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Evidence of Interaction Between CDK4 and CDKN1A

The interaction score between CDK4 and CDKN1A is 13.30.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between CDK4 and CDKN1A = 0.28

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 2.88E-3
Orthology N/A N/A
Domains Domains present in CDK4 and CDKN1A:
Domains in CDK4Domains in CDKN1A
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003175 Cyclin-dependent kinase inhibitor

The Chi square scores for co-occurrence of domains that are present in CDK4 and CDKN1A are listed below.

Domain 1Domain 2Chi Square
IPR000719 Protein kinase IPR003175 Cyclin-dependent kinase inhibitor 0.280343
IPR008271 Serine/threonine protein kinase, active site IPR003175 Cyclin-dependent kinase inhibitor 0.00046931

The background colour of the table refers to:

  • Blue Domain is only present in CDK4
  • Yellow Domain is only present in CDKN1A
  • Green Domain is present in both CDK4 and CDKN1A

 0.083
Post-translational Modifications

Protein: CDK4

PTMResidueReference
Phosphorylation 172 PubMed, HPRD

Protein: CDKN1A

PTMResidueReference
N-acetylserine 1 HPRD
Phosphorylation 57 PubMed, HPRD
Phosphorylation 130 PubMed, HPRD
Phosphorylation 145 PubMed, HPRD
Phosphorylation 146 PubMed, HPRD
Phosphoserine 145 PubMed, HPRD
Phosphoserine 159 PubMed, HPRD
Phosphothreonine 144 PubMed, HPRD
Proteolytic Cleavage 112 PubMed, HPRD
Proteolytic Cleavage 149 PubMed, HPRD
Localisation

Protein: CDK4

LocalisationReference
Cytoplasm HPRD

Protein: CDKN1A

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between CDK4 and CDKN1A that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between CDK4 andCDKN1A. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , CDK4 has 1493 interactors and CDKN1A has 735 interactors of which there are 611 common interactors.

