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Evidence of Interaction Between SNAP23 and STX1A

The interaction score between SNAP23 and STX1A is 2.93E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology
OrganismSNAP23 OrthologueSTX1A OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00010470 1 IPI00166679 0.078
bakers yeast YGR009C 1 YMR183C 1
  • Immunoprecipitation
  • Xlinking

Get References From PubMed
bakers yeast YGR009C 1 YPL232W 0.673
  • Immunoprecipitation
  • Xlinking
  • InVitroBinding
  • AffinityCaptureWestern
  • ReconstitutedComplex
  • DosageRescue
  • SyntheticRescue

Get References From PubMed
bakers yeast YMR017W 0.082 YMR183C 1
bakers yeast YMR017W 0.082 YPL232W 0.673
  • InVitroBinding
  • AffinityCaptureWestern

Get References From PubMed
worm O62414 0.127 O18657 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains Domains present in SNAP23 and STX1A:
Domains in SNAP23Domains in STX1A
IPR000727 Target SNARE coiled-coil domain
IPR000928 SNAP-25
IPR000727 Target SNARE coiled-coil domain
IPR006011 Syntaxin, N-terminal
IPR006012 Syntaxin/epimorphin family

The Chi square scores for co-occurrence of domains that are present in SNAP23 and STX1A are listed below.

Domain 1Domain 2Chi Square
IPR000928 SNAP-25 IPR006012 Syntaxin/epimorphin family 529.711
IPR000928 SNAP-25 IPR000727 Target SNARE coiled-coil domain 381.656
IPR000928 SNAP-25 IPR006011 Syntaxin, N-terminal 278.506
IPR000727 Target SNARE coiled-coil domain IPR006012 Syntaxin/epimorphin family 264.313
IPR000727 Target SNARE coiled-coil domain IPR000727 Target SNARE coiled-coil domain 185.931
IPR000727 Target SNARE coiled-coil domain IPR006011 Syntaxin, N-terminal 179.057

The background colour of the table refers to:

  • Blue Domain is only present in SNAP23
  • Yellow Domain is only present in STX1A
  • Green Domain is present in both SNAP23 and STX1A

 0.540
Post-translational Modifications

Protein: SNAP23

PTMResidueReference
Acetylation 1 PubMed, HPRD
N-acetylmethionine 1 HPRD
Palmitoylation 80 PubMed, HPRD
Palmitoylation 83 PubMed, HPRD
Palmitoylation 85 PubMed, HPRD
Palmitoylation 87 PubMed, HPRD
Phosphorylation 23 PubMed, HPRD
Phosphorylation 24 PubMed, HPRD
Phosphorylation 161 PubMed, HPRD

Protein: STX1A

PTMResidueReference
Phosphorylation 14 PubMed, HPRD
Phosphorylation 188 PubMed, HPRD
Localisation

Protein: SNAP23

LocalisationReference
Golgi HPRD
Nucleus HPRD
Plasma membrane HPRD
Endosome HPRD
Cytoplasm HPRD

Protein: STX1A

LocalisationReference
Plasma membrane HPRD
Transitive Score

The common interactors between SNAP23 and STX1A that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SNAP23 andSTX1A. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SNAP23 has 637 interactors and STX1A has 239 interactors of which there are 147 common interactors.

