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Evidence of Interaction Between B2M and LILRB1

The interaction score between B2M and LILRB1 is 31.50.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between B2M and LILRB1 = 0.63

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 7.78E-3
Orthology N/A N/A
Domains Domains present in B2M and LILRB1:
Domains in B2MDomains in LILRB1
IPR007110 Immunoglobulin-like
IPR003006 Immunoglobulin/major histocompatibility complex
IPR003597 Immunoglobulin C-type
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like

The Chi square scores for co-occurrence of domains that are present in B2M and LILRB1 are listed below.

Domain 1Domain 2Chi Square
IPR003597 Immunoglobulin C-type IPR007110 Immunoglobulin-like 217.957
IPR003006 Immunoglobulin/major histocompatibility complex IPR007110 Immunoglobulin-like 134.367
IPR007110 Immunoglobulin-like IPR007110 Immunoglobulin-like 88.0803
IPR007110 Immunoglobulin-like IPR003599 Immunoglobulin subtype 62.3737
IPR003597 Immunoglobulin C-type IPR003599 Immunoglobulin subtype 47.8783
IPR003006 Immunoglobulin/major histocompatibility complex IPR003599 Immunoglobulin subtype 34.6989

The background colour of the table refers to:

  • Blue Domain is only present in B2M
  • Yellow Domain is only present in LILRB1
  • Green Domain is present in both B2M and LILRB1

 0.044
Post-translational Modifications

Protein: B2M

PTMResidueReference
Pyrrolidone carboxylic acid 22 PubMed, HPRD

Protein: LILRB1

PTMResidueReference
Phosphotyrosine 533 HPRD
Phosphotyrosine 614 HPRD
Phosphotyrosine 644 HPRD
Localisation

Protein: B2M

LocalisationReference
Secreted HPRD

Protein: LILRB1

LocalisationReference
Plasma membrane HPRD
Transitive Score

The common interactors between B2M and LILRB1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between B2M andLILRB1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , B2M has 663 interactors and LILRB1 has 1007 interactors of which there are 430 common interactors.