Common InteractorName of Common InteractorScore for CDK4-Interactor (?)Score for CDKN1A-Interactor (?)
CCND1 CCND1, BCL1, PRAD1: G1/S-specific cyclin-D1 53.10 0.191
CCND2 CCND2: G1/S-specific cyclin-D2 28.90 0.041
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 6.17 0.034
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.917 0.077
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.852 0.032
NPM1 NPM1, NPM: Nucleophosmin 0.822 0.032
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 0.763 0.027
PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 0.763 0.027
CCNB1 Cyclin B1 0.763 0.191
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.704 0.114
CDC20 CDC20: Cell division cycle protein 20 homolog 0.385 0.026
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.372 0.0453
TRIM28 TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta 0.307 0.026
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.307 0.124
LSM2 LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2 0.276 0.032
MSH6 MSH6, GTBP: DNA mismatch repair protein MSH6 0.276 0.026
ELAVL1 ELAVL1, HUR: ELAV-like protein 1 0.276 0.032
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.276 0.077
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 0.276 0.032
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.276 0.032
SNRPC SNRPC: U1 small nuclear ribonucleoprotein C 0.276 0.0425
CDK2 CDK2: Cell division protein kinase 2 0.276 0.077
POLA2 POLA2: DNA polymerase subunit alpha B 0.276 0.026
PABPC4 PABPC4, APP1, PABP4: Polyadenylate-binding protein 4 0.276 0.0425
EIF3S9 EIF3S9: Eukaryotic translation initiation factor 3 subunit 9 0.276 0.032
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.275 0.037
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.275 0.096
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.275 0.032
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.275 0.0453
CSK CSK: Tyrosine-protein kinase CSK 0.275 0.037
MKI67 MKI67: Antigen KI-67 0.269 0.026
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.251 0.075
PLEK PLEK, P47: Pleckstrin 0.251 0.026
ROCK1 ROCK1: Rho-associated protein kinase 1 0.251 0.077
TUBB TUBB, TUBB5, OK/SW-cl.56: Tubulin beta chain 0.241 0.032
NAP1L1 NAP1L1, NRP: Nucleosome assembly protein 1-like 1 0.233 0.026
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.233 0.077
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.225 0.077
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.225 0.075
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.225 0.0453
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.225 0.077
DOK1 DOK1: Docking protein 1 0.225 0.032
RB1 RB1: Retinoblastoma-associated protein 0.210 0.152
EIF4G1 EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1 0.210 0.070
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.191 0.036
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.188 0.127
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.188 0.077
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.171 0.0453
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.171 0.052
CCNH CCNH: Cyclin-H 0.171 0.191
SOS1 SOS1: Son of sevenless homolog 1 0.171 0.062
SYK SYK: Tyrosine-protein kinase SYK 0.171 0.0453
NF2 NF2, SCH: Merlin 0.165 0.028
MAP2K5 N/A 0.165 0.049
EEF2K EEF2K: Elongation factor 2 kinase 0.165 0.083
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.165 0.049
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.165 0.028
NSBP1 NSBP1: Nucleosome-binding protein 1 0.165 0.028
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.165 0.049
NBN NBN, NBS, NBS1, P95: Nibrin 0.163 0.026
BATF BATF: Basic leucine zipper transcriptional factor ATF-like 0.155 0.026
HMGA2 HMGA2, HMGIC: High mobility group protein HMGI-C 0.152 0.052
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.152 0.032
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.152 0.091
LYN LYN: Tyrosine-protein kinase Lyn 0.152 0.0453
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.152 0.032
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.148 0.028
CREB1 CREB1: cAMP response element-binding protein 0.148 0.028
CDC25C CDC25C: M-phase inducer phosphatase 3 0.148 0.028
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.148 0.028
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.148 0.049
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.148 0.165
CCNT2 CCNT2: Cyclin-T2 0.148 0.165
C10orf9 CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y 0.148 0.165
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.083
CDC25A CDC25A: M-phase inducer phosphatase 1 0.148 0.028
ELMO1 N/A 0.148 0.083
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.148 0.028
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.083
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.148 0.049
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.148 0.028
CENPA CENPA: Histone H3-like centromeric protein A 0.144 0.026
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.144 0.032
SET SET: Protein SET 0.144 0.032
ABCF1 N/A 0.144 0.026
XRCC6 XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1 0.144 0.032
