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Evidence of Interaction Between VAMP5 and STX7

The interaction score between VAMP5 and STX7 is 0.250.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between VAMP5 and STX7 = 0.23

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

2.88E-3
Orthology N/A N/A
Domains Domains present in VAMP5 and STX7:
Domains in VAMP5Domains in STX7
IPR001388 Synaptobrevin
IPR000727 Target SNARE coiled-coil domain
IPR006011 Syntaxin, N-terminal
IPR006012 Syntaxin/epimorphin family

The Chi square scores for co-occurrence of domains that are present in VAMP5 and STX7 are listed below.

Domain 1Domain 2Chi Square
IPR001388 Synaptobrevin IPR000727 Target SNARE coiled-coil domain 1090.58
IPR001388 Synaptobrevin IPR006012 Syntaxin/epimorphin family 761.571
IPR001388 Synaptobrevin IPR006011 Syntaxin, N-terminal 732.41

The background colour of the table refers to:

  • Blue Domain is only present in VAMP5
  • Yellow Domain is only present in STX7
  • Green Domain is present in both VAMP5 and STX7

0.217
Post-translational Modifications

Protein: VAMP5

PTMResidueReference

Protein: STX7

PTMResidueReference
Acetylation 2 PubMed, HPRD
N-acetylserine 1 HPRD
Phosphorylation 79 PubMed, HPRD
Localisation

Protein: VAMP5

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD

Protein: STX7

LocalisationReference
Lysosome HPRD
Endosome HPRD
Secreted HPRD
Cytoplasm HPRD
Transitive Score No Transitive data was used in the prediction of this interaction. N/A
Total Score 0.250