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Evidence of Interaction Between JUN and MAPK8

The interaction score between JUN and MAPK8 is 13.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology N/A N/A
Domains Domains present in JUN and MAPK8:
Domains in JUNDomains in MAPK8
IPR004827 Basic-leucine zipper (bZIP) transcription factor
IPR008917 Eukaryotic transcription factor, DNA-binding
IPR002112 Transcription factor Jun
IPR005643 Jun-like transcription factor
IPR011616 bZIP_1.
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008351 JNK MAP kinase

The Chi square scores for co-occurrence of domains that are present in JUN and MAPK8 are listed below.

Domain 1Domain 2Chi Square
IPR005643 Jun-like transcription factor IPR008351 JNK MAP kinase 20.898
IPR002112 Transcription factor Jun IPR008351 JNK MAP kinase 20.898
IPR005643 Jun-like transcription factor IPR003527 MAP kinase 11.6783
IPR002112 Transcription factor Jun IPR003527 MAP kinase 11.6783
IPR011616 bZIP_1. IPR008351 JNK MAP kinase 11.599
IPR008917 Eukaryotic transcription factor, DNA-binding IPR008351 JNK MAP kinase 10.8998
IPR004827 Basic-leucine zipper (bZIP) transcription factor IPR000719 Protein kinase 8.28186
IPR011616 bZIP_1. IPR003527 MAP kinase 5.68082
IPR008917 Eukaryotic transcription factor, DNA-binding IPR003527 MAP kinase 5.24231
IPR011616 bZIP_1. IPR000719 Protein kinase 4.81072
IPR004827 Basic-leucine zipper (bZIP) transcription factor IPR008351 JNK MAP kinase 4.74134
IPR008917 Eukaryotic transcription factor, DNA-binding IPR000719 Protein kinase 3.61835
IPR002112 Transcription factor Jun IPR000719 Protein kinase 2.75196
IPR005643 Jun-like transcription factor IPR000719 Protein kinase 2.75196
IPR004827 Basic-leucine zipper (bZIP) transcription factor IPR003527 MAP kinase 1.58426
IPR008917 Eukaryotic transcription factor, DNA-binding IPR002290 Serine/threonine protein kinase 0.250234
IPR002112 Transcription factor Jun IPR002290 Serine/threonine protein kinase 0.193106
IPR005643 Jun-like transcription factor IPR002290 Serine/threonine protein kinase 0.193106
IPR008917 Eukaryotic transcription factor, DNA-binding IPR008271 Serine/threonine protein kinase, active site 0.186644
IPR005643 Jun-like transcription factor IPR008271 Serine/threonine protein kinase, active site 0.00160563
IPR002112 Transcription factor Jun IPR008271 Serine/threonine protein kinase, active site 0.00160563
IPR004827 Basic-leucine zipper (bZIP) transcription factor IPR008271 Serine/threonine protein kinase, active site 0.00153394
IPR011616 bZIP_1. IPR002290 Serine/threonine protein kinase 0.00142746
IPR004827 Basic-leucine zipper (bZIP) transcription factor IPR002290 Serine/threonine protein kinase 0.000586009
IPR011616 bZIP_1. IPR008271 Serine/threonine protein kinase, active site 0.000116789

The background colour of the table refers to:

  • Blue Domain is only present in JUN
  • Yellow Domain is only present in MAPK8
  • Green Domain is present in both JUN and MAPK8

 0.109
Post-translational Modifications

Protein: JUN

PTMResidueReference
Acetylation 271 PubMed, HPRD
Phosphorylation 63 PubMed, HPRD
Phosphorylation 73 PubMed, HPRD
Phosphorylation 170 PubMed, HPRD
Phosphorylation 231 PubMed, HPRD
Phosphorylation 249 PubMed, HPRD
Phosphoserine 63 PubMed, HPRD
Phosphoserine 73 PubMed, HPRD

Protein: MAPK8

PTMResidueReference
Phosphorylation 183 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 377 PubMed, HPRD
Phosphothreonine 183 PubMed, HPRD
Phosphotyrosine 185 PubMed, HPRD
Localisation

Protein: JUN

LocalisationReference
Nucleus HPRD

Protein: MAPK8

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between JUN and MAPK8 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between JUN andMAPK8. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , JUN has 854 interactors and MAPK8 has 1413 interactors of which there are 446 common interactors.

