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Evidence of Interaction Between PIK3R2 and FYN

The interaction score between PIK3R2 and FYN is 268.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

N/A
Orthology
OrganismPIK3R2 OrthologueFYN OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00607759 0.536 IPI00029769 0.172
human IPI00607759 0.536 IPI00016871 0.411
human IPI00607759 0.536 IPI00013864 0.058
human IPI00607759 0.536 IPI00298625 0.117
human IPI00607759 0.536 IPI00479530 0.12
human IPI00607759 0.536 IPI00396447 0.309
human IPI00607759 0.536 IPI00013981 0.47
human IPI00607759 0.536 IPI00328867 0.386
human IPI00607759 0.536 IPI00306217 0.097
human IPI00465250 0.585 IPI00029769 0.172
human IPI00465250 0.585 IPI00016871 0.411
human IPI00465250 0.585 IPI00013864 0.058
human IPI00465250 0.585 IPI00298625 0.117
human IPI00465250 0.585 IPI00479530 0.12
human IPI00465250 0.585 IPI00396447 0.309
human IPI00465250 0.585 IPI00013981 0.47
human IPI00465250 0.585 IPI00328867 0.386
human IPI00465250 0.585 IPI00306217 0.097
worm Q9N597 0.536 Q9BKW3 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.23E-3
Domains Domains present in PIK3R2 and FYN:
Domains in PIK3R2Domains in FYN
IPR008936 Rho GTPase activation protein
IPR001452 SH3
IPR000198 RhoGAP domain
IPR000980 SH2 motif
IPR001720 PI3 kinase, P85 regulatory subunit
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR001452 SH3
IPR000980 SH2 motif

The Chi square scores for co-occurrence of domains that are present in PIK3R2 and FYN are listed below.

Domain 1Domain 2Chi Square
IPR000980 SH2 motif IPR008266 Tyrosine protein kinase, active site 383.26
IPR000980 SH2 motif IPR001245 Tyrosine protein kinase 238.73
IPR001452 SH3 IPR008266 Tyrosine protein kinase, active site 164.706
IPR001452 SH3 IPR001245 Tyrosine protein kinase 100.857
IPR000980 SH2 motif IPR000719 Protein kinase 82.1364
IPR000980 SH2 motif IPR011009 Protein kinase-like 59.6059
IPR001452 SH3 IPR000980 SH2 motif 59.5667
IPR000980 SH2 motif IPR000980 SH2 motif 36.445
IPR001720 PI3 kinase, P85 regulatory subunit IPR008266 Tyrosine protein kinase, active site 28.9958
IPR008936 Rho GTPase activation protein IPR001452 SH3 27.5985
IPR001452 SH3 IPR000719 Protein kinase 27.1334
IPR000198 RhoGAP domain IPR001452 SH3 27.0617
IPR008936 Rho GTPase activation protein IPR000980 SH2 motif 23.5086
IPR000198 RhoGAP domain IPR000980 SH2 motif 22.7927
IPR001720 PI3 kinase, P85 regulatory subunit IPR001245 Tyrosine protein kinase 20.8688
IPR001452 SH3 IPR011009 Protein kinase-like 20.4416
IPR001720 PI3 kinase, P85 regulatory subunit IPR001452 SH3 16.1413
IPR001720 PI3 kinase, P85 regulatory subunit IPR000980 SH2 motif 14.0342
IPR001720 PI3 kinase, P85 regulatory subunit IPR011009 Protein kinase-like 9.64929
IPR001720 PI3 kinase, P85 regulatory subunit IPR000719 Protein kinase 9.22233
IPR008936 Rho GTPase activation protein IPR008266 Tyrosine protein kinase, active site 9.21621
IPR000198 RhoGAP domain IPR008266 Tyrosine protein kinase, active site 7.61405
IPR008936 Rho GTPase activation protein IPR001245 Tyrosine protein kinase 5.16024
IPR000198 RhoGAP domain IPR001245 Tyrosine protein kinase 3.84971
IPR001452 SH3 IPR001452 SH3 3.15089
IPR008936 Rho GTPase activation protein IPR000719 Protein kinase 0.485319
IPR000198 RhoGAP domain IPR000719 Protein kinase 0.472387
IPR008936 Rho GTPase activation protein IPR011009 Protein kinase-like 0.0380864
IPR000198 RhoGAP domain IPR011009 Protein kinase-like 0.00301614

The background colour of the table refers to:

  • Blue Domain is only present in PIK3R2
  • Yellow Domain is only present in FYN
  • Green Domain is present in both PIK3R2 and FYN

1.30
Post-translational Modifications

Protein: PIK3R2

PTMResidueReference
Phosphotyrosine 464 HPRD

Protein: FYN

PTMResidueReference
Dephosphorylation 420 PubMed, HPRD
Dephosphorylation 531 PubMed, HPRD
Myristoylation 2 PubMed, HPRD
Palmitoylation 3 PubMed, HPRD
Phosphorylation 28 PubMed, HPRD
Phosphorylation 30 PubMed, HPRD
Phosphorylation 39 PubMed, HPRD
Phosphorylation 420 PubMed, HPRD
Phosphorylation 531 PubMed, HPRD
Phosphotyrosine 530 HPRD
Proteolytic Cleavage 19 PubMed, HPRD
Localisation

Protein: PIK3R2

LocalisationReference
Plasma membrane HPRD
Cytoplasm HPRD

Protein: FYN

LocalisationReference
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between PIK3R2 and FYN that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between PIK3R2 andFYN. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , PIK3R2 has 968 interactors and FYN has 1745 interactors of which there are 902 common interactors.

