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Evidence of Interaction Between EFNB2 and EPHB1

The interaction score between EFNB2 and EPHB1 is 763.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between EFNB2 and EPHB1 = 0.07

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.85E-3
Orthology
OrganismEFNB2 OrthologueEPHB1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00024307 0.452 IPI00008318 0.487
human IPI00024307 0.452 IPI00016645 0.405
human IPI00024307 0.452 IPI00005222 0.344
human IPI00024307 0.452 IPI00419636 0.099
human IPI00024307 0.452 IPI00418427 0.457
human IPI00019501 0.244 IPI00008318 0.487
  • Other
  • InVitro
  • InVivo

Get References From PubMed
human IPI00019501 0.244 IPI00016645 0.405
human IPI00019501 0.244 IPI00005222 0.344
human IPI00019501 0.244 IPI00419636 0.099
human IPI00019501 0.244 IPI00418427 0.457
worm Q9U3M2 1 O61460 0.405
  • pullDown

Get References From PubMed
fly Q8ST77 1 O96435 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 3.01
Domains Domains present in EFNB2 and EPHB1:
Domains in EFNB2Domains in EPHB1
IPR008972 Cupredoxin
IPR001799 Ephrin
IPR006209 EGF-like domain
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR001090 Ephrin receptor, ligand binding
IPR001426 Receptor tyrosine kinase, class V
IPR001660 Sterile alpha motif SAM
IPR003961 Fibronectin, type III
IPR003962 Fibronectin, type III subdomain

The Chi square scores for co-occurrence of domains that are present in EFNB2 and EPHB1 are listed below.

Domain 1Domain 2Chi Square
IPR001799 Ephrin IPR001090 Ephrin receptor, ligand binding 1988.46
IPR001799 Ephrin IPR001426 Receptor tyrosine kinase, class V 1988.46
IPR008972 Cupredoxin IPR001426 Receptor tyrosine kinase, class V 708.194
IPR008972 Cupredoxin IPR001090 Ephrin receptor, ligand binding 708.194
IPR001799 Ephrin IPR001660 Sterile alpha motif SAM 683.581
IPR001799 Ephrin IPR003962 Fibronectin, type III subdomain 427.381
IPR008972 Cupredoxin IPR001660 Sterile alpha motif SAM 235.778
IPR008972 Cupredoxin IPR003962 Fibronectin, type III subdomain 169.591
IPR001799 Ephrin IPR003961 Fibronectin, type III 147.446
IPR008972 Cupredoxin IPR006209 EGF-like domain 96.6944
IPR001799 Ephrin IPR008266 Tyrosine protein kinase, active site 73.3233
IPR001799 Ephrin IPR001245 Tyrosine protein kinase 64.1366
IPR001799 Ephrin IPR006209 EGF-like domain 50.0861
IPR008972 Cupredoxin IPR003961 Fibronectin, type III 42.4026
IPR001799 Ephrin IPR000719 Protein kinase 30.3648
IPR008972 Cupredoxin IPR008266 Tyrosine protein kinase, active site 16.4698
IPR008972 Cupredoxin IPR001245 Tyrosine protein kinase 13.2721
IPR008972 Cupredoxin IPR000719 Protein kinase 2.76992

The background colour of the table refers to:

  • Blue Domain is only present in EFNB2
  • Yellow Domain is only present in EPHB1
  • Green Domain is present in both EFNB2 and EPHB1

 0.980
Post-translational Modifications

Protein: EFNB2

PTMResidueReference
Phosphorylation 304 PubMed, HPRD
Phosphorylation 330 PubMed, HPRD

Protein: EPHB1

PTMResidueReference
Phosphorylation 594 PubMed, HPRD
Phosphorylation 600 PubMed, HPRD
Phosphorylation 928 PubMed, HPRD
Phosphotyrosine 594 PubMed, HPRD
Phosphotyrosine 600 PubMed, HPRD
Phosphotyrosine 778 PubMed, HPRD
Phosphotyrosine 928 PubMed, HPRD
Localisation

Protein: EFNB2

LocalisationReference
Plasma membrane HPRD

Protein: EPHB1

LocalisationReference
Plasma membrane HPRD
Transitive Score

The common interactors between EFNB2 and EPHB1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EFNB2 andEPHB1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EFNB2 has 700 interactors and EPHB1 has 1414 interactors of which there are 431 common interactors.