Common InteractorName of Common InteractorScore for JUN-Interactor (?)Score for MAPK8-Interactor (?)
FOS FOS, G0S7: Proto-oncogene protein c-fos 2.90E3 0.109
FOSL2 FOSL2, FRA2: Fos-related antigen 2 856.00 0.109
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 65.60 0.083
JUND JUND: Transcription factor jun-D 39.70 0.109
JUNB JUNB: Transcription factor jun-B 24.40 0.109
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 3.89 0.049
MAFG MAFG: Transcription factor MafG 2.17 0.109
BATF BATF: Basic leucine zipper transcriptional factor ATF-like 1.50 0.109
ETS2 ETS2: Protein C-ets-2 0.416 0.109
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.385 0.083
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.385 0.109
BACH1 BACH1: Transcription regulator protein BACH1 0.307 0.109
ELF1 ELF1: ETS-related transcription factor Elf-1 0.307 0.109
H1FX H1FX: Histone H1x 0.307 0.049
NFKBIA NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha 0.276 0.028
CEBPB CEBPB, TCF5, PP9092: CCAAT/enhancer-binding protein beta 0.275 0.109
FOXJ2 FOXJ2, FHX: Forkhead box protein J2 0.251 0.049
BRPF1 BRPF1, BR140: Peregrin 0.225 0.028
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.225 0.083
HIST1H1E HIST1H1E, H1F4: Histone H1.4 0.225 0.049
ATF1 ATF1: Cyclic AMP-dependent transcription factor ATF-1 0.225 0.109
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.225 0.109
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.225 0.049
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.225 0.083
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.210 0.083
IRF3 IRF3: Interferon regulatory factor 3 0.191 0.049
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.188 0.083
NR4A2 NR4A2, NOT, NURR1, TINUR: Orphan nuclear receptor NR4A2 0.188 0.049
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.188 0.083
HIST1H1D HIST1H1D, H1F3: Histone H1.3 0.171 0.049
NFE2L2 NFE2L2, NRF2: Nuclear factor erythroid 2-related factor 2 0.171 0.109
FOXO1A FOXO1A, FKHR: Forkhead box protein O1A 0.171 0.049
ATF6 ATF6: Cyclic AMP-dependent transcription factor ATF-6 alpha 0.171 0.109
FOXM1 FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1 0.165 0.049
HTATIP HTATIP, TIP60: Histone acetyltransferase HTATIP 0.165 0.049
MAPK15 N/A 0.165 0.083
ELF2 ELF2, NERF: ETS-related transcription factor Elf-2 0.165 0.109
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.165 0.083
SP100 N/A 0.155 0.04
RXRA RXRA, NR2B1: Retinoic acid receptor RXR-alpha 0.155 0.049
ERF ERF: ETS domain-containing transcription factor ERF 0.152 0.109
GTF2F2 N/A 0.152 0.049
CEBPA CEBPA: CCAAT/enhancer-binding protein alpha 0.152 0.109
CREB1 CREB1: cAMP response element-binding protein 0.148 0.109
HIST1H1C HIST1H1C, H1F2: Histone H1.2 0.148 0.049
FARSLA FARSA, FARS, FARSL, FARSLA: Phenylalanyl-tRNA synthetase alpha chain 0.148 0.049
AHR AHR: Aryl hydrocarbon receptor precursor 0.146 0.04
IRS2 IRS2: Insulin receptor substrate 2 0.144 0.165
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.140 0.0333
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.139 0.083
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.139 0.083
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.139 0.165
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.136 0.083
HSF1 HSF1, HSTF1: Heat shock factor protein 1 0.136 0.109
HIST1H1B HIST1H1B, H1F5: Histone H1.5 0.136 0.049
FOXO3A FOXO3A, FKHRL1: Forkhead box protein O3A 0.136 0.049
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.136 0.083
ETS1 ETS1, EWSR2: Protein C-ets-1 0.136 0.109
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.129 0.980
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.127 0.083
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.127 0.083
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.127 0.083
NR3C1 NR3C1, GRL: Glucocorticoid receptor 0.127 0.049
NFATC1 N/A 0.127 0.049
MYB MYB: Myb proto-oncogene protein 0.123 0.049
ERG ERG: Transcriptional regulator ERG 0.123 0.109
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.118 0.083
VDR VDR, NR1I1: Vitamin D3 receptor 0.114 0.049
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.114 0.083
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.114 0.083
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.114 0.083
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.114 0.083
SMAD2 SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2 0.114 0.049
