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Evidence of Interaction Between PSMB2 and PSMA6

The interaction score between PSMB2 and PSMA6 is 1.78E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between PSMB2 and PSMA6 = 0.69

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 7.78E-3
Orthology
OrganismPSMB2 OrthologuePSMA6 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YER012W 1 YGL011C 1
  • Immunoprecipitation
  • AffinityCaptureMS

Get References From PubMed
worm P91477 1 O17586 1
fly Q9VQE5 0.109 Q9XZJ4 1
fly Q9VJJ0 1 Q9XZJ4 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains Domains present in PSMB2 and PSMA6:
Domains in PSMB2Domains in PSMA6
IPR000243 Peptidase T1A, proteasome beta-subunit
IPR001353 20S proteasome, A and B subunits
IPR001353 20S proteasome, A and B subunits
IPR000426 Proteasome alpha-subunit

The Chi square scores for co-occurrence of domains that are present in PSMB2 and PSMA6 are listed below.

Domain 1Domain 2Chi Square
IPR001353 20S proteasome, A and B subunits IPR000426 Proteasome alpha-subunit 1084.67
IPR000243 Peptidase T1A, proteasome beta-subunit IPR000426 Proteasome alpha-subunit 998.751
IPR001353 20S proteasome, A and B subunits IPR001353 20S proteasome, A and B subunits 972.655
IPR000243 Peptidase T1A, proteasome beta-subunit IPR001353 20S proteasome, A and B subunits 960.483

The background colour of the table refers to:

  • Blue Domain is only present in PSMB2
  • Yellow Domain is only present in PSMA6
  • Green Domain is present in both PSMB2 and PSMA6

 0.265
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: PSMB2

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: PSMA6

LocalisationReference
Nucleus HPRD
Mitochondrion HPRD
Cytoplasm HPRD
Ribosome HPRD
Transitive Score

The common interactors between PSMB2 and PSMA6 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between PSMB2 andPSMA6. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , PSMB2 has 257 interactors and PSMA6 has 188 interactors of which there are 144 common interactors.