Common InteractorName of Common InteractorScore for PIK3R2-Interactor (?)Score for FYN-Interactor (?)
INSR INSR: Insulin receptor precursor 388.00 0.878
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 315.00 1.01E3
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 250.00 422.00
BMX N/A 2.42 1.30
INSL3 JAK3: Tyrosine-protein kinase JAK3 1.98 1.30
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 1.53 0.617
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 1.53 0.617
RPL3 RPL3, OK/SW-cl.32: 60S ribosomal protein L3 1.42 0.025
FLT4 VEGFR3 long form 1.37 0.553
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 1.33 0.878
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 1.30 1.30
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 1.20 1.30
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 1.17 1.30
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 1.17 1.17
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 1.07 563.00
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 1.07 563.00
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 1.07 1.17
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 1.05 1.30
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 1.01 0.878
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.980 0.980
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.980 0.980
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.980 0.980
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.975 1.30
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.975 1.30
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.902 0.980
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.878 0.878
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.878 0.980
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.878 0.878
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.878 0.878
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.874 1.17
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.872 1.30
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.808 0.878
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.808 0.878
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.808 0.878
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.808 1.01E3
LYN LYN: Tyrosine-protein kinase Lyn 0.781 1.17
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.781 563.00
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.781 563.00
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.781 1.30
SYK SYK: Tyrosine-protein kinase SYK 0.781 1.30
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.781 1.30
JAK1 0.781 1.30
CSK CSK: Tyrosine-protein kinase CSK 0.781 1.17
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.775 1.30
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.770 1.30
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.731 0.980
MET MET: Hepatocyte growth factor receptor precursor 0.731 0.980
HCK N/A 0.694 1.17
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.694 1.17
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.694 1.17
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.655 0.878
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.655 0.878
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.655 0.878
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.655 0.878
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.655 422.00
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.617 0.617
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.617 0.617
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.586 0.878
KIT KIT: Mast/stem cell growth factor receptor precursor 0.577 422.00
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.577 0.878
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.553 0.553
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.520 0.878
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.520 0.878
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.520 0.878
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.483 0.483
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.448 0.980
ALK ALK: ALK tyrosine kinase receptor precursor 0.361 0.483
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.265 0.265
TNK1 TNK1: Non-receptor tyrosine-protein kinase TNK1 0.237 0.237
TLN2 TLN2: Uncharacterized protein TLN2 0.225 0.148
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.225 0.165
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.225 0.148
MUSK MUSK: Muscle, skeletal receptor tyrosine protein kinase precursor 0.225 0.217
INSRR INSRR, IRR: Insulin receptor-related protein precursor 0.225 0.195
FGFR2 N/A 0.217 0.217
RET urf-ret: Urf-ret protein 0.200 0.217
STYK1 STYK1, NOK: Tyrosine protein-kinase STYK1 0.200 0.217
AMHR2 AMHR2, AMHR: Anti-Muellerian hormone type-2 receptor precursor 0.200 0.217
TYRO3 TYRO3, BYK, DTK, RSE, SKY: Tyrosine-protein kinase receptor TYRO3 precursor 0.200 0.217
DDR1 DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE: Epithelial discoidin domain-con 0.195 0.195
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.191 1.30
CTTN CTTN, EMS1: Src substrate cortactin 0.191 4.22
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.191 0.165
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.191 0.165
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.191 0.165
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.191 0.165
ROR2 ROR2, NTRKR2: Tyrosine-protein kinase transmembrane receptor ROR2 precursor 0.179 0.195
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.177 0.265
FYN N/A 0.176 0.265
MATK DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212 0.176 0.265
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.171 0.148
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.171 0.148
MYO3A MYO3A: Myosin IIIA 0.171 0.148
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.171 0.148
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.171 0.148
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.171 0.148
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.171 0.148
PRLR PRLR: Prolactin receptor precursor 0.166 0.109
TP73 TP73, P73: Tumor protein p73 0.166 0.109
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.166 0.109
MAPKAPK5 N/A 0.165 0.165
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.165 0.165
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.165
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.165 0.165
PSCD2 N/A 0.165 0.165
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.165 0.165
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.165 1.30
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.165 0.148
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.165
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.165 0.165
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.165 1.30
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.165 0.165
MAPK15 N/A 0.165 0.165
NF2 NF2, SCH: Merlin 0.165 0.165
AMPH AMPH, AMPH1: Amphiphysin 0.165 0.165
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.165 0.165
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.165 0.165
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.165
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 1.30
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.165 0.165
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.165 0.165
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.152 0.165
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.152 0.165
SPTAN1 N/A 0.152 0.165
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.152 0.165
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.148 0.098
