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Evidence of Interaction Between CAP1 and CFL1

The interaction score between CAP1 and CFL1 is 664.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between CAP1 and CFL1 = 0.57

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

6.27E-3
Orthology
OrganismCAP1 OrthologueCFL1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YNL138W 1 YLL050C 1
  • Immunoprecipitation
  • AffinityCaptureMS

Get References From PubMed

worm Q95YA9 1 Q9UAU4 0.791
fly Q9VPX7 1 P45594 1
fly Q9VPX7 1 Q9VWR1 0.432

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.593
Domains No domains were used in calculating likelihood of interaction 4.85E-3
Post-translational Modifications

Protein: CAP1

PTMResidueReference
Acetylation 2 PubMed, HPRD
N-acetylalanine 1 HPRD

Protein: CFL1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 3 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 3 PubMed, HPRD
Phosphotyrosine 139 HPRD
Localisation

Protein: CAP1

LocalisationReference
Cytoplasm HPRD

Protein: CFL1

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD
Secreted HPRD
Cytoplasm HPRD
Cytoskeleton HPRD
Transitive Score

The common interactors between CAP1 and CFL1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between CAP1 andCFL1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , CAP1 has 143 interactors and CFL1 has 750 interactors of which there are 69 common interactors.

Common InteractorName of Common InteractorScore for CAP1-Interactor (?)Score for CFL1-Interactor (?)
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 12.60 0.046
ACTG1 ACTB: Actin, cytoplasmic 1 12.60 122.00
ACTB ACTG1, ACTB, ACTG: Actin, cytoplasmic 2 2.39 41.20
VAV1 VAV1, VAV: Proto-oncogene vav 1.19 0.038
HCK N/A 1.19 0.087
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 1.19 0.087
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.722 0.029
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.722 0.148
NULL N/A 0.593 0.593
CAP2 CAP2: Adenylyl cyclase-associated protein 2 0.593 0.593
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.583 0.148
DUSP14 DUSP14, MKP6: Dual specificity protein phosphatase 14 0.443 0.029
CRKL CRKL: Crk-like protein 0.430 0.038
NCK2 NCK2: Cytoplasmic protein NCK2 0.430 0.038
CRK N/A 0.352 0.046
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.232 0.148
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.232 0.098
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.232 0.047
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.232 0.025
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.232 0.148
CFL2 CFL2: Cofilin-2 0.232 1.33
DSTN DSTN, ACTDP, DSN: Destrin 0.213 1.53
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.213 0.0308
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.173 0.0308
CTTN CTTN, EMS1: Src substrate cortactin 0.152 0.029
DKFZp686D0972 ACT: Actin-like protein (Fragment) 0.119 0.119
NULL N/A 0.119 0.119
NULL N/A 0.119 0.119
ACTC ACTC1, ACTC: Actin, alpha cardiac muscle 1 0.078 0.950
PHLPPL PHLPPL, KIAA0931: PH domain leucine-rich repeat protein phosphatase-like 0.071 0.089
ACTA2 ACTA2, ACTSA, GIG46, ACTVS: Actin, aortic smooth muscle 0.071 0.754
ACTG2 ACTG2, ACTA3, ACTL3, ACTSG: Actin, gamma-enteric smooth muscle 0.071 0.837
ACTA1 ACTA1, ACTA: Actin, alpha skeletal muscle 0.071 0.754
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.065 0.254
SUPT5H SUPT5H, SPT5, SPT5H: Transcription elongation factor SPT5 0.054 0.054
WDR1 N/A 0.053 0.036
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.053 0.027
CD44 N/A 0.053 0.027
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.053 0.027
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.053 0.0425
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.053 0.027
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.053 0.070
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.0479 0.046
STAT6 STAT6: Signal transducer and activator of transcription 6 0.0479 0.046
LYN LYN: Tyrosine-protein kinase Lyn 0.0479 0.071
GMIP GMIP: GEM-interacting protein 0.0479 0.038
YWHAB YWHAB: 14-3-3 protein beta/alpha 0.0479 0.046
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.0479 12.30
MSN MSN: Moesin 0.0479 0.046
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.0479 0.038
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.0479 0.046
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.0479 0.038
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.030 0.045
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.029 0.0333
COL5A2 COL5A2: Collagen alpha-2(V) chain precursor 0.029 0.029
COL1A2 COL1A2: Collagen alpha-2(I) chain precursor 0.029 0.029
COL5A1 N/A 0.027 0.028
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.026 0.030
HNRPH3 HNRPH3: Heterogeneous nuclear ribonucleoprotein H3 0.026 0.030
RGS2 RGS2, G0S8: Regulator of G-protein signaling 2 0.025 0.0425
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.025 0.0425
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.025 0.0425
RBM3 RBM3, RNPL: Putative RNA-binding protein 3 0.025 0.027
CRLF3 N/A 0.025 0.027
PLEK PLEK, P47: Pleckstrin 0.025 0.027
SAT SAT1, SAT: Diamine acetyltransferase 1 0.025 0.0425
MARK2 N/A 0.025 0.0425
ELF1 ELF1: ETS-related transcription factor Elf-1 0.025 0.027
AHNAK AHNAK: AHNAK protein 0.025 0.032
0.572
Total Score 664.00