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Evidence of Interaction Between GNA14 and CHRM2

The interaction score between GNA14 and CHRM2 is 293.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between GNA14 and CHRM2 = 0.08

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

1.85E-3
Orthology
OrganismGNA14 OrthologueCHRM2 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00220578 0.162 IPI00023456 0.075
human IPI00337415 0.162 IPI00023456 0.075
human IPI00288947 0.054 IPI00023456 0.075
  • Other
  • InVivo

Get References From PubMed

worm Q8T3G5 0.054 Q9U7D5 0.075

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

1.07
Domains Domains present in GNA14 and CHRM2:
Domains in GNA14Domains in CHRM2
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR011025 Transducin, alpha subunit, insertion
IPR000654 G-protein alpha subunit, group Q
IPR000276 Rhodopsin-like GPCR superfamily
IPR000995 Muscarinic acetylcholine receptor
IPR001065 Muscarinic acetylcholine receptor M2

The Chi square scores for co-occurrence of domains that are present in GNA14 and CHRM2 are listed below.

Domain 1Domain 2Chi Square
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit IPR000276 Rhodopsin-like GPCR superfamily 1146.41
IPR011025 Transducin, alpha subunit, insertion IPR000276 Rhodopsin-like GPCR superfamily 1012.26
IPR000654 G-protein alpha subunit, group Q IPR000276 Rhodopsin-like GPCR superfamily 560.059
IPR000654 G-protein alpha subunit, group Q IPR001065 Muscarinic acetylcholine receptor M2 243.448
IPR000654 G-protein alpha subunit, group Q IPR000995 Muscarinic acetylcholine receptor 214.497
IPR011025 Transducin, alpha subunit, insertion IPR000995 Muscarinic acetylcholine receptor 104.457
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit IPR000995 Muscarinic acetylcholine receptor 85.3953
IPR011025 Transducin, alpha subunit, insertion IPR001065 Muscarinic acetylcholine receptor M2 71.9722
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit IPR001065 Muscarinic acetylcholine receptor M2 59.0326

The background colour of the table refers to:

  • Blue Domain is only present in GNA14
  • Yellow Domain is only present in CHRM2
  • Green Domain is present in both GNA14 and CHRM2

1.05
Post-translational Modifications

Protein: GNA14

PTMResidueReference
ADP-ribosylarginine 179 PubMed, HPRD

Protein: CHRM2

PTMResidueReference
Glycosylation 2 PubMed, HPRD
Glycosylation 3 PubMed, HPRD
Glycosylation 6 PubMed, HPRD
Localisation

Protein: GNA14

LocalisationReference
Plasma membrane HPRD

Protein: CHRM2

LocalisationReference
Plasma membrane HPRD
Endosome HPRD
Transitive Score

The common interactors between GNA14 and CHRM2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between GNA14 andCHRM2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , GNA14 has 813 interactors and CHRM2 has 406 interactors of which there are 76 common interactors.