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.144 0.0425
DDX21 DDX21: Nucleolar RNA helicase 2 0.144 0.032
BARD1 BARD1: BRCA1-associated RING domain protein 1 0.144 0.026
EIF4G2 EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2 0.139 0.0425
RELA RELA, NFKB3: Transcription factor p65 0.139 0.052
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.139 0.152
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.139 0.026
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.139 0.062
RIN1 RIN1: Ras and Rab interactor 1 0.136 0.026
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.136 0.037
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.136 0.037
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.136 0.109
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.132 0.077
MAD2L1 MAD2L1, MAD2: Mitotic spindle assembly checkpoint protein MAD2A 0.129 0.026
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.129 0.096
CBX3 CBX3: Chromobox protein homolog 3 0.129 0.026
YARS YARS: Tyrosyl-tRNA synthetase, cytoplasmic 0.129 0.032
SYNCRIP SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q 0.129 0.032
TP53 TP53, P53: Cellular tumor antigen p53 0.129 0.0425
SSB SSB: Lupus La protein 0.129 0.032
EIF2S2 EIF2S2, EIF2B: Eukaryotic translation initiation factor 2 subunit 2 0.129 0.052
SNRPB2 SNRPB2: U2 small nuclear ribonucleoprotein B'' 0.129 0.0425
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.129 0.0453
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 0.129 0.052
APEX1 APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase 0.129 0.026
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 0.129 0.032
XPO1 XPO1, CRM1: Exportin-1 0.129 0.037
SMC1L1 SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos 0.129 0.026
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.129 0.055
SFRS1 SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1 0.129 0.026
NOL1 N/A 0.129 0.026
H2AFX H2AFX, H2AX: Histone H2A.x 0.129 0.026
HNRPF HNRPF: Heterogeneous nuclear ribonucleoprotein F 0.129 0.032
ZNF330 ZNF330, NOA36: Zinc finger protein 330 0.129 0.032
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.129 0.026
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.129 0.032
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.129 0.026
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.129 0.032
LMNB1 LMNB1, LMN2, LMNB: Lamin-B1 0.129 0.026
ERF ERF: ETS domain-containing transcription factor ERF 0.127 0.0425
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.123 0.057
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.123 0.052
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.123 0.037
CCNG1 CCNG1, CCNG, CYCG1: Cyclin-G1 0.123 0.050
PPP1R8 N/A 0.118 0.026
HSF1 HSF1, HSTF1: Heat shock factor protein 1 0.114 0.032
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.114 0.155
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.114 0.037
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.114 0.077
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.114 0.036
DAXX DAXX, BING2, DAP6: Death domain-associated protein 6 0.114 0.026
JAK1 0.111 0.037
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.111 0.026
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.111 0.055
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.111 0.029
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.111 0.037
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.111 0.032
IRS1 IRS1: Insulin receptor substrate 1 0.109 0.0425
BMX N/A 0.109 0.037
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.099 0.033
DAB2 DAB2, DOC2: Disabled homolog 2 0.097 0.0425
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.097 0.026
HCK N/A 0.097 0.0453
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.097 0.026
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.097 0.029
TUBA6 TUBA1C, TUBA6: Tubulin alpha-1C chain 0.0971 0.026
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.096 0.055
ETS2 ETS2: Protein C-ets-2 0.096 0.032
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.096 0.032
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.096 0.062
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.088 0.049
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.088 0.037
RNPS1 RNPS1, LDC2: RNA-binding protein with serine-rich domain 1 0.087 0.026
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.087 0.052
GNB2L1 Lung cancer oncogene 7 0.087 0.032
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.087 0.127
TCOF1 N/A 0.087 0.026
HNRPA0 HNRPA0: Heterogeneous nuclear ribonucleoprotein A0 0.087 0.026
KIF23 N/A 0.087 0.026
TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 0.087 0.032
TXN TXN, TRDX, TRX, TRX1: Thioredoxin 0.087 0.036
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.086 0.091
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.086 0.062
NFE2L2 NFE2L2, NRF2: Nuclear factor erythroid 2-related factor 2 0.086 0.070
NFATC2 NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2 0.083 0.028
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.083 0.049
NFATC3 NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3 0.083 0.028
