PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between CSE1L and RAN

The interaction score between CSE1L and RAN is 2.02E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between CSE1L and RAN = 0.89

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

0.027

Orthology

Organism	CSE1L Orthologue		RAN Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
bakers yeast	YGL238W	1	YLR293C	1	Y2H AffinityChromatography InVitroBinding AffinityCaptureWestern ReconstitutedComplex Get References From PubMed
bakers yeast	YGL238W	1	YOR185C	0.86
worm	Q965V4	1	O17915	1
fly	Q9XZU1	1	Q9VZ23	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.593

Domains

Domains present in CSE1L and RAN:

Domains in CSE1L

Domains in RAN

IPR001494	Importin-beta, N-terminal
IPR005043	CAS/CSE, C-terminal
IPR011989	ARM-like.

IPR001806	Ras GTPase superfamily
IPR002041	GTP-binding nuclear protein Ran
IPR005225	Small GTP-binding protein domain
IPR013753	Ras

The Chi square scores for co-occurrence of domains that are present in CSE1L and RAN are listed below.

Domain 1		Domain 2		Chi Square
IPR011989	ARM-like.	IPR001806	Ras GTPase superfamily	0.973757
IPR011989	ARM-like.	IPR005225	Small GTP-binding protein domain	0.895278
IPR011989	ARM-like.	IPR013753	Ras	0.298074

The background colour of the table refers to:

Blue Domain is only present in CSE1L
Yellow Domain is only present in RAN
Green Domain is present in both CSE1L and RAN

0.056

Post-translational Modifications

Protein: CSE1L

PTM	Residue	Reference
N-acetylmethionine	1	HPRD

Protein: RAN

PTM	Residue	Reference
Phosphotyrosine	147	HPRD

Localisation

Protein: CSE1L

Localisation	Reference
Nucleus	HPRD
Secreted	HPRD
Cytoplasm	HPRD

Protein: RAN

Localisation	Reference
Nucleus	HPRD
Mitochondrion	HPRD
Cytoplasm	HPRD

Transitive Score

The common interactors between CSE1L and RAN that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between CSE1L andRAN. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , CSE1L has 413 interactors and RAN has 1090 interactors of which there are 226 common interactors.