Common InteractorName of Common InteractorScore for B2M-Interactor (?)Score for LILRB1-Interactor (?)
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 43.10 0.852
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 34.70 0.174
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 34.70 0.515
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 11.50 0.174
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 4.07 0.515
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 4.07 0.515
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 3.28 0.140
HLA-E HLA-E, XXbac-BPG34K20.2-001: MHC class Ib antigen 2.91 0.067
HLA-F HLA-F, HLA-5.4, HLAF: HLA class I histocompatibility antigen, alpha chain F prec 2.91 0.083
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 1.60 0.140
PTPNS1 SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP: Tyrosine-protein phosphatase non-rec 1.53 0.051
TAPBPL TAPBPL: Tapasin-related protein precursor 1.36 0.083
AZGP1 AZGP1, tcag7.638: Alpha-2-glycoprotein 1, zinc-binding 1.05 0.044
HLA-DRB5 HLA-Dw12: Cell surface glycoprotein 0.824 0.137
HLA-DRB5 HLA-DRB3: HLA class II histocompatibility antigen, DRB3-1 beta chain precursor 0.824 0.083
HLA-DPA1 HLA-DPA1, HLA-DP1A, HLASB: HLA class II histocompatibility antigen, DP alpha cha 0.824 0.083
MICB MICB: MHC class I polypeptide-related sequence B (Fragment) 0.824 0.039
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.692 0.037
HLA-DQB1 HLA-DQB, HLA-DRB1: HLA class II histocompatibility antigen, DQ(1) beta chain pre 0.666 0.067
CD1D CD1D: T-cell surface glycoprotein CD1d precursor 0.666 0.293
HLA-DQA1 HLA-DQA1: HLA class II histocompatibility antigen, DQ(5) alpha chain precursor 0.666 0.041
FCGRT FCGRT, FCRN: IgG receptor FcRn large subunit p51 precursor 0.491 0.137
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.486 0.287
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.486 0.515
CD1C CD1C: T-cell surface glycoprotein CD1c precursor 0.402 0.041
CD69 CD69: Early activation antigen CD69 0.340 0.152
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.340 0.251
HLA-DRB5 N/A 0.265 0.027
HLA-DRB5 N/A 0.265 0.027
HFE HFE, HLAH: Hereditary hemochromatosis protein precursor 0.265 0.027
HLA-DQA1 HLA-DQA2, HLA-DXA: HLA class II histocompatibility antigen, DQ(6) alpha chain pr 0.265 0.027
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.253 0.917
CD53 CD53, MOX44, TSPAN25: Leukocyte surface antigen CD53 0.231 0.083
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.228 1.81
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.228 0.416
ST8SIA4 ST8SIA4, PST, PST1, SIAT8D: CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransfe 0.214 0.274
OSM OSM: Oncostatin-M precursor 0.191 0.126
CRLF3 N/A 0.179 0.041
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.166 0.109
THPO THPO, MGDF: Thrombopoietin precursor 0.165 0.109
LOC653509 SFTPA1, PSAP, SFTP1, SFTPA: Pulmonary surfactant-associated protein A1 precursor 0.165 0.109
FGG FGG, PRO2061: Fibrinogen gamma chain precursor 0.165 0.044
CSF3 CSF3, GCSF: Granulocyte colony-stimulating factor precursor 0.165 0.109
NULL A1BG: Alpha-1B-glycoprotein precursor 0.165 0.165
KITLG KITLG, MGF, SCF: Kit ligand precursor 0.165 0.109
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.165 0.109
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.162 1.19
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.162 0.561
STAT6 STAT6: Signal transducer and activator of transcription 6 0.162 0.561
VAV1 VAV1, VAV: Proto-oncogene vav 0.162 0.340
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.162 0.561
PPBP PPBP, CTAP3, SCYB7, TGB1, THBGB1: Platelet basic protein precursor 0.155 0.202
FGL2 FGL2: Fibroleukin precursor 0.140 0.486
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.138 0.085
ITGAE ITGAE: Integrin alpha-E precursor 0.138 0.140
ITGB7 ITGB7: Integrin beta-7 precursor 0.138 0.251
