PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between DDX39 and STRN3

The interaction score between DDX39 and STRN3 is 0.250.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

N/A

Orthology

Organism	DDX39 Orthologue		STRN3 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
human	IPI00328343	0.759	IPI00003016	0.208	Y2H Get References From PubMed
worm	Q18212	1	Q17406	1
fly	Q27268	0.45	Q9VLT9	0.188

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

1.07

Domains

Domains present in DDX39 and STRN3:

Domains in DDX39

Domains in STRN3

IPR001410	DEAD/DEAH box helicase
IPR001650	Helicase, C-terminal
IPR011545	DEAD/DEAH_N.

IPR001680

G-protein beta WD-40 repeat

The Chi square scores for co-occurrence of domains that are present in DDX39 and STRN3 are listed below.

Domain 1		Domain 2		Chi Square
IPR001410	DEAD/DEAH box helicase	IPR001680	G-protein beta WD-40 repeat	4.8123
IPR001650	Helicase, C-terminal	IPR001680	G-protein beta WD-40 repeat	0.607238
IPR011545	DEAD/DEAH_N.	IPR001680	G-protein beta WD-40 repeat	0.551125

The background colour of the table refers to:

Blue Domain is only present in DDX39
Yellow Domain is only present in STRN3
Green Domain is present in both DDX39 and STRN3

6.5E-4

Post-translational Modifications

Protein: DDX39

PTM	Residue	Reference

Protein: STRN3

PTM	Residue	Reference
Phosphoserine	229	HPRD

Localisation

Protein: DDX39

Localisation	Reference
Nucleus	HPRD
Nucleolus	HPRD

Protein: STRN3

No localisation data was used in calculating likelihood of interaction

Transitive Score

The common interactors between DDX39 and STRN3 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between DDX39 andSTRN3. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , DDX39 has 133 interactors and STRN3 has 31 interactors of which there are 2 common interactors.

Common Interactor	Name of Common Interactor	Score for DDX39-Interactor (?)	Score for STRN3-Interactor (?)
SNRPD1	SNRPD1: Small nuclear ribonucleoprotein Sm D1	0.123	0.046
SNRPD3	SNRPD3: Small nuclear ribonucleoprotein Sm D3	0.123	0.046

2.15E-3

Total Score

0.250