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.083 0.083
ELF2 ELF2, NERF: ETS-related transcription factor Elf-2 0.083 0.028
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.083 0.049
MAPK15 N/A 0.083 0.083
BID BID: BH3-interacting domain death agonist 0.083 0.028
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.078 0.032
YEATS2 KIAA1197, YEATS2: YEATS domain-containing protein 2 0.078 0.032
MTA1 MTA1: Metastasis-associated protein MTA1 0.078 0.026
NME2 NME2, NM23B: Nucleoside diphosphate kinase B 0.078 0.027
TIAL1 TIAL1: Nucleolysin TIAR 0.078 0.026
HDAC1 HDAC1, RPD3L1: Histone deacetylase 1 0.078 0.026
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.078 0.077
WEE1 WEE1: Wee1-like protein kinase 0.078 0.077
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.078 0.032
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.078 0.096
TDG TDG: G/T mismatch-specific thymine DNA glycosylase 0.078 0.026
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.078 0.062
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.078 0.032
PAK1IP1 PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1 0.078 0.026
SKIIP SNW1, SKIIP, SKIP: SNW domain-containing protein 1 0.078 0.026
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.078 0.096
HDAC2 HDAC2: Histone deacetylase 2 0.078 0.032
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.078 0.032
RARS RARS: Arginyl-tRNA synthetase, cytoplasmic 0.078 0.036
VCP VCP: Transitional endoplasmic reticulum ATPase 0.078 0.036
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.078 0.049
PSMD1 PSMD1: 26S proteasome non-ATPase regulatory subunit 1 0.078 0.155
SND1 SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1 0.078 0.0425
WBSCR1 EIF4H, KIAA0038, WBSCR1, WSCR1: Eukaryotic translation initiation factor 4H 0.078 0.0425
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.078 0.062
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.077 0.077
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.077 0.0453
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.083
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.075 0.083
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.075 0.083
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.075 0.049
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.075 0.083
TSC2 TSC2, TSC4: Tuberin 0.075 0.049
GIT2 N/A 0.075 0.028
HIST1H1C HIST1H1C, H1F2: Histone H1.2 0.075 0.028
RBL1 RBL1: Retinoblastoma-like protein 1 0.075 0.165
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.075 0.083
CCNC CCNC: Cyclin-C 0.074 0.041
MAFG MAFG: Transcription factor MafG 0.071 0.026
YWHAQ YWHAQ: 14-3-3 protein theta 0.070 0.057
API5 N/A 0.070 0.026
EMD EMD, EDMD, STA: Emerin 0.070 0.0425
TGIF2 TGIF2: Homeobox protein TGIF2 0.070 0.026
HD HD, IT15: Huntingtin 0.070 0.037
BAZ2A BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A 0.070 0.026
RBM3 RBM3, RNPL: Putative RNA-binding protein 3 0.070 0.0425
ZNF318 ZNF318, HRIHFB2436: Zinc finger protein 318 0.070 0.026
DRIM UTP20, DRIM: Small subunit processome component 20 homolog 0.070 0.077
SREBF2 N/A 0.070 0.026
AOF2 AOF2, KIAA0601, LSD1: Lysine-specific histone demethylase 1 0.070 0.026
IPO7 IPO7: Uncharacterized protein IPO7 0.070 0.0453
RDBP RDBP, NELFE, RD: Negative elongation factor E 0.070 0.032
MNAR PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1 0.070 0.032
SH2BP1 CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog 0.070 0.026
MYBBP1A MYBBP1A, P160: Myb-binding protein 1A 0.070 0.032
ATF6 ATF6: Cyclic AMP-dependent transcription factor ATF-6 alpha 0.069 0.0425
GTF2A1 GTF2A1, TF2A1: Transcription initiation factor IIA subunit 1 0.069 0.026
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.069 0.055
CTDP1 CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase 0.069 0.026
ETS1 ETS1, EWSR2: Protein C-ets-1 0.069 0.026
ATM ATM: Serine-protein kinase ATM 0.069 0.049
RBM7 0.063 0.052
SF3B4 SF3B4, SAP49: Splicing factor 3B subunit 4 0.063 0.032
MRE11A MRE11A, HNGS1, MRE11: Double-strand break repair protein MRE11A 0.063 0.026
GAPD GAPDH, GAPD, CDABP0047, OK/SW-cl.12: Glyceraldehyde-3-phosphate dehydrogenase 0.063 0.027
SEC31L1 N/A 0.063 0.070
YY1 YY1: Transcriptional repressor protein YY1 0.063 0.026
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.063 0.0453
DDX41 DDX41, ABS: Probable ATP-dependent RNA helicase DDX41 0.063 0.026
GGCX GGCX, GC: Vitamin K-dependent gamma-carboxylase 0.063 0.232
PRDX1 PRDX1, PAGA, PAGB, TDPX2: Peroxiredoxin-1 0.063 0.036
ENO1 ENO1, ENO1L1, MBPB1, MPB1: Alpha-enolase 0.063 0.036
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.063 0.026
WDR79 N/A 0.063 0.032
COPB2 COPB2: Coatomer subunit beta' 0.063 0.070
PAPOLA PAPOLA, PAP: Poly(A) polymerase alpha 0.063 0.026
KPNA2 KPNA2, RCH1, SRP1: Importin subunit alpha-2 0.063 0.057
SEC24C SEC24C, KIAA0079: Protein transport protein Sec24C 0.063 0.0425
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.063 0.062
ARMET ARMET, ARP: Protein ARMET precursor 0.063 0.052
SMAD2 SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2 0.063 0.032