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.114 0.083
CXorf9 N/A 0.114 0.028
CTDP1 CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase 0.114 0.049
STK10 STK10: Uncharacterized protein STK10 0.114 0.083
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.114 0.083
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.114 0.083
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.114 0.165
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.114 0.083
RPS6KB1 N/A 0.114 0.083
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.114 0.083
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.114 0.083
STAT6 STAT6: Signal transducer and activator of transcription 6 0.111 0.165
HSF2 HSF2, HSTF2: Heat shock factor protein 2 0.111 0.109
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.109 0.083
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.099 0.083
DDIT3 DDIT3, CHOP, GADD153: DNA damage-inducible transcript 3 0.098 0.109
ETV1 ETV1, ER81: ETS translocation variant 1 0.098 0.109
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.098 0.049
HIST1H1A HIST1H1A, H1F1: Histone H1.1 0.097 0.049
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.097 0.049
RFX1 RFX1: MHC class II regulatory factor RFX1 0.097 0.049
CEBPE CEBPE: CCAAT/enhancer-binding protein epsilon 0.097 0.109
ID2 ID2: DNA-binding protein inhibitor ID-2 0.0971 0.04
STAT2 STAT2: Signal transducer and activator of transcription 2 0.096 0.109
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.096 0.083
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.096 0.109
RB1 RB1: Retinoblastoma-associated protein 0.096 0.049
ROCK1 ROCK1: Rho-associated protein kinase 1 0.096 0.165
NBN NBN, NBS, NBS1, P95: Nibrin 0.096 0.04
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.096 0.083
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.090 0.083
ELK1 ELK1: ETS domain-containing protein Elk-1 0.088 0.109
FOXL2 FOXL2: Forkhead box protein L2 0.088 0.049
MYST4 MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4 0.088 0.049
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.088 0.049
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.087 0.083
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.087 0.049
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.086 0.083
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.086 0.109
SMAD3 SMAD3, MADH3: Mothers against decapentaplegic homolog 3 0.086 0.049
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.086 0.165
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.086 0.083
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.086 0.049
RELA RELA, NFKB3: Transcription factor p65 0.086 0.049
RBL2 RBL2, RB2: Retinoblastoma-like protein 2 0.086 0.049
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.086 0.083
EEA1 EEA1, ZFYVE2: Early endosome antigen 1 0.086 0.028
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.086 0.083
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.086 0.049
SMAD4 SMAD4, DPC4, MADH4: Mothers against decapentaplegic homolog 4 0.086 0.049
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.086 0.083
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.083 0.083
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.083 0.083
NFATC3 NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3 0.083 0.049
NFATC2 NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2 0.083 0.049
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.083
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.081 0.083
KIAA0690 N/A 0.078 0.028
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.077 0.083
UBTF UBTF, UBF, UBF1: Nucleolar transcription factor 1 0.077 0.04
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.077 0.083
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.077 0.049
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.077 0.083
SOX8 SOX8: Transcription factor SOX-8 0.075 0.04
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.075 0.083
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.075 0.083
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.075 0.083
RBL1 RBL1: Retinoblastoma-like protein 1 0.075 0.049
SMAD1 SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1 0.075 0.049
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.075 0.083
C10orf9 CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y 0.075 0.109