Common Interactor	Name of Common Interactor	Score for CSE1L-Interactor (?)	Score for RAN-Interactor (?)
KPNA6	N/A	9.63	4.88
KPNA5	KPNA5: Importin subunit alpha-6	7.31	1.45
ARFGEF2	ARFGEF2, ARFGEP2, BIG2: Brefeldin A-inhibited guanine nucleotide-exchange protei	6.79	0.275
KPNA1	KPNA1, RCH2: Importin subunit alpha-1	3.96	0.982
LAMR1	RPSA, LAMBR, LAMR1: 40S ribosomal protein SA	3.61	23.90
TUBB	TUBB, TUBB5, OK/SW-cl.56: Tubulin beta chain	0.823	0.066
KPNB1	KPNB1, NTF97: Importin subunit beta-1	0.549	145.00
PPIA	PPIA, CYPA: Peptidyl-prolyl cis-trans isomerase A	0.461	0.129
SSB	SSB: Lupus La protein	0.435	0.141
ARFGEF1	ARFGEF1, ARFGEP1, BIG1: Brefeldin A-inhibited guanine nucleotide-exchange protei	0.375	0.028
CTNNB1	CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1	0.372	0.188
STIP1	STIP1: Stress-induced-phosphoprotein 1	0.287	0.430
CAD	CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase	0.276	0.276
BUB1B	BUB1B, BUBR1, MAD3L: Mitotic checkpoint serine/threonine-protein kinase BUB1 bet	0.263	0.053
G3BP	G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1	0.257	0.129
KPNA2	KPNA2, RCH1, SRP1: Importin subunit alpha-2	0.257	0.045
RBMX	RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G	0.228	0.157
MATR3	MATR3, KIAA0723: Matrin-3	0.228	0.0446
SNRPB2	SNRPB2: U2 small nuclear ribonucleoprotein B''	0.204	0.141
EIF3S9	EIF3S9: Eukaryotic translation initiation factor 3 subunit 9	0.204	0.141
PABPC4	PABPC4, APP1, PABP4: Polyadenylate-binding protein 4	0.204	0.141
SFRS1	SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1	0.204	0.066
TIAL1	TIAL1: Nucleolysin TIAR	0.204	0.066
SNRPA	SNRPA: U1 small nuclear ribonucleoprotein A	0.204	0.033
HNRPF	HNRPF: Heterogeneous nuclear ribonucleoprotein F	0.204	0.066
SYNCRIP	SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q	0.204	0.066
ELAVL1	ELAVL1, HUR: ELAV-like protein 1	0.204	0.141
GTPBP4	GTPBP4, CRFG, NOG1: Nucleolar GTP-binding protein 1	0.179	0.054
PRKDC	PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit	0.179	0.917
EIF5AP1	EIF5A: Eukaryotic translation initiation factor 5A-1	0.174	0.025
MAPRE1	MAPRE1: Microtubule-associated protein RP/EB family member 1	0.156	0.385
TCP1	CCT1, CCTA, TCP1: T-complex protein 1 subunit alpha	0.144	0.144
CCT2	CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta	0.144	0.048
EIF2S1	EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1	0.141	0.141
PCNA	PCNA: Proliferating cell nuclear antigen	0.141	0.066
EEF2	EEF2, EF2: Elongation factor 2	0.139	0.063
RNPS1	RNPS1, LDC2: RNA-binding protein with serine-rich domain 1	0.138	0.074
RBM14	RBM14, SIP: RNA-binding protein 14	0.138	0.0446
FANCG	FANCG, XRCC9: Fanconi anemia group G protein	0.137	0.042
CDK2	CDK2: Cell division protein kinase 2	0.129	0.241
PPID	PPID, CYP40, CYPD: 40 kDa peptidyl-prolyl cis-trans isomerase	0.126	0.045
SFRS4	SFRS4, SRP75: Splicing factor, arginine/serine-rich 4	0.123	0.040
SFRS10	SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10	0.123	0.040
SFRS2	SFRS2: Splicing factor, arginine/serine-rich 2	0.123	0.066
PABPN1	PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2	0.123	0.040
NUTF2	NUTF2, NTF2: Nuclear transport factor 2	0.123	1.82
KPNA3	KPNA3: Importin subunit alpha-3	0.123	0.038
RANBP1	RANBP1: Ran-specific GTPase-activating protein	0.123	69.60
NUP50	NUP50, NPAP60L, PRO1146: Nucleoporin 50 kDa	0.123	0.123
DKFZP686O1684	N/A	0.119	0.191
RPSAP15	LAMR1P15: Laminin receptor-like protein LAMRL5	0.119	0.191
NULL	RPSA: Ribosomal protein SA	0.119	0.191
LOC388122		0.119	0.191