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.148 1.30
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.148 0.148
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.148 0.148
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.148 0.148
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.148
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.148 0.148
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.148 0.148
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.148 0.025
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.148 0.148
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.148
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.148
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.148 0.148
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.148 0.148
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.148 0.148
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.148 0.148
RAB5B RAB5B: Ras-related protein Rab-5B 0.148 0.025
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.148 0.148
ELMO1 N/A 0.148 0.148
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.148 170.00
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.148 0.148
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.148 0.148
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.148 0.148
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.148 0.148
CDC2 CDC2: Cell division control protein 2 homolog 0.148 0.148
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.148 0.148
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.148 0.165
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.148 0.148
STAT3 0.148 1.17
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.148 0.148
ARHGEF7 N/A 0.148 0.148
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.148 0.148
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.148 1.17
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.148 0.148
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.148 0.148
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.148
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.148 0.148
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.148 0.148
KIAA0031 EFTUD2, KIAA0031, SNRP116: 116 kDa U5 small nuclear ribonucleoprotein component 0.148 0.025
ROR1 ROR1, NTRKR1: Tyrosine-protein kinase transmembrane receptor ROR1 precursor 0.145 0.195
RYK RYK, JTK5A: Tyrosine-protein kinase RYK precursor 0.145 0.217
TIE1 TIE1, TIE: Tyrosine-protein kinase receptor Tie-1 precursor 0.143 0.217
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.136 0.148
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.136 0.148
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.136 0.148
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.136 0.148
RRAD RRAD, RAD: GTP-binding protein RAD 0.136 0.028
DAB1 DAB1: Disabled homolog 1 0.136 71.20
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.136 0.148
CDK5 CDK5: Cell division protein kinase 5 0.136 0.148
PLD1 PLD1: Phospholipase D1 0.136 0.148
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.136 0.148
TTN N/A 0.136 0.148
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.136 0.148
RDX RDX: Radixin 0.136 0.148
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.136 0.148
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.136 0.148
LTK LTK, TYK1: Leukocyte tyrosine kinase receptor precursor 0.128 0.195
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.126 0.109
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.126 0.109
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.125 0.187
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.123 0.165
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.123 0.165
COBL N/A 0.123 0.165
RHOB RHOB, ARH6, ARHB: Rho-related GTP-binding protein RhoB precursor 0.123 0.025
GAB1 GAB1: GRB2-associated-binding protein 1 0.123 0.165
GRLF1 N/A 0.123 0.165
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.123 0.165
CDKL5 N/A 0.123 0.165
TUBA6 TUBA1C, TUBA6: Tubulin alpha-1C chain 0.113 0.098
CDK4 CDK4: Cell division protein kinase 4 0.111 0.148
DAB2 DAB2, DOC2: Disabled homolog 2 0.111 0.148
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.111 0.148
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.111 0.148
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.111 0.148
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.111 0.148
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.111 0.148
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.111 0.148
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.111 0.148
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.111 0.148
STAM2 STAM2: Signal transducing adapter molecule 2 0.111 0.148
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.111 0.148
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.111 0.148
PSD TYL: TYL protein 0.111 0.148
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.111 0.148
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.111 0.165
RAN RAN, ARA24, OK/SW-cl.81: GTP-binding nuclear protein Ran 0.111 0.025
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.111 0.148
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.111 0.148
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.111 0.148
APS SH2B2, APS: SH2B adapter protein 2 0.111 1.17
WEE1 WEE1: Wee1-like protein kinase 0.111 0.165
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.111 0.148
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.111 0.148
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.111 0.148
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.111 71.20
CDK2 CDK2: Cell division protein kinase 2 0.111 0.148
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.111 0.148
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.111 0.148
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.111 0.148
PRKAA1 N/A 0.110 0.165
VASP VASP: Vasodilator-stimulated phosphoprotein 0.110 0.165
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.110 1.30
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.110 0.165
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.110 0.028
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.110 1.30
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.110 0.165
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.109 0.109
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.109 0.109
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.109 0.109
LAT LAT: Linker for activation of T-cells family member 1 0.109 0.109
CCR2 CCR2, CMKBR2: C-C chemokine receptor type 2 0.109 0.109
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.109 0.109
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.109 0.109
NULL A1BG: Alpha-1B-glycoprotein precursor 0.109 0.109
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.109 0.098
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.109 0.109
KIR3DL1 N/A 0.109 0.109
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.109 0.098
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.109 0.109
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.109 0.109
FN1 N/A 0.109 0.109
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.109 0.109
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.109 0.109
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.109 0.109
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.109 0.165
DAPK2 DAPK2: Death-associated protein kinase 2 0.109 0.165
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.109 0.165
GAB2 N/A 0.109 0.165
IRS1 IRS1: Insulin receptor substrate 1 0.109 0.165
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.109 0.165