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.075 0.083
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.075 0.083
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.075 0.083
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.083
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.075 0.083
CDC2 CDC2: Cell division control protein 2 homolog 0.075 0.083
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.075 0.083
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.075 0.109
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.075 0.109
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.075 0.049
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.075 0.165
CCNT2 CCNT2: Cyclin-T2 0.075 0.109
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.075 0.083
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.075 0.028
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.075 0.083
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.075 0.165
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.075 0.049
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.075 0.083
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.073 0.083
HIF1A HIF1A, MOP1: Hypoxia-inducible factor 1 alpha 0.071 0.04
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.071 0.083
HMGB2 HMGB2, HMG2: High mobility group protein B2 0.069 0.04
RERE RERE, ARG, ARP, ATN1L, KIAA0458: Arginine-glutamic acid dipeptide repeats protei 0.069 0.049
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.069 0.083
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.069 0.04
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.069 0.083
SOX4 SOX4: Transcription factor SOX-4 0.069 0.04
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.069 0.083
CDK6 CDK6: Cell division protein kinase 6 0.069 0.083
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.069 0.083
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.067 0.028
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.064 0.028
AGTPBP1 AGTPBP1, RP11-30C23.1-005, hCG_1743691: AGTPBP1 protein 0.063 0.028
KIAA1012 KIAA1012: Protein TRS85 homolog 0.063 0.083
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.063 0.165
SMAD7 SMAD7, MADH7, MADH8: Mothers against decapentaplegic homolog 7 0.062 0.049
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.062 0.083
PRKAA1 N/A 0.062 0.083
CDKL5 N/A 0.062 0.083
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.062 0.083
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.062 0.083
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.060 0.049
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.060 0.083
CDK5 CDK5: Cell division protein kinase 5 0.056 0.083
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.056 0.083
CCND1 CCND1, BCL1, PRAD1: G1/S-specific cyclin-D1 0.056 0.109
NR4A1 CDNA FLJ16818 fis, clone TRACH1000193, highly similar to Orphan nuclear receptor 0.056 0.049
CCNH CCNH: Cyclin-H 0.056 0.109
NR5A1 NR5A1, AD4BP, FTZF1, SF1: Steroidogenic factor 1 0.056 0.049
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.056 0.083
STK16 N/A 0.055 0.083
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.055 0.083
PGR PGR, NR3C3: Progesterone receptor 0.055 0.049
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.055 0.083
PPARA PPARA, NR1C1, PPAR: Peroxisome proliferator-activated receptor alpha 0.055 0.049
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.054 0.165
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.052 0.096
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.052 0.083
MAPKAPK5 N/A 0.052 0.083
HES6 HES6: Transcription cofactor HES-6 0.052 0.04
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.052 0.083
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.052 0.083
ARNT ARNT: Aryl hydrocarbon receptor nuclear translocator 0.052 0.04
CCAR1 CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1 0.052 0.028
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.052 0.083
SAT SAT1, SAT: Diamine acetyltransferase 1 0.052 0.028
MAPK7 mitogen-activated protein kinase 7 isoform 1 0.052 0.028
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.052 0.028
VIM VIM: Vimentin 0.052 0.04
ATF2 N/A 0.051 0.051
ELK3 ELK3, NET, SAP2: ETS domain-containing protein Elk-3 0.051 0.051
EXOC2 N/A 0.051 0.028
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.051 0.165
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.051 0.083