CFP CFP, PFC: Properdin precursor 0.132 0.029
RIN3 N/A 0.130 0.108
OSTF1 N/A 0.130 0.065
ARHGAP4 ARHGAP4, KIAA0131, RGC1, RHOGAP4: Rho GTPase-activating protein 4 0.130 0.065
PF4 PF4, CXCL4, SCYB4: Platelet factor 4 precursor 0.127 0.166
XCL1 XCL1, LTN, SCYC1: Lymphotactin precursor 0.127 0.100
CD44 N/A 0.125 0.260
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.125 0.430
SFTPA2 SFTPA2, PSAP, SFTP1, SFTPA: Pulmonary surfactant-associated protein A2 precursor 0.123 0.072
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.123 0.033
IL6 IL6, IFNB2: Interleukin-6 precursor 0.123 0.072
REG1B REG1A, PSPS, REG: Lithostathine 1 alpha precursor 0.123 0.072
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.111 0.0416
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.111 0.416
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.111 1.81
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.111 1.81
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.111 0.140
EPO EPO: Erythropoietin precursor 0.110 0.072
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.109 0.165
KLRD1 KLRD1, CD94: Natural killer cells antigen CD94 0.109 0.165
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.109 0.165
CSH2 GH1: Somatotropin precursor 0.109 0.072
VTN VTN: Vitronectin precursor 0.109 0.072
CRP CRP, PTX1: C-reactive protein precursor [Contains: C-reactive protein(1-205)] 0.109 0.072
HPX HPX: Hemopexin precursor 0.109 0.072
APCS APCS, PTX2: Serum amyloid P-component precursor 0.109 0.072
CLEC3B CLEC3B, TNA: Tetranectin precursor 0.109 0.072
FGA N/A 0.109 0.072
CLEC2B CLEC2B, AICL, CLECSF2, IFNRG1: C-type lectin domain family 2 member B 0.108 0.067
ADAM8 ADAM8, MS2: ADAM 8 precursor 0.108 0.067
ADAM10 ADAM10, KUZ, MADM: ADAM 10 precursor 0.108 0.083
SEMA4D SEMA4D, CD100, SEMAJ: Semaphorin-4D precursor 0.108 0.050
ITGAL ITGAL, CD11A: Integrin alpha-L precursor 0.108 0.050
BTN3A3 BTN3A3, BTF3: Butyrophilin subfamily 3 member A3 precursor 0.108 0.041
CSPG2 N/A 0.103 0.228
IL3 IL3: Interleukin-3 precursor 0.098 0.072
HLA-DRA 0.087 0.087
TGFB1 TGFB1, TGFB: Transforming growth factor beta-1 precursor 0.084 0.035
CCL26 CCL26, SCYA26, UNQ216/PRO242: Small-inducible cytokine A26 precursor 0.083 0.109
OPTC OPTC, OPT: Opticin precursor 0.083 0.083
CCL15 CCL15, MIP5, NCC3, SCYA15: Small-inducible cytokine A15 precursor 0.083 0.109
PLAT PLAT: Tissue-type plasminogen activator precursor 0.083 0.049
FN1 N/A 0.083 0.083
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.082 0.152
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.082 0.191
CD7 CD7: T-cell antigen CD7 precursor 0.082 0.051
CD82 CD82, KAI1, SAR2, ST6, TSPAN27: CD82 antigen 0.082 0.064
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.082 0.852
MSN MSN: Moesin 0.076 0.340
LYN LYN: Tyrosine-protein kinase Lyn 0.076 1.19
CSK CSK: Tyrosine-protein kinase CSK 0.076 0.274
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.076 0.340
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.076 0.128
JAK1 0.076 0.202
FNBP1 N/A 0.076 0.202
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.076 0.274
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.076 0.166
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.076 0.561
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.076 0.274
CXorf9 N/A 0.076 0.340
ITGA3 ITGA3, MSK18: Integrin alpha-3 precursor 0.072 0.098
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.067 0.123
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.067 0.123
CD3D CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor 0.067 0.109
ITGA2B ITGA2B, GP2B, ITGAB: Integrin alpha-IIb precursor 0.067 0.051
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.067 0.109
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.067 0.085
FCN1 FCN1, FCNM: Ficolin-1 precursor 0.067 0.231
