PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between MCM7 and CDC6

The interaction score between MCM7 and CDC6 is 1.59E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between MCM7 and CDC6 = 0.85

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

0.027

Orthology

Organism	MCM7 Orthologue		CDC6 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
bakers yeast	YBR202W	1	YJL194W	1	ReconstitutedComplex CoLocalization Get References From PubMed
worm	O16297	1	P91155	1
fly	Q9XYU0	1	Q9VSM9	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.593

Domains

Domains present in MCM7 and CDC6:

Domains in MCM7

Domains in CDC6

IPR003593	AAA ATPase
IPR001208	MCM
IPR008050	MCM protein 7

IPR003593	AAA ATPase
IPR003959	AAA ATPase, central region
IPR011991	Wing_hlx_DNA_bd.

The Chi square scores for co-occurrence of domains that are present in MCM7 and CDC6 are listed below.

Domain 1		Domain 2		Chi Square
IPR003593	AAA ATPase	IPR003959	AAA ATPase, central region	133.351
IPR001208	MCM	IPR003593	AAA ATPase	127.202
IPR003593	AAA ATPase	IPR003593	AAA ATPase	89.0695
IPR001208	MCM	IPR003959	AAA ATPase, central region	15.8911
IPR008050	MCM protein 7	IPR003593	AAA ATPase	15.8734
IPR001208	MCM	IPR011991	Wing_hlx_DNA_bd.	5.30628
IPR003593	AAA ATPase	IPR011991	Wing_hlx_DNA_bd.	0.00778109

The background colour of the table refers to:

Blue Domain is only present in MCM7
Yellow Domain is only present in CDC6
Green Domain is present in both MCM7 and CDC6

0.027

Post-translational Modifications

Protein: MCM7

PTM	Residue	Reference

Protein: CDC6

PTM	Residue	Reference
Phosphorylation	54	PubMed, HPRD
Phosphorylation	74	PubMed, HPRD
Phosphorylation	106	PubMed, HPRD

Localisation

Protein: MCM7

Localisation	Reference
Nucleus	HPRD
Nucleoplasm	HPRD
Cytoplasm	HPRD

Protein: CDC6

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD

Transitive Score

The common interactors between MCM7 and CDC6 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MCM7 andCDC6. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MCM7 has 165 interactors and CDC6 has 931 interactors of which there are 112 common interactors.