Common InteractorName of Common InteractorScore for EFNB2-Interactor (?)Score for EPHB1-Interactor (?)
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 1.57E3 46.90
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 1.36E3 65.60
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 1.36E3 82.20
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 1.18E3 71.20
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 1.08E3 53.10
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 1.08E3 53.10
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 1.08E3 65.60
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 149.00 0.171
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 86.60 65.60
NEO1 NEO1, NGN: Neogenin precursor 1.33 0.171
FN1 N/A 1.30 0.165
ITGB4 N/A 1.13 0.109
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 1.07 0.097
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.980 0.165
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.878 0.148
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.735 0.064
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.735 0.090
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.644 0.109
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.617 0.051
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 0.617 0.051
FN1 FN1, FN: Fibronectin precursor 0.617 0.051
STIM1 STIM1, GOK: Stromal interaction molecule 1 precursor 0.617 0.051
NRCAM NRCAM, KIAA0343: Neuronal cell adhesion molecule precursor 0.617 0.051
DCC DCC: Netrin receptor DCC precursor 0.577 0.136
PHC3 PHC3, EDR3, PH3: Polyhomeotic-like protein 3 0.553 0.046
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.483 0.098
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.483 0.062
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.445 0.090
TP73 TP73, P73: Tumor protein p73 0.320 0.063
SCML2 SCML2: Sex comb on midleg-like protein 2 0.320 0.063
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.286 0.360
PTPRT PTPRT, KIAA0283: Receptor-type tyrosine-protein phosphatase T precursor 0.265 0.027
CXorf9 N/A 0.256 0.058
NOTCH3 NOTCH3: Neurogenic locus notch homolog protein 3 precursor 0.225 0.111
SLIT2 SLIT2, SLIL3: Slit homolog 2 protein precursor 0.225 0.064
PTPRD PTPRD: PTPRD protein 0.217 0.027
PRSS1 PRSS1, TRP1, TRY1, TRYP1: Trypsin-1 precursor 0.191 0.081
ELA3B ELA3B: Elastase-3B precursor 0.191 0.081
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.191 0.081
MEP1A MEP1A: Meprin A subunit alpha precursor 0.181 0.111
TNC TNC, HXB: Tenascin precursor 0.171 0.088
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.171 0.090
KLK1 KLK1: Kallikrein-1 precursor 0.171 0.073
MET MET: Hepatocyte growth factor receptor precursor 0.166 0.152
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.166 0.152
F11 F11: Coagulation factor XI precursor 0.165 0.109
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.165 0.165
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.165 0.165
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.165 0.109
BGLAP BGLAP: Osteocalcin precursor 0.165 0.109
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.152 0.081
LGALS3 LGALS3, MAC2: Galectin-3 0.152 0.0727
PROZ PROZ: Vitamin K-dependent protein Z precursor 0.152 0.126
PRSS22 PRSS22, BSSP4, SP001LA, PRSS26, UNQ302/PRO343: Brain-specific serine protease 4 0.152 0.126
PTPRZ1 N/A 0.148 0.136
TMPRSS2 TMPRSS2, PRSS10: Transmembrane protease, serine 2 precursor 0.148 0.097
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.148 0.097
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.148 0.097
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.148 0.171
HGF HGF, HPTA: Hepatocyte growth factor precursor 0.148 0.148
CNTN1 CNTN1: Contactin-1 precursor 0.148 0.148
CNTN4 CNTN4: Contactin-4 precursor 0.148 0.148
F7 F7: Coagulation factor VII precursor 0.148 0.098
BMP1 N/A 0.148 0.098
PLAT PLAT: Tissue-type plasminogen activator precursor 0.148 0.098
KLK3 KLK3, APS: Prostate-specific antigen precursor 0.148 0.098
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.148 0.098
PTPRS PTPRS: Protein tyrosine phosphatase, receptor type, S 0.143 0.0308
THBS1 THBS1, TSP, TSP1: Thrombospondin-1 precursor 0.136 0.064
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.136 0.111
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.136 0.171
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.136 0.097
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.136 0.113
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.128 0.063