SKIV2L SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti 0.063 0.026
SRF SRF: Serum response factor 0.063 0.0425
MBD3 MBD3: Methyl-CpG-binding domain protein 3 0.063 0.032
TAF6 TAF6, TAF2E, TAFII70: Transcription initiation factor TFIID subunit 6 0.063 0.026
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.063 0.055
AKAP8 AKAP8, AKAP95: A-kinase anchor protein 8 0.063 0.026
NOC2L NOC2L: Nucleolar complex protein 2 homolog 0.063 0.0425
CDK7 CDK7, MO15: Cell division protein kinase 7 0.063 0.210
KIAA0683 DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized 0.063 0.026
BACH1 BACH1: Transcription regulator protein BACH1 0.062 0.026
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.057 0.025
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.056 0.033
JUNB JUNB: Transcription factor jun-B 0.056 0.026
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.056 0.077
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.056 0.096
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.056 0.062
RBL2 RBL2, RB2: Retinoblastoma-like protein 2 0.056 0.098
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.056 0.055
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.056 0.055
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.056 0.062
CTTN CTTN, EMS1: Src substrate cortactin 0.055 0.036
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.055 0.062
RAB4A N/A 0.052 0.028
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.052 0.083
AFF1 N/A 0.052 0.026
IFI16 N/A 0.052 0.032
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.052 0.062
XRCC1 XRCC1: DNA-repair protein XRCC1 0.052 0.032
GSTP1 GSTP1, FAEES3, GST3: Glutathione S-transferase P 0.052 0.0446
NR3C1 NR3C1, GRL: Glucocorticoid receptor 0.052 0.0425
STK16 N/A 0.052 0.127
GTF2F2 N/A 0.052 0.0425
IKBKG IKBKG, FIP3, NEMO: NF-kappa-B essential modulator 0.052 0.026
CCNK 0.051 0.051
SALF GTF2A1L, ALF, GTF2A1LF: TFIIA-alpha and beta-like factor 0.049 0.026
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.049 0.049
JUN JUN: Transcription factor AP-1 0.049 0.026
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.049 0.062
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.049 0.027
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.049 0.055
DDIT3 DDIT3, CHOP, GADD153: DNA damage-inducible transcript 3 0.048 0.026
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.047 0.083
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.047 0.028
RREB1 RREB1, FINB: RAS-responsive element-binding protein 1 0.046 0.026
EIF3S4 EIF3S4: Eukaryotic translation initiation factor 3 subunit 4 0.046 0.032
TAF10 TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10 0.046 0.032
C20orf4 C20orf4, CGI-23, PRO0225: Uncharacterized protein C20orf4 0.046 0.032
SYMPK SYMPK, SPK: Symplekin 0.046 0.026
COPA COPA: Coatomer subunit alpha 0.046 0.052
RPS6KB1 N/A 0.046 0.077
PABPC1 PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1 0.046 0.032
RBMX2 RBMX2, CGI-79: RNA-binding motif protein, X-linked 2 0.046 0.026
FHOD1 FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1 0.046 0.096
CRSP2 MED14, ARC150, CRSP2, CXorf4, DRIP150, EXLM1, RGR1, TRAP170: Mediator of RNA pol 0.046 0.032
CORO1C CORO1C, CRNN4: Coronin-1C 0.046 0.052
CLTC CLTC, CLH17, CLTCL2, KIAA0034: Clathrin heavy chain 1 0.046 0.032
COPE COPE: Coatomer subunit epsilon 0.046 0.0425
CTNNB1 CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1 0.046 0.124
FKBP5 FKBP5, AIG6, FKBP51: FK506-binding protein 5 0.046 0.026
SAPS3 N/A 0.046 0.026
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.044 0.037
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.044 0.055
CDK5R1 CDK5R1, CDK5R, NCK5A: Cyclin-dependent kinase 5 activator 1 precursor 0.044 0.110
PPP2R5A PPP2R5A: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha 0.043 0.032
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.0425 0.077
ZNF267 ZNF267: Zinc finger protein 267 0.0425 0.026
NCOA3 N/A 0.0425 0.026
SP100 N/A 0.0425 0.026
PDLIM1 PDLIM1, CLIM1, CLP36: PDZ and LIM domain protein 1 0.0425 0.036
IRF3 IRF3: Interferon regulatory factor 3 0.0425 0.026
WDR1 N/A 0.0425 0.070
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.0425 0.026
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.041 0.031
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.038 0.052
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.038 0.077
SP3 SP3: Transcription factor Sp3 0.038 0.026
FLII FLII, FLIL: Protein flightless-1 homolog 0.038 0.027
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.038 0.124
TCEB3 TCEB3, MSTP059: Transcription elongation factor B polypeptide 3 0.038 0.052
BRD2 BRD2, KIAA9001, RING3: Bromodomain-containing protein 2 0.038 0.026
ESRRA ESRRA, ERR1, ESRL1, NR3B1: Steroid hormone receptor ERR1 0.038 0.026
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.038 0.026
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.038 0.055
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.038 0.032
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.038 0.096
TLN1 TLN1: Uncharacterized protein TLN1 0.038 0.027
FKBP1A FKBP1A, FKBP1, FKBP12: FK506-binding protein 1A 0.038 0.087