LILRA3 LILRA3, ILT6, LIR4: Leukocyte immunoglobulin-like receptor subfamily A member 3 0.067 0.293
LILRA1 LIR6, LILRA1: Leukocyte immunoglobulin-like receptor subfamily A member 1 precur 0.067 0.293
CD93 CD93, C1QR1, MXRA4: Complement component C1q receptor precursor 0.067 0.137
ITGAX ITGAX, CD11C: Integrin alpha-X precursor 0.065 0.137
LILRB2 N/A 0.065 0.881
LY75 LY75, CD205: Lymphocyte antigen 75 precursor 0.065 0.041
CD300A CD300A, CMRF35H: CMRF35-H antigen precursor 0.065 0.067
BTN3A2 BTN3A2, BT3.2, BTF3, BTF4: Butyrophilin subfamily 3 member A2 precursor 0.065 0.0308
FCER1G FCER1G: High affinity immunoglobulin epsilon receptor subunit gamma precursor 0.065 0.881
CD86 CD86, CD28LG2: T-lymphocyte activation antigen CD86 precursor 0.065 0.293
CD37 CD37, TSPAN26: Leukocyte antigen CD37 0.065 0.050
MMP9 MMP9, CLG4B: Matrix metalloproteinase-9 precursor 0.064 0.033
CGB CGB, CGB3, CGB5, CGB7, CGB8: Choriogonadotropin subunit beta precursor 0.062 0.032
GDF15 GDF15, MIC1, PDF, PLAB, PTGFB: Growth/differentiation factor 15 precursor 0.062 0.032
S100A4 S100A4, CAPL, MTS1: Protein S100-A4 0.061 0.057
ERP29 ERP29, C12orf8, ERP28: Endoplasmic reticulum protein ERp29 precursor 0.061 0.0278
FYB FYB, SLAP130: FYN-binding protein 0.061 0.065
SCAP2 SKAP2, PRAP, RA70, SAPS, SCAP2, SKAP55R: Src kinase-associated phosphoprotein 2 0.061 0.692
CNTN1 CNTN1: Contactin-1 precursor 0.056 0.056
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.056 0.056
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.056 0.165
IL4 IL4: Interleukin-4 precursor 0.056 0.044
IFNG IFNG: Interferon gamma precursor 0.056 0.044
CNTN4 CNTN4: Contactin-4 precursor 0.056 0.056
FCN3 FCN3, FCNH, HAKA1: Ficolin-3 precursor 0.056 0.044
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.056 0.056
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.056 0.109
ANGPTL6 AGF, UNQ152/PRO178, ANGPTL6, ARP5: Angiopoietin-related protein 6 precursor 0.056 0.044
BMP1 N/A 0.056 0.044
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.056 0.044
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.056 0.029
CCL1 CCL1, SCYA1: Small-inducible cytokine A1 precursor 0.056 0.065
RLN2 RLN2: Prorelaxin H2 precursor [Contains: Relaxin B chain; Relaxin A chain] 0.056 0.033
F8 F8, F8C: Coagulation factor VIII precursor 0.056 0.033
IL2RA IL2RA: Interleukin-2 receptor alpha chain precursor 0.056 0.029
PCOLCE PCOLCE, PCPE1: Procollagen C-endopeptidase enhancer 1 precursor 0.055 0.029
C1S C1S: Complement C1s subcomponent precursor 0.055 0.029
ITIH1 ITIH1, IGHEP1: Inter-alpha-trypsin inhibitor heavy chain H1 precursor 0.055 0.055
COL15A1 COL15A1: Collagen alpha-1(XV) chain precursor [Contains: Endostatin 0.055 0.029
TSHB TSHB: Thyrotropin subunit beta precursor 0.055 0.032
THBS1 THBS1, TSP, TSP1: Thrombospondin-1 precursor 0.055 0.032
C3 0.055 0.032
FSHB FSHB: Follitropin subunit beta precursor 0.055 0.032
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.055 0.037
APOH APOH, B2G1: Beta-2-glycoprotein 1 precursor 0.055 0.032
ITGAM ITGAM, CD11B, CR3A: Integrin alpha-M precursor 0.053 0.083
IGSF6 IGSF6, DORA: Immunoglobulin superfamily member 6 precursor. 0.053 0.293
TSPAN14 TSPAN14, TM4SF14: Tetraspanin-14 0.053 0.041
CD302 CD302, CLEC13A, DCL1, KIAA0022: CD302 antigen precursor 0.053 0.293
SIGIRR SIGIRR, UNQ301/PRO342: Single Ig IL-1-related receptor 0.053 0.0308
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.052 0.0727
MMP7 MMP7, MPSL1, PUMP1: Matrilysin precursor 0.051 0.029
IL1B IL1B, IL1F2: Interleukin-1 beta precursor 0.051 0.051
MMP13 MMP13: Collagenase 3 precursor 0.051 0.051
FGF23 FGF23, HYPF, UNQ3027/PRO9828: Fibroblast growth factor 23 precursor 0.051 0.0407
CD63 CD63, MLA1, TSPAN30: CD63 antigen 0.051 0.0416
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.051 0.109
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.051 0.123
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.051 0.124