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.126 0.123
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.126 0.191
F3 F3: Tissue factor precursor 0.126 0.109
APCS APCS, PTX2: Serum amyloid P-component precursor 0.123 0.081
SHBG SHBG: Sex hormone-binding globulin precursor 0.123 0.100
CFI CFI, IF: Complement factor I precursor 0.123 0.081
COL5A1 N/A 0.123 0.072
F12 F12: Coagulation factor XII precursor 0.123 0.081
C2 C2: Complement C2 precursor 0.123 0.081
PROS1 PROS1, PROS: Vitamin K-dependent protein S precursor 0.123 0.081
UMOD UMOD: Uromodulin precursor 0.123 0.123
COL16A1 COL16A1: Collagen alpha-1(XVI) chain precursor 0.123 0.072
CFB CFB, BF, BFD: Complement factor B precursor 0.123 0.081
HGFAC HGFAC: Hepatocyte growth factor activator precursor 0.123 0.123
C1R C1R: Complement C1r subcomponent precursor 0.123 0.081
MGP MGP, MGLAP, GIG36: Matrix Gla protein precursor 0.123 0.081
COL15A1 COL15A1: Collagen alpha-1(XV) chain precursor [Contains: Endostatin 0.123 0.081
CMA1 CMA1, CYH, CYM: Chymase precursor 0.123 0.081
HP HP: Haptoglobin precursor [Contains: Haptoglobin alpha chain; Haptoglobin beta c 0.123 0.081
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.114 0.073
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.113 0.097
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.113 0.136
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.113 0.111
F9 F9: Coagulation factor IX precursor 0.111 0.073
FAT2 FAT2, CDHF8, KIAA0811, MEGF1: Protocadherin Fat 2 precursor 0.111 0.171
C7 C7: Complement component C7 precursor 0.111 0.073
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.111 0.064
F10 F10: Coagulation factor X precursor 0.111 0.111
PLG PLG: Plasminogen precursor 0.111 0.073
C8B C8B: Complement component C8 beta chain precursor 0.111 0.090
DLG2 DLG2: Disks large homolog 2 0.111 0.090
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.111 0.064
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.111 0.064
F2 F2: Prothrombin precursor 0.111 0.073
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.111 0.073
KLK6 KLK6, PRSS18, PRSS9: Kallikrein-6 precursor 0.111 0.073
NOTCH4 N/A 0.111 0.171
GZMB Endogenous granzyme B 0.110 0.081
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.109 0.165
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.109 0.165
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.109 0.165
DLK1 DLK1, DLK: Delta-like protein precursor 0.109 0.165
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.109 0.165
EMR2 EMR2: EGF-like module-containing mucin-like hormone receptor-like 2 precursor 0.109 0.165
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.109 0.165
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.109 0.165
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.109 0.165
PRTN3 PRTN3, MBN: Myeloblastin precursor 0.109 0.065
C8A C8A: Complement component C8 alpha chain precursor 0.109 0.081
F5 F5: Coagulation factor V precursor 0.109 0.644
MUC2 MUC2, SMUC: Mucin-2 precursor 0.109 0.081
C1S C1S: Complement C1s subcomponent precursor 0.109 0.072
ELA2 ELA2: Leukocyte elastase precursor 0.109 0.072
CTSG CTSG: Cathepsin G precursor 0.109 0.072
AZU1 AZU1: Azurocidin precursor 0.109 0.072
LGALS1 LGALS1: Galectin-1 0.109 0.065
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.109 0.191
KALRN DUET, TRAD: Serine/threonine-protein kinase Duet 0.105 0.032
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.100 0.152
AREG AREG, SDGF: Amphiregulin precursor 0.100 0.109
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.098 0.100
CSPG2 N/A 0.098 0.065
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.098 0.148
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.098 0.025
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.098 0.025
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.098 0.148
JAG2 JAG2: Jagged-2 precursor 0.098 0.148
ATRN N/A 0.098 0.148
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.098 0.148
TMPRSS9 N/A 0.098 0.148
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.098 0.148
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.098 0.148
LPA LPA: Apolipoprotein(a) precursor 0.097 0.073
C6 C6: Complement component C6 precursor 0.097 0.090
LAMA2 LAMA2: Uncharacterized protein LAMA2 0.097 0.073
C9 C9: Complement component C9 precursor [Contains: Complement component C9a; Compl 0.097 0.073
ALK ALK: ALK tyrosine kinase receptor precursor 0.097 0.090