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.051 0.165
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.050 0.083
NFIB N/A 0.049 0.049
ESR1 ESR1, ESR, NR3A1: Estrogen receptor 0.049 0.049
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.049 0.083
NEDD4L NEDD4L, KIAA0439, NEDL3: E3 ubiquitin-protein ligase NEDD4-like protein 0.049 0.028
ESRRA ESRRA, ERR1, ESRL1, NR3B1: Steroid hormone receptor ERR1 0.049 0.049
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.049 0.083
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.049 0.083
WDHD1 WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1 0.049 0.04
PPARG CREB3L2-PPARgamma 0.049 0.049
SOX11 SOX11: Transcription factor SOX-11 0.049 0.04
CDK4 CDK4: Cell division protein kinase 4 0.049 0.083
SALL1 SALL1, SAL1: Sal-like protein 1 0.049 0.028
CDK7 CDK7, MO15: Cell division protein kinase 7 0.049 0.083
LEF1 LEF1: Lymphoid enhancer-binding factor 1 0.049 0.04
STAT4 STAT4: Signal transducer and activator of transcription 4 0.049 0.109
DYRK3 N/A 0.049 0.083
CDK2 CDK2: Cell division protein kinase 2 0.049 0.083
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.049 0.083
CDK5R1 CDK5R1, CDK5R, NCK5A: Cyclin-dependent kinase 5 activator 1 precursor 0.049 0.049
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.049 0.083
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.049 0.083
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.049 0.083
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.048 0.083
DAPK2 DAPK2: Death-associated protein kinase 2 0.048 0.083
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.047 0.083
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.047 0.083
TFAP4 TFAP4: Transcription factor AP-4 0.047 0.04
TAL2 TAL2: T-cell acute lymphocytic leukemia protein 2 0.047 0.04
NCOA3 NCOA3, AIB1, RAC3, TRAM1: Nuclear receptor coactivator 3 0.047 0.04
MAX MAX: Protein max 0.047 0.04
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.047 0.0333
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.047 0.083
MLXIPL MLXIPL, MIO, WBSCR14: Williams-Beuren syndrome chromosome region 14 protein 0.047 0.04
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.046 0.028
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.046 0.049
EIF4G2 EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2 0.046 0.049
PIK4CB PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic, 0.046 0.028
DIAPH1 Diaphanous 1 0.046 0.028
GSK3B N/A 0.046 0.028
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.046 0.034
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.0453 0.165
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.0446 0.165
ALOX5 ALOX5, LOG5: Arachidonate 5-lipoxygenase 0.0446 0.028
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.044 0.083
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.044 0.083
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.044 0.083
CCNB1 Cyclin B1 0.044 0.109
MYO3A MYO3A: Myosin IIIA 0.044 0.083
NR1D1 NR1D1, EAR1, HREV, THRAL: Orphan nuclear receptor NR1D1 0.044 0.049
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.044 0.083
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.044 0.083
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.044 0.165
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.044 0.083
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.044 0.083
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.044 0.083
STAT3 0.044 0.165
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.043 0.109
TRIM25 TRIM25, EFP, RNF147, ZNF147: Tripartite motif-containing protein 25 0.043 0.028
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.043 0.083
MYCN MYCN, NMYC: N-myc proto-oncogene protein 0.043 0.04
TCF3 TCF3, E2A, ITF1: Transcription factor E2-alpha 0.043 0.04
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.0425 0.109
MARK2 N/A 0.0425 0.028
PLEK PLEK, P47: Pleckstrin 0.0425 0.109
GAB2 N/A 0.0425 0.165
VCPIP1 VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135 0.0425 0.028
CDKN2D CDKN2D: Cyclin-dependent kinase 4 inhibitor D 0.0425 0.028
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.0425 0.165
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.0425 0.083
PTMA N/A 0.0425 0.04
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.041 0.083
MAP2K5 N/A 0.04 0.165
TRIM39 TRIM39, RNF23, TFP: Tripartite motif-containing protein 39 0.04 0.028
