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Evidence of Interaction Between CSNK2B and CSNK2A1

The interaction score between CSNK2B and CSNK2A1 is 117.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between CSNK2B and CSNK2A1 = 0.79

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.013
Orthology
OrganismCSNK2B OrthologueCSNK2A1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YOR039W 1 YIL035C 1
  • Y2H
  • Immunoprecipitation
  • Other
  • AffinityCaptureMS
  • CoPurification
  • DosageRescue

Get References From PubMed
worm P28548 1 P18334 1
  • Other

Get References From PubMed
fly P08182 1 P08181 1
  • Y2H

Get References From PubMed

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 3.01
Domains No domains were used in calculating likelihood of interaction 0.022
Post-translational Modifications

Protein: CSNK2B

PTMResidueReference
Phosphorylation 2 PubMed, HPRD
Phosphorylation 3 PubMed, HPRD
Phosphorylation 209 PubMed, HPRD
Phosphoserine 2 PubMed, HPRD

Protein: CSNK2A1

PTMResidueReference
Phosphorylation 182 PubMed, HPRD
Phosphorylation 344 PubMed, HPRD
Phosphorylation 360 PubMed, HPRD
Phosphorylation 362 PubMed, HPRD
Phosphorylation 370 PubMed, HPRD
Localisation

Protein: CSNK2B

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: CSNK2A1

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between CSNK2B and CSNK2A1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between CSNK2B andCSNK2A1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , CSNK2B has 148 interactors and CSNK2A1 has 1892 interactors of which there are 108 common interactors.

Common InteractorName of Common InteractorScore for CSNK2B-Interactor (?)Score for CSNK2A1-Interactor (?)
EIF3S9 EIF3S9: Eukaryotic translation initiation factor 3 subunit 9 5.94 73.00
EIF3S8 EIF3S8: Eukaryotic translation initiation factor 3 subunit 8 5.94 0.129
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 5.94 34.20
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 5.94 73.00
EIF3S4 EIF3S4: Eukaryotic translation initiation factor 3 subunit 4 3.59 0.063
PES1 PES1: Pescadillo homolog 1 3.05 14.00
HDAC2 HDAC2: Histone deacetylase 2 2.90 102.00
CAD CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase 2.51 0.385
MTF1 MTF1: Metal regulatory transcription factor 1 2.14 0.046
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 2.14 0.078
SUPT16H SUPT16H, FACT140, FACTP140: FACT complex subunit SPT16 1.84 3.05
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 1.33 0.086
BRD3 BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3 1.33 12.30
CHD1 CHD1: Chromodomain-helicase-DNA-binding protein 1 1.15 1.15
PDCL PDCL: Phosducin-like protein 0.865 0.049
HIST1H4A HIST1H4A, H4/A, HIST1H4B, H4/I, H4/G, HIST1H4D, H4/B, H4/J, HIST1H4F, HIST4H4, H 0.759 4.36
HDAC1 HDAC1, RPD3L1: Histone deacetylase 1 0.722 20.40
BRD2 BRD2, KIAA9001, RING3: Bromodomain-containing protein 2 0.722 4.15
FOXK2 N/A 0.593 0.593
SUPT5H SUPT5H: Uncharacterized protein SUPT5H 0.593 0.593
GTPBP4 0.593 0.593
SH2BP1 0.593 0.593
NOL6 NOL6: Nucleolar protein 6 0.593 0.593
KLF13 KLF13, BTEB3, NSLP1: Krueppel-like factor 13 0.566 0.046
CSNK2A2 CSNK2A2, CK2A2: Casein kinase II subunit alpha' 0.267 0.538
HSPA8 HSPA8, HSC70, HSP73, HSPA10: Heat shock cognate 71 kDa protein 0.232 0.025
BRD4 N/A 0.232 1.33
BRDT N/A 0.119 0.119
FLJ14977 N/A 0.119 0.119
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.081 4.27
CHD2 N/A 0.080 0.038
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.068 0.144
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.061 0.129
CDK4 CDK4: Cell division protein kinase 4 0.061 0.129
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.061 0.233
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.061 0.276
CDK2 CDK2: Cell division protein kinase 2 0.061 0.129
CDK7 CDK7, MO15: Cell division protein kinase 7 0.061 0.078
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.061 0.078
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.055 0.260
PSME3 PSME3: Proteasome activator complex subunit 3 0.053 0.053
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.049 0.063
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.049 0.129
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.049 0.372
WEE1 WEE1: Wee1-like protein kinase 0.049 0.063
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.049 0.372
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.049 0.275
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.049 0.063
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.049 0.046
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.049 0.233
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.049 0.078
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.049 0.063
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.049 0.129
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.0479 1.62
PABPC4 PABPC4, APP1, PABP4: Polyadenylate-binding protein 4 0.0479 0.129
CPSF5 NUDT21, CFIM25, CPSF25, CPSF5: Cleavage and polyadenylation specificity factor s 0.0479 0.038
SNRPC SNRPC: U1 small nuclear ribonucleoprotein C 0.0479 0.276
STK16 N/A 0.0407 0.0425
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.0407 0.070
ROCK1 ROCK1: Rho-associated protein kinase 1 0.0407 0.307
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.036 0.063
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.036 0.275
RPS6KB1 N/A 0.036 0.078
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.036 0.188
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.036 0.046
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.036 0.063
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.036 0.063
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.036 0.275
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.036 0.275
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.036 0.038
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.036 0.038
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.036 0.063
PRKAA1 N/A 0.033 0.032
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.033 0.0425
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.033 0.0425
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.033 0.0425
STK10 STK10: Uncharacterized protein STK10 0.030 0.046
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.030 0.063
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.030 0.029
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.030 0.139
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.030 0.063
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.030 0.046
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.030 0.086
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.030 0.046
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.030 0.038
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.030 0.038
CSK CSK: Tyrosine-protein kinase CSK 0.027 0.461
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.027 0.372
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.0253 0.0425
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.0253 0.032
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.0253 0.0425
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.0253 0.0425
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.0253 0.032
PRKCB1 PRKCB1, PKCB, PRKCB: Protein kinase C beta type 0.0253 0.0253
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.0253 0.0425
LIMK2 LIMK2: LIM domain kinase 2 0.0253 0.032
RNPS1 RNPS1, LDC2: RNA-binding protein with serine-rich domain 1 0.025 0.144
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.025 0.144
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.025 0.307
TRIM28 TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta 0.025 0.144
ABCF1 N/A 0.025 0.144
XRCC6 XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1 0.025 0.307
SET SET: Protein SET 0.025 0.307
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.025 0.307
PHB2 PHB2, BAP, REA: Prohibitin-2 0.025 0.087
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.025 0.107
RDBP RDBP, NELFE, RD: Negative elongation factor E 0.025 0.144
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.025 0.307
2.15E-3
Total Score 117.00