Common InteractorName of Common InteractorScore for SNAP23-Interactor (?)Score for STX1A-Interactor (?)
VAMP4 VAMP4: Vesicle-associated membrane protein 4 128.00 173.00
SNAP25 SNAP25, SNAP: Synaptosomal-associated protein 25 62.80 171.00
SEC22L1 SEC22B, SEC22L1: Vesicle-trafficking protein SEC22b 33.30 7.47
VAMP2 VAMP2, SYB2: Vesicle-associated membrane protein 2 33.30 160.00
VAMP3 VAMP3, SYB3: Vesicle-associated membrane protein 3 25.70 30.70
STX7 STX7: Syntaxin-7 13.70 0.097
STX12 STX12: Syntaxin-12 6.70 0.028
STX3A STX3, STX3A: Syntaxin-3 6.70 0.448
STX4A STX4, STX4A: Syntaxin-4 6.70 0.404
STX1B2 STX1B, STX1B1, STX1B2: Syntaxin-1B 6.70 0.682
EPIM STX2, EPIM, STX2A, STX2B, STX2C: Syntaxin-2 6.70 0.682
STX11 STX11: Syntaxin-11 6.70 0.404
SYBL1 SYBL1: Synaptobrevin-like protein 1 1.53 0.322
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.980 0.109
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.878 0.113
STXBP2 STXBP2, UNC18B: Syntaxin-binding protein 2 0.715 0.477
SNAP29 SNAP29: Synaptosomal-associated protein 29 0.237 0.084
STXBP1 N/A 0.232 0.232
NAPA N/A 0.196 0.067
STXBP3 STXBP3: Syntaxin-binding protein 3 0.143 0.107
VAMP5 VAMP5, HSPC191: Vesicle-associated membrane protein 5 0.141 0.145
VAMP1 VAMP1, SYB1: Vesicle-associated membrane protein 1 0.141 0.251
STX6 STX6: Syntaxin-6 0.141 0.027
YKT6 YKT6: Synaptobrevin homolog YKT6 0.126 0.141
VAMP8 VAMP8: Vesicle-associated membrane protein 8 0.126 0.103
STX19 STX19: Syntaxin-19 0.119 0.064
VAMP1 N/A 0.119 0.119
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.109 0.109
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.109 0.065
VCP VCP: Transitional endoplasmic reticulum ATPase 0.098 0.058
ABCC1 ABCC1, MRP, MRP1: Multidrug resistance-associated protein 1 0.075 0.030
SYTL4 Endocrine transmitter regulatory protein 0.0688 0.0688
CLTC CLTC, CLH17, CLTCL2, KIAA0034: Clathrin heavy chain 1 0.062 0.057
Sep-05 SEPT5, PNUTL1: Septin-5 0.051 0.051
STXBP1 STXBP1, UNC18A: Syntaxin-binding protein 1 0.051 0.265
CDC10 SEPT7, CDC10: Septin-7 0.051 0.051
TRAF2 TRAF2, TRAP3: TNF receptor-associated factor 2 0.049 0.033
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.049 0.044
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.049 0.049
RAB11FIP5 RAB11FIP5, GAF1, KIAA0857, RIP11: Rab11 family-interacting protein 5 0.049 0.041
DSP DSP: Desmoplakin 0.049 0.034
FKBP8 DKFZp686M22160: Putative uncharacterized protein DKFZp686M22160 (Fragment) 0.049 0.067
STIP1 STIP1: Stress-induced-phosphoprotein 1 0.049 0.055
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.049 0.037
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.049 0.032
NASP NASP: Nuclear autoantigenic sperm protein 0.049 0.049
SRPR SRPR: Uncharacterized protein SRPR 0.049 0.033
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.049 0.029
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.049 0.029
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.049 0.0446
MCF2 MCF2, DBL: Proto-oncogene DBL 0.049 0.0453
SPTAN1 N/A 0.049 0.153
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.049 0.049
DNAJC7 DNAJC7, TPR2, TTC2: DnaJ homolog subfamily C member 7 0.049 0.033
SPAG1 SPAG1: Sperm-associated antigen 1 0.049 0.029
TRIM39 TRIM39, RNF23, TFP: Tripartite motif-containing protein 39 0.049 0.049
BIRC4 BIRC4, API3, IAP3, XIAP: Baculoviral IAP repeat-containing protein 4 0.049 0.032
TMEM1 TMEM1, EHOC1: Transmembrane protein 1 0.049 0.029
NEDD5 SEPT2, DIFF6, KIAA0158, NEDD5: Septin-2 0.046 0.0273
Sep-11 SEPT11: Septin-11 0.046 0.053
SLC6A3 SLC6A3, DAT1: Sodium-dependent dopamine transporter 0.046 0.034
SCFD1 SCFD1, C14orf163, FKSG23, KIAA0917, STXBP1L2: Sec1 family domain-containing prot 0.046 0.0273
Sep-03 N/A 0.046 0.046
SLC6A5 SLC6A5, GLYT2, NET1: Sodium- and chloride-dependent glycine transporter 2 0.046 0.030
PPID PPID, CYP40, CYPD: 40 kDa peptidyl-prolyl cis-trans isomerase 0.044 0.029
ACTN1 ACTN1: Alpha-actinin-1 0.044 0.033
EEF2K EEF2K: Elongation factor 2 kinase 0.044 0.044
SGTA SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A 0.044 0.041
MDN1 MDN1, KIAA0301: Midasin 0.044 0.029
WWC2 WW and C2 domain containing 2 0.044 0.033
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.044 0.032
FKBP4 FKBP4: FK506-binding protein 4 0.044 0.041
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.044 0.026
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.044 0.029
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.044 0.033
FREQ FREQ, FLUP, NCS1: Neuronal calcium sensor 1 0.044 0.032