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.051 0.075
CD55 CD55, CR, DAF: Complement decay-accelerating factor precursor 0.051 0.0286
C6 C6: Complement component C6 precursor 0.049 0.029
F9 F9: Coagulation factor IX precursor 0.049 0.029
SPARC SPARC, ON: SPARC precursor 0.049 0.029
VWF VWF, F8VWF: von Willebrand factor precursor 0.049 0.029
C9 C9: Complement component C9 precursor [Contains: Complement component C9a; Compl 0.049 0.032
C1R C1R: Complement C1r subcomponent precursor 0.049 0.029
SRPR SRPR: Uncharacterized protein SRPR 0.049 0.070
LCP1 LCP1, PLS2: Plastin-2 0.049 0.153
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.049 0.083
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.046 0.340
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.046 1.19
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.046 0.757
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.046 0.105
SYK SYK: Tyrosine-protein kinase SYK 0.046 1.19
HCK N/A 0.046 1.19
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.046 1.19
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.046 0.063
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.046 0.340
TPP2 TPP2: Tripeptidyl-peptidase 2 0.046 0.051
S100A7 S100A7, PSOR1: Protein S100-A7 0.045 0.032
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.044 0.056
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.044 0.165
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.044 0.165
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.044 0.165
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.044 0.165
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.044 0.056
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.044 0.056
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.044 0.165
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.044 0.165
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.044 0.165
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.044 0.165
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.044 0.056
BSG N/A 0.044 0.056
KIR3DL1 N/A 0.044 0.165
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.044 0.165
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.044 0.165
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.044 0.056
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.044 0.165
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.044 0.165
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.044 0.165
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.044 0.165
ACE ACE, DCP, DCP1: Angiotensin-converting enzyme, somatic isoform precursor 0.044 0.056
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.044 0.165
ATRN N/A 0.044 0.056
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.044 0.165
PZP PZP: Pregnancy zone protein precursor 0.044 0.033
MYD88 0.042 0.293
LGALS9 N/A 0.042 0.027
ALK ALK: ALK tyrosine kinase receptor precursor 0.0416 0.081
SFTPD SFTPD, PSPD, SFTP4: Pulmonary surfactant-associated protein D precursor 0.0416 0.037
REG1B REG1B, REGL: Lithostathine 1 beta precursor 0.0416 0.029
THBD THBD, THRM: Thrombomodulin precursor 0.0416 0.0416
IL18 IL18, IGIF, IL1F4: Interleukin-18 precursor 0.0416 0.0407
MMP11 MMP11, STMY3: Stromelysin-3 precursor 0.0416 0.033
CSF2 CSF2, GMCSF: Granulocyte-macrophage colony-stimulating factor precursor 0.0416 0.033
MMP1 MMP1, CLG: Interstitial collagenase precursor 0.0416 0.029
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.0416 0.109
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.0416 0.029
IL1RN IL1RN, IL1F3, IL1RA: Interleukin-1 receptor antagonist protein precursor 0.0416 0.0407
CEACAM6 CEACAM6, NCA: Carcinoembryonic antigen-related cell adhesion molecule 6 precurso 0.0416 0.029
PRG2 PRG2, MBP: Bone marrow proteoglycan precursor 0.0416 0.029
CCL5 CCL5, D17S136E, SCYA5: Small-inducible cytokine A5 precursor 0.041 0.0407
