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Evidence of Interaction Between ARRB2 and AP1B1

The interaction score between ARRB2 and AP1B1 is 0.250.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

N/A
Orthology
OrganismARRB2 OrthologueAP1B1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00293857 0.527 IPI00220991 0.776
  • Y2H
  • InVitro

Get References From PubMed

worm P51485 0.527 Q9N4F3 1
fly Q9V393 1 Q24253 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

1.07
Domains No domains were used in calculating likelihood of interaction 6.5E-4
Post-translational Modifications

Protein: ARRB2

PTMResidueReference
Phosphorylation 382 PubMed, HPRD

Protein: AP1B1

PTMResidueReference
Localisation

Protein: ARRB2

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD
Cytoplasm HPRD

Protein: AP1B1

LocalisationReference
Golgi HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between ARRB2 and AP1B1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between ARRB2 andAP1B1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , ARRB2 has 262 interactors and AP1B1 has 103 interactors of which there are 3 common interactors.

Common InteractorName of Common InteractorScore for ARRB2-Interactor (?)Score for AP1B1-Interactor (?)
CLTCL1 CLTCL1, CLH22, CLTCL, CLTD: Clathrin heavy chain 2 1.29 0.077
CLTC CLTC, CLH17, CLTCL2, KIAA0034: Clathrin heavy chain 1 0.042 0.566
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.025 0.027
2.15E-3
Total Score 0.250