PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between GALR3 and CXCL3

The interaction score between GALR3 and CXCL3 is 0.250.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between GALR3 and CXCL3 = 0.24

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

2.88E-3

Orthology

N/A

Domains

Domains present in GALR3 and CXCL3:

Domains in GALR3

Domains in CXCL3

IPR000276	Rhodopsin-like GPCR superfamily
IPR000405	Galanin receptor
IPR003908	Galanin 3 receptor

IPR001811	Small chemokine, interleukin-8 like
IPR001089	Small chemokine, C-X-C subfamily
IPR002473	Small chemokine, C-X-C/Interleukin 8

The Chi square scores for co-occurrence of domains that are present in GALR3 and CXCL3 are listed below.

Domain 1		Domain 2		Chi Square
IPR000276	Rhodopsin-like GPCR superfamily	IPR001811	Small chemokine, interleukin-8 like	356.918
IPR000276	Rhodopsin-like GPCR superfamily	IPR002473	Small chemokine, C-X-C/Interleukin 8	12.2117
IPR000276	Rhodopsin-like GPCR superfamily	IPR001089	Small chemokine, C-X-C subfamily	7.10155

The background colour of the table refers to:

Blue Domain is only present in GALR3
Yellow Domain is only present in CXCL3
Green Domain is present in both GALR3 and CXCL3

0.217

Post-translational Modifications

No PTMs were used in calculating likelihood of interaction

Localisation

No localisation data was used in calculating likelihood of interaction

Protein: CXCL3

Localisation	Reference
Secreted	HPRD

Transitive Score

No Transitive data was used in the prediction of this interaction.

N/A

Total Score

0.250