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Evidence of Interaction Between NTSR1 and CCL27

The interaction score between NTSR1 and CCL27 is 0.250.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between NTSR1 and CCL27 = 0.28

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 2.88E-3
Orthology N/A N/A
Domains Domains present in NTSR1 and CCL27:
Domains in NTSR1Domains in CCL27
IPR000276 Rhodopsin-like GPCR superfamily
IPR003984 Neurotensin receptor
IPR003985 Neurotensin type 1 receptor
IPR000827 Small chemokine, C-C subfamily
IPR001811 Small chemokine, interleukin-8 like

The Chi square scores for co-occurrence of domains that are present in NTSR1 and CCL27 are listed below.

Domain 1Domain 2Chi Square
IPR000276 Rhodopsin-like GPCR superfamily IPR000827 Small chemokine, C-C subfamily 379.333
IPR000276 Rhodopsin-like GPCR superfamily IPR001811 Small chemokine, interleukin-8 like 356.918

The background colour of the table refers to:

  • Blue Domain is only present in NTSR1
  • Yellow Domain is only present in CCL27
  • Green Domain is present in both NTSR1 and CCL27

 0.217
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: NTSR1

LocalisationReference
Plasma membrane HPRD

Protein: CCL27

LocalisationReference
Nucleus HPRD
Secreted HPRD
Cytoplasm HPRD
Transitive Score No Transitive data was used in the prediction of this interaction. N/A
Total Score 0.250