NULL	N/A	0.119	0.191
LOC389672	hypothetical protein LOC389672	0.119	0.191
VCP	VCP: Transitional endoplasmic reticulum ATPase	0.118	0.078
SSRP1	SSRP1, FACT80: FACT complex subunit SSRP1	0.112	0.141
CDC20	CDC20: Cell division cycle protein 20 homolog	0.112	0.141
RDBP	RDBP, NELFE, RD: Negative elongation factor E	0.111	0.0446
HNRPA0	HNRPA0: Heterogeneous nuclear ribonucleoprotein A0	0.111	0.036
VDP	DKFZp451D234: Putative uncharacterized protein DKFZp451D234	0.100	0.233
RBM7		0.100	0.040
SAFB	SAFB, HAP, HET, SAFB1: Scaffold attachment factor B	0.100	0.032
PABPC1	PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1	0.100	0.040
SF3B4	SF3B4, SAP49: Splicing factor 3B subunit 4	0.100	0.040
RBM15	RBM15, OTT: Putative RNA-binding protein 15	0.100	0.040
WBSCR1	EIF4H, KIAA0038, WBSCR1, WSCR1: Eukaryotic translation initiation factor 4H	0.100	0.066
FKBP4	FKBP4: FK506-binding protein 4	0.093	0.139
SGTA	SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A	0.093	0.139
RANBP2	RANBP2, NUP358: E3 SUMO-protein ligase RanBP2	0.093	0.225
MSN	MSN: Moesin	0.086	0.225
AKT1	AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase	0.086	0.225
VIL2	N/A	0.086	0.225
RBM3	RBM3, RNPL: Putative RNA-binding protein 3	0.082	0.036
CSTF3	CSTF3: Cleavage stimulation factor 77 kDa subunit	0.081	0.081
CAND1	CAND1, KIAA0829, TIP120, TIP120A: Cullin-associated NEDD8-dissociated protein 1	0.081	0.081
RANBP5		0.081	69.60
LRPPRC		0.081	0.081
CNAP1	NCAPD2, CAPD2, CNAP1, KIAA0159: Condensin complex subunit 1	0.081	0.081
RAP1B	RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor	0.076	0.038
FKBP5	FKBP5, AIG6, FKBP51: FK506-binding protein 5	0.076	0.114
UTX	UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein	0.076	0.139
XPO1	XPO1, CRM1: Exportin-1	0.075	202.00
EIF5B	EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B	0.075	0.129
CDC23	CDC23: Cell division cycle protein 23 homolog	0.075	0.241
PSMD11	PSMD11: 26S proteasome non-ATPase regulatory subunit 11	0.075	0.048
PSMC1	PSMC1: 26S protease regulatory subunit 4	0.075	0.129
PSMD1	PSMD1: 26S proteasome non-ATPase regulatory subunit 1	0.075	0.385
SRP72	CaM kinase II isoform	0.074	0.038
ST13	ST13, FAM10A1, HIP, SNC6: Hsc70-interacting protein	0.074	0.038
NR3C1	NR3C1, GRL: Glucocorticoid receptor	0.074	0.027
LOC387867	Uncharacterized protein ENSP00000354495	0.071	0.114
WAS	WAS, IMD2: Wiskott-Aldrich syndrome protein	0.069	0.171
PPP2R5A	PPP2R5A: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha	0.069	0.086
RBM6	RBM6, DEF3: RNA-binding protein 6	0.067	0.027
DSG2	DSG2: Desmoglein-2 precursor	0.067	0.027
TP53	TP53, P53: Cellular tumor antigen p53	0.066	0.066
H2AFX	H2AFX, H2AX: Histone H2A.x	0.066	0.066
TRIP13	TRIP13: Thyroid receptor-interacting protein 13	0.065	0.129
ATAD2	ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2	0.065	0.078
MAP2K2	MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki	0.063	0.146
PSTPIP1	PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1	0.062	0.077
GAB1	GAB1: GRB2-associated-binding protein 1	0.062	0.109
KIF23	N/A	0.059	0.0446
SMARCA4	SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4	0.059	0.074
XRCC6	XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1	0.059	0.074
E2F1	E2F1, RBBP3: Transcription factor E2F1	0.059	0.0446
MKI67	MKI67: Antigen KI-67	0.059	0.074
JUP	JUP, CTNNG, DP3: Junction plakoglobin	0.058	0.114
AIP	AIP, XAP2: AH receptor-interacting protein	0.058	0.114
SPAG6	SPAG6, PF16: Sperm-associated antigen 6	0.056	0.083
PKP4	PKP4: Plakophilin-4	0.056	0.083