EEA1 EEA1, ZFYVE2: Early endosome antigen 1 0.044 0.029
TRIP13 TRIP13: Thyroid receptor-interacting protein 13 0.044 0.058
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.044 0.058
AIP AIP, XAP2: AH receptor-interacting protein 0.044 0.029
COPE COPE: Coatomer subunit epsilon 0.044 0.026
KIAA0664 KIAA0664: Putative eukaryotic translation initiation factor 3 subunit 0.044 0.029
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.044 0.029
CDC23 CDC23: Cell division cycle protein 23 homolog 0.044 0.026
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.044 0.026
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.044 0.058
RASA3 RASA3: Ras GTPase-activating protein 3 0.044 0.029
NAPG NAPG, SNAPG: Gamma-soluble NSF attachment protein 0.044 0.029
SPAST SPAST, KIAA1083, SPG4: Spastin 0.044 0.098
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.044 0.029
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.044 0.026
KIAA1012 KIAA1012: Protein TRS85 homolog 0.044 0.029
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.044 0.026
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.044 0.026
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.044 0.058
STUB1 STUB1, CHIP, PP1131: STIP1 homology and U box-containing protein 1 0.044 0.051
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.044 0.026
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.044 0.0818
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.044 0.044
FER1L3 FER1L3, KIAA1207, MYOF: Myoferlin 0.044 0.026
C20orf4 C20orf4, CGI-23, PRO0225: Uncharacterized protein C20orf4 0.044 0.026
PSMD11 PSMD11: 26S proteasome non-ATPase regulatory subunit 11 0.044 0.029
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.044 0.033
FKBP5 FKBP5, AIG6, FKBP51: FK506-binding protein 5 0.044 0.029
ACTN4 ACTN4: Alpha-actinin-4 0.044 0.044
KLC2 KLC2: Kinesin light chain 2 0.044 0.137
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.044 0.137
VAV1 VAV1, VAV: Proto-oncogene vav 0.044 0.029
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.044 0.026
TRIM25 TRIM25, EFP, RNF147, ZNF147: Tripartite motif-containing protein 25 0.044 0.029
RIMS1 RIMS1, KIAA0340, Nbla00761, RAB3IP2, RIM1: Regulating synaptic membrane exocytos 0.044 0.051
RAD18 RAD18, RNF73: E3 ubiquitin-protein ligase RAD18 0.044 0.030
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.044 0.026
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.044 0.051
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.044 0.044
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.04 0.056
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.036 0.036
RAB5B RAB5B: Ras-related protein Rab-5B 0.036 0.075
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.036 0.050
STAM2 STAM2: Signal transducing adapter molecule 2 0.036 0.028
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.036 0.036
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.036 0.071
CTTN CTTN, EMS1: Src substrate cortactin 0.036 0.033
SORBS3 SORBS3, SCAM1: Vinexin 0.036 0.027
CFTR CFTR: Cystic fibrosis transmembrane conductance regulator ATP-binding cassette s 0.034 0.025
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.034 0.035
UHRF1 0.034 0.034
RYR2 RYR2: Ryanodine receptor 2 0.034 0.027
MLL2 MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2 0.034 0.034
C20orf18 N/A 0.034 0.034
PPL PPL, KIAA0568: Periplakin 0.034 0.055
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.034 0.0513
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.034 0.025
MYCBP2 MYCBP2, KIAA0916, PAM: Probable E3 ubiquitin-protein ligase MYCBP2 0.030 0.056
LETM1 LETM1: Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial 0.030 0.025
RNF20 0.030 0.030
ZFYVE16 ZFYVE16, KIAA0305: Zinc finger FYVE domain-containing protein 16 0.030 0.028
RNF113A RNF113A, RNF113, ZNF183: RING finger protein 113A 0.030 0.030
ABCB9 ABCB9, KIAA1520: ATP-binding cassette sub-family B member 9 precursor 0.030 0.030
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.030 0.056
RFFL RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin 0.030 0.030
C14orf4 C14orf4, KIAA1865, My039: RING finger protein C14orf4 0.030 0.030
RNF11 RNF11, CGI-123: RING finger protein 11 0.030 0.076
NAPB CDNA FLJ39175 fis, clone OCBBF2003593, highly similar to BETA-SOLUBLE NSF ATTACH 0.029 0.028
STXBP5 STXBP5, LLGL3: Syntaxin-binding protein 5 0.0288 0.0288
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.028 0.028
STXBP5L N/A 0.0258 0.0258
0.572
Total Score 2.93E4