PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between GTF2A1 and GTF2A2

The interaction score between GTF2A1 and GTF2A2 is 45.20.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between GTF2A1 and GTF2A2 = 0.16

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

2.30E-3

Orthology

Organism	GTF2A1 Orthologue		GTF2A2 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
bakers yeast	YOR194C	1	YKL058W	1	Immunoprecipitation Other AffinityChromatography InVitroBinding Y2H AffinityCaptureMS Get References From PubMed
worm	O44625	1	Q9NEX2	1
fly	P52654	1	P52656	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.593

Domains

No domains were used in calculating likelihood of interaction

1.48E-3

Post-translational Modifications

Protein: GTF2A1

PTM	Residue	Reference
Phosphorylation	280	PubMed, HPRD
Phosphorylation	281	PubMed, HPRD
Phosphorylation	316	PubMed, HPRD
Phosphorylation	321	PubMed, HPRD
Phosphoserine	280	PubMed, HPRD
Phosphoserine	281	PubMed, HPRD
Phosphoserine	316	PubMed, HPRD
Phosphoserine	321	PubMed, HPRD

Protein: GTF2A2

PTM	Residue	Reference

Localisation

Protein: GTF2A1

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD

Protein: GTF2A2

Localisation	Reference
Nucleus	HPRD

Transitive Score

The common interactors between GTF2A1 and GTF2A2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between GTF2A1 andGTF2A2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , GTF2A1 has 523 interactors and GTF2A2 has 12 interactors of which there are 4 common interactors.

Common Interactor	Name of Common Interactor	Score for GTF2A1-Interactor (?)	Score for GTF2A2-Interactor (?)
GTF2B	GTF2B, TF2B, TFIIB: Transcription initiation factor IIB	4.95	0.890
TBP	TBP, GTF2D1, TF2D, TFIID: TATA-box-binding protein	4.72	19.70
TBPL2		0.071	0.071
OGG1	N/A	0.027	0.027

0.347

Total Score

45.20