MYH9 MYH9: Myosin-9 0.038 0.052
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.038 0.062
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.038 0.077
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.038 0.0453
POLR2A POLR2A: Uncharacterized protein POLR2A 0.038 0.026
TXNRD1 TXNRD1: Thioredoxin reductase 1, cytoplasmic precursor 0.038 0.0446
HDLBP HDLBP, HBP, VGL: Vigilin 0.038 0.074
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.038 0.062
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.038 0.062
CSDA CSDA, DBPA: DNA-binding protein A 0.038 0.026
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.038 0.062
CDK6 CDK6: Cell division protein kinase 6 0.038 0.055
SGTA SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A 0.038 0.032
PIK4CB PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic, 0.038 0.026
WARS WARS, IFI53, WRS: Tryptophanyl-tRNA synthetase, cytoplasmic 0.038 0.027
CUL4B N/A 0.038 0.026
DUSP22 DUSP22, JSP1, MKPX: Dual specificity protein phosphatase 22 0.038 0.026
JUP JUP, CTNNG, DP3: Junction plakoglobin 0.038 0.124
FZR1 N/A 0.038 0.026
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.038 0.062
RRAS RRAS: Ras-related protein R-Ras precursor 0.035 0.036
RRAD RRAD, RAD: GTP-binding protein RAD 0.035 0.026
CEBPB CEBPB, TCF5, PP9092: CCAAT/enhancer-binding protein beta 0.035 0.032
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.033 0.039
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.033 0.025
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.032 0.055
ID3 ID3, 1R21, HEIR-1: DNA-binding protein inhibitor ID-3 0.032 0.0425
LIMK2 LIMK2: LIM domain kinase 2 0.032 0.075
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.032 0.049
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.032 0.096
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.032 0.077
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.032 0.055
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.032 0.055
GTF3C1 N/A 0.032 0.026
DBN1 DBN1, D0S117E: Drebrin 0.032 0.027
VDP DKFZp451D234: Putative uncharacterized protein DKFZp451D234 0.032 0.0513
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.029 0.031
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.029 0.0513
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.029 0.039
SHC1 SHC1, RP11-307C12.1-001, hCG_1997126: SHC 0.029 0.074
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.029 0.055
BCDO2 PTS: 6-pyruvoyl tetrahydrobiopterin synthase 0.029 0.0425
LIMD1 LIMD1: LIM domain-containing protein 1 0.029 0.026
PARD3 N/A 0.029 0.036
CRK N/A 0.029 0.036
YWHAE YWHAE: 14-3-3 protein epsilon 0.029 0.075
TRIM25 TRIM25, EFP, RNF147, ZNF147: Tripartite motif-containing protein 25 0.029 0.052
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.029 0.077
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.029 0.096
MTF1 MTF1: Metal regulatory transcription factor 1 0.029 0.026
ARID3A ARID3A, DRIL1, DRIL3, DRX, E2FBP1: AT-rich interactive domain-containing protein 0.029 0.026
ZNF217 ZNF217, ZABC1: Zinc finger protein 217 0.029 0.026
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.029 0.077
SMCX JARID1C, DXS1272E, SMCX, XE169: Histone demethylase JARID1C 0.029 0.032
HIF1A HIF1A, MOP1: Hypoxia-inducible factor 1 alpha 0.029 0.087
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.029 0.096
GSK3B N/A 0.029 0.032
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.029 0.077
SMAD3 SMAD3, MADH3: Mothers against decapentaplegic homolog 3 0.029 0.0425
CLASP1 CLASP1, KIAA0622, MAST1: CLIP-associating protein 1 0.029 0.055
GNB1 GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0.029 0.026
ARPC1B ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B 0.029 0.0425
YWHAZ YWHAZ: 14-3-3 protein zeta/delta 0.029 0.075
FLNB FLNB, FLN1L, FLN3, TABP, TAP: Filamin-B 0.029 0.0446
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.029 0.127
C20orf18 N/A 0.028 0.028
MAPKAPK5 N/A 0.028 0.083
C13orf8 N/A 0.028 0.028
CCAR1 CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1 0.028 0.028
ZNF295 ZNF295, KIAA1227, ZBTB21: Zinc finger protein 295 0.028 0.028
MLL4 WBP7, HRX2, KIAA0304, MLL2, MLL4, TRX2: WW domain-binding protein 7 0.028 0.028
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.028 0.083
IRF7 N/A 0.028 0.028
PTBP1 PTBP1: Polypyrimidine tract binding protein 1 0.028 0.028
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.028 0.083
PKP4 PKP4: Plakophilin-4 0.028 0.049
WDR54 N/A 0.028 0.028
TFAP4 TFAP4: Transcription factor AP-4 0.028 0.028
TMPO TMPO, LAP2: Lamina-associated polypeptide 2 isoform alpha 0.028 0.028
ZNF579 ZNF579: Zinc finger protein 579 0.028 0.028
DSP DSP: Desmoplakin 0.028 0.028
NES N/A 0.028 0.028
HTATIP HTATIP, TIP60: Histone acetyltransferase HTATIP 0.028 0.028
HES6 HES6: Transcription cofactor HES-6 0.028 0.028
CORO6 N/A 0.028 0.028
C14orf151 C14orf151: Uncharacterized protein C14orf151 (Fragment) 0.028 0.028
DKFZp434K1815 DKFZp434K1815, hCG_1736780: Putative uncharacterized protein DKFZp434K1815 0.028 0.028
DNAJC13 DNAJC13, KIAA0678, RME8: DnaJ homolog subfamily C member 13 0.028 0.049
NIPA1 NIPA1: Non-imprinted in Prader-Willi/Angelman syndrome region protein 1 0.028 0.028
