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Evidence of Interaction Between POLR2D and POLR2L

The interaction score between POLR2D and POLR2L is 56.60.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between POLR2D and POLR2L = 0.27

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

2.88E-3
Orthology
OrganismPOLR2D OrthologuePOLR2L OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YJL140W 1 YOR210W 1
  • AffinityCaptureMS

Get References From PubMed

worm O02092 1 Q9GR61 1
fly Q8I0A4 1 Q9VC49 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.593
Domains No domains were used in calculating likelihood of interaction 1.48E-3
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: POLR2D

LocalisationReference
ER HPRD
Nucleus HPRD
Cytoplasm HPRD

Protein: POLR2L

LocalisationReference
Nucleus HPRD
Nucleolus HPRD
Transitive Score

The common interactors between POLR2D and POLR2L that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between POLR2D andPOLR2L. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , POLR2D has 19 interactors and POLR2L has 129 interactors of which there are 11 common interactors.

Common InteractorName of Common InteractorScore for POLR2D-Interactor (?)Score for POLR2L-Interactor (?)
POLR2H POLR2H: DNA-directed RNA polymerases I, II, and III subunit RPABC3 1.10 0.890
POLR2G POLR2G: DNA-directed RNA polymerase II subunit RPB7 0.890 0.890
POLR2A POLR2A: Uncharacterized protein POLR2A 0.890 0.538
POLR2B POLR2B: DNA-directed RNA polymerase II subunit RPB2 0.890 0.657
POLR2F POLR2F, POLRF: DNA-directed RNA polymerases I, II, and III subunit RPABC2 0.657 1.82
POLR2E POLR2E: DNA-directed RNA polymerases I, II, and III subunit RPABC1 0.657 1.82
POLR2J N/A 0.593 0.593
GTF2F2 GTF2F2: Uncharacterized protein GTF2F2 0.593 0.593
POLR2C POLR2C, A-152E5.7: DNA-directed RNA polymerase II subunit RPB3 0.408 0.408
POLR2I POLR2I: DNA-directed RNA polymerase II subunit RPB9 0.354 0.354
TMLHE TMLHE, TMLH: Trimethyllysine dioxygenase, mitochondrial precursor 0.116 0.116
0.347
Total Score 56.60