<<< Back to ABCD3

Evidence of Interaction Between ABCD3 and ABCD2

The interaction score between ABCD3 and ABCD2 is 40.50.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between ABCD3 and ABCD2 = 0.01

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

1.85E-3
Orthology
OrganismABCD3 OrthologueABCD2 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YPL147W 0.08 YPL147W 1
worm Q18597 0.296 O45730 1
worm Q18598 1 O45730 1
fly Q9VWC8 1 Q8IMC0 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.23E-3
Domains Domains present in ABCD3 and ABCD2:
Domains in ABCD3Domains in ABCD2
IPR003593 AAA ATPase
IPR003439 ABC transporter
IPR005283 Peroxysomal long chain fatty acyl transporter
IPR010509 ABC transporter, N-terminal
IPR011527 ABC_membrane_1.
IPR003593 AAA ATPase
IPR003439 ABC transporter
IPR010509 ABC transporter, N-terminal
IPR011527 ABC_membrane_1.

The Chi square scores for co-occurrence of domains that are present in ABCD3 and ABCD2 are listed below.

Domain 1Domain 2Chi Square
IPR003593 AAA ATPase IPR003593 AAA ATPase 89.0695

The background colour of the table refers to:

  • Blue Domain is only present in ABCD3
  • Yellow Domain is only present in ABCD2
  • Green Domain is present in both ABCD3 and ABCD2

0.265
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: ABCD3

LocalisationReference
Peroxisome HPRD

Protein: ABCD2

LocalisationReference
Peroxisome HPRD
Transitive Score

The common interactors between ABCD3 and ABCD2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between ABCD3 andABCD2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , ABCD3 has 67 interactors and ABCD2 has 32 interactors of which there are 30 common interactors.

Common InteractorName of Common InteractorScore for ABCD3-Interactor (?)Score for ABCD2-Interactor (?)
ABCD1 ABCD1, ALD: ATP-binding cassette sub-family D member 1 74.90 0.218
ABCC4 ABCC4, MRP4: Multidrug resistance-associated protein 4 0.360 0.156
TAP2 TAP2, ABCB3, PSF2, RING11, Y1: Antigen peptide transporter 2 0.305 0.244
ABCD4 ABCD4, PXMP1L: ATP-binding cassette sub-family D member 4 0.274 0.156
ABCC5 ABCC5, MRP5: Multidrug resistance-associated protein 5 0.274 0.156
ABCC9 ABCC9, SUR2: ATP-binding cassette transporter sub-family C member 9 0.265 0.265
ABCC3 N/A 0.265 0.265
ABCB5 ABCB5: ATP-binding cassette sub-family B member 5 0.237 0.237
ABCB6 0.237 0.237
ABCB9 ABCB9, KIAA1520: ATP-binding cassette sub-family B member 9 precursor 0.237 0.237
ABCB10 ABCB10: ATP-binding cassette sub-family B member 10, mitochondrial precursor 0.237 0.237
ABCB4 ABCB4, MDR3, PGY3: Multidrug resistance protein 3 0.197 0.174
PEX19 PEX19, HK33, OK/SW-cl.22, PXF: Peroxisomal biogenesis factor 19 0.191 0.083
ABCB1 ABCB1, MDR1, PGY1: Multidrug resistance protein 1 0.177 0.177
ABCC2 ABCC2, CMOAT, CMOAT1, CMRP, MRP2: Canalicular multispecific organic anion transp 0.177 0.218
CFTR CFTR: Cystic fibrosis transmembrane conductance regulator ATP-binding cassette s 0.174 0.197
ABCC3 ABCC3, CMOAT2, MLP2, MRP3: Canalicular multispecific organic anion transporter 2 0.156 0.156
ABCC6 ABCC6, ARA, MRP6: Multidrug resistance-associated protein 6 0.156 0.177
ABCC1 ABCC1, MRP, MRP1: Multidrug resistance-associated protein 1 0.126 0.126
PPAPDC1B PPAPDC1B, HTPAP: Phosphatidic acid phosphatase type 2 domain-containing protein 0.119 0.593
ABCB11 ABCB11, BSEP: Bile salt export pump 0.075 0.116
SLC7A4 SLC7A4: Uncharacterized protein SLC7A4 0.064 0.119
TAP1 N/A 0.0288 0.0288
ABCC6 ara: Anthracycline resistance associated protein 0.0288 0.0288
ABCB8 ABCB8, MABC1: ATP-binding cassette sub-family B member 8, mitochondrial precurso 0.0288 0.0288
ABCB7 ABCB7, ABC7: ATP-binding cassette sub-family B member 7, mitochondrial precursor 0.0288 0.0288
ABCC8 ABCC8, HRINS, SUR, SUR1: ATP-binding cassette transporter sub-family C member 8 0.0288 0.0288
ABCC13 ABCC13, C21orf73, PRED6: Putative ATP-binding cassette transporter sub-family C 0.0288 0.0288
ABCG1 ABCG1, ABC8, WHT1: ATP-binding cassette sub-family G member 1 0.027 0.027
ABCF2 ABCF2, HUSSY-18: ATP-binding cassette sub-family F member 2 0.027 0.027
0.572
Total Score 40.50