Common InteractorName of Common InteractorScore for PSMB2-Interactor (?)Score for PSMA6-Interactor (?)
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 691.00 1.64E3
PSMA5 PSMA5: Proteasome subunit alpha type-5 691.00 323.00
PSMB1 PSMB1, PSC5: Proteasome subunit beta type-1 precursor 691.00 691.00
PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 691.00 195.00
PSMA4 PSMA4, PSC9: Proteasome subunit alpha type-4 691.00 323.00
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 691.00 691.00
PSMA7 PSMA7: Proteasome subunit alpha type-7 323.00 691.00
PSMB6 PSMB6, LMPY: Proteasome subunit beta type-6 precursor 323.00 195.00
PSMB3 PSMB3: Proteasome subunit beta type-3 323.00 195.00
PSMB9 PSMB9, LMP2, RING12: Proteasome subunit beta type-9 precursor 31.70 23.40
PSMA8 PSMA8, PSMA7L: Proteasome subunit alpha type-7-like 12.60 12.60
CDK2 CDK2: Cell division protein kinase 2 6.55 0.074
PSMA1 PSMA1, PROS30, PSC2: Proteasome subunit alpha type-1 2.91 2.91
PSMB4 N/A 1.82 1.82
NULL RcPSMB3 (Fragment) 1.37 1.37
PSMD1 PSMD1: 26S proteasome non-ATPase regulatory subunit 1 1.10 0.890
PSMD12 PSMD12: 26S proteasome non-ATPase regulatory subunit 12 0.890 0.657
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.612 2.15
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.596 0.739
PSMB5 DKFZp686I0180: Putative uncharacterized protein DKFZp686I0180 (Fragment) 0.593 0.593
CTRL PSMB10, MECL1: Proteasome subunit beta type-10 precursor 0.491 0.824
PSMA1 N/A 0.354 1.79
PSMB5 PSMB5, LMPX: Proteasome subunit beta type-5 precursor 0.265 0.265
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.263 0.263
CDK4 CDK4: Cell division protein kinase 4 0.263 0.074
PPP2CB PPP2CB: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0.233 0.233
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.195 0.195
PLK2 PLK2, SNK: Serine/threonine-protein kinase PLK2 0.179 0.145
PLK3 PLK3, CNK, FNK, PRK: Serine/threonine-protein kinase PLK3 0.179 0.225
PSMB8 PSMB8, DAQB-69D7.6-002, DASS-67H14.1-002, XXbac-BCX32M13.6-002, XXbac-BPG246D15. 0.179 0.221
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.137 0.067
BUB1 0.123 0.060
BUB1B BUB1B, BUBR1, MAD3L: Mitotic checkpoint serine/threonine-protein kinase BUB1 bet 0.123 0.074
MELK MELK, KIAA0175: Maternal embryonic leucine zipper kinase 0.123 0.074
AURKB AURKB, AIK2, AIM1, ARK2, STK12: Serine/threonine-protein kinase 12 0.123 0.060
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.123 0.074
NULL N/A 0.119 0.119
PPP2CA PPP2CA: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 0.108 0.132
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.074 0.074
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.074 0.036
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.074 0.060
CDK7 CDK7, MO15: Cell division protein kinase 7 0.074 0.060
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.074 0.263
WEE1 WEE1: Wee1-like protein kinase 0.074 0.044
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.074 0.074
RIPK2 RIPK2, CARDIAK, UNQ277/PRO314/PRO34092, RICK, RIP2: Receptor-interacting serine/ 0.067 0.050
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.067 0.067
STK16 N/A 0.067 0.0308
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.060 0.123
CSNK1A1 CSNK1A1: Casein kinase I isoform alpha 0.060 0.074
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.060 0.044
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.060 0.074
RP6-213H19.1 MST4, MASK: Serine/threonine-protein kinase MST4 0.060 0.074
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.060 0.123
TTK TTK, MPS1L1: Dual specificity protein kinase TTK 0.059 0.059
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.059 0.059
VRK2 VRK2: Serine/threonine-protein kinase VRK2 0.059 0.047
CSNK1G3 CSNK1G3: Casein kinase I isoform gamma-3 0.050 0.067
ROCK1 ROCK1: Rho-associated protein kinase 1 0.050 0.050
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.044 0.044
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.044 0.044
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.044 0.123
PIK3R4 PIK3R4: Phosphoinositide 3-kinase regulatory subunit 4 0.044 0.074
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.044 0.036
ARAF ARAF, ARAF1, PKS, PKS2: A-Raf proto-oncogene serine/threonine-protein kinase 0.044 0.036
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.044 0.074
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.044 0.044
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.044 0.044
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.044 0.044
NEK2 NEK2, NLK1: Serine/threonine-protein kinase Nek2 0.044 0.044
MAP4K2 MAP4K2, GCK, RAB8IP: Mitogen-activated protein kinase kinase kinase kinase 2 0.044 0.044
DYRK4 DYRK4: Dual specificity tyrosine-phosphorylation-regulated kinase 4 0.044 0.060
RPS6KB1 N/A 0.044 0.074
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.044 0.028
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.044 0.060
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.044 0.060
CLK3 CLK3: Dual specificity protein kinase CLK3 0.044 0.044
CSNK1G2 CSNK1G2: Casein kinase I isoform gamma-2 0.044 0.123
VRK3 N/A 0.041 0.067
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.041 0.067
CAMK2G Calcium/calmodulin-dependent protein kinase isoform A (Fragment) 0.041 0.050
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.041 0.050
EIF2AK1 N/A 0.041 0.0308
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.038 0.038
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.036 0.036
IRAK4 IRAK4: Interleukin-1 receptor-associated kinase 4 0.036 0.044
CSNK1D CSNK1D: Casein kinase I isoform delta 0.036 0.060
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.036 0.074
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.036 0.074
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.036 0.028
CSNK2A2 CSNK2A2, CK2A2: Casein kinase II subunit alpha' 0.036 0.036
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.036 0.044
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.036 0.060
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.036 0.044
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.036 0.028
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.036 0.044
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.036 0.044
PRKD3 PRKD3, EPK2, PRKCN: Serine/threonine-protein kinase D3 0.036 0.044
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.036 0.060
ADRBK2 ADRBK2, BARK2, GRK3: Beta-adrenergic receptor kinase 2 0.036 0.044
STK17A STK17A, DRAK1: Serine/threonine-protein kinase 17A 0.036 0.028
ACVR2A ACVR2A, ACVR2: Activin receptor type-2A precursor 0.035 0.047
CDK9 CDK9, CDC2L4: Cell division protein kinase 9 0.035 0.059
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.0308 0.050
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.0308 0.041
DAPK3 DAPK3, ZIPK: Death-associated protein kinase 3 0.0308 0.0308
LIMK2 LIMK2: LIM domain kinase 2 0.0308 0.0308
DYRK2 DYRK2: Dual specificity tyrosine-phosphorylation-regulated kinase 2 0.0308 0.041
PSMB8 PSMB8, LMP7, RING10, Y2: Proteasome subunit beta type-8 precursor 0.0288 0.0288
PSMB4 PSMB4: Proteasome subunit beta type-4 precursor 0.0288 0.0288
GAK GAK: Cyclin G-associated kinase 0.029 0.047
CDK6 CDK6: Cell division protein kinase 6 0.028 0.044
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.028 0.060
PRKX PRKX, PKX1: Serine/threonine-protein kinase PRKX 0.028 0.044
WNK1 WNK1, KDP, KIAA0344, PRKWNK1: Serine/threonine-protein kinase WNK1 0.028 0.036
PIM1 N/A 0.028 0.028
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.028 0.036
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.028 0.036
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.028 0.060
STK10 STK10: Uncharacterized protein STK10 0.028 0.044
MAP4K5 MAP4K5: Mitogen-activated protein kinase kinase kinase kinase 5 0.028 0.044
NEK11 NEK11: Serine/threonine-protein kinase Nek11 0.027 0.027
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.027 0.027
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.027 0.027
MAPKAPK5 N/A 0.027 0.027
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.027 0.027
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.027 0.027
PDIK1L PDIK1L, CLIK1L: Serine/threonine-protein kinase PDIK1L 0.027 0.027
CDC2L2 N/A 0.027 0.027
STK35 STK35, CLIK1, PDIK1: Serine/threonine-protein kinase 35 0.027 0.027
RIPK5 RIPK5, KIAA0472, HDCMD38P, RIP5, SGK496: Receptor-interacting serine/threonine-p 0.027 0.027
MAP2K5 N/A 0.027 0.027
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.027 0.027
ALS2CR7 ALS2CR7: Serine/threonine-protein kinase ALS2CR7 0.027 0.027
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.027 0.027
NEK4 NEK4, STK2: Serine/threonine-protein kinase Nek4 0.027 0.027
CAMKK1 CAMKK1, CAMKKA: Calcium/calmodulin-dependent protein kinase kinase 1 0.027 0.027
PRKACB PRKACB: cAMP-dependent protein kinase, beta-catalytic subunit 0.027 0.027
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.027 0.027
GRK7 GRK7, GPRK7: G protein-coupled receptor kinase 7 precursor 0.027 0.027
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.027 0.027
MAPK15 N/A 0.027 0.027
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.027 0.027
ANKK1 ANKK1, PKK2, SGK288: Ankyrin repeat and protein kinase domain-containing protein 0.027 0.027
0.228
Total Score 1.78E4