Common Interactor	Name of Common Interactor	Score for MCM7-Interactor (?)	Score for CDC6-Interactor (?)
MCM3	MCM3: DNA replication licensing factor MCM3	209.00	1.62
MCM2	MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2	209.00	431.00
MCM4	MCM4, CDC21: DNA replication licensing factor MCM4	69.60	1.62
MCM5	MCM5, CDC46: DNA replication licensing factor MCM5	69.60	32.60
CDC7	CDC7, CDC7L1: Cell division cycle 7-related protein kinase	1.82	0.129
MCM6	MCM6: DNA replication licensing factor MCM6	0.789	0.263
PCNA	PCNA: Proliferating cell nuclear antigen	0.789	1.62
E2F1	E2F1, RBBP3: Transcription factor E2F1	0.293	0.917
CCNB2	CCNB2: G2/mitotic-specific cyclin-B2	0.263	69.60
CCNB1	Cyclin B1	0.263	86.60
CCNA2	CCNA2, CCN1, CCNA: Cyclin-A2	0.263	0.263
RFC5	RFC5: Replication factor C subunit 5	0.207	0.207
RFC3	RFC3: Replication factor C subunit 3	0.207	0.207
RFC4	RFC4: Replication factor C subunit 4	0.207	0.207
DNMT1	DNMT1, AIM, DNMT: DNA	0.137	0.087
CCNF	CCNF: G2/mitotic-specific cyclin-F	0.137	0.137
DHX15	DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase	0.137	0.083
YBX1	YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1	0.123	0.461
EIF2S1	EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1	0.123	0.461
POLR2H	POLR2H: DNA-directed RNA polymerases I, II, and III subunit RPABC3	0.123	0.156
ABCE1	ABCE1, RLI, OK/SW-cl.40, RNASEL1, RNASELI, RNS4I: ATP-binding cassette sub-famil	0.123	0.123
RPA1	RPA1, REPA1, RPA70: Replication protein A 70 kDa DNA-binding subunit	0.123	0.074
ORC1L	ORC1L, ORC1, PARC1: Origin recognition complex subunit 1	0.123	0.763
ORC2L	ORC2L, ORC2: Origin recognition complex subunit 2	0.123	19.70
ORC6L	ORC6L: Origin recognition complex subunit 6	0.123	0.123
KARS	KARS, KIAA0070: Lysyl-tRNA synthetase	0.108	0.053
TAF9	AK6, AD-004, CGI-137: Adenylate kinase isoenzyme 6	0.108	0.065
ATAD2	ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2	0.0968	0.503
PSMC3	PSMC3, TBP1: 26S protease regulatory subunit 6A	0.0968	0.059
ATAD3A	ATAD3A: ATPase family AAA domain-containing protein 3A	0.0968	0.059
RB1	RB1: Retinoblastoma-associated protein	0.083	0.416
RFX5	RFX5: DNA-binding protein RFX5	0.083	0.050
C18orf56	N/A	0.082	0.027
GTF2F1	GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha	0.074	0.139
CCNG1	CCNG1, CCNG, CYCG1: Cyclin-G1	0.074	0.060
XRCC3	XRCC3: DNA-repair protein XRCC3	0.074	0.074
MTA1	MTA1: Metastasis-associated protein MTA1	0.074	0.188
YARS	YARS: Tyrosyl-tRNA synthetase, cytoplasmic	0.074	0.461
FEN1	FEN1, RAD2: Flap endonuclease 1	0.0739	0.0479
BRCA2	BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein	0.067	0.515
EIF5AP1	EIF5A: Eukaryotic translation initiation factor 5A-1	0.067	0.416
ASCC3	ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3	0.060	0.044
SCYE1	SCYE1, EMAP2: Multisynthetase complex auxiliary component p43 [Contains: Endothe	0.060	0.044
EIF1AX	EIF1AX, EIF1A, EIF4C: Eukaryotic translation initiation factor 1A, X-chromosomal	0.060	0.044
GTF2B	GTF2B, TF2B, TFIIB: Transcription initiation factor IIB	0.060	0.225
EIF2B5	EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon	0.060	0.372
PIP5K3	PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase	0.060	0.114
MDN1	MDN1, KIAA0301: Midasin	0.060	0.275
POLR2G	POLR2G: DNA-directed RNA polymerase II subunit RPB7	0.060	0.036
SRP54	SRP54: Signal recognition particle 54 kDa protein	0.059	0.035
RUVBL1	RUVBL1, NMP238, TIP49, TIP49A: RuvB-like 1	0.059	0.059
PSMC2	PSMC2, MSS1: 26S protease regulatory subunit 7	0.059	65.00
DARS	DARS, PIG40: Aspartyl-tRNA synthetase, cytoplasmic	0.059	0.047