PROC PROC: Vitamin K-dependent protein C precursor 0.097 0.073
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.094 0.029
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.094 0.073
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.094 0.051
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.090 0.111
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.090 0.171
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.090 0.111
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.090 0.097
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.090 0.171
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.088 0.064
HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 0.088 0.073
CRLF3 N/A 0.088 0.110
THBD THBD, THRM: Thrombomodulin precursor 0.085 0.0416
SELE SELE, ELAM1: E-selectin precursor 0.081 0.123
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.081 0.123
EGF EGF: Pro-epidermal growth factor precursor 0.081 0.123
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.081 0.191
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.081 0.109
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.081 0.152
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.0794 0.644
PDLIM1 PDLIM1, CLIM1, CLP36: PDZ and LIM domain protein 1 0.0794 0.0263
INSR INSR: Insulin receptor precursor 0.073 0.111
LDLR LDLR: Low-density lipoprotein receptor precursor 0.073 0.111
KIT KIT: Mast/stem cell growth factor receptor precursor 0.073 0.097
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.073 0.171
MEP1B MEP1B: Meprin A subunit beta precursor 0.073 0.171
ST14 ST14, PRSS14, SNC19, TADG15: Suppressor of tumorigenicity protein 14 0.073 0.136
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.073 0.111
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.073 0.054
HPN HPN, TMPRSS1: Serine protease hepsin 0.073 0.111
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.0727 0.123
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.072 0.098
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.072 0.110
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.072 0.123
EPOR EPOR: Erythropoietin receptor precursor 0.072 0.109
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.072 0.109
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.072 0.191
PRLR PRLR: Prolactin receptor precursor 0.072 0.152
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.071 0.051
PCSK2 PCSK2, NEC2: Neuroendocrine convertase 2 precursor 0.071 0.057
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.071 0.033
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.071 0.033
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.071 0.090
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.0688 0.980
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.0688 0.049
MAPK15 N/A 0.0688 0.109
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.0688 0.980
MAP2K5 N/A 0.0688 0.049
PTGS1 PTGS1, COX1: Prostaglandin G/H synthase 1 precursor 0.0688 0.0688
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.0688 0.049
PDZD2 CDNA FLJ46853 fis, clone UTERU3009775, moderately similar to Rattus norvegicus P 0.0688 0.04
ITGB3 ITGB3, GP3A: Integrin beta-3 precursor 0.065 0.171
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.065 0.099
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.065 0.123
SORL1 SORL1: Sortilin-related receptor precursor 0.065 0.109
IL9R IL9R: Interleukin-9 receptor precursor 0.065 0.191
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.065 0.109
GHR GHR: Growth hormone receptor precursor 0.065 0.123
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.065 0.098
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.065 0.123
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.065 0.098
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.065 0.152
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.064 0.088
MBTPS2 MBTPS2, S2P: Membrane-bound transcription factor site-2 protease 0.064 0.171
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.064 0.029
LRP1 LRP1, A2MR, APR: Prolow-density lipoprotein receptor-related protein 1 precursor 0.064 0.097
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.064 0.097
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.063 0.032
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.062 0.878
MYO18A 0.062 0.036
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.062 0.878
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.062 0.098
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.062 0.098