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.0407 0.251
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.0407 0.123
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.0407 0.051
ASGR1 ASGR1: Asialoglycoprotein receptor 1 0.0407 0.251
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.0407 0.123
ITGB3 ITGB3, GP3A: Integrin beta-3 precursor 0.0407 0.152
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.041 0.253
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.041 0.124
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.041 0.253
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.041 0.035
GMIP GMIP: GEM-interacting protein 0.041 0.253
NDP NDP: Norrin precursor 0.039 0.033
CD83 CD83: CD83 antigen precursor 0.039 0.041
CD300C CD300C, CMRF35, CMRF35A: CMRF35-A antigen precursor 0.039 0.137
FCGR1A FCGR1A, FCG1, FCGR1, IGFR1: High affinity immunoglobulin gamma Fc receptor I pre 0.039 0.137
IL18R1 IL18R1, IL1RRP: Interleukin-18 receptor 1 precursor 0.039 0.041
TREM1 TREM1: Triggering receptor expressed on myeloid cells 1 precursor 0.039 0.083
MFAP3 MFAP3: Microfibril-associated glycoprotein 3 precursor 0.039 0.0308
DGCR2 DGCR2, IDD, KIAA0163: Integral membrane protein DGCR2/IDD precursor 0.039 0.041
FCER1A FCER1A, FCE1A: High affinity immunoglobulin epsilon receptor subunit alpha precu 0.039 0.083
FGF1 FGF1, FGFA: Heparin-binding growth factor 1 precursor 0.037 0.026
FGF5 FGF5: Fibroblast growth factor 5 precursor 0.037 0.026
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.037 0.037
DLG2 DLG2: Disks large homolog 2 0.037 0.072
ST6GAL1 ST6GAL1, SIAT1: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltrans 0.037 0.126
CD2AP CD2AP: CD2-associated protein 0.037 0.202
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.037 0.166
ST3GAL1 ST3GAL1, SIAT4, SIAT4A: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sia 0.037 0.0407
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.037 0.253
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.037 0.340
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.037 0.111
NCK2 NCK2: Cytoplasmic protein NCK2 0.037 0.100
NADK N/A 0.037 0.130
MYO1F MYO1F: Myosin-If 0.037 0.108
RNPEP RNPEP, APB: Aminopeptidase B 0.037 0.108
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.037 0.111
FYN N/A 0.037 0.032
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.037 0.026
FGB FGB: Fibrinogen beta chain precursor [Contains: Fibrinopeptide B] 0.037 0.029
MMP2 MMP2, CLG4A: 72 kDa type IV collagenase precursor 0.037 0.026
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.037 0.026
ANGPTL3 ANGPTL3, ANGPT5, UNQ153/PRO179: Angiopoietin-related protein 3 precursor 0.037 0.029
IL5 IL5: Interleukin-5 precursor 0.037 0.033
LIF LIF, HILDA: Leukemia inhibitory factor precursor 0.037 0.029
IL1A IL1A, IL1F1: Interleukin-1 alpha precursor 0.037 0.072
CEACAM5 CEACAM5, CEA: Carcinoembryonic antigen-related cell adhesion molecule 5 precurso 0.037 0.026
TNC TNC, HXB: Tenascin precursor 0.037 0.033
IL2 IL2: Interleukin 2 0.037 0.029
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.037 0.029
REG3A REG3A, HIP, PAP, PAP1: Regenerating islet-derived protein 3 alpha precursor 0.037 0.029
MMP8 CLG1, MMP8: Neutrophil collagenase precursor 0.037 0.029
ULBP2 ULBP2, N2DL2, UNQ463/PRO791, RAET1H: NKG2D ligand 2 precursor 0.037 0.033
MFAP4 MFAP4: Microfibril-associated glycoprotein 4 precursor 0.037 0.026
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.037 0.029
LAMA2 LAMA2: Uncharacterized protein LAMA2 0.037 0.072
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.037 0.026
PRL PRL: Prolactin precursor 0.037 0.029
CCR5 CCR5: CCR5 receptor (Fragment) 0.036 0.052
C5AR1 C5AR1, C5AR, C5R1: C5a anaphylatoxin chemotactic receptor 0.036 0.144
SORL1 SORL1: Sortilin-related receptor precursor 0.035 0.041
PRNP PRNP, PRIP, PRP: Major prion protein precursor 0.034 0.0338
