PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between ARRB2 and AP1B1

The interaction score between ARRB2 and AP1B1 is 0.250.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

N/A

Orthology

Organism	ARRB2 Orthologue		AP1B1 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
human	IPI00293857	0.527	IPI00220991	0.776	Y2H InVitro Get References From PubMed
worm	P51485	0.527	Q9N4F3	1
fly	Q9V393	1	Q24253	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

1.07

Domains

No domains were used in calculating likelihood of interaction

6.5E-4

Post-translational Modifications

Protein: ARRB2

PTM	Residue	Reference
Phosphorylation	382	PubMed, HPRD

Protein: AP1B1

PTM	Residue	Reference

Localisation

Protein: ARRB2

Localisation	Reference
Nucleus	HPRD
Plasma membrane	HPRD
Cytoplasm	HPRD

Protein: AP1B1

Localisation	Reference
Golgi	HPRD
Cytoplasm	HPRD

Transitive Score

The common interactors between ARRB2 and AP1B1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between ARRB2 andAP1B1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , ARRB2 has 262 interactors and AP1B1 has 103 interactors of which there are 3 common interactors.

Common Interactor	Name of Common Interactor	Score for ARRB2-Interactor (?)	Score for AP1B1-Interactor (?)
CLTCL1	CLTCL1, CLH22, CLTCL, CLTD: Clathrin heavy chain 2	1.29	0.077
CLTC	CLTC, CLH17, CLTCL2, KIAA0034: Clathrin heavy chain 1	0.042	0.566
RHOA	RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor	0.025	0.027

2.15E-3

Total Score

0.250