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.109 0.165
IRS2 IRS2: Insulin receptor substrate 2 0.109 0.165
CNN3 CNN3: Calponin-3 0.109 0.148
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.100 0.109
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.100 0.109
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.100 0.109
TUBB3 TUBB3, TUBB4: Tubulin beta-3 chain 0.100 0.109
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.100 0.109
SCML2 SCML2: Sex comb on midleg-like protein 2 0.100 0.109
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.099 0.148
PSCD4 PSCD4, CYT4: Cytohesin-4 0.099 0.148
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.099 0.148
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.099 7.88
VAV1 VAV1, VAV: Proto-oncogene vav 0.099 1.17
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.099 1.17
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.099 0.148
ATM ATM: Serine-protein kinase ATM 0.099 0.148
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.099 0.148
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.099 0.148
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.099 0.148
FNBP1 N/A 0.099 4.22
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.099 1.17
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.099 0.148
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.099 0.148
DYNC1LI1 DYNC1LI1, DNCLI1: Cytoplasmic dynein 1 light intermediate chain 1 0.099 0.025
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.099 0.148
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.099 7.88
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.099 0.148
DOK1 DOK1: Docking protein 1 0.099 0.148
RPS6KB1 N/A 0.099 0.148
STAT6 STAT6: Signal transducer and activator of transcription 6 0.099 1.17
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.099 0.148
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.099 0.148
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.099 0.148
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.099 0.148
RAP1A RAP1A, KREV1: Ras-related protein Rap-1A precursor 0.099 0.025
WASPIP N/A 0.099 7.88
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.099 0.148
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.099 0.148
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.098 0.165
ROCK1 ROCK1: Rho-associated protein kinase 1 0.098 0.165
STK16 N/A 0.098 0.165
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.098 0.165
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.098 1.30
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.098 1.30
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.098 0.165
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.098 0.165
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.098 0.165
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.098 0.165
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.098 1.30
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.098 0.165
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.098 0.165
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.098 0.165
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.098 0.098
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.098 0.098
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.098 0.098
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.098 0.098
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.098 0.098
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.098 0.878
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.098 0.098
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.098 0.098
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.098 0.098
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.098 0.098
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.098 0.098
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.098
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.097 0.148
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.097 0.148
SORBS3 SORBS3, SCAM1: Vinexin 0.097 71.20
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.097 199.00
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.097 0.148
NRAS NRAS, HRAS1: GTPase NRas precursor 0.097 0.025
CRKL CRKL: Crk-like protein 0.097 1.17
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.097 0.148
CDK7 CDK7, MO15: Cell division protein kinase 7 0.097 0.148
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.097 0.148
CDK6 CDK6: Cell division protein kinase 6 0.097 0.165
TLN1 TLN1: Uncharacterized protein TLN1 0.097 0.148
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.097 0.148
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.097 0.165
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.097 0.148
PLD2 PLD2: Phospholipase D2 0.097 0.148
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.097 0.148
DYRK3 N/A 0.097 0.148
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.097 0.148
RASA3 RASA3: Ras GTPase-activating protein 3 0.097 0.148
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.097 0.148
RPS6KA6 RPS6KA6, RSK4: Ribosomal protein S6 kinase alpha-6 0.094 0.062
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.093 0.148
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.090 0.878
K-ALPHA-1 TUBA1B: Tubulin alpha-1B chain 0.090 0.098
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.090 0.098
TUBB2A TUBB2A, TUBB2: Tubulin beta-2A chain 0.090 0.098
TUBB TUBB, TUBB5, OK/SW-cl.56: Tubulin beta chain 0.090 0.098
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.090 0.098
VIL2 N/A 0.088 0.148
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.088 0.148
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.088 0.148
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.088 0.165
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.088 0.148
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.088 0.148
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.088 0.148
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.088 0.148
EIF5B EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B 0.088 0.025
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.088 0.148
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.088 0.148
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.088 0.148
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.088 0.148
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.088 0.148
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.088 0.148
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.088 0.148
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.088 0.148
RRAS RRAS: Ras-related protein R-Ras precursor 0.088 0.025
CXorf9 N/A 0.088 0.148
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.088 563.00
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.088 0.148
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.088 0.148
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.088 0.148
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.088 0.148
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.088 0.148
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.088 0.148
CD2AP CD2AP: CD2-associated protein 0.088 0.148
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.088 0.148
EEF2 EEF2, EF2: Elongation factor 2 0.088 0.025
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.088 0.148
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.088 0.165
FABP3 FABP3, FABP11, MDGI: Fatty acid-binding protein, heart 0.086 0.075
SNCA SNCA, NACP, PARK1: Alpha-synuclein 0.083 0.165
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.083 0.083
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.081 0.109