NFIA NFIA, RP5-902P15.1-003, hCG_2032260: Nuclear factor I/A 0.028 0.028
TCF20 TCF20, KIAA0292, SPBP: Transcription factor 20 0.028 0.028
KIAA1443 HOMEZ, KIAA1443: Homeobox and leucine zipper protein Homez 0.028 0.028
AR AR, DHTR, NR3C4: Androgen receptor 0.028 0.028
HDAC7A N/A 0.028 0.028
ARNT ARNT: Aryl hydrocarbon receptor nuclear translocator 0.028 0.028
HNRPC HNRPC: Heterogeneous nuclear ribonucleoproteins C1/C2 0.028 0.028
CBFA2T2 CBFA2T2, EHT, MTGR1: Protein CBFA2T2 0.028 0.028
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.028 0.083
ZCCHC3 ZCCHC3, C20orf99: Zinc finger CCHC domain-containing protein 3 0.028 0.028
ZC3HAV1 ZC3HAV1, ZC3HDC2, PRO1677: Zinc finger CCCH type antiviral protein 1 0.028 0.028
PHLDB2 N/A 0.028 0.028
SNRPB N/A 0.028 0.028
ILF3 ILF3, DRBF, MPHOSPH4, NF90: Interleukin enhancer-binding factor 3 0.028 0.028
GPRASP2 GPRASP2: G-protein coupled receptor-associated sorting protein 2 0.028 0.028
UHRF1 0.028 0.028
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.028 0.083
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.028
ZNF644 ZNF644, KIAA1221, ZEP2: Zinc finger protein 644 0.028 0.028
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.028 0.083
SMARCAD1 SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator 0.028 0.028
ZNF265 N/A 0.028 0.028
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.028
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.028 0.083
POGZ POGZ, KIAA0461, Nbla00003: Pogo transposable element with ZNF domain 0.028 0.028
ZNF687 ZNF687, KIAA1441: Zinc finger protein 687 0.028 0.028
FOXM1 FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1 0.028 0.028
RAVER1 RAVER1, KIAA1978: Ribonucleoprotein PTB-binding 1 0.028 0.028
ATXN2L ATXN2L, A2D, A2LG, A2LP, A2RP: Ataxin-2-like protein 0.028 0.028
FLJ21816 PALB2, FANCN: Partner and localizer of BRCA2 0.028 0.028
ZFP91 ZFP91, FKSG11: Zinc finger protein 91 homolog 0.028 0.028
CDC2 CDC2: Cell division control protein 2 homolog 0.028 0.083
PPEF1 N/A 0.028 0.028
PPP1R12C PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C 0.028 0.028
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.028 0.083
MITF MITF: Microphthalmia-associated transcription factor 0.028 0.028
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.028 0.083
TLE3 TLE3, KIAA1547: Transducin-like enhancer protein 3 0.028 0.028
CABLES1 N/A 0.028 0.028
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.028 0.083
DUSP15 N/A 0.028 0.028
FLJ23436 N/A 0.028 0.028
SYTL4 Endocrine transmitter regulatory protein 0.028 0.028
MLL2 MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2 0.028 0.028
YWHAG YWHAG: 14-3-3 protein gamma 0.028 0.049
HDAC8 N/A 0.028 0.028
LOC642558 FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1 0.028 0.028
CUTL1 CUTL1: Homeobox protein cut-like 1 0.028 0.028
SPAG6 SPAG6, PF16: Sperm-associated antigen 6 0.028 0.049
KIF1B N/A 0.028 0.028
ZHX1 ZHX1: Zinc fingers and homeoboxes protein 1 0.028 0.028
JDP2 jdp2, JDP2: Jun dimerization protein 2 0.028 0.028
FOSL2 FOSL2, FRA2: Fos-related antigen 2 0.028 0.0425
MAPK7 mitogen-activated protein kinase 7 isoform 1 0.026 0.026
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.026 0.055
KRT18 KRT18: Uncharacterized protein KRT18 0.026 0.0425
FTH1 FTH1, FTH, OK/SW-cl.84, FTHL6, PIG15: Ferritin heavy chain 0.026 0.036
TRIM16 TRIM16, EBBP: Tripartite motif-containing protein 16 0.026 0.032
SNAI1 SNAI1, SNAH: Zinc finger protein SNAI1 0.026 0.026
VIM VIM: Vimentin 0.026 0.087
KIF1C N/A 0.026 0.032
EEA1 EEA1, ZFYVE2: Early endosome antigen 1 0.026 0.026
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.026 0.055
AHR AHR: Aryl hydrocarbon receptor precursor 0.026 0.0425
STRN3 STRN3, GS2NA, SG2NA: Striatin-3 0.026 0.032
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.026 0.062
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.026 0.055
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.026 0.055
TAL2 TAL2: T-cell acute lymphocytic leukemia protein 2 0.025 0.028
NEDD4 NEDD4: Uncharacterized protein NEDD4 0.025 0.028
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.025 0.028
raptor RAPTOR, KIAA1303: Regulatory-associated protein of mTOR 0.025 0.083
SMU1 SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog 0.025 0.028
RBM10 RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10 0.025 0.028
NCOA3 NCOA3, AIB1, RAC3, TRAM1: Nuclear receptor coactivator 3 0.025 0.028
NHN1 NHN1: Conserved nuclear protein NHN1 0.025 0.028
SEC13L1 N/A 0.025 0.028
SOX8 SOX8: Transcription factor SOX-8 0.025 0.028
FLJ40432 FLJ40432, hCG_2036624: CDNA FLJ40432 fis, clone TESTI2039227 0.025 0.028
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.025 0.083
MKI67IP MKI67IP, NIFK, NOPP34: MKI67 FHA domain-interacting nucleolar phosphoprotein 0.025 0.028
POLR1C POLR1C, POLR1E: DNA-directed RNA polymerases I and III subunit RPAC1 0.025 0.028
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.025 0.083
TIA1 TIA1: Nucleolysin TIA-1 isoform p40 0.025 0.028
ZNF174 ZNF174, ZSCAN8: Zinc finger protein 174 0.025 0.028
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.025 0.049