PTGS1 PTGS1, COX1: Prostaglandin G/H synthase 1 precursor 0.034 0.083
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.033 0.037
FIGF FIGF, VEGFD: Vascular endothelial growth factor D precursor 0.033 0.026
PRG4 PRG4, MSF, SZP: Proteoglycan-4 precursor 0.033 0.065
LGALS3BP LGALS3BP, M2BP: Galectin-3-binding protein precursor 0.033 0.029
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.033 0.109
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.033 0.037
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.033 0.033
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.033 0.0416
ADAMDEC1 ADAMDEC1: ADAM DEC1 precursor 0.033 0.0416
MME MME, EPN: Neprilysin 0.033 0.123
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.033 0.0416
KIT KIT: Mast/stem cell growth factor receptor precursor 0.033 0.109
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.033 0.123
CD151 CD151, TSPAN24: CD151 antigen 0.033 0.123
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.033 0.109
GPA33 GPA33: Cell surface A33 antigen precursor 0.033 0.037
ASGR2 ASGR2: Asialoglycoprotein receptor 2 0.033 0.152
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.033 0.098
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.033 0.152
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.032 0.055
HPN HPN, TMPRSS1: Serine protease hepsin 0.032 0.055
F3 F3: Tissue factor precursor 0.032 0.049
ECE1 ECE1: Endothelin-converting enzyme 1 0.032 0.0308
FCGR3B FCGR3B, CD16B, FCG3, FCGR3, IGFR3: Low affinity immunoglobulin gamma Fc region r 0.032 0.0308
LTK LTK, TYK1: Leukocyte tyrosine kinase receptor precursor 0.032 0.0308
ITGA5 ITGA5, FNRA: Integrin alpha-5 precursor 0.032 0.0308
SLAMF7 SLAMF7, CS1, UNQ576/PRO1138: SLAM family member 7 precursor 0.032 0.050
SIGLEC5 SIGLEC5, CD33L2, OBBP2: Sialic acid-binding Ig-like lectin 5 precursor 0.0308 0.0308
LILRA4 LILRA4, ILT7: Leukocyte immunoglobulin-like receptor subfamily A member 4 precur 0.0308 0.067
PRND PRND, DPL, UNQ1830/PRO3443: Prion-like protein doppel precursor 0.030 0.0338
CCL4 CCL4, CCL4L, LAG1, MIP1B, SCYA4, SCYA4L: Small-inducible cytokine A4 precursor 0.030 0.067
CD6 CD6: T-cell differentiation antigen CD6 precursor 0.030 0.032
SH3GLB1 SH3GLB1, CGI-61: SH3 domain GRB2-like protein B1 0.030 0.053
ARHGAP26 ARHGAP26, GRAF, KIAA0621, OPHN1L: Rho GTPase-activating protein 26 0.030 0.053
NCF2 NCF2: Neutrophil cytosol factor 2 0.030 0.231
MTM1 MTM1, CG2: Myotubularin 0.030 0.039
ZMPSTE24 ZMPSTE24, FACE1, STE24: CAAX prenyl protease 1 homolog 0.030 0.067
RNPEPL1 RNPEPL1: Arginyl aminopeptidase-like 1 0.030 0.039
MTMR1 MTMR1: Myotubularin-related protein 1 0.030 0.039
FLNA FLNA, FLN, FLN1: Filamin-A 0.030 0.074
DOK1 DOK1: Docking protein 1 0.030 0.125
FGF9 FGF9: Glia-activating factor precursor 0.030 0.026
PDGFA PDGFA, PDGF1: Platelet-derived growth factor A chain precursor 0.030 0.026
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.030 0.098
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.029 0.109
PTPRZ1 N/A 0.029 0.033
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.029 0.098
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.029 0.098
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.029 0.098
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.029 0.110
MET MET: Hepatocyte growth factor receptor precursor 0.029 0.110
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.029 0.037
ACE ACE, DCP, DCP1: Angiotensin-converting enzyme, testis-specific isoform precursor 0.029 0.033
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.029 0.110
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.029 0.033
DCC DCC: Netrin receptor DCC precursor 0.029 0.037
MEP1A MEP1A: Meprin A subunit alpha precursor 0.029 0.037
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.029 0.109
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.029 0.037