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.081 0.980
CEBPA CEBPA: CCAAT/enhancer-binding protein alpha 0.081 0.109
GHR GHR: Growth hormone receptor precursor 0.081 0.109
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.081 0.109
EPOR EPOR: Erythropoietin receptor precursor 0.081 0.109
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.081 0.109
STAT2 STAT2: Signal transducer and activator of transcription 2 0.081 0.980
CENPA CENPA: Histone H3-like centromeric protein A 0.081 0.109
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.081 0.109
IL9R IL9R: Interleukin-9 receptor precursor 0.081 0.109
SNCG SNCG, BCSG1, PERSYN, PRSN: Gamma-synuclein 0.080 0.165
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.078 0.148
STK10 STK10: Uncharacterized protein STK10 0.078 0.148
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.078 0.025
MSN MSN: Moesin 0.078 0.148
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.078 0.165
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.078 0.148
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.078 0.148
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.073 0.098
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.073 0.109
H2AFX H2AFX, H2AX: Histone H2A.x 0.073 0.098
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.073 0.098
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.073 0.098
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.0727 0.109
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.0727 0.109
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.0727 0.109
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.0727 0.109
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.0727 0.109
PLEK PLEK, P47: Pleckstrin 0.0727 0.109
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.0727 0.980
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.0727 0.109
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.0727 0.109
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.0727 0.109
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.072 0.109
MS4A1 MS4A1, CD20: B-lymphocyte antigen CD20 0.072 0.109
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.072 0.109
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.072 0.109
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.072 0.109
CD5 CD5, LEU1: T-cell surface glycoprotein CD5 precursor 0.072 0.109
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.072 0.109
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.072 0.109
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.072 0.109
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.072 0.109
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.071 0.148
NCK2 NCK2: Cytoplasmic protein NCK2 0.070 1.17
FABP5 FABP5: Fatty acid-binding protein, epidermal 0.069 0.075
FXR2 FXR2, FMR1L2: Fragile X mental retardation syndrome-related protein 2 0.069 0.075
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.0688 0.0688
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.067 0.109
PVR PVR, PVS: Poliovirus receptor precursor 0.067 0.109
ADCY3 ADCY3, KIAA0511: Adenylate cyclase type 3 0.067 0.049
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.065 0.098
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.065 0.098
H3F3A H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3 0.065 0.098
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.065 0.098
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.065 0.109
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.065 0.109
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.065 0.109
CD3D CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor 0.065 0.109
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.065 0.109
F3 F3: Tissue factor precursor 0.065 0.109
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.065 0.109
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.065 0.109
CCR5 CCR5: CCR5 receptor (Fragment) 0.065 0.109
ETS2 ETS2: Protein C-ets-2 0.065 0.109
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.065 0.109
LILRB1 N/A 0.065 0.109
MCF2 MCF2, DBL: Proto-oncogene DBL 0.064 0.165
TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 0.064 0.098
SOS1 SOS1: Son of sevenless homolog 1 0.064 0.098
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.064 0.098
HIST1H4A HIST1H4A, H4/A, HIST1H4B, H4/I, H4/G, HIST1H4D, H4/B, H4/J, HIST1H4F, HIST4H4, H 0.064 0.098
HD HD, IT15: Huntingtin 0.062 0.083
PHB2 PHB2, BAP, REA: Prohibitin-2 0.062 0.083
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.062 0.083
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.060 0.165
PDE6G DKFZp686N1686, PDE6G, hCG_38056: Putative uncharacterized protein DKFZp686N1686 0.059 0.051
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.058 0.109
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.058 0.098
STAT4 STAT4: Signal transducer and activator of transcription 4 0.058 0.878
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.058 422.00
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.058 0.098
HIST1H3A HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, 0.058 0.098
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.058 0.098
HIST3H3 HIST3H3, H3FT: Histone H3.1t 0.058 0.098
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.058 0.109
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.058 0.148
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.057 0.062
DLG2 DLG2: Disks large homolog 2 0.057 0.062
ATP4A ATP4A: Potassium-transporting ATPase alpha chain 1 0.057 0.049
PRKACB PRKACB: cAMP-dependent protein kinase, beta-catalytic subunit 0.056 0.165
MAP2K5 N/A 0.056 0.165
CNN2 CNN2: Calponin-2 0.056 0.148
GRK7 GRK7, GPRK7: G protein-coupled receptor kinase 7 precursor 0.056 0.056
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.056 0.165
PMP2 PMP2: Myelin P2 protein 0.056 0.075
FABP4 FABP4: Fatty acid-binding protein, adipocyte 0.056 0.075
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.056 0.028
FUBP1 N/A 0.056 0.083
KIAA1967 KIAA1967, DBC1: Protein KIAA1967 0.054 0.148
YWHAG YWHAG: 14-3-3 protein gamma 0.052 0.028
S100A16 S100A16, AAG13: Protein S100-A16 0.052 0.165
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.052 0.878
PTPNS1 SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP: Tyrosine-protein phosphatase non-rec 0.051 0.051
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
C6orf21 LY6G6F, C6orf21, G6F, LY6G6D, NG32: Lymphocyte antigen 6 complex locus protein G 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.617
C6orf25 G6B, C6orf25: Protein G6b precursor 0.051 0.051
CRK CRK: Proto-oncogene C-crk 0.051 0.617
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
KIRREL KIRREL, KIRREL1, NEPH1: Kin of IRRE-like protein 1 precursor 0.051 0.051
GRB10 N/A 0.051 0.617
DBNL DBNL, CMAP, PP5423, SH3P7: Drebrin-like protein 0.051 0.051
TJP2 TJP2, X104, ZO2: Tight junction protein ZO-2 0.051 0.051
UBAP2L N/A 0.051 0.051
MAPK7 MAPK7, ERK4, ERK5, PRKM7: Mitogen-activated protein kinase 7 0.051 0.046
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
CDC42EP1 CDC42EP1, BORG5, CEP1, MSE55: Cdc42 effector protein 1 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.617
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 0.051 0.051
GSK3B GSK3B: Glycogen synthase kinase-3 beta 0.051 0.051
MAPK11 MAPK11, PRKM11, SAPK2: Mitogen-activated protein kinase 11 0.051 0.051
PTPRA N/A 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
MT3 MT3: Metallothionein-3 0.051 0.165
CENTA1 CENTA1: Centaurin-alpha 1 0.051 0.0688
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.051 0.109
