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Evidence of Interaction Between ARPC1B and ACTG1

The interaction score between ARPC1B and ACTG1 is 39.40.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between ARPC1B and ACTG1 = 0.87

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology
OrganismARPC1B OrthologueACTG1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00333068 0.588 IPI00176593 0.764
bakers yeast YBR234C 0.588 YDL029W 1
  • Immunoprecipitation
  • Other
  • AffinityCaptureMS
  • AffinityCaptureWestern

Get References From PubMed
worm Q9U1R7 0.371 P53489 1
fly O97182 0.34 P45888 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.119
Domains No domains were used in calculating likelihood of interaction 8.25E-4
Post-translational Modifications

Protein: ARPC1B

PTMResidueReference
Acetylation 2 PubMed, HPRD
Phosphorylation 21 PubMed, HPRD

Protein: ACTG1

PTMResidueReference
Localisation

Protein: ARPC1B

LocalisationReference
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: ACTG1

LocalisationReference
Nucleolus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD
Transitive Score

The common interactors between ARPC1B and ACTG1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between ARPC1B andACTG1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , ARPC1B has 1054 interactors and ACTG1 has 209 interactors of which there are 82 common interactors.

Common InteractorName of Common InteractorScore for ARPC1B-Interactor (?)Score for ACTG1-Interactor (?)
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 7.50 69.60
CORO1C CORO1C, CRNN4: Coronin-1C 4.15 0.612
ACTR3 ACTR3, ARP3: Actin-related protein 3 3.51 42.20
ARPC3 ARPC3, ARC21: Actin-related protein 2/3 complex subunit 3 2.54 6.52
CORO1A CORO1A, CORO1: Coronin-1A 1.51 0.434
ARPC5 ARPC5, ARC16: Actin-related protein 2/3 complex subunit 5 1.36 1.31
ARPC2 ARPC2, ARC34, PRO2446: Actin-related protein 2/3 complex subunit 2 1.31 6.52
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.509 4.72
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.423 0.160
STAT6 STAT6: Signal transducer and activator of transcription 6 0.423 0.081
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.394 0.081
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.332 0.051
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.241 0.123
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.241 0.038
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.185 0.038
RAD23B RAD23B: UV excision repair protein RAD23 homolog B 0.179 0.890
GNB1 GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0.146 0.203
PLEK PLEK, P47: Pleckstrin 0.144 0.057
FLII FLII, FLIL: Protein flightless-1 homolog 0.141 0.074
ACTG1 ACTB: Actin, cytoplasmic 1 0.141 0.053
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.141 0.789
VAV1 VAV1, VAV: Proto-oncogene vav 0.141 0.263
LCP1 LCP1, PLS2: Plastin-2 0.141 0.263
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.141 209.00
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.129 0.782
DIAPH1 Diaphanous 1 0.129 3.89
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.129 0.081
ARPC5L N/A 0.119 0.593
MYO1E N/A 0.119 0.593
TMSB4X TMSB4X, TB4X, THYB4, TMSB4: Thymosin beta-4 0.111 0.293
MYO1F MYO1F: Myosin-If 0.109 6.55
CORO1B CORO1B: Coronin-1B 0.096 0.060
JAK1 0.090 0.038
ROCK1 ROCK1: Rho-associated protein kinase 1 0.087 0.0255
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.087 0.0255
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.078 0.074
MYH9 MYH9: Myosin-9 0.078 0.047
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.078 0.0968
MVP MVP, LRP: Major vault protein 0.074 0.0255
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.074 0.067
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.074 0.042
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.066 0.123
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.066 0.263
MSN MSN: Moesin 0.066 0.081
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.066 0.038
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.066 0.038
PSCD4 PSCD4, CYT4: Cytohesin-4 0.066 0.081
NULL N/A 0.064 0.119
NULL N/A 0.064 0.119
SEC24C SEC24C, KIAA0079: Protein transport protein Sec24C 0.063 0.074
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.063 1.10
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.063 0.123
PRG1 SRGN, PRG, PRG1: Serglycin precursor 0.053 0.027
TPP1 TPP1, CLN2, GIG1, UNQ267/PRO304: Tripeptidyl-peptidase 1 precursor 0.053 0.027
LRRFIP1 N/A 0.053 0.027
LAT2 LAT2, LAB, HSPC046, NTAL, WBS15, WBSCR15, WBSCR5: Linker for activation of T-cel 0.053 0.027
ARPC4 ARPC4, ARC20: Actin-related protein 2/3 complex subunit 4 0.053 0.027
PLCB2 0.051 0.081
ITGAE ITGAE: Integrin alpha-E precursor 0.049 0.027
CDV3 CDV3, H41: Protein CDV3 homolog 0.0479 0.0739
FLNA FLNA, FLN, FLN1: Filamin-A 0.0446 0.067
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.0446 0.067
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.040 0.123
WASPIP N/A 0.040 0.123
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.040 0.074
SEC24B SEC24B: Protein transport protein Sec24B 0.032 0.123
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.032 0.038
RAD23A RAD23A: UV excision repair protein RAD23 homolog A 0.028 0.053
PPEF1 N/A 0.028 0.027
C20orf24 N/A 0.027 0.027
CYBA CYBA: Cytochrome b-245 light chain 0.027 0.027
BID N/A 0.027 0.027
C9orf10 N/A 0.027 0.027
RNASET2 RNASET2, RNASE6PL: Ribonuclease T2 precursor 0.027 0.027
PRR13 N/A 0.027 0.027
IER2 IER2, ETR101: Immediate early response gene 2 protein 0.027 0.027
OAZ1 OAZ1, OAZ: Ornithine decarboxylase antizyme 0.027 0.027
C1orf38 N/A 0.027 0.027
ACTR3B ARP3beta, ACTR3B: Actin-like protein 3 homolog B 0.026 0.264
PARP4 PARP4, ADPRTL1, KIAA0177, PARPL: Poly [ADP-ribose] polymerase 4 0.0255 0.027
CORO2B CORO2B, KIAA0925: Coronin-2B 0.025 0.0421
SFRS2IP SFRS2IP, CASP11, SIP1: SFRS2-interacting protein 0.025 0.027
0.228
Total Score 39.40