SYK SYK: Tyrosine-protein kinase SYK 0.040 0.165
ID3 ID3, 1R21, HEIR-1: DNA-binding protein inhibitor ID-3 0.039 0.04
MDM4 MDM4, MDMX: Mdm4 protein 0.039 0.049
STAG2 STAG2, SA2: Cohesin subunit SA-2 0.038 0.028
COPA COPA: Coatomer subunit alpha 0.038 0.028
KIAA0683 DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized 0.038 0.028
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.038 0.028
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.038 0.083
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.038 1.30
DOK1 DOK1: Docking protein 1 0.038 0.165
COPE COPE: Coatomer subunit epsilon 0.038 0.083
USP34 USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34 0.038 0.028
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.038 0.165
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.038 0.152
FNBP1 N/A 0.038 0.028
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.038 0.165
PPP1R12A PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A 0.038 0.028
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 0.036 0.083
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.036 0.052
RGS2 RGS2, G0S8: Regulator of G-protein signaling 2 0.036 0.028
LTA4H LTA4H, LTA4: Leukotriene A-4 hydrolase 0.036 0.028
NLN NLN, AGTBP, KIAA1226: Neurolysin, mitochondrial precursor 0.036 0.028
HES1 HES1, HL, HRY: Transcription factor HES-1 0.035 0.04
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.035 0.109
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.035 0.083
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.035 0.083
MTA1 MTA1: Metastasis-associated protein MTA1 0.035 0.049
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.034 0.083
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.034 0.109
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.034 0.049
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.033 0.083
WWOX WWOX, FOR, WOX1: WW domain-containing oxidoreductase 0.033 0.028
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.033 0.165
DEF6 DEF6, IBP: Differentially expressed in FDCP 6 0.032 0.028
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.032 0.028
USP24 USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24 0.032 0.028
SH2BP1 CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog 0.032 0.028
EIF4G1 EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1 0.032 0.049
ARFGAP1 N/A 0.032 0.049
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.032 0.109
YWHAB YWHAB: 14-3-3 protein beta/alpha 0.032 0.028
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.032 0.165
FLII FLII, FLIL: Protein flightless-1 homolog 0.032 0.028
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.032 0.083
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.032 0.028
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.032 0.083
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.032 0.165
LYN LYN: Tyrosine-protein kinase Lyn 0.032 0.165
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.032 0.028
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.032 0.165
RAP1A RAP1A, KREV1: Ras-related protein Rap-1A precursor 0.032 0.052
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.032 0.165
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.031 0.083
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.031 0.165
HMGA2 HMGA2, HMGIC: High mobility group protein HMGI-C 0.031 0.109
MYF5 MYF5: Myogenic factor 5 0.0308 0.04
TAL1 TAL1, SCL, TCL5: T-cell acute lymphocytic leukemia protein 1 0.0308 0.04
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.0308 0.083
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.0308 0.083
LIMK2 LIMK2: LIM domain kinase 2 0.030 0.083
TRAF2 TRAF2, TRAP3: TNF receptor-associated factor 2 0.030 0.083
BIRC4 BIRC4, API3, IAP3, XIAP: Baculoviral IAP repeat-containing protein 4 0.030 0.052
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.029 0.083
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.029 0.165
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.029 0.028
DYNC1LI1 DYNC1LI1, DNCLI1: Cytoplasmic dynein 1 light intermediate chain 1 0.029 0.028
TMEM1 TMEM1, EHOC1: Transmembrane protein 1 0.029 0.083
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.029 0.083
NAP1L1 NAP1L1, NRP: Nucleosome assembly protein 1-like 1 0.029 0.049
KLHDC4 N/A 0.029 0.028
SAPS3 N/A 0.029 0.028
AIP AIP, XAP2: AH receptor-interacting protein 0.029 0.083