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.051 0.109
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.051 0.109
ITGB3 ITGB3, GP3A: Integrin beta-3 precursor 0.051 0.044
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.050 0.148
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.050 0.050
RASD1 RASD1, AGS1, DEXRAS1: Dexamethasone-induced Ras-related protein 1 precursor 0.050 0.025
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.050 0.148
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.050 0.165
GMIP GMIP: GEM-interacting protein 0.050 0.148
KALRN DUET, TRAD: Serine/threonine-protein kinase Duet 0.050 0.027
ARHGEF15 ARHGEF15, KIAA0915: Rho guanine nucleotide exchange factor 15 0.050 0.027
HES6 HES6: Transcription cofactor HES-6 0.049 0.049
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.049 0.148
SNCB SNCB: Beta-synuclein 0.048 0.165
S100A7 S100A7, PSOR1: Protein S100-A7 0.048 0.165
YWHAH YWHAH, YWHA1: 14-3-3 protein eta 0.048 0.028
GJA5 GJA5: Gap junction alpha-5 protein 0.047 0.051
CTLA4 CTLA4, CD152: Cytotoxic T-lymphocyte protein 4 precursor 0.047 0.051
CDC25A CDC25A: M-phase inducer phosphatase 1 0.047 0.148
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.047 0.165
GSN GSN: Gelsolin precursor 0.047 0.047
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.047 0.148
SVIL SVIL: Supervillin 0.047 0.047
ACTN4 ACTN4: Alpha-actinin-4 0.047 0.148
CDC25C CDC25C: M-phase inducer phosphatase 3 0.047 0.148
NOS1 NOS1: Nitric-oxide synthase, brain 0.046 0.025
VAV2 VAV2: Uncharacterized protein VAV2 0.046 0.553
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.046 0.553
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.046 0.046
LRIG2 LRIG2, KIAA0806, LIG2: Leucine-rich repeats and immunoglobulin-like domains prot 0.046 0.046
EPB41 EPB41, E41P: Protein 4.1 0.046 0.046
SYN1 SYN1: Synapsin-1 0.046 0.046
BCAR1 BCAR1, CAS, CRKAS: Breast cancer anti-estrogen resistance protein 1 0.046 22.10
MAPK14 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2: Mitogen-activated protein kinase 14 0.046 0.046
RIN1 RIN1: Ras and Rab interactor 1 0.046 1.17
GRIN2A GRIN2A, NMDAR2A: Glutamate [NMDA] receptor subunit epsilon-1 precursor 0.046 0.030
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.046 0.098
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.046 0.098
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.0453 0.109
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.0453 0.049
KIF22 KIF22, KID, KNSL4: Kinesin-like protein KIF22 0.0453 0.049
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.045 0.0688
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.045 0.0688
NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 0.044 0.075
HDLBP HDLBP, HBP, VGL: Vigilin 0.044 0.075
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.044 0.075
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.044 0.075
PCBP2 PCBP2: Poly(rC)-binding protein 2 0.044 0.075
WWC2 WW and C2 domain containing 2 0.044 0.025
FER1L3 FER1L3, KIAA1207, MYOF: Myoferlin 0.044 0.025
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.044 0.109
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.044 0.109
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.044 0.109
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.044 0.109
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.044 0.109
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.044 0.109
ADCY6 ADCY6, KIAA0422: Adenylate cyclase type 6 0.044 0.044
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.044 0.044
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.044 0.044
STOM STOM, BND7, EPB72: Erythrocyte band 7 integral membrane protein 0.044 0.044
FREQ FREQ, FLUP, NCS1: Neuronal calcium sensor 1 0.043 0.148
MYL4 MYL4, MLC1, PRO1957: Myosin light polypeptide 4 0.043 0.148
VIL1 VIL1, VIL: Villin-1 0.043 0.052
HPCA HPCA, BDR2: Neuron-specific calcium-binding protein hippocalcin 0.043 0.165
RGS16 RGS16, RGSR: Regulator of G-protein signaling 16 0.0425 0.028
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.042 0.046
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.0416 0.165
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.0407 0.109
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.0407 0.109
FASLG FASLG, APT1LG1, FASL, TNFSF6: Tumor necrosis factor ligand superfamily member 6 0.0407 0.109
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.0407 0.109
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.0407 0.109
GRIK2 GRIK2, GLUR6: Glutamate receptor, ionotropic kainate 2 precursor 0.041 0.044
HPN HPN, TMPRSS1: Serine protease hepsin 0.041 0.049
GRIN1 GRIN1, NMDAR1: Glutamate [NMDA] receptor subunit zeta-1 precursor 0.041 0.044
KCNJ12 KCNJ12, IRK2, KCNJN1: ATP-sensitive inward rectifier potassium channel 12 0.041 0.044
KIF3A KIF3A, KIF3: Kinesin-like protein KIF3A 0.041 0.044
GRIA1 GRIA1, GLUH1, GLUR1: Glutamate receptor 1 precursor 0.041 21.10
GRIA4 GRIA4, GLUR4: Glutamate receptor 4 precursor 0.041 0.044
KRTHA8 KRTHA8, HHA8, HKA8: Keratin, type I cuticular Ha8 0.041 0.027
HIST2H2AC HIST2H2AC, H2AFQ: Histone H2A type 2-C 0.040 0.098
CNTN4 CNTN4: Contactin-4 precursor 0.040 0.098
CNTN1 CNTN1: Contactin-1 precursor 0.040 0.098
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.040 46.90
BSG N/A 0.040 0.098
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.040 0.098
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.040 0.148
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.039 0.083
TNIK TNIK, KIAA0551: TRAF2 and NCK-interacting protein kinase 0.038 0.051
SYN2 SYN2: Synapsin-2 0.038 0.051
GJB1 GJB1, CX32: Gap junction beta-1 protein 0.038 0.051
GJA1 GJA1, GJAL: Gap junction alpha-1 protein 0.038 0.051
PITPNM1 PITPNM1: Uncharacterized protein PITPNM1 0.038 0.075
FKBP8 DKFZp686M22160: Putative uncharacterized protein DKFZp686M22160 (Fragment) 0.038 0.028
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.037 0.050
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.037 0.148
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.037 0.148
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.037 0.165
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.037 0.165
KCNJ1 KCNJ1, ROMK1: ATP-sensitive inward rectifier potassium channel 1 0.037 0.04
KIF23 N/A 0.037 0.049
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.037 0.109
TNF TNF, TNFA, TNFSF2: Tumor necrosis factor precursor 0.037 0.049
LIMK2 LIMK2: LIM domain kinase 2 0.037 0.165
VWF VWF, F8VWF: von Willebrand factor precursor 0.037 0.062
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.037 0.062
MCOLN1 MCOLN1, ML4, MSTP080: Mucolipin-1 0.037 0.062
NEO1 NEO1, NGN: Neogenin precursor 0.036 0.098
PTPRZ1 N/A 0.036 0.109
NCKIPSD NCKIPSD, AF3P21, SPIN90: SH3 adapter protein SPIN90 0.036 0.027
CETN1 CETN1, CEN1, CETN: Centrin-1 0.036 0.109
GGA3 GGA3, KIAA0154: ADP-ribosylation factor-binding protein GGA3 0.036 0.044
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.035 0.148
CHP CHP: Calcium-binding protein p22 0.035 0.148
EHD2 EHD2, PAST2: EH domain-containing protein 2 0.035 0.148
KLC2 KLC2: Kinesin light chain 2 0.035 0.047
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.035 0.165
GRIN2B GRIN2B, NMDAR2B: Glutamate [NMDA] receptor subunit epsilon-2 precursor 0.035 0.030
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.034 0.052
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.034 0.165
SYN3 SYN3: Synapsin-3 0.034 0.046
CACNG2 CACNG2: Voltage-dependent calcium channel gamma-2 subunit 0.034 0.046
PECAM1 PECAM1: Platelet endothelial cell adhesion molecule precursor 0.034 0.051
CDC42EP3 CDC42EP3, BORG2, CEP3: Cdc42 effector protein 3 0.034 0.051