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.029 0.098
INSR INSR: Insulin receptor precursor 0.029 0.109
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.029 0.098
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.029 0.098
KEL KEL: Kell blood group glycoprotein 0.029 0.037
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.029 0.098
NOTCH2 NOTCH2: Neurogenic locus notch homolog protein 2 precursor 0.0286 0.430
TLR2 TLR2, TIL4: Toll-like receptor 2 precursor 0.0286 0.613
UNC84B UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2: Sad1/unc-84-like protein 2 0.0286 0.096
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.0286 0.041
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.0286 0.260
TLN2 TLN2: Uncharacterized protein TLN2 0.0278 0.033
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.027 0.274
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.027 0.081
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.027 0.091
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.027 0.081
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.027 0.166
VIL2 N/A 0.027 0.100
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.027 0.081
CANX CANX: Calnexin precursor 0.027 0.127
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.027 0.081
CRKL CRKL: Crk-like protein 0.027 0.126
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.027 0.202
CNTN5 CNTN5: Contactin-5 precursor 0.027 0.027
SIRPD N/A 0.027 0.027
PSG4 PSG4, CGM4, PSG9: Pregnancy-specific beta-1-glycoprotein 4 precursor 0.027 0.027
KIRREL2 KIRREL2, NEPH3, UNQ5827/PRO19646: Kin of IRRE-like protein 2 precursor 0.027 0.027
CRLF1 CRLF1, ZCYTOR5, UNQ288/PRO327: Cytokine receptor-like factor 1 precursor 0.027 0.027
C20orf102 N/A 0.027 0.027
CNTNAP1 CNTNAP1, CASPR, NRXN4: Contactin-associated protein 1 precursor 0.027 0.027
PSG6 PSG6, CGM3, PSGGB: Pregnancy-specific beta-1-glycoprotein 6 precursor 0.027 0.027
MGC33530 N/A 0.027 0.027
NEGR1 NEGR1, UNQ2433/PRO4993: Neuronal growth regulator 1 precursor 0.027 0.027
FCAR FCAR, CD89: Immunoglobulin alpha Fc receptor precursor 0.027 0.027
NTN4 NTN4: Netrin-4 precursor 0.027 0.027
MADCAM1 MADCAM1: Mucosal addressin cell adhesion molecule 1 precursor 0.027 0.027
PSG11 PSG11, PSG13, PSG14: Pregnancy-specific beta-1-glycoprotein 11 precursor 0.027 0.027
SIGLEC11 N/A 0.027 0.027
CLEC14A CLEC14A, C14orf27, UNQ236/PRO269, EGFR5: C-type lectin domain family 14 member A 0.027 0.027
CNTN6 CNTN6: Contactin-6 precursor 0.027 0.027
PTPRT PTPRT, KIAA0283: Receptor-type tyrosine-protein phosphatase T precursor 0.027 0.027
SIGLEC6 N/A 0.027 0.027
HAPLN4 HAPLN4, BRAL2, KIAA1926: Hyaluronan and proteoglycan link protein 4 precursor 0.027 0.027
LILRB3 LILRB3, ILT5, LIR3: Leukocyte immunoglobulin-like receptor subfamily B member 3 0.027 0.027
ROBO1 N/A 0.027 0.027
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.026 0.037
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.026 0.033
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.026 0.033
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.026 0.033
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.026 0.109
ITGAV ITGAV, MSK8, VNRA: Integrin alpha-V precursor 0.026 0.033
ITGB4 N/A 0.026 0.037
MEP1B MEP1B: Meprin A subunit beta precursor 0.026 0.109
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.026 0.109
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.026 0.098
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.026 0.098
MBTPS2 MBTPS2, S2P: Membrane-bound transcription factor site-2 protease 0.026 0.037
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.026 0.110
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.026 0.037
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.026 0.098
SELE SELE, ELAM1: E-selectin precursor 0.026 0.098
MARCO MARCO, SCARA2: Macrophage receptor MARCO 0.025 0.062
0.572
Total Score 31.50