PSMC1	PSMC1: 26S protease regulatory subunit 4	0.059	0.245
TRIP13	TRIP13: Thyroid receptor-interacting protein 13	0.059	0.503
PSMC6	PSMC6, SUG2: 26S protease regulatory subunit S10B	0.059	0.035
FXR1	FXR1: Fragile X mental retardation syndrome-related protein 1	0.059	0.245
SSBP1	SSBP1, SSBP: Single-stranded DNA-binding protein, mitochondrial precursor	0.055	0.0331
BARD1	BARD1: BRCA1-associated RING domain protein 1	0.053	0.385
H1FX	H1FX: Histone H1x	0.050	0.077
ORC3L	ORC3L, LATHEO: Origin recognition complex subunit 3	0.050	0.050
ELF1	ELF1: ETS-related transcription factor Elf-1	0.050	0.077
TOP2A	TOP2A, TOP2: DNA topoisomerase 2-alpha	0.049	0.307
RUVBL2	RUVBL2, TIP48, CGI-46, TIP49B: RuvB-like 2	0.047	0.035
VCP	VCP: Transitional endoplasmic reticulum ATPase	0.047	0.181
CCNC	CCNC: Cyclin-C	0.044	0.044
EXOSC2	EXOSC2, RRP4: Exosome complex exonuclease RRP4	0.044	0.275
RPA2	RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit	0.044	0.086
GCLC	GCLC, GLCL, GLCLC: Glutamate--cysteine ligase catalytic subunit	0.044	0.036
EIF1AY	EIF1AY: Eukaryotic translation initiation factor 1A, Y-chromosomal	0.044	0.044
GTF2E2	GTF2E2, TF2E2: Transcription initiation factor IIE subunit beta	0.044	0.036
CSDA	CSDA, DBPA: DNA-binding protein A	0.044	0.114
CCND3	CCND3: G1/S-specific cyclin-D3	0.044	0.028
ETV6	ETV6, TEL, TEL1: Transcription factor ETV6	0.044	0.114
GTF2F2	N/A	0.041	0.155
ERG	ERG: Transcriptional regulator ERG	0.041	0.127
IRF3	IRF3: Interferon regulatory factor 3	0.041	0.077
SMC1L1	SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos	0.038	0.233
HSF1	HSF1, HSTF1: Heat shock factor protein 1	0.036	0.086
CCND2	CCND2: G1/S-specific cyclin-D2	0.036	0.028
HSF2	HSF2, HSTF2: Heat shock factor protein 2	0.036	0.086
NARS	NARS, ASNS: Asparaginyl-tRNA synthetase, cytoplasmic	0.035	0.029
XAB1	XAB1, MBDIN, HUSSY-23: XPA-binding protein 1	0.0331	0.027
SRPR	SRPR: Uncharacterized protein SRPR	0.032	0.126
FOXJ2	FOXJ2, FHX: Forkhead box protein J2	0.0308	0.077
ERF	ERF: ETS domain-containing transcription factor ERF	0.0308	0.096
BCS1L	BCS1L, BCS1: Mitochondrial chaperone BCS1	0.029	0.029
CCNH	CCNH: Cyclin-H	0.028	0.136
FOXO3A	FOXO3A, FKHRL1: Forkhead box protein O3A	0.028	0.086
HIST1H1D	HIST1H1D, H1F3: Histone H1.3	0.028	0.069
CCNL1	CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1	0.028	0.136
HIST1H1E	HIST1H1E, H1F4: Histone H1.4	0.028	0.069
HMMR	HMMR: Hyaluronan-mediated motility receptor	0.027	0.027
GTSE1	GTSE1: G2 and S phase-expressed protein 1	0.027	0.025
KIAA0101	PAF, KIAA0101, L5, NS5ATP9: PCNA-associated factor	0.027	0.027
CDCA8	CDCA8, PESCRG3: Borealin	0.027	0.027
SMC4L1	N/A	0.027	0.027
MCM10	N/A	0.027	0.027
ZWINT	N/A	0.027	0.027
TPX2	TPX2, C20orf1, C20orf2, DIL2, HCA519: Targeting protein for Xklp2	0.027	0.053
DKFZp762E1312	FAKTS, FLEG1: 14-3-3-associated AKT substrate	0.027	0.027
GMNN	GMNN: Geminin	0.027	0.053
RAD51AP1	N/A	0.027	0.027
TACC3	TACC3, ERIC1: Transforming acidic coiled-coil-containing protein 3	0.027	0.068
PRSS15	LONP1, PRSS15: Lon protease homolog, mitochondrial precursor	0.027	0.027
ABCC4	ABCC4, MRP4: Multidrug resistance-associated protein 4	0.027	0.027
FOXM1	FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1	0.027	0.083
DNAH11	N/A	0.027	0.027
ABCF2	ABCF2, HUSSY-18: ATP-binding cassette sub-family F member 2	0.027	0.027
ELF2	ELF2, NERF: ETS-related transcription factor Elf-2	0.027	0.083
HTATIP	HTATIP, TIP60: Histone acetyltransferase HTATIP	0.027	0.083
RPA3	RPA3, REPA3, RPA14: Replication protein A 14 kDa subunit	0.027	0.027

0.572

Total Score

1.59E4