CNN1 CNN1: Calponin-1 0.034 0.046
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.033 0.148
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.033 0.148
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.033 0.148
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.0333 0.087
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.033 0.165
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.033 0.165
LIG4 LIG4: DNA ligase 4 0.033 0.036
CLTC CLTC, CLH17, CLTCL2, KIAA0034: Clathrin heavy chain 1 0.033 0.036
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.033 0.109
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.033 0.109
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.033 0.109
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.033 0.109
GPA33 GPA33: Cell surface A33 antigen precursor 0.033 0.109
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.033 0.109
SEMA5A SEMA5A, SEMAF: Semaphorin-5A precursor 0.033 0.044
SDC4 SDC4: Syndecan-4 precursor 0.033 0.044
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.033 0.148
RAB32 RAB32: Ras-related protein Rab-32 0.033 0.056
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.033 0.165
IRF3 IRF3: Interferon regulatory factor 3 0.033 0.049
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.033 0.062
ATP2B1 N/A 0.032 0.049
CAMKV CAMKV: Uncharacterized protein CAMKV 0.032 0.025
NOL3 N/A 0.032 0.028
NEF3 NEFM, NEF3, NFM: Neurofilament medium polypeptide 0.032 0.028
EPN1 N/A 0.032 0.028
LCP1 LCP1, PLS2: Plastin-2 0.031 0.148
YWHAB YWHAB: 14-3-3 protein beta/alpha 0.031 0.025
SEC24B SEC24B: Protein transport protein Sec24B 0.031 0.047
FLII FLII, FLIL: Protein flightless-1 homolog 0.031 0.047
ACTN1 ACTN1: Alpha-actinin-1 0.031 0.148
RYR2 RYR2: Ryanodine receptor 2 0.031 0.0688
ALOX5 ALOX5, LOG5: Arachidonate 5-lipoxygenase 0.031 0.052
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.031 0.165
YWHAQ YWHAQ: 14-3-3 protein theta 0.031 0.028
JUP JUP, CTNNG, DP3: Junction plakoglobin 0.0308 0.075
EPM2A EPM2A: Laforin 0.0308 0.027
MAP2K7 MAP2K7, JNKK2, MEK7, MKK7, PRKMK7: Dual specificity mitogen-activated protein ki 0.0308 0.027
SPTBN4 SPTBN4, KIAA1642, SPTBN3: Spectrin beta chain, brain 3 0.0308 0.027
CAMK2A CAMK2A, CAMKA, KIAA0968: Calcium/calmodulin-dependent protein kinase type II alp 0.0308 0.027
AHI1 N/A 0.0308 0.027
ASB1 ASB1: Uncharacterized protein ASB1 0.0308 0.027
PRKG2 PRKG2, PRKGR2: cGMP-dependent protein kinase 2 0.0308 0.027
ASB4 ASB4: Ankyrin repeat and SOCS box protein 4 0.0308 0.027
TRIM46 TRIM46, TRIFIC: Tripartite motif-containing protein 46 0.0308 0.027
CLDN3 CLDN3, C7orf1, CPETR2: Claudin-3 0.030 0.051
KCNH2 KCNH2, ERG, ERG1, HERG, HERG1: Potassium voltage-gated channel subfamily H membe 0.030 0.030
HNRPH3 HNRPH3: Heterogeneous nuclear ribonucleoprotein H3 0.030 0.030
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.030 0.030
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.0296 0.148
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.0296 0.148
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.030 0.098
DCC DCC: Netrin receptor DCC precursor 0.030 0.098
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.030 0.098
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.030 0.098
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.030 0.098
CRLF3 N/A 0.029 0.109
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.029 0.109
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.029 0.109
CXCR4 CXCR4: C-X-C chemokine receptor type 4 0.029 0.109
CD7 CD7: T-cell antigen CD7 precursor 0.029 0.109
SORL1 SORL1: Sortilin-related receptor precursor 0.029 0.098
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.029 0.044
ITGB7 ITGB7: Integrin beta-7 precursor 0.029 0.044
IL8RB IL8RB, CXCR2: High affinity interleukin-8 receptor B 0.029 0.049
SLC9A1 SLC9A1, APNH1, NHE1: Sodium/hydrogen exchanger 1 0.029 0.049
ADAMDEC1 ADAMDEC1: ADAM DEC1 precursor 0.029 0.109
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.029 0.109
EGF EGF: Pro-epidermal growth factor precursor 0.029 0.109
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.029 0.109
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.029 0.109
ITGB4 N/A 0.029 0.109
APEX1 APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase 0.029 0.044
HES1 HES1, HL, HRY: Transcription factor HES-1 0.029 0.044
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.029 0.044
PARVA PARVA, MXRA2: Alpha-parvin 0.029 0.025
ARVCF ARVCF: Armadillo repeat protein deleted in velo-cardio-facial syndrome 0.029 0.025
CDO1 CDO1: Cysteine dioxygenase type 1 0.029 0.025
ENO2 ENO2: Gamma-enolase 0.029 0.025
MTAP MTAP, MSAP: S-methyl-5-thioadenosine phosphorylase 0.029 0.025
BLK BLK: Tyrosine-protein kinase BLK 0.0288 0.0288
TTN TTN: Uncharacterized protein TTN (Fragment) 0.0288 0.0288
BTK BTK kinase deficient isoform 6: Dominant-negative kinase-deficient Brutons tyros 0.0288 0.0288
NULL N/A 0.0288 0.0288
NTRK3 N/A 0.0288 0.0288
DDR2 DDR2, NTRKR3, TKT, TYRO10: Discoidin domain-containing receptor 2 precursor 0.0288 0.0288
ROS1 ROS1: Proto-oncogene tyrosine-protein kinase ROS precursor 0.0288 0.0288
FES Proto-oncogene c-fes variant 4 0.0288 0.0288
FES FES, FPS: Proto-oncogene tyrosine-protein kinase Fes/Fps 0.0288 0.0288
NULL N/A 0.0288 0.0288
FES Proto-oncogene c-fes variant 3 0.0288 0.0288
NTRK3 NTRK3, TRKC: NT-3 growth factor receptor precursor 0.0288 0.0288
MUSK MUSK: MUSK protein 0.0288 0.0288
TESK2 TESK2: Dual specificity testis-specific protein kinase 2 0.0288 0.0288
NULL Tyrosine kinase 0.0288 0.0288
AATK apoptosis-associated tyrosine kinase 0.0288 0.0288
LNX1 N/A 0.028 0.028
CDC42 N/A 0.028 0.028
PPP1R12C PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C 0.028 0.028
ZNF687 ZNF687, KIAA1441: Zinc finger protein 687 0.028 0.028
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
C9orf88 N/A 0.028 0.028
SH2D3A SH2D3A, NSP1, UNQ175/PRO201: SH2 domain-containing protein 3A 0.028 0.028
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.028 0.052
CASP9 CASP9, MCH6: Caspase-9 precursor 0.028 0.028
STAP2 Uncharacterized protein ENSP00000317912 0.028 0.028
PDE5A PDE5A, PDE5: cGMP-specific 3',5'-cyclic phosphodiesterase 0.028 0.028
PHLDB2 N/A 0.028 0.028
CASP6 CASP6, MCH2: Caspase-6 precursor 0.028 0.028
CCAR1 CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1 0.028 0.028
SIVA SIVA1, SIVA: Apoptosis regulatory protein Siva 0.028 0.028
GPRASP2 GPRASP2: G-protein coupled receptor-associated sorting protein 2 0.028 0.028
AXIN1 0.028 0.028
NCF4 N/A 0.028 0.028
AHSA2 AHSA2, DKFZp564C236, hCG_15158: Putative uncharacterized protein DKFZp564C236 0.028 0.028
TRIM39 TRIM39, RNF23, TFP: Tripartite motif-containing protein 39 0.028 0.028
CASP1 CASP1, IL1BC, IL1BCE: Caspase-1 precursor 0.028 0.028
SPAG6 SPAG6, PF16: Sperm-associated antigen 6 0.028 0.028
CASP8 CASP8, MCH5: Caspase-8 precursor 0.028 0.083
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.028
AKAP12 AKAP12, AKAP250: A-kinase anchor protein 12 0.028 0.083
PKP4 PKP4: Plakophilin-4 0.028 0.028
ABLIM1 ABLIM1, RP11-317F20.1-001: Actin binding LIM protein 1 0.028 0.028
PTPN7 N/A 0.028 0.028
MATK 0.028 0.028
SLC9A3R2 SLC9A3R2: SLC9A3R2 protein (Fragment) 0.028 0.028
CACNB2 N/A 0.028 0.028
WRNIP1 WRNIP1, WHIP: ATPase WRNIP1 0.028 0.025
RYR1 0.028 0.062
KCNB1 KCNB1: Potassium voltage-gated channel subfamily B member 1 0.028 0.030
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.028 0.148
SEC24C SEC24C, KIAA0079: Protein transport protein Sec24C 0.028 0.047
YWHAZ YWHAZ: 14-3-3 protein zeta/delta 0.028 0.025
HPCAL1 HPCAL1, BDR1: Hippocalcin-like protein 1 0.028 0.148
RASAL1 RASAL1, RASAL: RasGAP-activating-like protein 1 0.028 11.50