IRS1	IRS1: Insulin receptor substrate 1	0.055	0.109
HPRT1	HPRT1, HPRT: Hypoxanthine-guanine phosphoribosyltransferase	0.054	0.025
ESPL1	N/A	0.054	0.307
CHAF1B	CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B	0.0525	0.066
CDC6	CDC6, CDC18L: Cell division control protein 6 homolog	0.0525	0.066
RBBP4	RBBP4, RBAP48: Histone-binding protein RBBP4	0.0525	0.033
HMGB2	HMGB2, HMG2: High mobility group protein B2	0.0525	0.066
CSTF1	CSTF1: Cleavage stimulation factor 50 kDa subunit	0.0525	0.040
CSPG6	SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3	0.0525	0.066
SMC1L1	SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos	0.0525	0.066
TRAF2	TRAF2, TRAP3: TNF receptor-associated factor 2	0.052	0.052
AP2B1	AP2B1: Uncharacterized protein AP2B1	0.051	0.191
RANGAP1	RANGAP1, SD: Ran GTPase-activating protein 1	0.051	0.087
G3BP2	G3BP2, KIAA0660: Ras GTPase-activating protein-binding protein 2	0.050	0.025
ARL5A	ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A	0.050	0.025
CPNE1	RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12	0.050	0.025
RAB5B	RAB5B: Ras-related protein Rab-5B	0.050	0.025
RANBP3	N/A	0.050	0.050
CCT4	CCT4, CCTD, SRB: T-complex protein 1 subunit delta	0.048	0.144
PSMA3	PSMA3, PSC8: Proteasome subunit alpha type-3	0.048	0.276
HSPD1		0.048	0.276
PSMA2	PSMA2, PSC3: Proteasome subunit alpha type-2	0.048	0.276
EPRS	EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes:	0.048	0.276
CCT6A	CCT6A, CCT6, CCTZ: T-complex protein 1 subunit zeta	0.048	0.048
CTPS	CTPS: CTP synthase 1	0.048	0.276
MLH1	MLH1, COCA2: DNA mismatch repair protein Mlh1	0.048	0.048
RACGAP1	RACGAP1, KIAA1478, MGCRACGAP: Rac GTPase-activating protein 1	0.048	0.129
RAF1	RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase	0.046	0.275
TYK2	TYK2: Non-receptor tyrosine-protein kinase TYK2	0.046	0.046
FKBP8	DKFZp686M22160: Putative uncharacterized protein DKFZp686M22160 (Fragment)	0.046	0.069
ANAPC5	ANAPC5, APC5: Anaphase-promoting complex subunit 5	0.045	0.241
IEF-SSP-9502	PWP1: Periodic tryptophan protein 1 homolog	0.045	0.129
MAP3K5	MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5	0.0425	0.060
PKP3	PKP3: Plakophilin-3	0.0416	0.062
IPO9	IPO9, IMP9, HSPC273, KIAA1192, RANBP9: Importin-9	0.041	0.140
BRCA2	BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein	0.041	0.052
HD	HD, IT15: Huntingtin	0.041	0.210
MNAR	PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1	0.041	0.210
IPO7	IPO7: Uncharacterized protein IPO7	0.041	0.416
HNRPH3	HNRPH3: Heterogeneous nuclear ribonucleoprotein H3	0.040	0.030
EWSR1	EWSR1, EWS: RNA-binding protein EWS	0.040	0.030
ACTG1	ACTB: Actin, cytoplasmic 1	0.038	3.97
STAT5A	STAT5A, STAT5: Signal transducer and activator of transcription 5A	0.038	0.038
SCC-112	N/A	0.038	0.038
SPAG1	SPAG1: Sperm-associated antigen 1	0.037	0.049
MAPRE2	MAPRE2, RP1: Microtubule-associated protein RP/EB family member 2	0.037	0.069
TOP2A	TOP2A, TOP2: DNA topoisomerase 2-alpha	0.037	0.074
PTEN	PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du	0.037	0.063
NRAS	NRAS, HRAS1: GTPase NRas precursor	0.037	0.078
ATR	ATR, FRP1: Serine/threonine-protein kinase ATR	0.037	0.188
PIP5K3	PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase	0.037	0.372
NBN	NBN, NBS, NBS1, P95: Nibrin	0.035	0.340
RABEP1	RABEP1, RABPT5, RABPT5A: Rab GTPase-binding effector protein 1	0.035	0.035
MCM3	MCM3: DNA replication licensing factor MCM3	0.033	0.141
MAD2L1	MAD2L1, MAD2: Mitotic spindle assembly checkpoint protein MAD2A	0.033	0.141
MCM4	MCM4, CDC21: DNA replication licensing factor MCM4	0.033	0.141
