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Evidence of Interaction Between TGFBR2 and PDLIM5

The interaction score between TGFBR2 and PDLIM5 is 0.250.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between TGFBR2 and PDLIM5 = 0.24

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

2.88E-3
Orthology
OrganismTGFBR2 OrthologuePDLIM5 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm Q8ITX8 0.091 Q17878 0.06

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.23E-3
Domains Domains present in TGFBR2 and PDLIM5:
Domains in TGFBR2Domains in PDLIM5
IPR000719 Protein kinase
IPR000472 TGF-beta receptor/activin receptor, type I/II
IPR008271 Serine/threonine protein kinase, active site
IPR000333 Activin type II receptor
IPR001781 Zn-binding protein, LIM
IPR001478 PDZ/DHR/GLGF domain

The Chi square scores for co-occurrence of domains that are present in TGFBR2 and PDLIM5 are listed below.

Domain 1Domain 2Chi Square
IPR000719 Protein kinase IPR001478 PDZ/DHR/GLGF domain 8.68759
IPR008271 Serine/threonine protein kinase, active site IPR001478 PDZ/DHR/GLGF domain 2.78154
IPR008271 Serine/threonine protein kinase, active site IPR001781 Zn-binding protein, LIM 0.471046
IPR000333 Activin type II receptor IPR001478 PDZ/DHR/GLGF domain 0.229948
IPR000472 TGF-beta receptor/activin receptor, type I/II IPR001478 PDZ/DHR/GLGF domain 0.0693969
IPR000719 Protein kinase IPR001781 Zn-binding protein, LIM 0.0307996

The background colour of the table refers to:

  • Blue Domain is only present in TGFBR2
  • Yellow Domain is only present in PDLIM5
  • Green Domain is present in both TGFBR2 and PDLIM5

2.65E-3
Post-translational Modifications

Protein: TGFBR2

PTMResidueReference
Phosphorylation 238 PubMed, HPRD
Phosphorylation 250 PubMed, HPRD
Phosphorylation 253 PubMed, HPRD
Phosphorylation 254 PubMed, HPRD
Phosphorylation 284 PubMed, HPRD
Phosphorylation 361 PubMed, HPRD
Phosphorylation 434 PubMed, HPRD
Phosphorylation 441 PubMed, HPRD
Phosphorylation 449 PubMed, HPRD
Phosphorylation 576 PubMed, HPRD
Phosphorylation 578 PubMed, HPRD

Protein: PDLIM5

PTMResidueReference
N-acetylserine 1 HPRD
Localisation

Protein: TGFBR2

LocalisationReference
Plasma membrane HPRD
Secreted HPRD
Cytoplasm HPRD

Protein: PDLIM5

LocalisationReference
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between TGFBR2 and PDLIM5 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between TGFBR2 andPDLIM5. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , TGFBR2 has 843 interactors and PDLIM5 has 206 interactors of which there are 52 common interactors.

Common InteractorName of Common InteractorScore for TGFBR2-Interactor (?)Score for PDLIM5-Interactor (?)
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.166 0.037
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.148 0.037
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.148 0.040
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.126 0.046
VASP VASP: Vasodilator-stimulated phosphoprotein 0.126 0.0416
STAT6 STAT6: Signal transducer and activator of transcription 6 0.113 2.04
RRAS RRAS: Ras-related protein R-Ras precursor 0.113 0.027
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.113 0.819
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.113 0.037
VAV1 VAV1, VAV: Proto-oncogene vav 0.113 0.033
MAP2K5 N/A 0.109 0.056
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.100 0.085
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.100 0.0416
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.098 0.050
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.098 0.050
STAT3 0.098 2.21
STAT4 STAT4: Signal transducer and activator of transcription 4 0.094 1.02
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.094 0.650
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.090 27.70
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.088 8.08
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.083 0.044
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.083 0.044
RRAD RRAD, RAD: GTP-binding protein RAD 0.081 0.030
CD59 CD59, MIC11, MIN1, MIN2, MIN3, MSK21: CD59 glycoprotein precursor 0.080 0.027
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.075 0.040
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.067 0.046
MCF2 MCF2, DBL: Proto-oncogene DBL 0.065 0.033
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.065 0.0296
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.064 0.046
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.064 0.0296
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.062 1.55
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.058 0.0296
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.055 0.029
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.051 0.058
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.051 0.037
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.051 0.126
CNN2 CNN2: Calponin-2 0.049 0.056
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.046 0.030
LPXN LPXN, LDLP: Leupaxin 0.041 1.65
PRKD3 PRKD3, EPK2, PRKCN: Serine/threonine-protein kinase D3 0.036 3.25
HSP90AA1 Hsp89-alpha-delta-N 0.033 0.246
SIPA1L1 SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein 0.033 1.45
CNN3 CNN3: Calponin-3 0.032 0.085
MICAL-L1 MICALL1, KIAA1668, MIRAB13: MICAL-like protein 1 0.030 0.085
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.029 4.15
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.029 4.60
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.029 6.45
GPR126 DREG: Developmentally regulated G-protein-coupled receptor alpha 1 0.028 0.044
EMR2 EMR2: EGF-like module-containing mucin-like hormone receptor-like 2 precursor 0.028 0.044
LPP LPP: Lipoma-preferred partner 0.0263 0.041
FHL1 FHL1, SLIM1: Four and a half LIM domains protein 1 0.0263 0.030
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.025 0.040
0.228
Total Score 0.250