 0.026 0.077
WNT2B WNT2B, WNT13: Protein Wnt-2b precursor 0.026 0.043
IFNA14 IFNA14: Interferon alpha-14 precursor 0.026 0.032
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.025 0.644
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.025 0.037
BMX N/A 0.025 0.902
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.025 0.081
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.025 0.0453
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.025 0.051
FGG FGG, PRO2061: Fibrinogen gamma chain precursor 0.025 0.148
HGF HGF, HPTA: Hepatocyte growth factor precursor 0.025 0.025
LOC641705 AMY2A: Pancreatic alpha-amylase precursor 0.025 0.025
CPB2 CPB2: Carboxypeptidase B2 precursor 0.025 0.025
VNN1 VNN1: Pantetheinase precursor 0.025 0.025
CA11 CA11, CARP2, UNQ211/PRO237: Carbonic anhydrase-related protein 11 precursor 0.025 0.025
SCRIB N/A 0.025 0.025
UNC5D N/A 0.025 0.025
ANGPTL6 AGF, UNQ152/PRO178, ANGPTL6, ARP5: Angiopoietin-related protein 6 precursor 0.025 0.148
COL12A1 COL12A1, COL12A1L: Collagen alpha-1(XII) chain precursor 0.025 0.148
ATRX ATRX, RAD54L, XH2: Transcriptional regulator ATRX 0.025 0.025
KLK3 KLK3, APS: Prostate-specific antigen precursor 0.025 0.025
COL18A1 N/A 0.025 0.025
LOC653509 SFTPA1, PSAP, SFTP1, SFTPA: Pulmonary surfactant-associated protein A1 precursor 0.025 0.148
ITM2C ITM2C, BRI3, hucep-14, NPD018, PSEC0047: Integral membrane protein 2C 0.025 0.025
0.347
Total Score 1.77E4