Common InteractorName of Common InteractorScore for GNA14-Interactor (?)Score for CHRM2-Interactor (?)
HTR2C HTR2C, HTR1C: 5-hydroxytryptamine receptor 2C 418.00 0.136
HTR2A HTR2A, HTR2: 5-hydroxytryptamine receptor 2A 105.00 0.028
GNA11 GNA11, GA11: Guanine nucleotide-binding protein subunit alpha-11 51.30 518.00
GNAI1 GNAI1: Guanine nucleotide-binding protein G(i), alpha-1 subunit 38.90 518.00
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 1 33.70 1.17
GNAT1 GNAT1, GNATR: Guanine nucleotide-binding protein G(t), alpha-1 subunit 31.00 0.874
GNAZ GNAZ: Guanine nucleotide-binding protein G(z) subunit alpha 31.00 1.07
GNAI3 GNAI3: Guanine nucleotide-binding protein G(k) subunit alpha 19.90 298.00
GNAT2 GNAT2, GNATC: Guanine nucleotide-binding protein G(t), alpha-2 subunit 19.90 1.07
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 4.65 0.029
OPRM1 OPRM1, MOR1: Mu-type opioid receptor 1.37 0.030
EDNRB EDNRB, ETRB: Endothelin B receptor precursor 1.30 0.083
C3AR1 C3AR1, AZ3B, C3R1, HNFAG09: C3a anaphylatoxin chemotactic receptor 1.30 0.083
CCR2 CCR2, CMKBR2: C-C chemokine receptor type 2 1.30 0.083
OPRD1 OPRD1, OPRD: Delta-type opioid receptor 1.26 0.028
AVPR1A AVPR1A, AVPR1: Vasopressin V1a receptor 1.26 0.046
EDG1 EDG1: Sphingosine 1-phosphate receptor Edg-1 1.21 0.055
F2R F2R, CF2R, PAR1, TR: Proteinase-activated receptor 1 precursor 1.21 0.062
DRD1 DRD1: D(1A) dopamine receptor 1.07 0.069
TSHR N/A 1.07 0.049
PTAFR PTAFR, PAFR: Platelet-activating factor receptor 1.05 0.083
DRD2 DRD2: D(2) dopamine receptor 1.05 0.083
TBXA2R TBXA2R: Thromboxane A2 receptor 1.05 0.083
RGS7 RGS7: Regulator of G-protein signaling 7 1.02 0.042
AVPR1B AVPR1B, AVPR3, VPR3: Vasopressin V1b receptor 1.02 0.028
RHO RHO, OPN2: Rhodopsin 0.975 0.077
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.970 0.077
F2RL1 F2RL1, GPR11, PAR2: Proteinase-activated receptor 2 precursor 0.970 0.062
HTR6 HTR6: 5-hydroxytryptamine receptor 6 0.970 0.096
P2RY4 P2RY4, NRU: P2Y purinoceptor 4 0.970 0.127
GPR23 LPA4, GPR23, P2RY9: Lysophosphatidic acid receptor 4 0.970 0.062
MC4R MC4R: Melanocortin receptor 4 0.970 0.127
RGS4 RGS4: Regulator of G-protein signaling 4 0.902 0.081
PTGIR PTGIR, PRIPR: Prostacyclin receptor 0.874 0.050
BDKRB2 BDKRB2, BKR2: B2 bradykinin receptor 0.821 0.031
F2RL2 F2RL2, PAR3: Proteinase-activated receptor 3 precursor 0.786 0.062
CXCR4 CXCR4: C-X-C chemokine receptor type 4 0.775 0.056
C5AR1 C5AR1, C5AR, C5R1: C5a anaphylatoxin chemotactic receptor 0.775 0.049
CCR5 CCR5: CCR5 receptor (Fragment) 0.775 0.055
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.770 0.044
RGS16 RGS16, RGSR: Regulator of G-protein signaling 16 0.731 0.100
SSTR3 SSTR3: Somatostatin receptor type 3 0.704 0.056
TACR2 TACR2, NK2R, NKNAR, TAC2R: Substance-K receptor 0.704 0.069
F2RL3 F2RL3, PAR4: Proteinase-activated receptor 4 precursor 0.692 0.096
GNAQ GNAQ, GAQ: Guanine nucleotide-binding protein G(q) subunit alpha 0.658 0.874
LTB4R LTB4R, BLT, BLT1, BLTR, CMKRL1, GPR16, P2RY7: Leukotriene B4 receptor 1 0.624 0.056
FPR1 FPR1: fMet-Leu-Phe receptor 0.624 0.049
IL8RB IL8RB, CXCR2: High affinity interleukin-8 receptor B 0.624 0.062
FPRL1 FPRL1, FPR2, FPRH1, LXA4R: FMLP-related receptor I 0.624 0.062
TRHR TRHR: Thyrotropin-releasing hormone receptor 0.559 0.069
RGS18 RGS18, RGS13: Regulator of G-protein signaling 18 0.543 0.044
AXIN1 0.543 0.109
GNAI2 Galphai2 protein 0.469 0.693
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.448 31.30
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.357 0.081
RGS2 RGS2, G0S8: Regulator of G-protein signaling 2 0.322 0.0727
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.320 0.064
RGS19 RGS19, GAIP, GNAI3IP: Regulator of G-protein signaling 19 0.288 0.065
ADORA3 ADORA3, UNQ1931/PRO4406: Adenosine A3 receptor 0.265 0.027
HTR1F HTR1F, HTR1EL: 5-hydroxytryptamine receptor 1F 0.265 0.027
GRK7 GRK7, GPRK7: G protein-coupled receptor kinase 7 precursor 0.217 0.044
GRK4 GPRK2L, GRK4, GPRK4: G protein-coupled receptor kinase 4 0.195 9.04
GRIK2 GRIK2, GLUR6: Glutamate receptor, ionotropic kainate 2 precursor 0.097 0.054
CASR CASR, GPRC2A, PCAR1: Extracellular calcium-sensing receptor precursor 0.085 0.032
GP1BA N/A 0.077 0.026
GPRC5A GPRC5A, GPCR5A, RAI3, RAIG1: Retinoic acid-induced protein 3 0.056 0.028
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.050 0.047
GRIA4 GRIA4, GLUR4: Glutamate receptor 4 precursor 0.046 0.054
GRIN1 GRIN1, NMDAR1: Glutamate [NMDA] receptor subunit zeta-1 precursor 0.037 0.035
GRIA1 GRIA1, GLUH1, GLUR1: Glutamate receptor 1 precursor 0.033 0.054
SNAP25 N/A 0.028 0.028
LAT LAT: Linker for activation of T-cells family member 1 0.028 0.028
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 2 0.026 1.20
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.026 0.032
SNAP23 SNAP23: Synaptosomal-associated protein 23 0.025 0.025
STOM STOM, BND7, EPB72: Erythrocyte band 7 integral membrane protein 0.025 0.025
2.15E-3
Total Score 293.00