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.062 0.098
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.062 0.098
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.062 0.098
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.062 0.044
GOPC GOPC, CAL, FIG: Golgi-associated PDZ and coiled-coil motif-containing protein 0.062 0.036
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.062 0.098
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.062 0.044
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.062 0.098
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.062 0.098
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.062 0.098
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.062 0.062
UNC84B UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2: Sad1/unc-84-like protein 2 0.058 0.099
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.058 0.097
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.058 0.056
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.058 0.136
NOTCH2 NOTCH2: Neurogenic locus notch homolog protein 2 precursor 0.058 0.088
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.058 0.110
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.058 0.110
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.057 0.090
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.057 0.148
FKBP9 FKBP9, FKBP60, FKBP63: FK506-binding protein 9 precursor 0.057 0.041
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.057 0.577
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.057 0.067
SIPA1L1 SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein 0.057 0.033
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.057 0.033
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.057 0.046
PARD3 N/A 0.057 0.033
PDGFA PDGFA, PDGF1: Platelet-derived growth factor A chain precursor 0.052 0.081
ITGB7 ITGB7: Integrin beta-7 precursor 0.052 0.088
COL6A3 COL6A3: Collagen alpha-3(VI) chain precursor 0.051 0.051
MST1 MST1, D3F15S2, DNF15S2, HGFL: Hepatocyte growth factor-like protein precursor 0.051 0.051
KLKB1 N/A 0.051 0.051
PAPPA PAPPA: Pappalysin-1 precursor 0.051 0.051
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.051 0.051
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
MARK2 N/A 0.051 0.051
PLAU PLAU: Urokinase-type plasminogen activator precursor 0.051 0.051
MAP3K9 MAP3K9, MLK1, PRKE1: Mitogen-activated protein kinase kinase kinase 9 0.051 0.051
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.051 0.051
LTBP1 LTBP1: Latent-transforming growth factor beta-binding protein, isoform 1S precur 0.051 0.051
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.051 0.051
NCAM1 N/A 0.051 0.051
OLFM1 OLFM1, NOE1, NOEL1: Noelin precursor 0.051 0.051
ITGB1 ITGB1, FNRB, MDF2, MSK12: Integrin beta-1 precursor 0.051 0.051
MARK1 MARK1, KIAA1477, MARK: Serine/threonine-protein kinase MARK1 0.051 0.051
TJP2 TJP2, X104, ZO2: Tight junction protein ZO-2 0.051 0.051
DLG1 DLG1: Disks large homolog 1 0.051 0.051
MMRN1 MMRN1, ECM, EMILIN4, MMRN: Multimerin-1 precursor 0.051 0.051
ELTD1 ELTD1, RP11-143H12.1-002: EGF, latrophilin and seven transmembrane domain contai 0.051 0.051
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.051 0.072
BMX N/A 0.051 1.48
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.051 0.731
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.051 0.072
LIMK2 LIMK2: LIM domain kinase 2 0.051 0.030
COL12A1 COL12A1, COL12A1L: Collagen alpha-1(XII) chain precursor 0.050 0.040
SPOCK1 SPOCK1, SPOCK, TIC1, TICN1: Testican-1 precursor 0.050 0.040
VWF VWF, F8VWF: von Willebrand factor precursor 0.046 0.064
CNTN3 CNTN3, KIAA1496, PANG: Contactin-3 precursor 0.046 0.046
AGC1 AGC1, CSPG1, MSK16: Aggrecan core protein precursor 0.046 0.046
LMO7 N/A 0.046 0.046
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.046 0.046
MLLT4 N/A 0.046 0.046
FLT4 VEGFR3 long form 0.046 0.046
MAPK14 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2: Mitogen-activated protein kinase 14 0.046 0.046
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.046 0.033
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.046 0.057
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.046 0.033
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.046 0.058
FKBP10 FKBP10, FKBP65, PSEC0056: FK506-binding protein 10 precursor 0.046 0.041
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.046 0.058
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.046 0.090