NPM1	NPM1, NPM: Nucleophosmin	0.033	0.141
CBX3	CBX3: Chromobox protein homolog 3	0.033	0.066
LSM5	LSM5: U6 snRNA-associated Sm-like protein LSm5	0.033	0.033
CCNB1	Cyclin B1	0.033	0.141
MSH6	MSH6, GTBP: DNA mismatch repair protein MSH6	0.033	0.141
SNRPD1	SNRPD1: Small nuclear ribonucleoprotein Sm D1	0.033	0.423
ARVCF	ARVCF: Armadillo repeat protein deleted in velo-cardio-facial syndrome	0.033	0.044
SRC	SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src	0.032	0.032
ABL1	ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1	0.032	0.0425
EIF2B5	EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon	0.032	0.040
ORC1L	ORC1L, ORC1, PARC1: Origin recognition complex subunit 1	0.032	0.066
ANP32B	ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb	0.032	0.066
BLM	BLM, RECQ2, RECQL3: Bloom syndrome protein	0.032	0.040
EDD1	EDD1, EDD, HYD, KIAA0896: E3 ubiquitin-protein ligase EDD1	0.032	0.233
WRN	WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase	0.032	0.032
GTF2F1	GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha	0.032	0.040
EIF3S2	EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2	0.032	0.141
PAK1IP1	PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1	0.032	0.040
PPP1R8	N/A	0.032	0.040
ROCK1	ROCK1: Rho-associated protein kinase 1	0.030	0.307
CTNND2	CTNND2, NPRAP: Catenin delta-2	0.0296	0.050
SHC1	SHC1, RP11-307C12.1-001, hCG_1997126: SHC	0.029	0.038
CFL1	CFL1, CFL: Cofilin-1	0.029	0.046
MAPK1	MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1	0.029	0.071
KIF22	KIF22, KID, KNSL4: Kinesin-like protein KIF22	0.0286	0.036
YWHAG	YWHAG: 14-3-3 protein gamma	0.028	0.028
BUB3	N/A	0.027	0.027
C22orf18	N/A	0.027	0.027
SMC4L1	N/A	0.027	0.027
MRPL22	MRPL22, HSPC158: 39S ribosomal protein L22, mitochondrial precursor	0.027	0.027
PTD004	N/A	0.027	0.027
SERBP1	N/A	0.027	0.027
EPS15	EPS15, AF1P: Epidermal growth factor receptor substrate 15	0.027	0.071
RPA2	RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit	0.027	0.063
FNBP1	N/A	0.027	0.139
PSMD5	PSMD5, KIAA0072: 26S proteasome non-ATPase regulatory subunit 5	0.027	0.037
BTK	BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK	0.027	0.372
PLD1	PLD1: Phospholipase D1	0.027	0.275
CD22	CD22, SIGLEC2: B-cell receptor CD22 precursor	0.027	0.027
LCK	LCK: Proto-oncogene tyrosine-protein kinase LCK	0.026	0.032
SPTA1	SPTA1, SPTA: Spectrin alpha chain, erythrocyte	0.026	0.048
IKBKB	IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta	0.026	0.048
MAPK7	mitogen-activated protein kinase 7 isoform 1	0.026	0.026
BTAF1	BTAF1, TAF172: TATA-binding protein-associated factor 172	0.026	0.111
CLTC	CLTC, CLH17, CLTCL2, KIAA0034: Clathrin heavy chain 1	0.026	0.040
CTNNBL1	N/A	0.0255	0.0255
HSP90AB1	HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta	0.025	0.307
NME1	NME1, NDPKA, NM23: Nucleoside diphosphate kinase A	0.025	0.307
UBAP2L	UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like	0.025	0.144
STOML2	STOML2, SLP2, HSPC108: Stomatin-like protein 2	0.025	0.307
BIRC5	BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5	0.025	0.144
MAPK6	MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6	0.025	0.269
BCR	N/A	0.025	0.025
CDC25C	CDC25C: M-phase inducer phosphatase 3	0.025	0.025
FYN	FYN: Proto-oncogene tyrosine-protein kinase Fyn	0.025	0.025
CDC2	CDC2: Cell division control protein 2 homolog	0.025	0.047
PTK2B	PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta	0.025	0.025
CFL2	CFL2: Cofilin-2	0.025	0.025

0.347

Total Score

2.02E4