TBC1D1 TBC1D1, KIAA1108: TBC1 domain family member 1 0.0273 0.046
TAOK1 TAOK1, KIAA1361, MAP3K16: Serine/threonine-protein kinase TAO1 0.0273 0.046
LIG1 LIG1: DNA ligase 1 0.027 0.036
CD44 N/A 0.027 0.049
VEPH1 VEPH1, KIAA1692, VEPH: Ventricular zone-expressed PH domain-containing protein h 0.027 0.027
ASB14 ASB14: Ankyrin repeat and SOCS box protein 14 0.027 0.027
OSBPL6 OSBPL6, ORP6: Oxysterol-binding protein-related protein 6 0.027 0.027
PTPN13 N/A 0.027 0.027
RASGRF2 RASGRF2: Ras protein-specific guanine nucleotide-releasing factor 2 (Fragment) 0.027 0.027
NEBL N/A 0.027 0.027
CDC2L2 N/A 0.027 0.027
DOK6 DOK6: Uncharacterized protein DOK6 0.027 0.027
PXK PXK: PX domain-containing protein kinase-like protein 0.027 0.027
NEK4 NEK4, STK2: Serine/threonine-protein kinase Nek4 0.027 0.027
FANK1 FANK1, HSD13, UNQ6504/PRO21382: Fibronectin type 3 and ankyrin repeat domains pr 0.027 0.027
ASB12 ASB12: Ankyrin repeat and SOCS box protein 12 0.027 0.027
CENTB5 KIAA1716, CENTB5: Centaurin-beta 5 0.027 0.027
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.027 0.265
CAMKK1 CAMKK1, CAMKKA: Calcium/calmodulin-dependent protein kinase kinase 1 0.027 0.027
NOXA1 NOXA1, RP13-927H1.1-001: NADPH oxidase activator 1 0.027 0.027
CASKIN1 N/A 0.027 0.027
ASB6 ASB6: Ankyrin repeat and SOCS box protein 6 0.027 0.027
ASB3 ASB3: ASB3 protein 0.027 0.027
STK35 STK35, CLIK1, PDIK1: Serine/threonine-protein kinase 35 0.027 0.027
OSBPL9 N/A 0.027 0.027
MPP4 MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4 0.027 0.027
PSD3 N/A 0.027 0.027
UBL7 UBL7, BMSCUBP, SB132: Ubiquitin-like protein 7 0.027 0.027
STAC STAC: SH3 and cysteine-rich domain-containing protein 0.027 0.027
ALS2CR7 ALS2CR7: Serine/threonine-protein kinase ALS2CR7 0.027 0.027
TRIM9 TRIM9, KIAA0282, RNF91: Tripartite motif-containing protein 9 0.027 0.027
EFS EFS: Embryonal Fyn-associated substrate 0.027 0.027
PLEKHA4 PLEKHA4, PEPP1: Pleckstrin homology domain-containing family A member 4 0.027 0.027
RASGRF1 RASGRF1, CDC25: Guanine nucleotide-releasing protein 0.027 0.027
DOK5 DOK5, C20orf180: Docking protein 5 0.027 0.027
SORBS2 N/A 0.027 0.027
SOCS4 SOCS4, SOCS7: Suppressor of cytokine signaling 4 0.027 0.265
APBB1 APBB1, FE65, RIR: Amyloid beta A4 precursor protein-binding family B member 1 0.027 0.027
ARHGEF1 ARHGEF1: Rho guanine nucleotide exchange factor 1 0.027 0.027
SH2D1B SH2D1B, EAT2: SH2 domain-containing protein 1B 0.027 0.265
ASB7 ASB7: Ankyrin repeat and SOCS box protein 7 0.027 0.027
CISH CISH, G18: Cytokine-inducible SH2-containing protein 0.027 0.265
MID2 N/A 0.027 0.027
SHANK1 SHANK1: SH3 and multiple ankyrin repeat domains protein 1 0.027 0.027
CADPS2 CADPS2, CAPS2, KIAA1591: Calcium-dependent secretion activator 2 0.027 0.027
ANKK1 ANKK1, PKK2, SGK288: Ankyrin repeat and protein kinase domain-containing protein 0.027 0.027
ASB2 ASB2: Ankyrin repeat and SOCS box protein 2 0.027 0.027
SRA1 APBB3, FE65L2: Amyloid beta A4 precursor protein-binding family B member 3 0.027 0.027
WSB1 WSB1, SWIP1: WD repeat and SOCS box-containing protein 1 0.027 0.027
PDIK1L PDIK1L, CLIK1L: Serine/threonine-protein kinase PDIK1L 0.027 0.027
NEK11 NEK11: Serine/threonine-protein kinase Nek11 0.027 0.027
ASB10 ASB10: Ankyrin repeat and SOCS box protein 10 0.027 0.027
PLEKHA3 PLEKHA3, FAPP1: Pleckstrin homology domain-containing family A member 3 0.027 0.027
ABI3 ABI3, NESH: ABI gene family member 3 0.027 0.027
PPP1R9A PPP1R9A, KIAA1222: Neurabin-1 0.027 0.027
FAM43A N/A 0.027 0.027
ASB17 ASB17: Ankyrin repeat and SOCS box protein 17 0.027 0.027
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
RIPK5 RIPK5, KIAA0472, HDCMD38P, RIP5, SGK496: Receptor-interacting serine/threonine-p 0.027 0.027
CADPS CADPS, CAPS, CAPS1, KIAA1121: Calcium-dependent secretion activator 1 0.027 0.027
TOM1L1 TOM1L1, SRCASM: TOM1-like protein 1 0.0263 0.049
ANXA1 ANXA1, ANX1, LPC1: Annexin A1 0.0263 0.04
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.026 0.109
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.026 0.109
TAF10 TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10 0.026 0.044
TAF6 TAF6, TAF2E, TAFII70: Transcription initiation factor TFIID subunit 6 0.026 0.044
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.026 0.098
FES N/A 0.0258 0.0258
LMO7 LMO7, FBX20, FBXO20, KIAA0858: LIM domain only protein 7 0.026 0.028
BIRC4 BIRC4, API3, IAP3, XIAP: Baculoviral IAP repeat-containing protein 4 0.026 0.028
ESPL1 N/A 0.026 0.028
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.026 0.028
NME1 NME1, NDPKA, NM23: Nucleoside diphosphate kinase A 0.026 0.028
AANAT AANAT, SNAT: Serotonin N-acetyltransferase 0.026 0.028
NEFH NEFH, KIAA0845, NFH: Neurofilament heavy polypeptide 0.026 0.028
GFAP GFAP: Glial fibrillary acidic protein 0.026 0.028
NEDD4L NEDD4L, KIAA0439, NEDL3: E3 ubiquitin-protein ligase NEDD4-like protein 0.026 0.028
RGS4 RGS4: Regulator of G-protein signaling 4 0.026 0.028
PAK3 PAK3, OPHN3: Serine/threonine-protein kinase PAK 3 0.026 0.028
FANCA FANCA, FAA, FACA, FANCH: Fanconi anemia group A protein 0.026 0.028
PEA15 PEA15: Astrocytic phosphoprotein PEA-15 0.026 0.083
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.026 0.028
PRPH PRPH, NEF4, PRPH1: Peripherin 0.026 0.028
PDE4A N/A 0.026 0.028
CSH2 GH1: Somatotropin precursor 0.025 0.034
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.025 0.025
PPP1R9B PPP1R9B, PPP1R6: Neurabin-2 0.025 0.025
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 0.025
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.025 0.025
GIT2 N/A 0.025 0.025
SPAST SPAST, KIAA1083, SPG4: Spastin 0.025 0.025
LTA4H LTA4H, LTA4: Leukotriene A-4 hydrolase 0.025 0.025
RAC1 N/A 0.025 0.025
PDE4B PDE4B, DPDE4: cAMP-specific 3',5'-cyclic phosphodiesterase 4B 0.025 0.025
DPP8 DPP8, DPRP1, MSTP097, MSTP135, MSTP141: Dipeptidyl peptidase 8 0.025 0.025
NCOA5 NCOA5, KIAA1637: Nuclear receptor coactivator 5 0.025 0.028
CFL2 CFL2: Cofilin-2 0.025 0.047
BCOR N/A 0.025 0.025
HSPA8 HSPA8, HSC70, HSP73, HSPA10: Heat shock cognate 71 kDa protein 0.025 0.025
CAMKK1 N/A 0.025 0.025
RAD50 RAD50: DNA repair protein RAD50 0.025 0.025
GOPC GOPC, CAL, FIG: Golgi-associated PDZ and coiled-coil motif-containing protein 0.025 0.025
PRKCB1 N/A 0.025 0.025
DBNL N/A 0.025 0.025
MAP2K3 N/A 0.025 0.025
DCP1B DCP1B: mRNA-decapping enzyme 1B 0.025 0.025
ADK ADK: Adenosine kinase 0.025 0.025
SH3PX3 SH3PX3, DKFZp666B159, hCG_1731072: SH3 and PX domain-containing protein 3. 0.025 0.025
RSN CLIP1, CYLN1, RSN: CAP-Gly domain-containing linker protein 1 0.025 0.025
G3BP2 G3BP2, KIAA0660: Ras GTPase-activating protein-binding protein 2 0.025 0.025
TSC2 TSC2, TSC4: Tuberin 0.025 0.083
MYO18A 0.025 0.028
LMO6 LMO6: LIM domain only protein 6 0.025 0.025
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.025 0.075
CAMK2A N/A 0.025 0.025
GRK6 N/A 0.025 0.025
UBE2R2 UBE2R2, CDC34B, UBC3B: Ubiquitin-conjugating enzyme E2 R2 0.025 0.025
EPN2 N/A 0.025 0.025
UBE2A UBE2A, RAD6A: Ubiquitin-conjugating enzyme E2 A 0.025 0.025
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.025
CHTF18 RUVBL, CHTF18: Protein CTF18 homolog. 0.025 0.025
NDNL2 NDNL2, HCA4, MAGEG1: Melanoma-associated antigen G1 0.025 0.025
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.025 0.075
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.025 0.025
BCR N/A 0.025 0.028
KCNAB2 KCNAB2, KCNA2B, KCNK2: Voltage-gated potassium channel subunit beta-2 0.025 0.075
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.025 0.025
SCRIB N/A 0.025 0.025
PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 0.025 0.025
CARHSP1 CARHSP1: Calcium-regulated heat stable protein 1 0.025 0.025
0.572
Total Score 268.00