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.046 0.064
P4HB P4HB, ERBA2L, PDI, PDIA1, PO4DB: Protein disulfide-isomerase precursor 0.046 0.041
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.046 0.065
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.046 0.065
XRCC1 XRCC1: DNA-repair protein XRCC1 0.046 0.045
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.046 0.065
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.046 0.065
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.046 0.032
STK16 N/A 0.045 0.081
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.045 0.902
A2M A2M, FWP007: Alpha-2-macroglobulin precursor 0.0425 0.032
CEACAM6 CEACAM6, NCA: Carcinoembryonic antigen-related cell adhesion molecule 6 precurso 0.0425 0.072
SFTPA2 SFTPA2, PSAP, SFTP1, SFTPA: Pulmonary surfactant-associated protein A2 precursor 0.0425 0.072
EGFL4 MEGF8, C19orf49, EGFL4, KIAA0817: Multiple epidermal growth factor-like domains 0.042 0.042
CSK CSK: Tyrosine-protein kinase CSK 0.041 0.520
HCK N/A 0.041 0.520
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.041 0.586
LYN LYN: Tyrosine-protein kinase Lyn 0.041 0.520
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.041 0.520
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.041 0.073
SYK SYK: Tyrosine-protein kinase SYK 0.041 0.577
RPS6KB1 N/A 0.041 0.058
JAK1 0.041 0.586
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.041 0.065
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.041 0.520
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.041 0.581
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.041 1.48
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.041 0.065
PDIA6 PDIA6, TXNDC7: Protein disulfide-isomerase A6 precursor 0.041 0.041
RIMS1 RIMS1, KIAA0340, Nbla00761, RAB3IP2, RIM1: Regulating synaptic membrane exocytos 0.041 0.033
CANX CANX: Calnexin precursor 0.041 0.046
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.041 0.064
LMAN2 LMAN2, C5orf8: Vesicular integral-membrane protein VIP36 precursor 0.041 0.037
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.041 0.058
NOS1 NOS1: Nitric-oxide synthase, brain 0.041 0.054
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.041 0.041
MINPP1 MINPP1, MIPP, UNQ900/PRO1917: Multiple inositol polyphosphate phosphatase 1 prec 0.041 0.037
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.041 0.058
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.041 0.058
SFTPD SFTPD, PSPD, SFTP4: Pulmonary surfactant-associated protein D precursor 0.038 0.064
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.037 0.058
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.037 0.073
SGSH SGSH, HSS: N-sulphoglucosamine sulphohydrolase precursor 0.037 0.037
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.037 0.520
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.037 0.064
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.037 0.029
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.037 0.058
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.037 0.655
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.037 0.073
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.037 0.065
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.037 0.026
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.037 0.058
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.037 0.808
LMAN1 LMAN1, ERGIC53, F5F8D: Protein ERGIC-53 precursor 0.037 0.046
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.037 0.073
ROCK1 ROCK1: Rho-associated protein kinase 1 0.036 0.072
TAOK1 TAOK1, KIAA1361, MAP3K16: Serine/threonine-protein kinase TAO1 0.034 0.030
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.033 0.577
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.033 0.520
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.033 0.520
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.033 0.058
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.032 0.123
C1QA C1QA: Complement C1q subcomponent subunit A precursor 0.032 0.081
CEL CEL, RP11-326L24.2-001: Carboxyl ester lipase 0.032 0.037
CCK CCK: Cholecystokinins precursor 0.032 0.072
COL17A1 COL17A1, BP180, BPAG2: Collagen alpha-1(XVII) chain 0.032 0.072
CLEC3B CLEC3B, TNA: Tetranectin precursor 0.032 0.072
SPINT2 SPINT2, HAI2, KOP: Kunitz-type protease inhibitor 2 precursor 0.032 0.098
LGALS3BP LGALS3BP, M2BP: Galectin-3-binding protein precursor 0.032 0.037