PSIP1 PSIP1, DFS70, LEDGF, PSIP2: PC4 and SFRS1-interacting protein 0.025 0.028
HIST3H2A HIST3H2A: Histone H2A type 3 0.025 0.028
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.025 0.083
OSR1 OSR1, ODD: Protein odd-skipped-related 1 0.025 0.028
LMNA LMNA, LMN1: Lamin-A/C 0.025 0.028
FARSLA FARSA, FARS, FARSL, FARSLA: Phenylalanyl-tRNA synthetase alpha chain 0.025 0.028
KCTD1 0.025 0.028
MAPK8IP3 N/A 0.025 0.028
MAX MAX: Protein max 0.025 0.028
HNRPUL1 HNRPUL1, E1BAP5: Heterogeneous nuclear ribonucleoprotein U-like protein 1 0.025 0.028
ARID4A ARID4A, RBBP1, RBP1: AT-rich interactive domain-containing protein 4A 0.025 0.028
DIDO1 N/A 0.025 0.028
C14orf4 C14orf4, KIAA1865, My039: RING finger protein C14orf4 0.025 0.028
MLXIPL MLXIPL, MIO, WBSCR14: Williams-Beuren syndrome chromosome region 14 protein 0.025 0.028
EDF1 EDF1: Endothelial differentiation-related factor 1 0.025 0.028
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 0.028
RFFL RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin 0.025 0.028
HTATIP N/A 0.025 0.028
ISL2 ISL2: Insulin gene enhancer protein ISL-2 0.025 0.028
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.025 0.083
PRKCB1 N/A 0.025 0.028
HNRPA2B1 HNRPA2B1: Heterogeneous nuclear ribonucleoproteins A2/B1 0.025 0.028
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.025 0.083
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.025 0.083
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.025 0.028
BRD4 N/A 0.025 0.028
BCOR N/A 0.025 0.028
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.025 0.028
PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 0.025 0.028
MAP2K3 N/A 0.025 0.028
GATAD2B GATAD2B, KIAA1150: Transcriptional repressor p66 beta 0.025 0.028
CAMK2A N/A 0.025 0.028
PHF16 PHF16, JADE3, KIAA0215: Protein Jade-3 0.025 0.028
SAP14 SF3B14, CGI-110, HSPC175, HT006: Pre-mRNA branch site protein p14 0.025 0.028
REXO1 REXO1, ELOABP1, KIAA1138, TCEB3BP1: RNA exonuclease 1 homolog 0.025 0.028
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.025 0.028
SYAP1 SYAP1, PRO3113: Synapse-associated protein 1 0.025 0.028
RBBP6 RBBP6, P2PR, My038, PACT, RBQ1: Retinoblastoma-binding protein 6 0.025 0.028
NSUN2 NSUN2, SAKI, TRM4: tRNA 0.025 0.028
NFYA NFYA: Nuclear transcription factor Y subunit alpha 0.025 0.028
ZNF598 ZNF598: Zinc finger protein 598 0.025 0.028
SSBP4 SSBP4: Single-stranded DNA-binding protein 4 0.025 0.028
WWTR1 WWTR1, TAZ: WW domain-containing transcription regulator protein 1 0.025 0.028
BUB3 BUB3: Mitotic checkpoint protein BUB3 0.025 0.028
GRK6 N/A 0.025 0.028
NIPBL N/A 0.025 0.083
DDX20 DDX20, DP103, GEMIN3: Probable ATP-dependent RNA helicase DDX20 0.025 0.028
RNF20 0.025 0.028
SFRS9 SFRS9, SRP30C: Splicing factor, arginine/serine-rich 9 0.025 0.028
SETD3 SETD3, C14orf154: SET domain-containing protein 3 0.025 0.028
HNRPM HNRPM, NAGR1: Heterogeneous nuclear ribonucleoprotein M 0.025 0.028
TCEA1 N/A 0.025 0.028
PPP1R9B PPP1R9B, PPP1R6: Neurabin-2 0.025 0.028
RNF113A RNF113A, RNF113, ZNF183: RING finger protein 113A 0.025 0.028
HNRPH3 HNRPH3: Heterogeneous nuclear ribonucleoprotein H3 0.025 0.028
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.025 0.083
CAMKK1 N/A 0.025 0.028
PRDM2 PRDM2, RIZ: PR domain zinc finger protein 2 0.025 0.028
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.025 0.028
NUP98 N/A 0.025 0.028
HNRPD HNRPD, AUF1: Heterogeneous nuclear ribonucleoprotein D0 0.025 0.028
TRERF1 TRERF1, BCAR2, RAPA, TREP132: Transcriptional-regulating factor 1 0.025 0.028
IWS1 IWS1, IWS1L: IWS1 homolog 0.025 0.028
ADK ADK: Adenosine kinase 0.025 0.028
SMAD1 SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1 0.025 0.028
SMN2 SMN1, SMN, SMN2, SMNC, SMNT: Survival motor neuron protein 0.025 0.028
C20orf77 N/A 0.025 0.028
HIST2H2AC HIST2H2AC, H2AFQ: Histone H2A type 2-C 0.025 0.028
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.025 0.028
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.025 0.083
MSL3L1 MSL3L1: Male-specific lethal 3-like 1 0.025 0.028
ATRX ATRX, RAD54L, XH2: Transcriptional regulator ATRX 0.025 0.028
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.028
SMARCA2 SMARCA2, BRM, SNF2A, SNF2L2: Probable global transcription activator SNF2L2 0.025 0.028
ATXN2L N/A 0.025 0.028
CARHSP1 CARHSP1: Calcium-regulated heat stable protein 1 0.025 0.028
SON 0.025 0.028
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.025 0.083
HOXA10 HOXA10, HOX1H: Homeobox protein Hox-A10 0.025 0.028
DLX3 DLX3: Homeobox protein DLX-3 0.025 0.028
MIER1 MIER1, KIAA1610: Mesoderm induction early response protein 1 0.025 0.028
CETN1 CETN1, CEN1, CETN: Centrin-1 0.025 0.028
GEMIN5 GEMIN5: Gem-associated protein 5 0.025 0.028
FAF1 FAF1, CGI-03: FAS-associated factor 1 0.025 0.028
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.025 0.083
ZFPM1 ZFPM1, FOG1: Zinc finger protein ZFPM1 0.025 0.028
PURB PURB: Transcriptional activator protein Pur-beta 0.025 0.028
DHX8 DHX8, DDX8: ATP-dependent RNA helicase DHX8 0.025 0.028
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.025 0.083
HEXIM2 HEXIM2, L3: Protein HEXIM2 0.025 0.028
0.347
Total Score 13.30