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.029 0.028
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.029 0.980
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.029 0.165
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.029 0.083
PPP1R8 N/A 0.029 0.04
SOS1 SOS1: Son of sevenless homolog 1 0.029 0.109
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.029 0.083
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.029 0.083
PPP1R12C PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C 0.028 0.028
NSBP1 NSBP1: Nucleosome-binding protein 1 0.028 0.109
PPEF1 N/A 0.028 0.028
RAB4A N/A 0.028 0.04
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.028
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.028
GPRASP2 GPRASP2: G-protein coupled receptor-associated sorting protein 2 0.028 0.028
ZNF687 ZNF687, KIAA1441: Zinc finger protein 687 0.028 0.028
NF2 NF2, SCH: Merlin 0.028 0.165
BID BID: BH3-interacting domain death agonist 0.028 0.109
C14orf151 C14orf151: Uncharacterized protein C14orf151 (Fragment) 0.028 0.028
PHLDB2 N/A 0.028 0.028
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.028 0.083
HAND1 HAND1, EHAND: Heart- and neural crest derivatives-expressed protein 1 0.028 0.04
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.028 0.083
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.028 0.083
WEE1 WEE1: Wee1-like protein kinase 0.028 0.083
THOP1 THOP1: Thimet oligopeptidase 0.027 0.028
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.027 0.165
VAV2 VAV2, RP11-153P4.1-003: Vav 2 oncogene 0.027 0.028
FTH1 FTH1, FTH, OK/SW-cl.84, FTHL6, PIG15: Ferritin heavy chain 0.027 0.028
TRADD TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein 0.027 0.083
DAPP1 N/A 0.027 0.028
MVP MVP, LRP: Major vault protein 0.027 0.028
CIITA CIITA, MHC2TA: MHC class II transactivator 0.027 0.083
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.027 0.028
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.027 0.028
LIMS1 N/A 0.027 0.028
FLNA FLNA, FLN, FLN1: Filamin-A 0.027 0.028
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.026 0.083
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.026 0.165
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.026 0.165
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.026 0.109
MYCBP2 MYCBP2, KIAA0916, PAM: Probable E3 ubiquitin-protein ligase MYCBP2 0.026 0.049
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.026 0.165
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.026 0.028
CDKN1A CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1: Cyclin-dependent kinase inhi 0.026 0.049
ABCF1 N/A 0.026 0.028
FAM65A FAM65A, KIAA1930: Protein FAM65A 0.026 0.028
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.026 0.083
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.026 0.980
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.026 0.028
CHUK N/A 0.026 0.028
IRS1 IRS1: Insulin receptor substrate 1 0.026 0.165
CDC25C CDC25C: M-phase inducer phosphatase 3 0.025 0.165
PPP1R9B PPP1R9B, PPP1R6: Neurabin-2 0.025 0.028
CDC25A CDC25A: M-phase inducer phosphatase 1 0.025 0.165
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.025 0.028
ELMO1 N/A 0.025 0.165
GIT2 N/A 0.025 0.083
PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 0.025 0.028
MAP2K3 N/A 0.025 0.028
ADK ADK: Adenosine kinase 0.025 0.028
GATAD2B GATAD2B, KIAA1150: Transcriptional repressor p66 beta 0.025 0.049
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 0.028
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.025 0.028
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.025 0.04
CARHSP1 CARHSP1: Calcium-regulated heat stable protein 1 0.025 0.028
CAMKK1 N/A 0.025 0.028
PRKCB1 N/A 0.025 0.028
CAMK2A N/A 0.025 0.028
GRK6 N/A 0.025 0.028
BCOR N/A 0.025 0.028
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.025 1.30
EEF2K EEF2K: Elongation factor 2 kinase 0.025 0.165
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.025 0.028
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.025 0.028
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.025 0.980
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.025 1.30
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.025 0.028
HNRPH3 HNRPH3: Heterogeneous nuclear ribonucleoprotein H3 0.025 0.0333
LMNA LMNA, LMN1: Lamin-A/C 0.025 0.04
NIPBL N/A 0.025 0.028
0.299
Total Score 13.00