TACSTD1 TACSTD1, GA733-2, M1S2, M4S1, MIC18, TROP1: Tumor-associated calcium signal tran 0.032 0.081
MFAP4 MFAP4: Microfibril-associated glycoprotein 4 precursor 0.029 0.058
FGF9 FGF9: Glia-activating factor precursor 0.029 0.113
SERPINI1 SERPINI1, PI12: Neuroserpin precursor 0.029 0.064
FIGF FIGF, VEGFD: Vascular endothelial growth factor D precursor 0.029 0.073
SPON1 SPON1, KIAA0762, VSGP: Spondin-1 precursor 0.029 0.090
CPA2 CPA2: Carboxypeptidase A2 precursor 0.029 0.033
PNLIP PNLIP: Pancreatic triacylglycerol lipase precursor 0.029 0.073
CPB1 CPB1, CPB, PCPB: Carboxypeptidase B precursor 0.029 0.033
COL4A1 N/A 0.029 0.064
IL4 IL4: Interleukin-4 precursor 0.028 0.109
CD46 N/A 0.028 0.109
TFPI TFPI, LACI, TFPI1: Tissue factor pathway inhibitor precursor 0.028 0.109
CCL15 CCL15, MIP5, NCC3, SCYA15: Small-inducible cytokine A15 precursor 0.028 0.049
DSP DSP: Desmoplakin 0.028 0.049
NULL A1BG: Alpha-1B-glycoprotein precursor 0.028 0.165
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.028 0.165
RTN4R RTN4R, NOGOR, UNQ330/PRO526: Reticulon-4 receptor precursor 0.028 0.083
LRG1 LRG1, LRG: Leucine-rich alpha-2-glycoprotein precursor 0.028 0.083
OPTC OPTC, OPT: Opticin precursor 0.028 0.083
LOC643930 CCL3L1, D17S1718, G0S19-2, SCYA3L1: Small-inducible cytokine A3-like 1 precursor 0.028 0.049
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.028 0.165
CFHR1 CFHR1, CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, HFL1, HFL2: Complement factor H-relate 0.028 0.109
DCN DCN: Decorin precursor 0.028 0.049
CSF3 CSF3, GCSF: Granulocyte colony-stimulating factor precursor 0.028 0.109
ECM1 ECM1: Extracellular matrix protein 1 precursor 0.028 0.049
KITLG KITLG, MGF, SCF: Kit ligand precursor 0.028 0.109
C1QTNF4 C1QTNF4, CTRP4: Complement C1q tumor necrosis factor-related protein 4 precursor 0.028 0.049
IFNG IFNG: Interferon gamma precursor 0.028 0.109
CCL26 CCL26, SCYA26, UNQ216/PRO242: Small-inducible cytokine A26 precursor 0.028 0.049
AZGP1 AZGP1, tcag7.638: Alpha-2-glycoprotein 1, zinc-binding 0.028 0.109
C4A C4A: Complement C4-A precursor 0.028 0.109
ZP3 ZP3, ZP3A, ZP3B, ZPC: Zona pellucida sperm-binding protein 3 precursor 0.028 0.028
THPO THPO, MGDF: Thrombopoietin precursor 0.028 0.109
MMRN2 MMRN2, EMILIN3: Multimerin-2 precursor 0.028 0.049
TNN TNN: Tenascin-N precursor 0.0273 0.030
NTN4 NTN4: Netrin-4 precursor 0.027 0.027
CLEC14A CLEC14A, C14orf27, UNQ236/PRO269, EGFR5: C-type lectin domain family 14 member A 0.027 0.027
GP2 GP2: Pancreatic secretory granule membrane major glycoprotein GP2 precursor 0.027 0.027
ROBO1 N/A 0.027 0.027
IL22RA2 IL22RA2, UNQ5793/PRO19598/PRO19822: Interleukin-22 receptor alpha-2 chain precur 0.027 0.027
TRIM42 TRIM42: Tripartite motif-containing protein 42 0.027 0.027
CRLF1 CRLF1, ZCYTOR5, UNQ288/PRO327: Cytokine receptor-like factor 1 precursor 0.027 0.027
MUC13 MUC13, DRCC1, UNQ6194/PRO20221, RECC: Mucin-13 precursor 0.027 0.027
NELL2 NELL2, NRP2: Protein kinase C-binding protein NELL2 precursor 0.027 0.027
IL5RA N/A 0.027 0.027
KREMEN2 KREMEN2, KRM2: Kremen protein 2 precursor 0.027 0.027
INPPL1 INPPL1, SHIP2: Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 0.0258 0.0258
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.026 0.081
PZP PZP: Pregnancy zone protein precursor 0.026 0.075
GDF15 GDF15, MIC1, PDF, PLAB, PTGFB: Growth/differentiation factor 15 precursor 0.026 0.081
NDP NDP: Norrin precursor 0.026 0.100
F8 F8, F8C: Coagulation factor VIII precursor 0.026 0.902
LUM LUM, LDC: Lumican precursor 0.026 0.032
C4BPA C4BPA, C4BP: C4b-binding protein alpha chain precursor 0.026 0.081
CXCL9 CXCL9, CMK, MIG, SCYB9: Small-inducible cytokine B9 precursor 0.026 0.057
REG1B REG1A, PSPS, REG: Lithostathine 1 alpha precursor 0.026 0.081
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.026 0.072
IL22 IL22, ILTIF, UNQ3099/PRO10096: Interleukin-22 precursor 0.026 0.166
CXCL10 CXCL10, INP10, SCYB10: Small-inducible cytokine B10 precursor 0.026 0.075
MFAP2 MFAP2, MAGP1: Microfibrillar-associated protein 2 precursor 0.026 0.072
SPINK1 SPINK1, PSTI: Pancreatic secretory trypsin inhibitor precursor 0.026 0.037
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.026 0.072
LOC653509 SFTPA1, PSAP, SFTP1, SFTPA: Pulmonary surfactant-associated protein A1 precursor 0.025 0.098
ANGPTL6 AGF, UNQ152/PRO178, ANGPTL6, ARP5: Angiopoietin-related protein 6 precursor 0.025 0.098
FCN3 FCN3, FCNH, HAKA1: Ficolin-3 precursor 0.025 0.098
FGG FGG, PRO2061: Fibrinogen gamma chain precursor 0.025 0.098
2.15E-3
Total Score 763.00